array:24 [
  "pii" => "S2173574320300630"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.02.016"
  "estado" => "S300"
  "fechaPublicacion" => "2020-05-01"
  "aid" => "1212"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Reumatol Clin. 2020;16:239-41"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X18300743"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2018.02.014"
      "estado" => "S300"
      "fechaPublicacion" => "2020-05-01"
      "aid" => "1212"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Reumatol Clin. 2020;16:239-41"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 684
        "formatos" => array:3 [
          "EPUB" => 43
          "HTML" => 428
          "PDF" => 213
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "S&#237;ndrome pulm&#243;n-ri&#241;&#243;n secundario a vasculitis por coca&#237;na&#47;levamisol&#58; reporte de caso"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "239"
            "paginaFinal" => "241"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Pulmonary-renal syndrome secondary to cocaine-levamisole-induced vasculitis&#58; A case report"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2344
                "Ancho" => 2083
                "Tamanyo" => 425381
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Rayos X de t&#243;rax con infiltrados difusos en ambos campos pulmonares&#46; B&#41; Opacidades mixtas generalizadas observadas en tomograf&#237;a de t&#243;rax de alta resoluci&#243;n&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mauricio Restrepo-Escobar, Dayana Sylva, Juan Guillermo Gamboa, Andr&#233;s Echeverri, Javier M&#225;rquez, Luis Fernando Pinto"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Mauricio"
                "apellidos" => "Restrepo-Escobar"
              ]
              1 => array:2 [
                "nombre" => "Dayana"
                "apellidos" => "Sylva"
              ]
              2 => array:2 [
                "nombre" => "Juan Guillermo"
                "apellidos" => "Gamboa"
              ]
              3 => array:2 [
                "nombre" => "Andr&#233;s"
                "apellidos" => "Echeverri"
              ]
              4 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "M&#225;rquez"
              ]
              5 => array:2 [
                "nombre" => "Luis Fernando"
                "apellidos" => "Pinto"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574320300630"
          "doi" => "10.1016/j.reumae.2018.02.016"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300630?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18300743?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001600000003/v1_202006131050/S1699258X18300743/v1_202006131050/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574320300617"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.03.010"
    "estado" => "S300"
    "fechaPublicacion" => "2020-05-01"
    "aid" => "1211"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2020;16:242-4"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical Case</span>"
      "titulo" => "Cryoglobulinemic vasculitis and psoriatic arthritis&#58; Case report of an unusual association"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "242"
          "paginaFinal" => "244"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis crioglobulin&#233;mica y artritis psori&#225;sica&#58; reporte de caso de una inusual asociaci&#243;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 468
              "Ancho" => 1250
              "Tamanyo" => 109560
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ischemic lesions in the fleshy parts of the fingers&#44; secondary to cryoglobulinemic vasculitis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Lizeth Yamile Urrea-Pineda, Sebasti&#225;n G&#243;mez-Jim&#233;nez, Daniel Jaramillo-Arroyave, Carlos Horacio Mu&#241;oz-Vahos, Adriana Luc&#237;a Vanegas-Garc&#237;a, Gloria Vasqu&#233;z, Mauricio Restrepo-Escobar, Luis Alonso Gonz&#225;lez-Naranjo"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Lizeth Yamile"
              "apellidos" => "Urrea-Pineda"
            ]
            1 => array:2 [
              "nombre" => "Sebasti&#225;n"
              "apellidos" => "G&#243;mez-Jim&#233;nez"
            ]
            2 => array:2 [
              "nombre" => "Daniel"
              "apellidos" => "Jaramillo-Arroyave"
            ]
            3 => array:2 [
              "nombre" => "Carlos Horacio"
              "apellidos" => "Mu&#241;oz-Vahos"
            ]
            4 => array:2 [
              "nombre" => "Adriana Luc&#237;a"
              "apellidos" => "Vanegas-Garc&#237;a"
            ]
            5 => array:2 [
              "nombre" => "Gloria"
              "apellidos" => "Vasqu&#233;z"
            ]
            6 => array:2 [
              "nombre" => "Mauricio"
              "apellidos" => "Restrepo-Escobar"
            ]
            7 => array:2 [
              "nombre" => "Luis Alonso"
              "apellidos" => "Gonz&#225;lez-Naranjo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X18300731"
        "doi" => "10.1016/j.reuma.2018.03.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18300731?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300617?idApp=UINPBA00004M"
    "url" => "/21735743/0000001600000003/v1_202006131316/S2173574320300617/v1_202006131316/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "S2173574320300587"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.06.009"
    "estado" => "S300"
    "fechaPublicacion" => "2020-05-01"
    "aid" => "1239"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2020;16:235-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Report</span>"
      "titulo" => "Elderly-onset Sarcoidosis&#58; A Single Center Comparative Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "235"
          "paginaFinal" => "238"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estudio comparativo entre la sarcoidosis de inicio en la edad adulta y en la tercera edad&#46; An&#225;lisis de 131 casos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Senol Kobak, Fidan Yildiz, Huseyin Semiz, Mehmet Orman"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Senol"
              "apellidos" => "Kobak"
            ]
            1 => array:2 [
              "nombre" => "Fidan"
              "apellidos" => "Yildiz"
            ]
            2 => array:2 [
              "nombre" => "Huseyin"
              "apellidos" => "Semiz"
            ]
            3 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Orman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300587?idApp=UINPBA00004M"
    "url" => "/21735743/0000001600000003/v1_202006131316/S2173574320300587/v1_202006131316/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Clinical Case</span>"
    "titulo" => "Pulmonary-renal syndrome secondary to cocaine-levamisole-induced vasculitis&#58; A case report"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "239"
        "paginaFinal" => "241"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mauricio Restrepo-Escobar, Dayana Sylva, Juan Guillermo Gamboa, Andr&#233;s Echeverri, Javier M&#225;rquez, Luis Fernando Pinto"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Mauricio"
            "apellidos" => "Restrepo-Escobar"
            "email" => array:1 [
              0 => "mauricio.restrepoe@udea.edu.co"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Dayana"
            "apellidos" => "Sylva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan Guillermo"
            "apellidos" => "Gamboa"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Andr&#233;s"
            "apellidos" => "Echeverri"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Javier"
            "apellidos" => "M&#225;rquez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Luis Fernando"
            "apellidos" => "Pinto"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Secci&#243;n de Reumatolog&#237;a&#44; Hospital Pablo Tob&#243;n Uribe&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad Pontificia Bolivariana&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Secci&#243;n de Medicina Interna&#44; Hospital Pablo Tob&#243;n Uribe&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome pulm&#243;n-ri&#241;&#243;n secundario a vasculitis por coca&#237;na&#47;levamisol&#58; reporte de caso"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2344
            "Ancho" => 2083
            "Tamanyo" => 425381
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Thoracic X-ray showing diffuse infiltrates in both pulmonary fields&#46; B&#41; Generalised mixed opacities observed in high resolution thoracic tomography&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Cocaine consumption is still a public health problem&#46; The adulteration of cocaine with substances such as levamisole leads to the appearance of additional medical problems&#46; Vasculitis caused by levamisole is highly heterogeneous in terms of clinical symptoms and analytical results&#44; hindering diagnosis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical observation</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 34 year-old male with a history of reactive arthritis and daily marihuana consumption&#46; He denied consuming cocaine&#46; He was admitted for one week due to general discomfort&#44; pallor&#44; a dry cough&#44; thoracic pain and dyspnea&#46; Mucocutaneous pallor&#44; hypoxemia and rale in the base of the lungs&#46; He was normotensive&#44; with no tachycardia or fever&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He had severe anaemia&#44; renal dysfunction and mixed opacities in both pulmonary fields &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> and <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; He was diagnosed pulmonary-renal syndrome and treatment commenced with high doses of steroids and blood cell transfusion&#46; At first the diagnosis of systemic lupus erythmatosus &#40;SLE&#41; was considered due to the finding of hypocomplementemia&#46; Additional studies found multiple antibody positivity&#58; ANCA &#40;antimyeloperoxidase and antiproteinase-3&#41;&#44; ANA&#44; anti-Ro&#44; anti-La&#44; lupus anticoagulant&#44; rheumatoid factor and anticardiolipin IgM&#46; Anti-Sm&#44;&#160;anti-DNA and anti-basement glomerular membrane antibodies were negative&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Diffuse endocapilar glomerulonephritis was observed in a renal biopsy&#44; with immune complex deposits and tubulointerstitial nephritis&#46; Fibrobroncoscoy confirmed alveolar haemorrhage &#40;haemosiderophages 40&#37;&#41; and ruled out infection&#46; During a subsequent evaluation perforation of the nasal septum was observed and the patient confirmed frequent consumption of cocaine&#46; As well as insisting on the cessation of consumption treatment with prednisolone continued&#44; with good clinical response and a rise in haemoglobin&#44; although there was only partial improvement in renal function&#44; so that additional monthly boli of cyclophosphamide were added&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">During recent years the number of cases of vasculitis associated with levamisole-adulterated cocaine consumption has increased&#46; This disease may compromise multiple organs and systems&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Alveolar haemorrhage is rare&#46; McGrath et al&#46; described a series of 30 cases of levamisole-induced ANCA vasculitis&#46; Three of the cases had alveolar haemorrhage&#44; and it was not possible to prove renal involvement in any of them&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Cases of pulmonary-renal syndrome are even rarer due to this entity&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">No definitive criteria for diagnosis of this syndrome exist&#46; Diagnosis is based on epidemiological&#44; clinical and analytical findings&#46; In the majority of cases it is not possible to prove contamination by levamisole&#44; as the test is not clinically available and measurement has to take place within 24<span class="elsevierStyleHsp" style=""></span>hrs&#46; of the previous consumption&#46; A high level of suspicion is necessary prior to probing for cocaine consumption&#46; Differential diagnosis is broad&#46; It may be confused with vasculitis associated with ANCA&#44; Goodpasture syndrome and even SLE&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Vasculopathy secondary to levamisole is characterised by high titers of p-ANCA directed against multiple rare antigens&#44; as well as concomitant positivity for c-ANCA&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">5&#44;6</span></a> a rare expression in patients with primary vasculitis&#46; Positivity for multiple antibodies and consumption as a complement may lead to confusion with SLE&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The rate of recurrence in the case of continued cocaine consumption is high&#46; The role of immunosuppressor therapy is unknown&#44; and no treatment patterns have been defined&#46; The patient responded partially to steroids and the suspension of the causal agent&#46; The addition of cyclophosphamide seems to have contributed to his final clinical improvement&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0050" class="elsevierStylePara elsevierViewall">This case represents a clinical challenge due to its atypical form of presentation&#44; the severity of its manifestations and the difficulty of diagnosis&#46; It is necessary to know the different clinical and analytical manifestations caused by cocaine&#47;levamisole consumption&#44; and to maintain a high level of suspicion regarding the possibility of this consumption&#44; which may be denied by the patient&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres1348448"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1240526"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1348449"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1240525"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Clinical observation"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conclusions"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interests"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-12-29"
    "fechaAceptado" => "2018-02-20"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1240526"
          "palabras" => array:5 [
            0 => "Vasculitis"
            1 => "Cocaine"
            2 => "Levamisole"
            3 => "Alveolar hemorrhage"
            4 => "Pulmonary-renal syndrome"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1240525"
          "palabras" => array:5 [
            0 => "Vasculitis"
            1 => "Coca&#237;na"
            2 => "Levamisol"
            3 => "Hemorragia alveolar"
            4 => "S&#237;ndrome pulm&#243;n-ri&#241;&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pulmonary-renal syndrome has rarely been reported as the clinical presentation of vasculitis caused by the consumption of cocaine adulterated with levamisole&#46; We report the case of a patient in whom we detected the clinical manifestations and indicate the difficulties that arose in relation to the diagnostic and therapeutic approach&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome pulm&#243;n-ri&#241;&#243;n rara vez ha sido reportado como cuadro cl&#237;nico de presentaci&#243;n de vasculitis causada por el consumo de coca&#237;na contaminada con levamisol&#46; Se reporta el caso de un paciente con este cuadro cl&#237;nico y se se&#241;alan las dificultades que se presentaron durante el abordaje diagn&#243;stico y terap&#233;utico&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Restrepo-Escobar M&#44; Sylva D&#44; Gamboa JG&#44; Echeverri A&#44; M&#225;rquez J&#44; Pinto LF&#46; S&#237;ndrome pulm&#243;n-ri&#241;&#243;n secundario a vasculitis por coca&#237;na&#47;levamisol&#58; reporte de caso &#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.reuma.2018.02.014">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2018&#46;02&#46;014</span></p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2344
            "Ancho" => 2083
            "Tamanyo" => 425381
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#41; Thoracic X-ray showing diffuse infiltrates in both pulmonary fields&#46; B&#41; Generalised mixed opacities observed in high resolution thoracic tomography&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Result&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinine &#40;0&#46;60-1&#46;10<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Urine analysis &#40;cells per high power field &#40;HPF&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proteins 75<span class="elsevierStyleHsp" style=""></span>mg&#47;leukocytes 0-5&#47;CAP&#47;erythrocytes 21-50&#47;HPF &#40;70&#37; crenated&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proteins in urine 24<span class="elsevierStyleHsp" style=""></span>hrs &#40;10-150<span class="elsevierStyleHsp" style=""></span>mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;410&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C Reactive protein &#40;0&#46;01-0&#46;82<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haemoglobin &#40;13&#46;0-17&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Haematocrit &#40;42&#46;0-52&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White cells &#40;4&#44;500-11&#44;000&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neutrophils &#40;1&#44;500-6&#44;100&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lymphocytes &#40;1&#44;500-3&#44;500&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eosinophils &#40;0-700&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Monocytes &#40;0-1&#44;000&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basophils &#40;0-200&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Platelets &#40;150-450<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;mm<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">315&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ferritine &#40;15-200<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitamin B<span class="elsevierStyleInf">12</span> &#40;124-732<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">492&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Folic acid &#40;3&#46;5-19&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Complement C3 &#40;82-185<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Complement C4 &#40;15-53<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA &#40;dilution&#44; pattern&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#58;640&#44; spotted&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-Ro &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-La &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-Sm &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-RNP &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Native anti-DNA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anticardiolipins IgM &#40;0-12&#46;5<span class="elsevierStyleHsp" style=""></span>MPL&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anticardiolipins IgG &#40;0-15<span class="elsevierStyleHsp" style=""></span>GPL&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Confirmatory lupus anticoagulant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normalised ratio 1&#46;72 &#40;positive&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-&#223;2 glycoprotein 1 IgG &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-&#223;2 glycoprotein 1 IgM &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANCA Anti MPO &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANCA Anti PR3 &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-glomerular basement membrane IgG &#40;0-20 units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rheumatoid factor &#40;0-30<span class="elsevierStyleHsp" style=""></span>UI&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prothrombin time &#40;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Partial thromboplastin time &#40;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2314089.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Analytical results&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cocaine-induced vasculitis&#58; Clinical and immunological spectrum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;R&#46; Espinoza"
                            1 => "A&#46;R&#46; Perez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11926-012-0283-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Rheumatol Rep"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "532"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22875288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cocaine-Levamisole-Induced Vasculitis&#47;Vasculopathy Syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Marquez"
                            1 => "L&#46; Aguirre"
                            2 => "C&#46; Mu&#241;oz"
                            3 => "A&#46; Echeverri"
                            4 => "M&#46; Restrepo"
                            5 => "L&#46;F&#46; Pinto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11926-017-0653-9"
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Rheumatol Rep"
                        "fecha" => "2017"
                        "volumen" => "19"
                        "paginaInicial" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28612332"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contaminated Cocaine and Antineutrophil Cytoplasmic Antibody-Associated Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; McGrath"
                            1 => "T&#46; Isakova"
                            2 => "H&#46;G&#46; Rennke"
                            3 => "A&#46;M&#46; Mottola"
                            4 => "K&#46;A&#46; Laliberte"
                            5 => "J&#46;L&#46; Niles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.03440411"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "2799"
                        "paginaFinal" => "2805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21980179"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine&#58; A series of 4 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;Q&#46; Carlson"
                            1 => "D&#46;S&#46; Tuot"
                            2 => "K&#46;Y&#46; Jen"
                            3 => "B&#46; Butcher"
                            4 => "J&#46; Graf"
                            5 => "R&#46; Sam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2014"
                        "volumen" => "93"
                        "paginaInicial" => "290"
                        "paginaFinal" => "297"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cocaine-induced midline destructive lesions-an autoimmune disease&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Trimarchi"
                            1 => "M&#46; Bussi"
                            2 => "R&#46;A&#46; Sinico"
                            3 => "P&#46; Meroni"
                            4 => "U&#46; Specks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.autrev.2012.08.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Autoimmun Rev"
                        "fecha" => "2013"
                        "volumen" => "12"
                        "paginaInicial" => "496"
                        "paginaFinal" => "500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22940554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathologic manifestations of levamisole-adulterated cocaine exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;L&#46; Nolan"
                            1 => "K&#46;Y&#46; Jen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13000-015-0279-z"
                      "Revista" => array:5 [
                        "tituloSerie" => "Diagn Pathol"
                        "fecha" => "2015"
                        "volumen" => "10"
                        "paginaInicial" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25943359"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001600000003/v1_202006131316/S2173574320300630/v1_202006131316/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43296"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001600000003/v1_202006131316/S2173574320300630/v1_202006131316/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300630?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 16. Issue 3.
Pages 239-241 (May - June 2020)
Visits
4187
Vol. 16. Issue 3.
Pages 239-241 (May - June 2020)
Clinical Case
Full text access
Pulmonary-renal syndrome secondary to cocaine-levamisole-induced vasculitis: A case report
Síndrome pulmón-riñón secundario a vasculitis por cocaína/levamisol: reporte de caso
Visits
4187
Mauricio Restrepo-Escobara,b,
Corresponding author
mauricio.restrepoe@udea.edu.co

Corresponding author.
, Dayana Sylvac, Juan Guillermo Gamboab,d, Andrés Echeverria, Javier Márqueza, Luis Fernando Pintoa
a Sección de Reumatología, Hospital Pablo Tobón Uribe, Medellín, Colombia
b Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
c Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia
d Sección de Medicina Interna, Hospital Pablo Tobón Uribe, Medellín, Colombia
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (1)
Table 1. Analytical results.
Abstract

Pulmonary-renal syndrome has rarely been reported as the clinical presentation of vasculitis caused by the consumption of cocaine adulterated with levamisole. We report the case of a patient in whom we detected the clinical manifestations and indicate the difficulties that arose in relation to the diagnostic and therapeutic approach.

Keywords:
Vasculitis
Cocaine
Levamisole
Alveolar hemorrhage
Pulmonary-renal syndrome
Resumen

El síndrome pulmón-riñón rara vez ha sido reportado como cuadro clínico de presentación de vasculitis causada por el consumo de cocaína contaminada con levamisol. Se reporta el caso de un paciente con este cuadro clínico y se señalan las dificultades que se presentaron durante el abordaje diagnóstico y terapéutico.

Palabras clave:
Vasculitis
Cocaína
Levamisol
Hemorragia alveolar
Síndrome pulmón-riñón
Full Text
Introduction

Cocaine consumption is still a public health problem. The adulteration of cocaine with substances such as levamisole leads to the appearance of additional medical problems. Vasculitis caused by levamisole is highly heterogeneous in terms of clinical symptoms and analytical results, hindering diagnosis.

Clinical observation

A 34 year-old male with a history of reactive arthritis and daily marihuana consumption. He denied consuming cocaine. He was admitted for one week due to general discomfort, pallor, a dry cough, thoracic pain and dyspnea. Mucocutaneous pallor, hypoxemia and rale in the base of the lungs. He was normotensive, with no tachycardia or fever.

He had severe anaemia, renal dysfunction and mixed opacities in both pulmonary fields (Fig. 1 and Table 1). He was diagnosed pulmonary-renal syndrome and treatment commenced with high doses of steroids and blood cell transfusion. At first the diagnosis of systemic lupus erythmatosus (SLE) was considered due to the finding of hypocomplementemia. Additional studies found multiple antibody positivity: ANCA (antimyeloperoxidase and antiproteinase-3), ANA, anti-Ro, anti-La, lupus anticoagulant, rheumatoid factor and anticardiolipin IgM. Anti-Sm, anti-DNA and anti-basement glomerular membrane antibodies were negative.

Figure 1.

A) Thoracic X-ray showing diffuse infiltrates in both pulmonary fields. B) Generalised mixed opacities observed in high resolution thoracic tomography.

(0.41MB).
Table 1.

Analytical results.

Analysis  Result 
Creatinine (0.60-1.10mg/dl)  2.16 
Urine analysis (cells per high power field (HPF)  Proteins 75mg/leukocytes 0-5/CAP/erythrocytes 21-50/HPF (70% crenated) 
Proteins in urine 24hrs (10-150mg)  1,410 
C Reactive protein (0.01-0.82mg/dl)  4.13 
Haemoglobin (13.0-17.0g/dl)  3.1 
Haematocrit (42.0-52.0%)  10.1 
White cells (4,500-11,000/mm38,100 
Neutrophils (1,500-6,100/mm32,800 
Lymphocytes (1,500-3,500/mm34,800 
Eosinophils (0-700/mm3100 
Monocytes (0-1,000/mm3400 
Basophils (0-200/mm3
Platelets (150-450×103/mm3315,000 
Ferritine (15-200ng/ml)  70 
Vitamin B12 (124-732pg/ml)  492 
Folic acid (3.5-19.5ng/ml)  10.3 
Complement C3 (82-185mg/dl)  75 
Complement C4 (15-53mg/dl)  9.9 
ANA (dilution, pattern)  1:640, spotted 
Anti-Ro (0-20 units)  118.6 
Anti-La (0-20 units)  87.6 
Anti-Sm (0-20 units)  4.4 
Anti-RNP (0-20 units)  5.3 
Native anti-DNA  Negative 
Anticardiolipins IgM (0-12.5MPL/ml)  29.5 
Anticardiolipins IgG (0-15GPL/ml)  2.9 
Confirmatory lupus anticoagulant  Normalised ratio 1.72 (positive) 
Anti-ß2 glycoprotein 1 IgG (0-20 units)  .70 
Anti-ß2 glycoprotein 1 IgM (0-20 units)  6.19 
ANCA Anti MPO (0-20 units)  105.5 
ANCA Anti PR3 (0-20 units)  48.7 
Anti-glomerular basement membrane IgG (0-20 units)  3.6 
Rheumatoid factor (0-30UI/ml)  40.6 
Prothrombin time (s)  11.2 
Partial thromboplastin time (s)  31.6 

Diffuse endocapilar glomerulonephritis was observed in a renal biopsy, with immune complex deposits and tubulointerstitial nephritis. Fibrobroncoscoy confirmed alveolar haemorrhage (haemosiderophages 40%) and ruled out infection. During a subsequent evaluation perforation of the nasal septum was observed and the patient confirmed frequent consumption of cocaine. As well as insisting on the cessation of consumption treatment with prednisolone continued, with good clinical response and a rise in haemoglobin, although there was only partial improvement in renal function, so that additional monthly boli of cyclophosphamide were added.

Discussion

During recent years the number of cases of vasculitis associated with levamisole-adulterated cocaine consumption has increased. This disease may compromise multiple organs and systems.1,2

Alveolar haemorrhage is rare. McGrath et al. described a series of 30 cases of levamisole-induced ANCA vasculitis. Three of the cases had alveolar haemorrhage, and it was not possible to prove renal involvement in any of them.3 Cases of pulmonary-renal syndrome are even rarer due to this entity.4

No definitive criteria for diagnosis of this syndrome exist. Diagnosis is based on epidemiological, clinical and analytical findings. In the majority of cases it is not possible to prove contamination by levamisole, as the test is not clinically available and measurement has to take place within 24hrs. of the previous consumption. A high level of suspicion is necessary prior to probing for cocaine consumption. Differential diagnosis is broad. It may be confused with vasculitis associated with ANCA, Goodpasture syndrome and even SLE.

Vasculopathy secondary to levamisole is characterised by high titers of p-ANCA directed against multiple rare antigens, as well as concomitant positivity for c-ANCA,5,6 a rare expression in patients with primary vasculitis. Positivity for multiple antibodies and consumption as a complement may lead to confusion with SLE.

The rate of recurrence in the case of continued cocaine consumption is high. The role of immunosuppressor therapy is unknown, and no treatment patterns have been defined. The patient responded partially to steroids and the suspension of the causal agent. The addition of cyclophosphamide seems to have contributed to his final clinical improvement.

Conclusions

This case represents a clinical challenge due to its atypical form of presentation, the severity of its manifestations and the difficulty of diagnosis. It is necessary to know the different clinical and analytical manifestations caused by cocaine/levamisole consumption, and to maintain a high level of suspicion regarding the possibility of this consumption, which may be denied by the patient.

Conflict of interests

The authors have no conflict of interests to declare.

References
[1]
L.R. Espinoza, A.R. Perez.
Cocaine-induced vasculitis: Clinical and immunological spectrum.
Curr Rheumatol Rep, 14 (2012), pp. 532-538
[2]
J. Marquez, L. Aguirre, C. Muñoz, A. Echeverri, M. Restrepo, L.F. Pinto.
Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.
Curr Rheumatol Rep, 19 (2017), pp. 36
[3]
M.M. McGrath, T. Isakova, H.G. Rennke, A.M. Mottola, K.A. Laliberte, J.L. Niles.
Contaminated Cocaine and Antineutrophil Cytoplasmic Antibody-Associated Disease.
Clin J Am Soc Nephrol, 6 (2011), pp. 2799-2805
[4]
A.Q. Carlson, D.S. Tuot, K.Y. Jen, B. Butcher, J. Graf, R. Sam, et al.
Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: A series of 4 cases.
Medicine (Baltimore), 93 (2014), pp. 290-297
[5]
M. Trimarchi, M. Bussi, R.A. Sinico, P. Meroni, U. Specks.
Cocaine-induced midline destructive lesions-an autoimmune disease?.
Autoimmun Rev, 12 (2013), pp. 496-500
[6]
A.L. Nolan, K.Y. Jen.
Pathologic manifestations of levamisole-adulterated cocaine exposure.
Diagn Pathol, 10 (2015), pp. 48

Please cite this article as: Restrepo-Escobar M, Sylva D, Gamboa JG, Echeverri A, Márquez J, Pinto LF. Síndrome pulmón-riñón secundario a vasculitis por cocaína/levamisol: reporte de caso . https://doi.org/10.1016/j.reuma.2018.02.014

Copyright © 2018. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?