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"copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S1699258X2400072X" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2024.06.004" "estado" => "S200" "fechaPublicacion" => "2024-09-11" "aid" => "1778" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Prevalencia del entesofito occipital en enfermedades reumáticas inflamatorias y no inflamatorias" "tienePdf" => "es" "tieneTextoCompleto" => "es" "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevalence of occipital enthesophyte in non-inflammatory and inflammatory rheumatic diseases" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 752 "Ancho" => 2150 "Tamanyo" => 116711 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tipos de morfología de entesofito occipital (flechas blancas): (A) normal, (B) artritis psoriásica, (C) espondiloartritis, (D) artritis reumatoide.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Natalia de la Torre Rubio, Jose Campos Esteban, José Luis Andréu Sánchez, Jesús Sanz Sanz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Natalia" "apellidos" => "de la Torre Rubio" ] 1 => array:2 [ "nombre" => "Jose" "apellidos" => "Campos Esteban" ] 2 => array:2 [ "nombre" => "José Luis" "apellidos" => "Andréu Sánchez" ] 3 => array:2 [ "nombre" => "Jesús" "apellidos" => "Sanz Sanz" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574324001278" "doi" => "10.1016/j.reumae.2024.06.002" "estado" => "S200" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574324001278?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X2400072X?idApp=UINPBA00004M" "url" => "/1699258X/unassign/S1699258X2400072X/v1_202409110429/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "S2173574324001291" "issn" => "21735743" "doi" => "10.1016/j.reumae.2024.10.002" "estado" => "S200" "fechaPublicacion" => "2024-10-29" "aid" => "1783" "documento" => "article" "crossmark" => 0 "subdocumento" => "crp" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Inclusion Body Myositis: A Late Diagnosis Case Report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Miositis por cuerpos de inclusión: informe de un caso de diagnóstico tardío" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 836 "Ancho" => 1742 "Tamanyo" => 171496 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Muscle biopsy from this case.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Modified trichrome Gomori (TMG) staining. Close-up 200× TMG, staining demonstrated muscle fibres of varying size, ballooning, aggregates of inflammatory cells with focal invasion of some muscle fibres, and substantial proliferation of connective tissue (A). Close-up 400× TMG, with obvious nuclear centralisation (arrow) (B). Close-up 400× MTG Vacuoles rimmed with granular material and filaments (star) classically observed in this pathology (C).</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Haematoxylin and eosin (H&E) staining. Close-up 100×, panoramic view of the biopsy displaying a major deviation from the general architecture, with enlarged spaces and substitution by connective tissue, fibre morphology with bulging and inflammatory infiltrate (D). Close-up at 400× (H&E) illustrates the inflammatory infiltrate surrounding the muscle fibre in greater detail (E), as well as abundant connective tissue.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Deysi Andrea Hernández-Rivero, Lisette Bazán-Rodríguez, María del Pilar Cruz-Domínguez, Gabriela Medina, Ana Lilia Peralta Amaro, Olga Vera-Lastra" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Deysi Andrea" "apellidos" => "Hernández-Rivero" ] 1 => array:2 [ "nombre" => "Lisette" "apellidos" => "Bazán-Rodríguez" ] 2 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Cruz-Domínguez" ] 3 => array:2 [ "nombre" => "Gabriela" "apellidos" => "Medina" ] 4 => array:2 [ "nombre" => "Ana Lilia" "apellidos" => "Peralta Amaro" ] 5 => array:2 [ "nombre" => "Olga" "apellidos" => "Vera-Lastra" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X24000834" "doi" => "10.1016/j.reuma.2024.07.003" "estado" => "S200" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X24000834?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574324001291?idApp=UINPBA00004M" "url" => "/21735743/unassign/S2173574324001291/v1_202410291641/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173574313000592" "issn" => "21735743" "doi" => "10.1016/j.reumae.2012.12.002" "estado" => "S200" "fechaPublicacion" => "2013-06-07" "aid" => "535" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "ret" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 485 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 220 "PDF" => 226 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "WITHDRAWN: Revascularized Abdominal Aortic Stenosis in a Patient With Takayasu's Arteritis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Karen Franco, Dorcas Cajigas, Joan Novo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Karen" "apellidos" => "Franco" ] 1 => array:2 [ "nombre" => "Dorcas" "apellidos" => "Cajigas" ] 2 => array:2 [ "nombre" => "Joan" "apellidos" => "Novo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1699258X13000259" "doi" => "10.1016/j.reuma.2012.12.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13000259?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000592?idApp=UINPBA00004M" "url" => "/21735743/unassign/S2173574313000592/v2_201406270017/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Prevalence of occipital enthesophyte in non-inflammatory and inflammatory rheumatic diseases" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Natalia de la Torre Rubio, Jose Campos Esteban, José Luis Andréu Sánchez, Jesús Sanz Sanz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Natalia" "apellidos" => "de la Torre Rubio" "email" => array:1 [ 0 => "ndltr.md@icloud.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Jose" "apellidos" => "Campos Esteban" ] 2 => array:2 [ "nombre" => "José Luis" "apellidos" => "Andréu Sánchez" ] 3 => array:2 [ "nombre" => "Jesús" "apellidos" => "Sanz Sanz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia del entesofito occipital en enfermedades reumáticas inflamatorias y no inflamatorias" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 752 "Ancho" => 2150 "Tamanyo" => 116711 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Types of occipital enthesophyte morphology (white arrows): (A) normal, (B) psoriatic arthritis, (C) spondyloarthritis, (D) rheumatoid arthritis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Entheses are regions of fibrocartilage located predominantly in extra-articular areas and constitute a major target in psoriatic arthritis (PsA), with a prevalence rate of 35%,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> as well as in spondyloarthritis (SpA), notably in HLA-B27 (human leukocyte antigen - B27)-negative patients.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> They have a specific immune microenvironment triggered by mechanical stress, genetic susceptibility, and microorganisms<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and their main function as a component of the enthesis-organ complex is to diffuse the concentration of mechanical stress on the bone surface away from the attachment.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Although enthesophytes are typically seen on plain X-rays in an asymptomatic elderly population, the occipital enthesophyte (OE) is present in 41% of all adults under the age of 30 years.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">To the best of our knowledge, OE has not been documented in inflammatory rheumatic diseases; therefore, our aim was to determine its prevalence in PsA, SpA, and rheumatoid arthritis (RA) and to compare it with patients with mechanical neck pain (MNP). We designed a retrospective descriptive study of the plain cervical X-rays in lateral projection of individuals over 18 years of age who attended the rheumatology department of a university hospital between July 2022 and January 2023; a total of 30 patients per group (120 in total) were studied. The reason for requesting the radiograph was neck pain in the MNP group (excluding traffic accidents and neck surgery) and RA, and as part of the diagnostic protocol in the PsA and SpA groups. The following variables were obtained: sex, age at the time the X-ray was performed, OE (yes/no) assessed by a rheumatologist with 25 years of experience and by a fourth-year rheumatology resident. The results are presented descriptively; Cohen’s Kappa coefficient was calculated to quantify the degree of agreement between the two rheumatologists; sex and prevalence were compared using the χ<span class="elsevierStyleSup">2</span> test, applying the Yates correction, and ANOVA was used for mean age.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Seventy-eight per cent (78%) were female and the mean age of the sample was 58.5 ± 15 years. The four groups were homogeneous in terms of sex and age, and stratified analysis failed to reveal any difference (p = 0.2 and p = 0.06, respectively), only a tendency toward greater presence in the elderly in the MNP group. Fifty-one per cent (51%) had OE, 23% in the MNP group and 60% in inflammatory diseases (70% SpA, 70% AP, and 40% RA), with OE being statistically significant in inflammatory rheumatic diseases (p < 0.001). Substantial agreement was reached overall (89%) and almost perfect agreement in SpA and PsA (97%). To describe them macroscopically, different OE morphologies were seen to be thicker in the SpA and PsA groups and thinner in the RA group (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In psoriatic patients the burden of bone erosions is not significantly greater than in healthy controls, whereas the differences in enthesophytes are far more pronounced.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The prevalence of asymptomatic enthesopathy with Doppler signal on ultrasound was significantly higher in psoriatic patients (77%) than in controls<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and has been proven to be specific to peripheral enthesitis in SpA.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Given that this was an exploratory study, there are several limitations: we did not correlate this enthesopathy with pain, type of psoriasis, HLA-B27 genetic predisposition, physical activity, or BMI. consequently, we will assess this in future studies using other imaging tests to determine whether it might be helpful in the early diagnosis of psoriasis patients without PsA7 or with nascent PsA and negative SpA-B27, and whether it might be a predictive factor for developing a more severe form of the disease.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">This research has not received any specific support from public sector agencies, the commercial sector, or non-profit organisations.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "xack784631" "titulo" => "Acknowledgements" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 752 "Ancho" => 2150 "Tamanyo" => 116711 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Types of occipital enthesophyte morphology (white arrows): (A) normal, (B) psoriatic arthritis, (C) spondyloarthritis, (D) rheumatoid arthritis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical profile and treatment utilisation based on HLA-B*27 status in axial spondyloarthritis: results from ASAS-PerSpA study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Chaudhary" 1 => "C. López-Medina" 2 => "M.A. Khan" 3 => "M. Dougados" 4 => "M. Magrey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "RMD Open." "fecha" => "2023" "volumen" => "9" "numero" => "3" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical enthesitis in a prospective longitudinal psoriatic arthritis cohort: incidence, prevalence, characteristics, and outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Polachek" 1 => "S. Li" 2 => "V. Chandran" 3 => "D.D. Gladman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/acr.23174" "Revista" => array:7 [ "tituloSerie" => "Arthritis Care Res (Hoboken)." "fecha" => "2017" "volumen" => "69" "numero" => "11" "paginaInicial" => "1685" "paginaFinal" => "1691" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27998023" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enthesitis: from pathophysiology to treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Schett" 1 => "R.J. Lories" 2 => "M.-A. D’Agostino" 3 => "D. Elewaut" 4 => "B. Kirkham" 5 => "E.R. Soriano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrrheum.2017.188" "Revista" => array:7 [ "tituloSerie" => "Nat Rev Rheumatol." "fecha" => "2017" "volumen" => "13" "numero" => "12" "paginaInicial" => "731" "paginaFinal" => "741" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29158573" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The “enthesis organ” concept: why enthesopathies may not present as focal insertional disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Benjamin" 1 => "B. Moriggl" 2 => "E. Brenner" 3 => "P. Emery" 4 => "D. McGonagle" 5 => "S. Redman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20566" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheum." 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Letter to the Editor
Available online 29 October 2024
Prevalence of occipital enthesophyte in non-inflammatory and inflammatory rheumatic diseases
Prevalencia del entesofito occipital en enfermedades reumáticas inflamatorias y no inflamatorias
Natalia de la Torre Rubio
, Jose Campos Esteban, José Luis Andréu Sánchez, Jesús Sanz Sanz
Corresponding author
Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain