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Vol. 19. Issue 1.
Pages 12-17 (January 2023)
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Vol. 19. Issue 1.
Pages 12-17 (January 2023)
Original article
Significance of platelets to lymphocytes and platelets to haemoglobin ratios in patients with systemic sclerosis
Importancia de las plaquetas para los linfocitos y las proporciones de plaquetas para la hemoglobina en pacientes con esclerosis sistémica
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Shymaa A. Sarhana,
Corresponding author
shymaasarhan0@gmail.com

Corresponding author.
, Yomna M. EL-Meliguib
a Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt
b Department of Clinical Pathology, National Cancer Institute, Cairo University, Egypt
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Abstract
Background

Systemic sclerosis (SSc) is a progressive autoimmune connective tissue disease. Platelets to lymphocytes (PLR) and platelets to haemoglobin ratios (PHR) are emerging biomarkers used in the assessment of activity and severity of various autoimmune diseases. This study was designed to clarify the association of PLR and PHR with SSc disease activity and its different manifestations.

Method

A cross-sectional study involved sixty SSc patients. Demographic, clinical data and investigations were done.

Results

PLR and PHR were correlated positively with ESR (r=0.351, p=0.003*), (r=0.620, p=0.000**), CRP (r=0.417, p=0.001*), (r=0.305, p=0.018**) and SSc activity index (r=0.292, p=0.024*), (r=0.359, p=0.005*). PLR and PHR were highly significantly related to digital ulcerations, musckeloskeletal, and pulmonary manifestations. Also, they had a significant relation to ground glass abnormalities on HRCT, mild restriction in pulmonary function tests and anti-scleroderma-70 antibodies. The cutoff value for PLR was 107.8 with high sensitivity 97.9% and specifity 92.3%, area under the curve (AUC=0.723, P 0.015) on receiver operating characteristic curve (ROC). PHR AUC (0.799, P .001), cut value was 23.5 at 95.7% sensitivity and 84.6% specifity.

Conclusion

PLR and PHR were significantly related to digital ulcerations, musculoskeletal, and pulmonary manifestations and can be considered as predictive biomarkers for the assessment of SSc disease activity and severity.

Keywords:
PLR
PHR
Systemic sclerosis
Activity
Manifestations
Resumen
Antecedentes

La esclerosis sistémica (ES) es una enfermedad autoinmune progresiva del tejido conectivo. Las proporciones de plaquetas a linfocitos (PLR) y de plaquetas a hemoglobina (PHR) son biomarcadores emergentes que se utilizan en la evaluación de la actividad y la gravedad de diversas enfermedades autoinmunes. Este estudio fue diseñado para aclarar la asociación de PLR y PHR con la actividad de la enfermedad de ES y sus diferentes manifestaciones.

Método

Estudio transversal en el que participaron 60 pacientes con ES. Se realizaron investigaciones y datos demográficos, clínicos.

Resultados

PLR y PHR se correlacionaron positivamente con la VSG (r=0,351; p=0,003 *), (r=0,620, p=0,000 **), CRP (r=0,417; p=0,001 *), (r=0,305; p=0,018 **) e índice de actividad de ES (r=0,292; p=0,024 *), (r=0,359; p=0,005 *). PLR y PHR se relacionaron de manera muy significativa con ulceraciones digitales, manifestaciones musculoesqueléticas y pulmonares. Además, tenían una relación significativa con las anomalías en vidrio esmerilado en la TCAR, la restricción leve en las pruebas de función pulmonar y los anticuerpos antiesclerodermia-70. El valor de corte para PLR fue 107,8 con alta sensibilidad (97,9%) y especificidad (92,3%), área bajo la curva (AUC=0,723; p=0,015) en la curva característica de funcionamiento del receptor (ROC). PHR AUC (0,799; p=0,001), el valor de corte fue 23,5 con una sensibilidad del 95,7% y una especificidad del 84,6%.

Conclusión

PLR y PHR pueden considerarse biomarcadores predictivos para la evaluación de la actividad y la gravedad de la enfermedad de ES.

Palabras clave:
PLR
PHR
Esclerosis sistémica
Actividad
Manifestaciones

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