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"titulo" => "Vertebral Osteonecrosis and Percutaneous Vertebroplasty"
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"titulo" => "Joint Infections Due to <span class="elsevierStyleItalic">Streptococcus agalactiae</span> in Non Immunocompromised Adults: Presentation of Two Cases"
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"autoresLista" => "Èlia Valls-Pascual, Juan José Alegre-Sancho, José Ivorra-Cortés, José Andrés Román-Ivorra, Nagore Fernández-Llanio-Comella, Inmaculada Chalmeta-Verdejo, Sonia Muñoz-Gil, José Miguel Senabre-Gallego"
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"apellidos" => "Román-Ivorra"
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"titulo" => "Infliximab in Ankylosing Spondylitis Associated With Chronic Hepatitis B Infection. Role of Lamivudine Therapy"
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"nombre" => "José Luis"
"apellidos" => "Calleja Panero"
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"nombre" => "Mónica"
"apellidos" => "Fernández-Castro"
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"nombre" => "José Luis"
"apellidos" => "Andreu Sánchez"
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"titulo" => "Infliximab en la espondilitis anquilosante asociada a infección crónica por el virus de la hepatitis B. Papel del tratamiento con lamivudina"
]
]
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1 => "Hepatitis B"
2 => "Infliximab"
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0 => "Espondilitis anquilosante"
1 => "Hepatitis B"
2 => "Infliximab"
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"resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anti-tumor necrosis factor-a (TNF) therapy has been associated with reactivation of hepatitis B virus infection. Case reports have suggested the concomitant need of lamivudine treatment in patients with HBV infection treated with antiTNFa agents. We describe a case of ankylosing spondylitis with positive HBV surface antigen (HBsAg) treated with infliximab and lamivudine. Clinical response was excellent but when lamivudine therapy was stopped, reactivation of replication viral occurred. After the reintroduction of lamivudine, viral replication was controlled and liver function tests were normalized. Preventive long-term lamivudine therapy is mandatory when anti-TNFa therapy is maintained in patients with chronic HBV infection.</p>"
]
"es" => array:1 [
"resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El tratamiento con agentes contra el factor de necrosis tumoral (TNF) alfa se ha asociado a la reactivación de la infección crónica por el virus de la hepatitis B. Algunos casos publicados indican la necesidad de tratamiento crónico con lamivudina cuando se utilizan los agentes anti-TNFa. Describimos el caso de un paciente con espondilitis anquilosante y antígeno de superficie positivo tratado con infliximab y lamivudina. La respuesta clínica fue excelente, pero cuando el paciente interrumpió el tratamiento con lamivudina, se observó reactivación de la replicación viral. Una vez reinstaurado dicho tratamiento, se controló nuevamente la replicación viral y se normalizaron las concentraciones de transaminasas. Esta observación indica que en pacientes con infección crónica por VHB que necesitan tratamiento anti-TNFa, se requiere un tratamiento preventivo a largo plazo con lamivudina.</p>"
]
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0 => array:2 [
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0 => array:2 [
"titulo" => "Effect of tumour necrosis factor alfa antagonists on derum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "J.R. Peterson"
1 => "F.C. Hsu"
2 => "P.A. Simkin"
3 => "M.H. Wener"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Ann Rheum Dis"
"fecha" => "2003"
"volumen" => "62"
"paginaInicial" => "1078"
"paginaFinal" => "1082"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/14583571"
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1 => array:3 [
"identificador" => "bib2"
"etiqueta" => "2."
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"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Safety of antitumour necrosis factor therapy in patients with chronic viral infections: hepatitis B, hepatitis C and HIV infection"
"autores" => array:1 [
0 => array:2 [
"etal" => false
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0 => "L.H. Calabrese"
1 => "N. Zein"
2 => "D. Vassilopoulos"
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"host" => array:1 [
0 => array:2 [
"doi" => "10.1136/ard.2004.028209"
"Revista" => array:8 [
"tituloSerie" => "Ann Rheum Dis"
"fecha" => "2004"
"volumen" => "63"
"numero" => "Suppl II"
"paginaInicial" => "ii18"
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"url" => "https://www.ncbi.nlm.nih.gov/pubmed/15479865"
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"identificador" => "bib3"
"etiqueta" => "3."
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"contribucion" => array:1 [
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"titulo" => "Reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:6 [
0 => "P. Ostuni"
1 => "C. Botsios"
2 => "L. Punzi"
3 => "P. Sfriso"
4 => "S. Todesco"
5 => "B. Hepatitis"
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0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Ann Rheum Dis"
"fecha" => "2003"
"volumen" => "62"
"paginaInicial" => "686"
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0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12810441"
"web" => "Medline"
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"titulo" => "Fulminant hepatitis after infliximab in a patient with hepatitis B virus treated for an adult onset Still's disease"
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0 => array:2 [
"etal" => false
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0 => "M. Michel"
1 => "C. Duvoux"
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"tituloSerie" => "J Rheumatol"
"fecha" => "2003"
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0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12858469"
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"titulo" => "Chronic hepatitis B reactivation following infliximab therapy in Crohn's disease patients: need for primary prophylaxis"
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"etal" => false
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0 => "M. Esteve"
1 => "C. Saro"
2 => "F. González-Huix"
3 => "F. Suárez"
4 => "M. Forné"
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"doi" => "10.1136/gut.2004.040675"
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"tituloSerie" => "Gut"
"fecha" => "2004"
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"url" => "https://www.ncbi.nlm.nih.gov/pubmed/15306601"
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"titulo" => "Infliximab therapy in a patient with Crohn's disease and chronic hepatitis B virus infection"
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0 => array:2 [
"etal" => false
"autores" => array:5 [
0 => "M.V. García-Sánchez"
1 => "F. Gómez"
2 => "A. Poyato"
3 => "E.M. Iglesias"
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"web" => "Medline"
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0 => array:2 [
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0 => array:2 [
"titulo" => "Infliximab therapy for Cronh's disease in a patient with chronic hepatitis B"
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0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "Y. Ueno"
1 => "S. Tanaka"
2 => "M. Shimamoto"
3 => "Y. Miyanaka"
4 => "T. Hiyama"
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"host" => array:1 [
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"tituloSerie" => "Dig Dis Sci"
"fecha" => "2005"
"volumen" => "50"
"paginaInicial" => "163"
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"url" => "https://www.ncbi.nlm.nih.gov/pubmed/15712655"
"web" => "Medline"
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"identificador" => "bib8"
"etiqueta" => "8."
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0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Reactivation of a latent precore mutant hepatitis B virus related chronic hepatitis during infliximab treatment for severe spondyloarthropathy"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "D. Wendling"
1 => "B. Auge"
2 => "D. Betttinger"
3 => "A. Lohse"
4 => "G. Le Huede"
5 => "S. Bresson-Hadni"
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"host" => array:1 [
0 => array:2 [
"doi" => "10.1136/ard.2004.031187"
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"tituloSerie" => "Ann Rheum Dis"
"fecha" => "2005"
"volumen" => "64"
"paginaInicial" => "788"
"paginaFinal" => "789"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/15834064"
"web" => "Medline"
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]
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"identificador" => "bib9"
"etiqueta" => "9."
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Infliximab therapy for rheumatic diseases in patients with chronic hepatitis B or C"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "O. Oniankitan"
1 => "C. Duvoux"
2 => "D. Challine"
3 => "A. Mallat"
4 => "X. Chevalier"
5 => "J.M. Pawlotsky"
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]
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0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "J Rheumatol"
"fecha" => "2004"
"volumen" => "31"
"paginaInicial" => "107"
"paginaFinal" => "109"
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0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/14705228"
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"identificador" => "bib10"
"etiqueta" => "10."
"referencia" => array:1 [
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"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Subfulminant hepatitis B after infliximab in Cronh's disease: Need for HBV-svreening?"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:5 [
0 => "G. Millonig"
1 => "M. Kern"
2 => "O. Ludwiczek"
3 => "K. Nachbaue"
4 => "W. Vogel"
]
]
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]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "World J Gastroenterol"
"fecha" => "2006"
"volumen" => "12"
"paginaInicial" => "974"
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0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/16521231"
"web" => "Medline"
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"etiqueta" => "11."
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0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Viral hepatitis B"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:4 [
0 => "C.L. Lai"
1 => "V. Ratziu"
2 => "M.F. Yuen"
3 => "T. Poynard"
]
]
]
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