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Vol. 17. Issue 10.
Pages 562-565 (December 2021)
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Vol. 17. Issue 10.
Pages 562-565 (December 2021)
Brief Report
Serum galectin-3 and TGF-beta levels in patients with sarcoidosis
Niveles séricos de galectina-3 y TGF-beta en pacientes con sarcoidosis
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Senol Kobaka,
Corresponding author
senolkobak@yahoo.com

Corresponding author.
, Muhittin Akyildizb, Ayse Gokdumanb, Tennur Atabayb, Huseyin Vuralb
a Istinye University Faculty of Medicine, Department of Internal Medicine and Rheumatology, WASOG Sarcoidosis Clinic, Turkey
b Sifa University Faculty of Medicine, Department of Biochemistry, Turkey
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Tables (3)
Table 1. Demographic, clinical and laboratory features of patients with sarcoidosis and healthy control group.
Table 2. Mean serum Gal-3 and TGF-beta levels in patients with sarcoidosis and control group.
Table 3. Correlation between serum Gal-3 and TGF-beta with clinical findings in patients with sarcoidosis.
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Abstract
Introduction

Sarcoidosis is a chronic granulomatous disease that develops with non-caseified granuloma formation. Galectin-3 is a multifunctional protein operating in biological processes such as fibrosis, angiogenesis, and immune activation.

Purpose

This study evaluates the levels of serum galectin-3 and TGF-beta in sarcoidosis patients to determine a possible correlation with clinical findings.

Material and method

Forty-four biopsy-proven sarcoidosis patients followed in a single centre and 41 age and sex-matched healthy volunteers were included in the study. The levels of serum galectin-3 and TGF-beta were evaluated by ELISA method.

Results

Among the 44 sarcoidosis patients, 13(29.5%) were male and 31(70.5%) were female. The average patient age was 47.4 and the average disease duration was 3.2 years. The level of serum galectin-3 was found to be the same as in the control group and had no significance statistically (p=.977). No correlation was determined between the level of serum galectin-3 and clinical and laboratory findings of sarcoidosis (p>.05). The level of serum TGF-beta was found to be higher in the sarcoidosis patients when compared to that of the control group (p=.005). While a correlation was found between serum TGF-beta and enthesitis, sacroiliitis, and arthralgia (p=.006, p=.034, p=.02), no correlation was determined on the other clinical and laboratory findings (p>.05).

Conclusion

While the level of serum galectin-3 was determined to be normal in sarcoidosis patients, a high level of serum TGF-beta was found. These findings show that TGF-beta may play an important role in sarcoidosis pathogenesis and the formation of granuloma.

Keywords:
Sarcoidosis
Galectin-3
TGF-beta
Resumen
Introducción

La sarcoidosis es una enfermedad granulomatosa crónica que se desarrolla con una formación de granuloma no caseificado. Galectina-3 es una proteína multifuncional que opera en procesos biológicos como la fibrosis, la angiogénesis y la activación inmune.

Propósito

Este estudio evalúa los niveles séricos de galectina-3 y TGF-beta en pacientes con sarcoidosis para determinar una posible correlación con los hallazgos clínicos.

Material y método

Fueron seguidos en un solo centro 44 pacientes con sarcoidosis probados por biopsia y se incluyeron en el estudio 41 voluntarios sanos de la misma edad y sexo. Los niveles séricos de galectina-3 y TGF-beta fueron evaluados por el método ELISA.

Resultados

Entre los 44 pacientes con sarcoidosis, 13 (29,5%) eran hombres y 31 (70,5%) eran mujeres. La edad promedio de los pacientes fue de 47,4 y la duración promedio de la enfermedad fue de 3,2 años. Se encontró que el nivel de galectina-3 en suero era el mismo que en el grupo control y no tenía significancia estadística (p = 0,977). No se determinó correlación entre el nivel sérico de galectina-3 y los hallazgos clínicos y de laboratorio de sarcoidosis (p > 0,05). El nivel de TGF-beta en suero se encontró más alto en los pacientes con sarcoidosis, en comparación con el del grupo control (p = 0,005). Si bien se encontró una correlación entre el TGF-beta sérico y la entesitis, sacroileítis y artralgia (p = 0,006, p = 0,034, p = 0,02), no se determinó correlación en los otros hallazgos clínicos y de laboratorio (p > 0,05).

Conclusión

Si bien se determinó que el nivel sérico de galectina-3 era normal en pacientes con sarcoidosis, se encontró un alto nivel de TGF-beta en suero. Estos hallazgos muestran que el TGF-beta puede desempeñar un papel importante en la patogénesis de la sarcoidosis y la formación de granuloma.

Palabras clave:
Sarcoidosis
Galectina-3
TGF-beta

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