array:24 [
  "pii" => "S2173574316000198"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2015.05.003"
  "estado" => "S300"
  "fechaPublicacion" => "2016-03-01"
  "aid" => "791"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2016;12:109-11"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1073
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 805
      "PDF" => 222
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X15000777"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2015.05.003"
      "estado" => "S300"
      "fechaPublicacion" => "2016-03-01"
      "aid" => "791"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Reumatol Clin. 2016;12:109-11"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10809
        "formatos" => array:3 [
          "EPUB" => 202
          "HTML" => 9017
          "PDF" => 1590
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Reumatolog&#237;a cl&#237;nica en im&#225;genes</span>"
        "titulo" => "Mal de Pott&#58; una causa infrecuente de dolor dorsolumbar en nuestros d&#237;as"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "109"
            "paginaFinal" => "111"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Pott&#39;s disease&#58; an Uncommon cause of thoracolumbar pain nowadays"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2153
                "Ancho" => 2667
                "Tamanyo" => 636856
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#41; En el estudio radiol&#243;gico se objetiva rarefacci&#243;n &#243;sea de los cuerpos vertebrales D11 y D12 con una gran erosi&#243;n en su margen anterior&#46; B&#41; En el estudio de resonancia magn&#233;tica se objetiva una lesi&#243;n y colecci&#243;n lobulada que compromete a D11&#44; D12 y su respectivo disco intervertebral &#40;flecha continua&#41; que es hipointenso en T1&#46; C&#41; Estudio de resonancia magn&#233;tica que es hiperintenso en T2&#46; D y E&#41; En el estudio de la tomograf&#237;a por emisi&#243;n de positrones se comprueba la alta actividad metab&#243;lica de las lesiones &#40;flecha discontinua&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Marco Aurelio Ram&#237;rez Huaranga, Roc&#237;o Arenal L&#243;pez, Joaqu&#237;n Anino Fern&#225;ndez, Natalia Villasanti Rivas"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Marco Aurelio"
                "apellidos" => "Ram&#237;rez Huaranga"
              ]
              1 => array:2 [
                "nombre" => "Roc&#237;o"
                "apellidos" => "Arenal L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "Joaqu&#237;n"
                "apellidos" => "Anino Fern&#225;ndez"
              ]
              3 => array:2 [
                "nombre" => "Natalia"
                "apellidos" => "Villasanti Rivas"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574316000198"
          "doi" => "10.1016/j.reumae.2015.05.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574316000198?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000777?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001200000002/v1_201603290234/S1699258X15000777/v1_201603290234/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574316000150"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.04.005"
    "estado" => "S300"
    "fechaPublicacion" => "2016-03-01"
    "aid" => "786"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2016;12:112-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1048
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 737
        "PDF" => 262
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Metallosis as a Cause of Pain and Inflammation in a Patient With a Knee Replacement&#58; A Case Description"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "112"
          "paginaFinal" => "113"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Metalosis como causa de dolor e inflamaci&#243;n en un paciente con pr&#243;tesis de rodilla&#58; descripci&#243;n de un caso"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Fig&#46; 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 733
              "Ancho" => 976
              "Tamanyo" => 394339
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Synovial biopsy&#58; black pigment infiltrating the synovial tissue&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "David Pescador, Ismael Calero-Paniagua, Mar&#237;a Dolores S&#225;nchez-Gonz&#225;lez, Carlos Montilla"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "David"
              "apellidos" => "Pescador"
            ]
            1 => array:2 [
              "nombre" => "Ismael"
              "apellidos" => "Calero-Paniagua"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a Dolores"
              "apellidos" => "S&#225;nchez-Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Montilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000728"
        "doi" => "10.1016/j.reuma.2015.04.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000728?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574316000150?idApp=UINPBA00004M"
    "url" => "/21735743/0000001200000002/v1_201604080059/S2173574316000150/v1_201604080059/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574316000204"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.05.004"
    "estado" => "S300"
    "fechaPublicacion" => "2016-03-01"
    "aid" => "792"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2016;12:107-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 928
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 689
        "PDF" => 190
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Hyperkeratotic Lesions and Pruritus in an Immunosuppressed Patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "107"
          "paginaFinal" => "108"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lesiones hiperquerat&#243;sicas y prurito en paciente inmunodeprimida"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figs&#46; 4 and 5"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4v5.jpeg"
              "Alto" => 1247
              "Ancho" => 977
              "Tamanyo" => 211790
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;4&#41; Image from the histological study under direct vision &#40;at 400&#215;&#41; showing a mite &#40;arrows&#41; and feces&#46; &#40;5&#41; Histological study under direct vision &#40;at 400&#215;&#41; showing eggs &#40;arrows&#41; and feces&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Varela-Veiga, Alejandro Vilas-Sueiro, Benigno Monteagudo, Beatriz Fern&#225;ndez-Jorge"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Varela-Veiga"
            ]
            1 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Vilas-Sueiro"
            ]
            2 => array:2 [
              "nombre" => "Benigno"
              "apellidos" => "Monteagudo"
            ]
            3 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Fern&#225;ndez-Jorge"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000789"
        "doi" => "10.1016/j.reuma.2015.05.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000789?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574316000204?idApp=UINPBA00004M"
    "url" => "/21735743/0000001200000002/v1_201604080059/S2173574316000204/v1_201604080059/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
    "titulo" => "Pott&#39;s Disease&#58; An Uncommon Cause of Thoracolumbar Pain Nowadays"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "109"
        "paginaFinal" => "111"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Marco Aurelio Ram&#237;rez Huaranga, Roc&#237;o Arenal L&#243;pez, Joaqu&#237;n Anino Fern&#225;ndez, Natalia Villasanti Rivas"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Marco Aurelio"
            "apellidos" => "Ram&#237;rez Huaranga"
            "email" => array:1 [
              0 => "hurauma&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Roc&#237;o"
            "apellidos" => "Arenal L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Joaqu&#237;n"
            "apellidos" => "Anino Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Natalia"
            "apellidos" => "Villasanti Rivas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital General Universitario de Ciudad Real&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital General Universitario de Ciudad Real&#44; Ciudad Real&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Mal de Pott&#58; una causa infrecuente de dolor dorsolumbar en nuestros d&#237;as"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 654
            "Ancho" => 975
            "Tamanyo" => 371522
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presence of multiple granulomas formed by the accumulation of epithelioid histiocytes &#40;arrow&#41;&#44; surrounded by central caseous necrosis &#40;star&#41; &#40;hematoxylin and eosin&#44; 400&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Report</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 42-year-old woman with controlled intrinsic asthma&#44; receiving chronic treatment with inhaled corticosteroids&#44; but not requiring systemic corticosteroid therapy on a regular basis&#46; Three years before the present consultation&#44; she had undergone chemotherapy with isoniazid for 12 months after a positive Mantoux test&#44; with no evidence of active disease&#44; after being in contact with a relative who had pulmonary tuberculosis&#46; She was admitted with a 3-month history of symptoms including mixed low back pain&#44; with night sweats and a feverish sensation&#46; The radiographic study revealed bone rarefaction in thoracic vertebral bodies T11 and T12&#44; but no changes in lung parenchyma or presence of mediastinal adenopathy&#46; Notable findings in the complementary tests were hemoglobin 11&#46;6<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; erythrocyte sedimentation rate 35<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#44; C-reactive protein 1&#46;49<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;normal value<span class="elsevierStyleHsp" style=""></span>&#60;0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and negative HIV test&#46; Magnetic resonance revealed evidence of spondylodiscitis with a bilateral paravertebral and anterior epidural abscess that affected vertebral bodies T11&#8211;T12&#44; a finding confirmed in a metabolic study carried out by positron emission tomography &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The microscopic study and culture of sputum&#44; as well as blood and urine cultures&#44; were negative&#44; even for mycobacteria&#46; As tuberculous spondylodiscitis &#40;TSD&#41; was suspected&#44; the decision was made to perform a computed tomography-guided biopsy and begin treatment with isoniazid&#44; rifampicin&#44; pyrazinamide and ethambutol&#59; analgesia with weak opioids&#59; and the use of rigid orthosis for the lumbar spine&#46; The histopathological study of the lesion revealed the presence of caseating granulomas suggestive of a tuberculous process&#44; although Ziehl-Neelsen staining was negative &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; After 12 months of antituberculous therapy&#44; the patient&#39;s course was satisfactory&#44; with no sequelae or limited axial mobility&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0010" class="elsevierStylePara elsevierViewall">Spondylodiscitis is an infection&#44; generally bacterial&#44; that affects the vertebral bodies and their respective adjacent discs&#44; leading to the destruction&#44; instability and subsequent ankylosis of the affected structures&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The incidence is estimated to be 2&#46;4&#8211;6 cases&#47;100<span class="elsevierStyleHsp" style=""></span>000 population&#47;year&#44; with a mortality rate of around 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> The determinant risk factors are the increased life expectancy&#44; the presence of previous vertebral lesions&#44; the presence of immunodeficiency&#44; the use of immunosuppressive therapy and the use of intravascular devices&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Skeletal tuberculosis represents 20&#37; of overall extrapulmonary cases&#59; vertebral involvement or Pott&#39;s disease accounts for 50&#37; of the cases affecting the skeleton and from 1&#37; to 5&#37; of all infections by <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> The spine is the site most frequently involved&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Tuberculous spondylodiscitis is a rare but very serious clinical condition that can result in a severe deformity and early neurological complications&#46; Despite the present availability of a greater number of effective complementary tests&#44; the diagnosis of TSD continues to be difficult and requires a high index of clinical suspicion&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> The disease can take the form of disseminated tuberculosis or endogenous reactivation of a latent focus&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> Treatment is basically medical&#44; consisting of the tuberculostatic drugs usually employed in pulmonary tuberculosis infection &#40;isoniazid&#44; rifampicin&#44; pyrazinamide or ethambutol&#41;&#44; and the mean duration is 12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Ethical Disclosures</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Protection of human and animal subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Confidentiality of data</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Right to privacy and informed consent</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Case Report"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Discussion"
        ]
        2 => array:3 [
          "identificador" => "sec0015"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of Interest"
        ]
        4 => array:2 [
          "identificador" => "xack211245"
          "titulo" => "Acknowledgment"
        ]
        5 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-03-17"
    "fechaAceptado" => "2015-05-05"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ram&#237;rez Huaranga MA&#44; Arenal L&#243;pez R&#44; Anino Fern&#225;ndez J&#44; Villasanti Rivas N&#46; Mal de Pott&#58; una causa infrecuente de dolor dorsolumbar en nuestros d&#237;as&#46; Reumatol Clin&#46; 2016&#59;12&#58;109&#8211;111&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2155
            "Ancho" => 2667
            "Tamanyo" => 638375
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; The radiological study shows bone rarefaction in thoracic vertebral bodies T11 and T12&#44; with marked erosion of their anterior borders&#46; &#40;B&#41; Magnetic resonance study shows a lobulated lesion and collection affecting T11&#44; T12 and their respective intervertebral disc &#40;arrow&#41;&#44; which is hypointense on a T1-weighted image&#46; &#40;C&#41; Magnetic resonance study showing hyperintensity on a T2-weighted image &#40;solid arrows&#41;&#46; &#40;D and E&#41; Positron emission tomography images confirming the high metabolic activity of the lesions &#40;broken arrows&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 654
            "Ancho" => 975
            "Tamanyo" => 371522
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presence of multiple granulomas formed by the accumulation of epithelioid histiocytes &#40;arrow&#41;&#44; surrounded by central caseous necrosis &#40;star&#41; &#40;hematoxylin and eosin&#44; 400&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Espondilodiscitis infecciosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Belzunegui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1699-258X(08)76162-X"
                      "Revista" => array:7 [
                        "tituloSerie" => "Reumatol Cl&#237;n"
                        "fecha" => "2008"
                        "volumen" => "4"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "13"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patogenia de las espondilodiscitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Vazquez"
                            1 => "A&#46; Atanes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Fund Reumatol"
                        "fecha" => "2007"
                        "volumen" => "8"
                        "paginaInicial" => "10"
                        "paginaFinal" => "14"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious spondylodiscitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Grammatico"
                            1 => "J&#46;M&#46; Besnier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Prat"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "970"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17695676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "UpToDate&#46; McDonald M&#46; Vertebral osteomyelitis and discitis in adults &#91;Sede web&#93;&#46; Uptodate Waltham&#44; Massachusetts&#46; Available from&#58; <a id="intr0010" class="elsevierStyleInterRef" href="http://www.uptodate.com/">http&#58;&#47;&#47;www&#46;uptodate&#46;com&#47;</a> &#91;accessed 17&#46;03&#46;15&#93;&#46;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spondylodiscitis&#44; nephrology department&#39;s experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Ram&#237;rez"
                            1 => "M&#46;D&#46; S&#225;nchez de la Nieta"
                            2 => "A&#46; Anaya"
                            3 => "M&#46; Arambarri"
                            4 => "G&#46; Caparr&#243;s"
                            5 => "F&#46; Rivera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2012.Oct.11587"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "250"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23511762"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of spinal tuberculosis&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Zhang"
                            1 => "J&#46; Ji"
                            2 => "B&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0300060513498023"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Int Med Res"
                        "fecha" => "2013"
                        "volumen" => "41"
                        "paginaInicial" => "1395"
                        "paginaFinal" => "1407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24045167"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spinal tuberculosis&#58; CT and MRI feature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Sinan"
                            1 => "H&#46; Al-Khawari"
                            2 => "M&#46; Ismail"
                            3 => "A&#46; Ben-Nakhi"
                            4 => "M&#46; Sheikh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Saudi Med"
                        "fecha" => "2003"
                        "volumen" => "24"
                        "paginaInicial" => "437"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15646161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculous spondylodiscitis&#58; epidemiology&#44; clinical features&#44; treatment&#44; and outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;M&#46; Trecarichi"
                            1 => "E&#46; Di Meco"
                            2 => "V&#46; Mazzotta"
                            3 => "M&#46; Fantoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Rev Med Pharmacol Sci"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "58"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23090810"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Establishing the diagnosis of tuberculous vertebral osteomyelitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;D&#46; Colmenero"
                            1 => "J&#46;D&#46; Ruiz-Mesa"
                            2 => "R&#46; Sanjuan-Jimenez"
                            3 => "B&#46; Sobrino"
                            4 => "P&#46; Morata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00586-012-2348-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Spine J"
                        "fecha" => "2013"
                        "volumen" => "22"
                        "paginaInicial" => "579"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22576157"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204513702948"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack211245"
        "titulo" => "Acknowledgment"
        "texto" => "<p id="par0045" class="elsevierStylePara elsevierViewall">We thank the Nuclear Medicine and Radiology Departments of Hospital General Universitario de Ciudad Real&#44; Spain&#44; for their collaboration and the facilities they made available to us for the preparation of the present article&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001200000002/v1_201604080059/S2173574316000198/v1_201604080059/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5795"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Images in Clinical Rheumatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001200000002/v1_201604080059/S2173574316000198/v1_201604080059/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574316000198?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 12. Issue 2.
Pages 109-111 (March - April 2016)
Visits
5421
Vol. 12. Issue 2.
Pages 109-111 (March - April 2016)
Images in Clinical Rheumatology
Full text access
Pott's Disease: An Uncommon Cause of Thoracolumbar Pain Nowadays
Mal de Pott: una causa infrecuente de dolor dorsolumbar en nuestros días
Visits
5421
Marco Aurelio Ramírez Huarangaa,
Corresponding author
hurauma@hotmail.com

Corresponding author.
, Rocío Arenal Lópeza, Joaquín Anino Fernándeza, Natalia Villasanti Rivasb
a Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
b Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Full Text
Case Report

The patient was a 42-year-old woman with controlled intrinsic asthma, receiving chronic treatment with inhaled corticosteroids, but not requiring systemic corticosteroid therapy on a regular basis. Three years before the present consultation, she had undergone chemotherapy with isoniazid for 12 months after a positive Mantoux test, with no evidence of active disease, after being in contact with a relative who had pulmonary tuberculosis. She was admitted with a 3-month history of symptoms including mixed low back pain, with night sweats and a feverish sensation. The radiographic study revealed bone rarefaction in thoracic vertebral bodies T11 and T12, but no changes in lung parenchyma or presence of mediastinal adenopathy. Notable findings in the complementary tests were hemoglobin 11.6g/dL, erythrocyte sedimentation rate 35mm/h, C-reactive protein 1.49mg/dL (normal value<0.5mg/dL) and negative HIV test. Magnetic resonance revealed evidence of spondylodiscitis with a bilateral paravertebral and anterior epidural abscess that affected vertebral bodies T11–T12, a finding confirmed in a metabolic study carried out by positron emission tomography (Fig. 1). The microscopic study and culture of sputum, as well as blood and urine cultures, were negative, even for mycobacteria. As tuberculous spondylodiscitis (TSD) was suspected, the decision was made to perform a computed tomography-guided biopsy and begin treatment with isoniazid, rifampicin, pyrazinamide and ethambutol; analgesia with weak opioids; and the use of rigid orthosis for the lumbar spine. The histopathological study of the lesion revealed the presence of caseating granulomas suggestive of a tuberculous process, although Ziehl-Neelsen staining was negative (Fig. 2). After 12 months of antituberculous therapy, the patient's course was satisfactory, with no sequelae or limited axial mobility.

Fig. 1.

(A) The radiological study shows bone rarefaction in thoracic vertebral bodies T11 and T12, with marked erosion of their anterior borders. (B) Magnetic resonance study shows a lobulated lesion and collection affecting T11, T12 and their respective intervertebral disc (arrow), which is hypointense on a T1-weighted image. (C) Magnetic resonance study showing hyperintensity on a T2-weighted image (solid arrows). (D and E) Positron emission tomography images confirming the high metabolic activity of the lesions (broken arrows).

(0.61MB).
Fig. 2.

Presence of multiple granulomas formed by the accumulation of epithelioid histiocytes (arrow), surrounded by central caseous necrosis (star) (hematoxylin and eosin, 400×).

(0.35MB).
Discussion

Spondylodiscitis is an infection, generally bacterial, that affects the vertebral bodies and their respective adjacent discs, leading to the destruction, instability and subsequent ankylosis of the affected structures.1 The incidence is estimated to be 2.4–6 cases/100000 population/year, with a mortality rate of around 5%.2 The determinant risk factors are the increased life expectancy, the presence of previous vertebral lesions, the presence of immunodeficiency, the use of immunosuppressive therapy and the use of intravascular devices.3–5

Skeletal tuberculosis represents 20% of overall extrapulmonary cases; vertebral involvement or Pott's disease accounts for 50% of the cases affecting the skeleton and from 1% to 5% of all infections by Mycobacterium tuberculosis.6 The spine is the site most frequently involved.7

Tuberculous spondylodiscitis is a rare but very serious clinical condition that can result in a severe deformity and early neurological complications. Despite the present availability of a greater number of effective complementary tests, the diagnosis of TSD continues to be difficult and requires a high index of clinical suspicion.8 The disease can take the form of disseminated tuberculosis or endogenous reactivation of a latent focus.9 Treatment is basically medical, consisting of the tuberculostatic drugs usually employed in pulmonary tuberculosis infection (isoniazid, rifampicin, pyrazinamide or ethambutol), and the mean duration is 12 months.8

Ethical DisclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflicts of Interest

The authors declare they have no conflicts of interest.

Acknowledgment

We thank the Nuclear Medicine and Radiology Departments of Hospital General Universitario de Ciudad Real, Spain, for their collaboration and the facilities they made available to us for the preparation of the present article.

References
[1]
J. Belzunegui.
Espondilodiscitis infecciosa.
Reumatol Clín, 4 (2008), pp. 13-17
[2]
R. Vazquez, A. Atanes.
Patogenia de las espondilodiscitis.
Semin Fund Reumatol, 8 (2007), pp. 10-14
[3]
L. Grammatico, J.M. Besnier.
Infectious spondylodiscitis.
Rev Prat, 57 (2007), pp. 970-978
[4]
UpToDate. McDonald M. Vertebral osteomyelitis and discitis in adults [Sede web]. Uptodate Waltham, Massachusetts. Available from: http://www.uptodate.com/ [accessed 17.03.15].
[5]
M.A. Ramírez, M.D. Sánchez de la Nieta, A. Anaya, M. Arambarri, G. Caparrós, F. Rivera, et al.
Spondylodiscitis, nephrology department's experience.
[6]
X. Zhang, J. Ji, B. Liu.
Management of spinal tuberculosis: a systematic review and meta-analysis.
J Int Med Res, 41 (2013), pp. 1395-1407
[7]
T. Sinan, H. Al-Khawari, M. Ismail, A. Ben-Nakhi, M. Sheikh.
Spinal tuberculosis: CT and MRI feature.
Ann Saudi Med, 24 (2003), pp. 437-441
[8]
E.M. Trecarichi, E. Di Meco, V. Mazzotta, M. Fantoni.
Tuberculous spondylodiscitis: epidemiology, clinical features, treatment, and outcome.
Eur Rev Med Pharmacol Sci, 16 (2012), pp. 58-72
[9]
J.D. Colmenero, J.D. Ruiz-Mesa, R. Sanjuan-Jimenez, B. Sobrino, P. Morata.
Establishing the diagnosis of tuberculous vertebral osteomyelitis.
Eur Spine J, 22 (2013), pp. 579-586

Please cite this article as: Ramírez Huaranga MA, Arenal López R, Anino Fernández J, Villasanti Rivas N. Mal de Pott: una causa infrecuente de dolor dorsolumbar en nuestros días. Reumatol Clin. 2016;12:109–111.

Copyright © 2015. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?