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Vol. 15. Issue 2.
Pages 63-68 (March - April 2019)
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Vol. 15. Issue 2.
Pages 63-68 (March - April 2019)
Special Article
DOI: 10.1016/j.reumae.2018.11.010
Launch and Preliminary Analysis of Hospital de La Princesa's Inter-specialists Biological Therapies Unit
Lanzamiento y análisis preliminar de la Unidad de Terapias Biológicas interespecialistas del Hospital de La Princesa
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José María Alvaro-Graciaa,b,
Corresponding author
jalvarogracia@gmail.com

Corresponding author.
, Miguel Arredondoa,c, Esteban Daudéna,d, Virginia Meca-Lallanaa,e, Alberto Morella,f, Javier P. Gisberta,g,h, Guillermo Fernández-Jiméneza,c, Rosario García de Vicuñab, Francisco Javier Aspai, María Jesús García de Yébenesj, Loreto Carmonaj
a Biologics Therapy Unit, Hospital Universitario de La Princesa, Madrid, Spain
b Rheumatology Service, Hospital de La Princesa, Madrid, Spain
c Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain
d Dermatology Service, Hospital de La Princesa, Madrid, Spain
e Neurology Service, Hospital de La Princesa, Madrid, Spain
f Hospital Pharmacy Service, Hospital de La Princesa, Madrid, Spain
g Gastroenterology Service, Hospital de La Princesa, Madrid, Spain
h Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain
i Medical Direction, Hospital de La Princesa, Madrid, Spain
j Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain
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Tables (3)
Table 1. Patients receiving any dose of any biological therapy at the centre in the study period. Description at the time of the first agent utilized, by specialty.
Table 2. Biological treatments (all treatment lines), by specialty and period.
Table 3. Reasons for biological treatment discontinuation.
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Abstract

We herein describe an inter-specialists unit for the monitoring and management of biological therapies and analyze the utilization of biological agents across specialties and diseases. Protocols and therapeutic objectives, as well as outcomes and protocol deviations, are shared and discussed periodically between specialists. All patients treated at one centre with any biological treatment from January 2000 by rheumatology, gastroenterology, dermatology, or neurology, regardless diagnosis, are identified by Clinical Pharmacy and included in an ongoing database that detects use and outcome. The drugs, survival, and reasons for discontinuation differ significantly across specialties. This approach has helped us recognizing the challenges and size of the problem of sharing expensive medications across specialties, and has served as a starting point to contribute to the better use of these compounds.

Keywords:
Biological therapy
Physician's practice patterns
Registries
Safety
Effectiveness
Protocol
Rheumatology
Dermatology
Neurology
Gastroenterology
Pharmacy
Resumen

A continuación describimos una unidad interservicios para el seguimiento y la gestión de las terapias biológicas, y analizamos la utilización de los agentes biológicos en las distintas especialidades y enfermedades. Los protocolos y los objetivos terapéuticos, así como los resultados y las desviaciones de los protocolos, se comparten y debaten periódicamente entre los especialistas. Todos los pacientes tratados en el centro con cualquier terapia biológica desde enero de 2000 por reumatología, gastroenterología, dermatología o neurología, independientemente del diagnóstico, son identificados por Farmacia Clínica e incluidos en una base de datos continua, que detecta el uso y los resultados. Los medicamentos, la supervivencia y las razones de interrupción del tratamiento difieren significativamente entre especialidades. Este enfoque nos ha ayudado a reconocer los retos y la magnitud del problema de compartir medicamentos costosos entre especialidades, y ha servido como punto de partida para contribuir a un mejor uso de los mismos.

Palabras clave:
Terapia biológica
Patrones de práctica del médico
Registros
Seguridad
Eficacia
Protocolo
Reumatología
Dermatología
Neurología
Gastroenterología
Farmacia

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