array:23 [
  "pii" => "S217357431070071X"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(10)70071-X"
  "estado" => "S300"
  "fechaPublicacion" => "2010-11-01"
  "aid" => "70071"
  "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2010"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2010;6:303-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2186
    "formatos" => array:3 [
      "EPUB" => 49
      "HTML" => 1298
      "PDF" => 839
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574310700721"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(10)70072-1"
    "estado" => "S300"
    "fechaPublicacion" => "2010-11-01"
    "aid" => "70072"
    "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "rev"
    "cita" => "Reumatol Clin. 2010;6:306-10"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2637
      "formatos" => array:3 [
        "EPUB" => 61
        "HTML" => 1481
        "PDF" => 1095
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Epigenetic therapies, a step beyond biologics for rheumatoid arthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "306"
          "paginaFinal" => "310"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Las terapias epigenéticas, más allá de los biológicos en el tratamiento de la artritis reumatoide"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Olga Sánchez-Pernaute"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Sánchez-Pernaute"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700721?idApp=UINPBA00004M"
    "url" => "/21735743/0000000600000006/v1_201305061614/S2173574310700721/v1_201305061614/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173574310700708"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(10)70070-8"
    "estado" => "S300"
    "fechaPublicacion" => "2010-11-01"
    "aid" => "70070"
    "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2010;6:299-302"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2240
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 1407
        "PDF" => 787
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Frequency of systemic manifestations in patients with primary Sjögren's syndrome in Argentina"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "299"
          "paginaFinal" => "302"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Frecuencia de manifestaciones sistémicas en pacientes con síndrome de Sjögren primario en Argentina"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Federico Zazzetti, Mariano Adolfo Rivero, Damián Elvio Duartes Noé, Alberto Gallacher, Amalia Schiel, Marina Claudia Khoury, Hugo Armando Laborde, Juan Carlos Barreira"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Federico"
              "apellidos" => "Zazzetti"
            ]
            1 => array:2 [
              "nombre" => "Mariano"
              "apellidos" => "Adolfo Rivero"
            ]
            2 => array:2 [
              "nombre" => "Damián Elvio"
              "apellidos" => "Duartes Noé"
            ]
            3 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Gallacher"
            ]
            4 => array:2 [
              "nombre" => "Amalia"
              "apellidos" => "Schiel"
            ]
            5 => array:2 [
              "nombre" => "Marina"
              "apellidos" => "Claudia Khoury"
            ]
            6 => array:2 [
              "nombre" => "Hugo"
              "apellidos" => "Armando Laborde"
            ]
            7 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Carlos Barreira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700708?idApp=UINPBA00004M"
    "url" => "/21735743/0000000600000006/v1_201305061614/S2173574310700708/v1_201305061614/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Severe flare of Behcet's disease with intense mucucutaneous manifestations"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "303"
        "paginaFinal" => "305"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "José M. Martín, Elisabeth Mateo, Carlos Monteagudo, Esperanza Jordá"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "José M."
            "apellidos" => "Martín"
            "email" => array:1 [
              0 => "jmmart@eresmas.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Elisabeth"
            "apellidos" => "Mateo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "Monteagudo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Esperanza"
            "apellidos" => "Jord&#225;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicios de Dermatolog&#237;a&#44; Hospital Cl&#237;nico Universitario&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Medicina Interna&#44; Hospital General Universitario&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Anatom&#237;a Patol&#243;gica&#44; Hospital Cl&#237;nico Universitario&#44; Valencia&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Brote severo de la enfermedad de Beh&#231;et con manifestaciones mucocut&#225;neas intensas"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-11-02"
    "fechaAceptado" => "2010-05-05"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec112568"
          "palabras" => array:2 [
            0 => "Cytomegalovirus"
            1 => "Behcet&#39;s disease"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec112569"
          "palabras" => array:2 [
            0 => "Citomegalovirus"
            1 => "Enfermedad de Beh&#231;et"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Behcet&#39;s disease is a multisystemic inflammatory disease with various manifestations at the skin level&#44; especially in the form of acne-like lesions or erythema nodosum&#46; Susceptibility to this disease is strongly linked to the presence of the HLA&#95;B51 allele&#44; although certain environmental factors such as infectious agents have also been implicated in its pathogenesis&#46; We present the case of a patient with Behcet&#39;s disease who developed a severe flare characterized by lesions similar to those seen in Sweet&#39;s syndrome&#46; Histologically we observed granulomatous vasculitis&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Behcet es un trastorno inflamatorio multisistemico que se manifiesta de forma muy variada a nivel cutaneo&#44; especialmente en forma de lesiones acneiformes o de eritema nodoso&#46; La susceptibilidad a padecer esta enfermedad se halla fuertemente ligada con la presencia del alelo HLA-B51&#44; aunque determinados factores ambientales como agentes infecciosos tambien se han implicado en la patogenesis&#46; Presentamos el caso de una paciente con una enfermedad de Behcet que desarrollo un brote severo con lesiones cutaneas analogas a las que se aprecian en el sindrome de Sweet&#46; Histologicamente se apreciaron fenomenos de vasculitis granulomatosa&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Sakane"
                            1 => "M&#46; Takeno"
                            2 => "N&#46; Suzuki"
                            3 => "G&#46; Inaba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199910213411707"
                      "Revista" => array:7 [
                        "tituloSerie" => "New Engl J Med"
                        "fecha" => "1999"
                        "volumen" => "341"
                        "paginaInicial" => "1284"
                        "paginaFinal" => "1291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10528040"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S000293780700395X"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A study of the cutaneous manifestations of Beh&#231;et&#39;s disease in patients from the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Balabanova"
                            1 => "K&#46;T&#46; Calamia"
                            2 => "C&#46; Perniciaro"
                            3 => "J&#46;D&#46; O&#8217;Duffy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1999"
                        "volumen" => "41"
                        "paginaInicial" => "540"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10495372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Type I herpes virus&#46; HLA phenotype and Beh&#231;et disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Sanchez-Roman"
                            1 => "M&#46;J&#46; Castillo-Palma"
                            2 => "R&#46; Torronteras Santiago"
                            3 => "J&#46;M&#46; Varela Aguilar"
                            4 => "F&#46; Lopez Checa"
                            5 => "F&#46; Sanchez Garcia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1992"
                        "volumen" => "98"
                        "paginaInicial" => "366"
                        "paginaFinal" => "368"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;M&#46; Magro"
                            1 => "A&#46;N&#46; Crowson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1995"
                        "volumen" => "34"
                        "paginaInicial" => "159"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7751087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;G&#46; Kaklamani"
                            1 => "G&#46; Variopoulos"
                            2 => "P&#46;G&#46; Kaklamanis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "1998"
                        "volumen" => "27"
                        "paginaInicial" => "197"
                        "paginaFinal" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9514126"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beh&#231;et&#39;s disease&#58; infectious aetiology&#44; new autoantigens&#44; and HLA-B51"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Direskeneli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2001"
                        "volumen" => "60"
                        "paginaInicial" => "996"
                        "paginaFinal" => "1002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11602462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous vasculitis in Beh&#231;et&#39;s disease&#58; a clinical and histopathologic study of 20 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;R&#46; Chen"
                            1 => "Y&#46; Kawahara"
                            2 => "S&#46; Miyakawa"
                            3 => "T&#46; Nishikawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1997"
                        "volumen" => "36"
                        "paginaInicial" => "689"
                        "paginaFinal" => "696"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9146529"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histologic and immunofluorescence findings of non-follicular papulopustular lesions in patients with Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Alpsoy"
                            1 => "S&#46; Uzun"
                            2 => "A&#46; Azman"
                            3 => "M&#46; Alpaslan Acar"
                            4 => "H&#46;R&#46; Memisoglu"
                            5 => "E&#46; Basaran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "521"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12941085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preliminary evidence for an association of Epstein-Barr virus with pre-ulcerative oral lesions in patients with recurrent aphthous ulcers or Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Sun"
                            1 => "J&#46;G&#46; Chang"
                            2 => "C&#46;T&#46; Chu"
                            3 => "B&#46;Y&#46; Liu"
                            4 => "J&#46;H&#46; Yuan"
                            5 => "C&#46;P&#46; Chiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "1998"
                        "volumen" => "27"
                        "paginaInicial" => "168"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9563572"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human cytomegalovirus as a potential etiologic agent in recurrent aphthous ulcers and Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Sun"
                            1 => "J&#46;G&#46; Chang"
                            2 => "C&#46;L&#46; Kao"
                            3 => "B&#46;Y&#46; Liu"
                            4 => "J&#46;T&#46; Wang"
                            5 => "C&#46;T&#46; Chu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "212"
                        "paginaFinal" => "218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8835817"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decreased serum level of antibody against human cytomegalovirus in patients with Beh&#231;et&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;B&#46; Lee"
                            1 => "Y&#46;J&#46; Kwon"
                            2 => "K&#46;C&#46; Shin"
                            3 => "Y&#46;W&#46; Song"
                            4 => "C&#46;G&#46; Park"
                            5 => "E&#46;S&#46; Hwang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00296-003-0394-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatol Int"
                        "fecha" => "2005"
                        "volumen" => "25"
                        "paginaInicial" => "33"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14600786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of serum antibodies against cytomegalovirus&#44; varicella zoster virus and human herpesvirus 6 in patients with recurrent aphtous stomatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46; Ghodratnama"
                            1 => "D&#46; Wray"
                            2 => "J&#46; Bagg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "1999"
                        "volumen" => "28"
                        "paginaInicial" => "12"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9890451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000600000006/v1_201305061614/S217357431070071X/v1_201305061614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17376"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Case Report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000006/v1_201305061614/S217357431070071X/v1_201305061614/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431070071X?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 6. Issue 6.
Pages 303-305 (November - December 2010)
Share
Share
Download PDF
More article options
Vol. 6. Issue 6.
Pages 303-305 (November - December 2010)
Full text access
Severe flare of Behcet's disease with intense mucucutaneous manifestations
Brote severo de la enfermedad de Behçet con manifestaciones mucocutáneas intensas
Visits
5776
José M. Martína,
Corresponding author
jmmart@eresmas.com

Corresponding author.
, Elisabeth Mateob, Carlos Monteagudoc, Esperanza Jordáa
a Servicios de Dermatología, Hospital Clínico Universitario, Valencia, Spain
b Medicina Interna, Hospital General Universitario, Valencia, Spain
c Anatomía Patológica, Hospital Clínico Universitario, Valencia, Spain
This item has received
Article information
Abstract

Behcet's disease is a multisystemic inflammatory disease with various manifestations at the skin level, especially in the form of acne-like lesions or erythema nodosum. Susceptibility to this disease is strongly linked to the presence of the HLA_B51 allele, although certain environmental factors such as infectious agents have also been implicated in its pathogenesis. We present the case of a patient with Behcet's disease who developed a severe flare characterized by lesions similar to those seen in Sweet's syndrome. Histologically we observed granulomatous vasculitis.

Keywords:
Cytomegalovirus
Behcet's disease
Resumen

La enfermedad de Behcet es un trastorno inflamatorio multisistemico que se manifiesta de forma muy variada a nivel cutaneo, especialmente en forma de lesiones acneiformes o de eritema nodoso. La susceptibilidad a padecer esta enfermedad se halla fuertemente ligada con la presencia del alelo HLA-B51, aunque determinados factores ambientales como agentes infecciosos tambien se han implicado en la patogenesis. Presentamos el caso de una paciente con una enfermedad de Behcet que desarrollo un brote severo con lesiones cutaneas analogas a las que se aprecian en el sindrome de Sweet. Histologicamente se apreciaron fenomenos de vasculitis granulomatosa.

Palabras clave:
Citomegalovirus
Enfermedad de Behçet
Full text is only aviable in PDF
References
[1.]
T. Sakane, M. Takeno, N. Suzuki, G. Inaba.
Behçet's disease.
New Engl J Med, 341 (1999), pp. 1284-1291
[2.]
M. Balabanova, K.T. Calamia, C. Perniciaro, J.D. O’Duffy.
A study of the cutaneous manifestations of Behçet's disease in patients from the United States.
J Am Acad Dermatol, 41 (1999), pp. 540-545
[3.]
J. Sanchez-Roman, M.J. Castillo-Palma, R. Torronteras Santiago, J.M. Varela Aguilar, F. Lopez Checa, F. Sanchez Garcia.
Type I herpes virus. HLA phenotype and Behçet disease.
Med Clin (Barc), 98 (1992), pp. 366-368
[4.]
C.M. Magro, A.N. Crowson.
Cutaneous manifestations of Behçet's disease.
Int J Dermatol, 34 (1995), pp. 159-165
[5.]
V.G. Kaklamani, G. Variopoulos, P.G. Kaklamanis.
Behçet's disease.
Semin Arthritis Rheum, 27 (1998), pp. 197-217
[6.]
H. Direskeneli.
Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51.
Ann Rheum Dis, 60 (2001), pp. 996-1002
[7.]
K.R. Chen, Y. Kawahara, S. Miyakawa, T. Nishikawa.
Cutaneous vasculitis in Behçet's disease: a clinical and histopathologic study of 20 patients.
J Am Acad Dermatol, 36 (1997), pp. 689-696
[8.]
E. Alpsoy, S. Uzun, A. Azman, M. Alpaslan Acar, H.R. Memisoglu, E. Basaran.
Histologic and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease.
J Eur Acad Dermatol Venereol, 17 (2003), pp. 521-524
[9.]
A. Sun, J.G. Chang, C.T. Chu, B.Y. Liu, J.H. Yuan, C.P. Chiang.
Preliminary evidence for an association of Epstein-Barr virus with pre-ulcerative oral lesions in patients with recurrent aphthous ulcers or Behçet's disease.
J Oral Pathol Med, 27 (1998), pp. 168-175
[10.]
A. Sun, J.G. Chang, C.L. Kao, B.Y. Liu, J.T. Wang, C.T. Chu.
Human cytomegalovirus as a potential etiologic agent in recurrent aphthous ulcers and Behçet's disease.
J Oral Pathol Med, 25 (1996), pp. 212-218
[11.]
E.B. Lee, Y.J. Kwon, K.C. Shin, Y.W. Song, C.G. Park, E.S. Hwang, et al.
Decreased serum level of antibody against human cytomegalovirus in patients with Behçet's disease.
Rheumatol Int, 25 (2005), pp. 33-36
[12.]
F. Ghodratnama, D. Wray, J. Bagg.
Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in patients with recurrent aphtous stomatitis.
J Oral Pathol Med, 28 (1999), pp. 12-15
Copyright © 2010. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?