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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Systemic sclerosis &#40;SSc&#41; is a rare autoimmune disease&#44; with a prevalence in Europe ranging from 7&#46;2 to 33&#46;9 cases per 100&#44;000 individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> This disease is characterized by progressive fibrosis of the skin and internal organs&#44; microvascular damage and cellular and humoral immunity abnormalities&#46; It primarily involves the microcirculation and Raynaud&#39;s phenomenon &#40;RP&#41; is typically the first and most prevalent manifestation of the disease&#44; occurring in more than 90&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Microvascular damage can be easily detected through nailfold videocapillaroscopy &#40;NVC&#41;&#44; which is a simple&#44; safe and non-invasive technique that allows a detailed assessment of nailfold capillaries&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> NVC shows a variety of morphological changes&#44; including microhemorrhages&#44; enlarged and giant capillaries&#44; impaired capillary architecture&#44; loss of capillaries with or without avascular areas and the presence of abnormal shapes&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a> Some authors have disclosed specific capillaroscopic patterns in SSc patients&#44; known as &#8220;scleroderma patterns&#8221;&#46; These patterns not only aid in the diagnostic process&#44; but also appear to correlate with consecutive stages of capillary damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5</span></a> The three NVC scleroderma patterns &#40;early&#44; active and late&#41; seem to reflect the evolution of SSc microangiopathy and may be useful in assessing microvascular damage&#46; Therefore&#44; NVC can be a diagnostic and a follow-up parameter to track microvascular changes over time&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">However&#44; there has been limited research and understanding regarding the impact of the severity of microvascular damage in predicting overall disease severity&#46; With the aim of assessing NVC as a marker of overall disease severity&#44; this study was conducted to evaluate microvascular damage using NVC among patients with SSc at disease onset and to assess associations between these changes and systemic involvement over a 3-year follow-up period&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0020" class="elsevierStylePara elsevierViewall">An observational retrospective cohort study was conducted with 3 years of follow-up&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Participants</span><p id="par0025" class="elsevierStylePara elsevierViewall">Patients aged 18 years or older&#44; classified as having SSc according to the 2013 American College of Rheumatology &#40;ACR&#41;&#47;European League Against Rheumatism &#40;EULAR&#41; criteria&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a> followed at a single tertiary rheumatology centre were included&#46; Those with psychiatric or cognitive disorders that could potentially interfere with data collection&#44; as well as patients who were physically or psychologically unable to communicate&#44; were excluded&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The Guideline for Good Clinical Practice of the International Conference on Harmonization and the ethical principles of the Declaration of Helsinki were followed&#46; Each patient signed informed consent and all data were anonymised in accordance with both the Portuguese Data Protection Law and the General Data Protection Regulation&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Data collection and measures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">NVC assessment</span><p id="par0035" class="elsevierStylePara elsevierViewall">NVC was performed by the same experienced rheumatologist with the same equipment in the first 6 months after the SSc diagnosis&#46; The nailfolds of the second to fifth fingers were examined bilaterally in each patient&#46; Detailed information regarding the number of capillaries&#44; presence of giant capillaries&#44; haemorrhages&#44; avascular areas and abnormal shapes were collected&#46; NVC assessments were conducted in accordance with the standardized capillaroscopy evaluation chart established by the EULAR Study Group on Microcirculation in Rheumatic Diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> Initially&#44; capillaroscopic parameters were classified according to the CAP Fast Track Algorithm in &#8220;scleroderma pattern&#8221; or &#8220;non-scleroderma pattern&#8221; &#40;including &#8220;normal pattern&#8221; and &#8220;non-specific abnormalities&#8221;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">8</span></a> Subsequently&#44; the NVC with a scleroderma pattern was further stratified into early&#44; active or late pattern&#46; 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The following clinical data were collected for all patients&#58; age&#44; gender&#44; smoking and drinking habits and comorbidities&#46; Regarding SSc-related details&#44; data on disease duration&#44; age at diagnosis and laboratory data&#44; including tests for specific autoantibodies &#40;such as anticentromere and antitopoisomerase-I antibodies&#44; among others&#41; were obtained&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To assess the extent of systemic involvement of SSc patients&#44; data on various visceral manifestations within the first 3 years after the diagnosis was collected&#46; Visceral involvement was defined as follows&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Pulmonary involvement</span>&#58; evidence of interstitial lung disease &#40;ILD&#41; on high-resolution computed tomography &#40;CT&#41; and&#47;or restrictive lung disease on pulmonary function tests&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Cardiac involvement</span>&#58; evidence of severe arrhythmias&#44; cardiac conduction blocks&#44; pericardial effusion &#40;&#62;10<span class="elsevierStyleHsp" style=""></span>mm and diffuse&#41;&#44; systolic &#40;ejection fraction &#60;50&#37;&#41;&#44; or diastolic dysfunction &#40;according to the ASE criteria<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Pulmonary arterial hypertension &#40;PAH&#41;</span>&#58; evidence of a mean pulmonary arterial pressure &#8805;25<span class="elsevierStyleHsp" style=""></span>mmHg measured by right heart catheterization with a pulmonary artery wedge pressure &#8804;15<span class="elsevierStyleHsp" style=""></span>mmHg&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Gastrointestinal involvement</span>&#58; presence of dysphagia and esophageal dysmotility on manometry&#44; symptoms of gastroesophageal reflux&#44; constipation&#44; pseudo-obstruction&#44; or diarrhoea&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Renal involvement</span>&#58; history of scleroderma renal crisis &#40;SRC&#41; and&#47;or progressive renal failure&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Muscle involvement</span>&#58; evidence of myositis in magnetic resonance imaging&#44; electromyography or muscle biopsy&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Joint involvement</span>&#58; presence of inflammatory polyarthralgia and&#47;or arthritis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Skin involvement</span>&#58; presence of skin thickness assessed by the modified Rodnan skin score &#40;mRSS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">10</span></a></p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">-</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Peripheral vascular involvement</span>&#58; occurrence of digital ulcers &#40;DU&#41; or&#47;and RP&#46;</p></li></ul></p><p id="par0095" class="elsevierStylePara elsevierViewall">The severity of visceral involvement was assessed using the Medsger&#39;s disease severity scale &#40;DSS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> The Medsger DSS comprises separate clinician ratings for nine domains&#58; &#40;1&#41; general domain assessing weight and anaemia&#59; &#40;2&#41; peripheral vascular domain assessing RP and digital ischaemia&#59; &#40;3&#41; joint&#47;tendon domain assessing flexed finger to palm distance&#59; &#40;4&#41; muscle domain assessing weakness&#59; &#40;5&#41; gastrointestinal &#40;GI&#41; domain assessing esophageal and small intestinal involvement&#59; &#40;6&#41; pulmonary domain assessing the degree of fibrosis and pulmonary hypertension&#59; &#40;7&#41; cardiac domain assessing arrhythmias and cardiac function&#59; &#40;8&#41; renal domain assessing renal function&#44; proteinuria and the need for dialysis and &#40;9&#41; skin domain assessing skin thickness&#46; Each organ system is graded on a scale from 0 &#40;no involvement&#41; to 4 &#40;end-stage involvement&#41;&#46; If the organ grade was 2 or higher&#44; it was classified as severe involvement&#46; To provide a global measure of disease severity&#44; the simple summation of the Medsger DSS for each domain was used&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0100" class="elsevierStylePara elsevierViewall">Descriptive statistics for normally distributed continuous variables were presented using the mean and standard deviation&#46; Categorical variables were presented by absolute and relative frequencies&#46; To compare groups across the four stages of microvascular damage&#44; the Chi-square test was employed for categorial variables&#44; while the <span class="elsevierStyleItalic">T</span>-test or ANOVA were utilized for normally distributed continuous variables&#44; and the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test was applied for continuous data that did not follow a normal distribution&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Pearson correlations were performed to assess the association between the severity of microvascular damage and the severity of visceral involvement for each domain of the Medsger DSS&#46; Correlations were categorized as weak &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;30&#41;&#44; moderate &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;30&#8211;0&#46;69&#41; or strong &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;70&#41;&#46; Univariate and multivariate logistic regression analysis were also conducted and odds ratios &#40;ORs&#41; along with their corresponding 95&#37; confidence intervals &#40;CIs&#41; were calculated&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Data analysis was performed using IBM SPSS for Windows &#40;version 26&#44; IBM Corporation Software Group&#44; New York&#44; NY&#44; USA&#41;&#46; Statistical significance was defined as a <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;05&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Demographic and clinical characteristics of SSc patients</span><p id="par0115" class="elsevierStylePara elsevierViewall">A total of 86 patients with SSc were included&#44; comprising 71 females &#40;82&#46;6&#37;&#41; with a mean age of onset of 52&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;9 years&#46; Among these patients&#44; 74 &#40;86&#46;1&#37;&#41; had a limited cutaneous disease&#44; 5 &#40;5&#46;8&#37;&#41; had a diffuse cutaneous disease and 7 &#40;8&#46;1&#37;&#41; presented with SSc sine scleroderma&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> provides a comprehensive overview of sociodemographic data&#44; comorbidities&#44; and the clinical and immunological characteristics of SSc patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">NVC patterns&#44; severity of microvascular damage and their association with visceral involvement</span><p id="par0120" class="elsevierStylePara elsevierViewall">At baseline&#44; NVC revealed a scleroderma pattern in 79 &#40;91&#46;9&#37;&#41; patients&#46; Among these&#44; 29 &#40;33&#46;7&#37;&#41; exhibited an early pattern&#44; 37 &#40;43&#46;0&#37;&#41; had an active pattern and 13 &#40;15&#46;1&#37;&#41; had a late pattern&#46; The remaining 7 patients who did not meet the capillaroscopic criterion had SSc-specific antibodies and presented with suggestive clinical manifestations&#46; Further details related to the NVC characteristics can be found in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">When comparing the four stages of microvascular damage&#44; we found significant differences among these groups concerning the incidence of digital ulcers &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#41;&#44; calcinosis &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and global disease severity score &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; all of which were higher in patients with a late scleroderma pattern&#46; However&#44; no statistically significant differences were found between groups concerning gender&#44; age at diagnosis&#44; subtype of SSc&#44; autoantibody profile or other visceral manifestations&#46; More detailed information was described in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">A moderate correlation was found between the severity of microvascular damage and the global measure of disease severity &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;55&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Also&#44; a moderate correlation was found between the severity of microvascular damage and the severity of peripheral vascular involvement &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;43&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and patients with a late pattern had a markedly increased risk of digital ulcers &#40;OR 4&#46;6&#44; 95&#37; CI 1&#46;3&#8211;16&#46;4&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; Furthermore&#44; a moderate correlation was found between the severity of microvascular damage and the severity of skin involvement &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;34&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Patients with a late pattern had an increased risk of severe skin involvement &#40;OR 4&#46;1&#44; 95&#37; CI 0&#46;9&#8211;19&#46;8&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#41;&#46; A weak correlation was found between the severity of microvascular damage and the severity of muscle involvement &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;24&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;029&#41;&#46; Further details regarding the correlations between the severity of microvascular damage and the severity of visceral involvement for each domain of the Medsger DSS can the found in <a class="elsevierStyleCrossRef" href="#sec0080">Supplementary Data Table 1</a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The presence of a late scleroderma pattern in NVC were predictive in univariate analysis of digital ulcers &#40;OR 6&#46;03&#44; 95&#37; CI 1&#46;52&#8211;23&#46;86&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; muscular involvement &#40;OR 13&#46;09&#44; 95&#37; CI 1&#46;09&#8211;156&#46;78&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#44; calcinosis &#40;OR 27&#46;22&#44; 95&#37; CI 5&#46;56&#8211;133&#46;33&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and worse global disease severity score &#40;OR 1&#46;67&#44; 95&#37; CI 1&#46;17&#8211;2&#46;38&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#46; Multivariate analysis adjusted for disease duration and gender confirmed late pattern as an independent predictor of calcinosis &#40;OR 42&#46;89&#44; 95&#37; CI 5&#46;53&#8211;332&#46;85&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; as observed in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">NVC is a unique&#44; non-invasive and easy technique that allows the morphological evaluation of the nailfold capillaries&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a> Its major role in rheumatology is to aid in the differential diagnosis of primary and secondary Raynaud&#39;s phenomenon&#46; Capillaroscopic changes can be observed in several connective tissue diseases&#44; namely in SSc&#44; systemic lupus erythematosus &#40;SLE&#41;&#44; dermatomyositis&#44; mixed connective tissue disease &#40;MCTD&#41;&#44; undifferentiated connective tissue disease&#44; rheumatoid arthritis and overlap syndromes&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a> In SSc&#44; these capillaroscopic changes are specific and detectable in the vast majority of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5</span></a> It is noteworthy that &#8220;scleroderma&#8221; type capillaroscopic changes have been validated and accepted as diagnostic criterion in the current 2013 European League Against Rheumatism &#40;EULAR&#41;&#47;American College of Rheumatology &#40;ACR&#41; classification criteria for SSc&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Beyond its crucial role in SSc diagnosis&#44; NVC may also serve as a valuable indicator of disease activity and severity&#44; as suggested by previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#8211;15</span></a> However&#44; most of these studies only examined specific manifestations of the disease and have not explored the association between the capillaroscopic changes and the overall disease severity&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In our study&#44; we identified a moderate correlation between the severity of microvascular damage&#44; as indicated by the worsening of the NVC patterns&#44; and the global measure of disease severity&#44; determined by the summation of the Medsger DSS for each domain&#46; Notably&#44; patients exhibiting a late scleroderma pattern had a significantly higher disease severity score and this pattern was predictive of a worse global disease severity score&#46; To the best of our knowledge&#44; only one other study&#44; conducted by Avouac et al&#46;&#44; has explored the correlation between the NVC changes and the global disease severity score using the Medsger DSS&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> Avouac et al&#46; reported that a reduction in the number of capillaries and the presence of neoangiogenesis were associated with the worsening of the Medsger DSS&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> Ingegnoli et al&#46; found that in cases of less severe organ involvement&#44; the early or active scleroderma patterns were more commonly observed&#44; whereas in more severe forms of the disease&#44; the late scleroderma pattern became more prevalent&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> These findings&#44; along with our own research&#44; strongly emphasize the crucial role of NVC as a predictor of the extent of internal organ involvement and the disease severity&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Regarding each specific manifestation&#44; we observed that patients exhibiting a late pattern in the NVC had a significantly increased risk of developing digital ulcers&#46; Additionally&#44; we identified a correlation between the severity of microvascular damage and the severity of peripheral vascular involvement&#46; These findings are in agreement with previous reports&#46; Avouac et al&#46; found that a reduction in the number of capillaries and the presence of neoangiogenesis were associated with the onset of new digital ulcers&#44; while other authors have reported that the risk of developing digital ulcers was significantly higher in patients with a late pattern&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">14&#44;18&#44;19</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Regarding calcinosis&#44; we found that patients exhibiting a late pattern in the NVC had a significantly higher risk of development of calcinosis and that the late scleroderma pattern was a predictor of calcinosis in both univariate and multivariate analyses&#46; Calcinosis was a relatively underexplored topic in previous research&#46; However&#44; two previous studies&#44; conducted by Morardet et al&#46; and Baron et al&#46;&#44; also found that calcinosis is independently associated with the late scleroderma pattern&#44; and particularly&#44; with severe capillary loss&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">20&#44;21</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Furthermore&#44; we found that patients with a late pattern in the NVC had a significantly increased risk of severe skin involvement&#46; We also identified a moderate correlation between the severity of microvascular damage and the extent of skin involvement&#46; These findings are well-supported in the literature&#44; as previous studies have reported that late patterns are associated with a more extensive skin involvement and a reduction in the number of capillaries may predict the progression of skin thickness&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">3&#44;14&#44;16&#44;18</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Moreover&#44; a weak correlation between the extent of microvascular damage and the severity of muscle involvement was found in our study&#46; Additionally&#44; a late scleroderma pattern appears to predict muscular involvement in SSc patients&#46; To the best of our knowledge&#44; only one study&#44; conducted by Smith et al&#46;&#44; has explored the link between NVC patterns at baseline and the severity of muscle involvement&#44; and no significant association was reported&#46; Given the limited number of patients in this study who exhibited muscle involvement&#44; we recommend caution in the interpretation of these results&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Contrary to previous reports&#44; our findings did not reveal any noteworthy correlation between the severity of microvascular damage and lung involvement&#44; including both ILD and PAH&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">14&#44;15&#44;22&#44;23</span></a> Most of our patients with lung involvement exhibited either an active or a late scleroderma pattern&#44; but no significant difference was found among the different NVC patterns&#46; It&#39;s worth noting that the absence of this association may be related to the limited number of patients with lung involvement&#44; particularly those with PAH&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Our study had some limitations that should be acknowledged&#46; Major limitations are related to the single-centre retrospective nature of the study&#46; Other limitation includes the small number of patients with cardiac and muscle involvement&#44; so generalization in these cases should be done cautiously&#46; Since we did not have any patient with renal involvement&#44; it was not possible to assess the association with NVC patterns&#46; Furthermore&#44; we did not assess the potential influence of medications taken prior to the NVC&#44; which could eventually interfere with the results of the NVC&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Further prospective studies with larger samples size are warranted&#44; especially to investigate the possible association between capillaroscopic changes and the overall disease severity&#44; as well as the possible associations between different organ involvement&#44; including muscle&#44; renal and cardiac involvement&#44; which have been poorly studied before&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusion</span><p id="par0190" class="elsevierStylePara elsevierViewall">In our study&#44; the overall disease severity in SSc is associated with the worsening of NVC pattern&#46; Also&#44; the severity of peripheral vascular involvement and extension of skin involvement was associated with worsening of NVC pattern&#46; Additionally&#44; the late scleroderma pattern seems to predict the presence of digital ulcers&#44; calcinosis&#44; muscular involvement and severe disease&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">This study highlights the importance of NVC as a prognostic tool and a possible predictor of systemic visceral involvement&#46; It may aid the physicians in risk stratification&#44; ensuring a careful monitoring and more aggressive treatment for patients at higher risk of a severe disease&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">None to declare&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Systemic sclerosis &#40;SSc&#41; is characterized by progressive fibrosis of the skin and internal organs&#44; microvascular damage and cellular and humoral immunity abnormalities&#46; Microvascular damage can be easily detected through nailfold videocapillaroscopy &#40;NVC&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective study of patients with SSc and a NVC performed within the first 6 months after diagnosis was conducted&#46; Visceral involvement in the first 3 years of the disease and NVC findings were collected&#46; The severity of microvascular damage was classified into four categories&#44; according to the worsening of the NVC patterns&#46; The severity of organ involvement was assessed by the disease severity scale of Medsger for each organ and as a global measure of disease severity&#44; the simple summation was used&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 86 patients with SSc were included&#46; A moderate correlation was found between the severity of microvascular damage and the global measure of disease severity &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;55&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; the severity of peripheral vascular involvement &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;43&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and the severity of skin involvement &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;34&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The presence of a late scleroderma pattern in NVC were predictive in univariate analysis of digital ulcers &#40;OR 6&#46;03&#44; 95&#37; CI 1&#46;52&#8211;23&#46;86&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; muscular involvement &#40;OR 13&#46;09&#44; 95&#37; CI 1&#46;09&#8211;156&#46;78&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#44; calcinosis &#40;OR 27&#46;22&#44; 95&#37; CI 5&#46;56&#8211;133&#46;33&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and worse global disease severity score &#40;OR 1&#46;67&#44; 95&#37; CI 1&#46;17&#8211;2&#46;38&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#46; Multivariate analysis adjusted for disease duration and gender confirmed late pattern as an independent predictor of calcinosis &#40;OR 42&#46;89&#44; 95&#37; CI 5&#46;53&#8211;332&#46;85&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion and conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In this study&#44; the worsening of NVC pattern in SSc was associated with the overall disease severity&#44; the severity of peripheral vascular involvement and extension of skin involvement&#46; This study highlights the importance of NVC as a prognostic tool and a possible predictor of systemic visceral involvement&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Materials and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Discussion and conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La esclerosis sist&#233;mica &#40;ES&#41; se caracteriza por fibrosis progresiva de la piel y &#243;rganos internos&#44; da&#241;o microvascular y anomal&#237;as en la inmunidad celular y humoral&#46; El da&#241;o microvascular puede detectarse f&#225;cilmente mediante la capilaroscopia periungueal &#40;CPU&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y m&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Un estudio retrospectivo en pacientes con ES que realizaron una CPU en los primeros 6 meses despu&#233;s del diagn&#243;stico&#46; Se recopilaron los hallazgos de la CPU y el compromiso visceral en los primeros 3 a&#241;os de la enfermedad&#46; La gravedad del da&#241;o microvascular se clasific&#243; en 4 categor&#237;as&#44; seg&#250;n el empeoramiento de los patrones de la CPU&#46; La gravedad del compromiso org&#225;nico se evalu&#243; mediante la escala de gravedad de la enfermedad de Medsger para cada &#243;rgano&#44; y como medida global de la gravedad de la enfermedad&#44; se utiliz&#243; la suma simple&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron un total de 86 pacientes con ES&#46; Se encontr&#243; una correlaci&#243;n moderada entre la gravedad del da&#241;o microvascular y la medida global de la gravedad de la enfermedad &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;55&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; la gravedad del compromiso vascular perif&#233;rico &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;43&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y la gravedad del compromiso cut&#225;neo &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;34&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La presencia de un patr&#243;n esclerod&#233;rmico tard&#237;o en la CPU fue predictiva en el an&#225;lisis univariado de &#250;lceras digitales &#40;OR&#58; 6&#44;03&#59; IC 95&#37;&#58; 1&#44;52-23&#44;86&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#44; compromiso muscular &#40;OR&#58; 13&#44;09&#59; IC 95&#37;&#58; 1&#44;09-156&#44;78&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#44; calcinosis &#40;OR&#58; 27&#44;22&#59; IC 95&#37;&#58; 5&#44;56-133&#44;33&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y peor puntuaci&#243;n global de la gravedad de la enfermedad &#40;OR&#58; 1&#44;67&#59; IC 95&#37;&#58; 1&#44;17-2&#44;38&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#46; El an&#225;lisis multivariado&#44; ajustado por la duraci&#243;n de la enfermedad y el g&#233;nero&#44; confirm&#243; el patr&#243;n tard&#237;o como un predictor independiente de la calcinosis &#40;OR&#58; 42&#44;89&#59; IC 95&#37;&#58; 5&#44;53-332&#44;85&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discusi&#243;n y conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En este estudio&#44; el empeoramiento del patr&#243;n de la CPU en la ES se asoci&#243; con la gravedad global de la enfermedad&#44; la gravedad del compromiso vascular perif&#233;rico y la extensi&#243;n del compromiso cut&#225;neo&#46; Este estudio destaca la importancia de la CPU como una herramienta pron&#243;stica y un posible predictor del compromiso visceral sist&#233;mico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Materiales y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Discusi&#243;n y conclusi&#243;n"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0210" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0080"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DSS&#58; disease severity score&#59; ILD&#58; interstitial lung disease&#59; PAH&#58; pulmonary arterial hypertension&#59; RP&#58; Raynaud phenomenon&#59; SD&#58; standard deviation&#59; SSc&#58; systemic sclerosis&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sociodemographic&#44; clinical and immunological characteristics&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">71 &#40;82&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Age at diagnosis&#44; years&#44; mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">SD</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">52&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Current&#47;former smoker&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20 &#40;23&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Alcohol consumption&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;15&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Comorbidities&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypertension</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dyslipidemia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20 &#40;23&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Cardiovascular disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Limited cutaneous disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">74 &#40;86&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Diffuse cutaneous disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Sine scleroderma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Visceral involvement&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peripheral involvement</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>RP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82 &#40;95&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>History of ulcers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;41&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Lung involvement</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ILD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;17&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PAH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Gastrointestinal involvement</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Esophageal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;30&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Intestinal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Muscle involvement</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Cardiac involvement</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Joint involvement</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;27&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Calcinosis&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;11&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of antinuclear antibodies&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;96&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of specific autoantibodies&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anticentromere</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;64&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Antitopoisomerase-I</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;15&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-PM-Scl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-RNA polymerase III</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-Ku</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Summation of the Medsger DSS&#44; mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">SD</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">79 &#40;91&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Early&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">29 &#40;33&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Active&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">13 &#40;15&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of giant capillaries&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;80&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of haemorrhages&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">62 &#40;72&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of abnormal shapes&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;18&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Presence of avascular areas&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;16&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NVC patterns</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Normal&#47;non-specific alterations &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Early pattern &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Active pattern &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Late pattern &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Female&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;57&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;82&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;83&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;92&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;259&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Age at diagnosis&#44; mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;962&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Subtype of SSc&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;593&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Limited cutaneous disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;85&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;89&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;83&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;84&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse cutaneous disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;10&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sine scleroderma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;10&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Autoantibody&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticentromere&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;42&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;75&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;62&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anti-RNA polymerase III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anti-PM-Scl&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Severe skin thickness &#40;mRSS</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">14&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">History of digital ulcers&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">History of calcinosis&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Gastrointestinal involvement&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lung involvement&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Muscle involvement&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cardiac involvement&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Diffuse cutaneous SSc&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Anticentromere antibody&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">History of digital ulcers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;52&#8211;23&#46;86&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;01</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;32&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;26&#8211;20&#46;40&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;448&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">History of calcinosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27&#46;22&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#46;56&#8211;133&#46;33&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">42&#46;89&nbsp;\t\t\t\t\t\t\n
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                            1 => "A&#46;L&#46; Herrick"
                            2 => "F&#46; Ingegnoli"
                            3 => "N&#46; Damjanov"
                            4 => "R&#46; De Angelis"
                            5 => "C&#46;P&#46; Denton"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.autrev.2020.102458"
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                        "tituloSerie" => "Autoimmun Rev"
                        "fecha" => "2020"
                        "volumen" => "19"
                        "paginaInicial" => "102458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31927087"
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                    0 => array:2 [
                      "titulo" => "Fast track algorithm&#58; how to differentiate a &#8220;scleroderma pattern&#8221; from a &#8220;non-scleroderma pattern&#8221;"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "A&#46;L&#46; Herrick"
                            3 => "O&#46; Distler"
                            4 => "M&#46;G&#46; Guerra"
                            5 => "C&#46;P&#46; Denton"
                          ]
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                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.autrev.2019.102394"
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                        "tituloSerie" => "Autoimmun Rev"
                        "fecha" => "2019"
                        "volumen" => "18"
                        "paginaInicial" => "102394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31520797"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Recommendations for the evaluation of left ventricular diastolic function by echocardiography&#58; an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "O&#46;A&#46; Smiseth"
                            2 => "C&#46;P&#46; Appleton"
                            3 => "B&#46;F&#46; Byrd 3rd"
                            4 => "H&#46; Dokainish"
                            5 => "T&#46; Edvardsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.echo.2016.01.011"
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                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2016"
                        "volumen" => "29"
                        "paginaInicial" => "277"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27037982"
                            "web" => "Medline"
                          ]
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                    ]
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              "identificador" => "bib0165"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of skin involvement in systemic sclerosis"
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                            0 => "G&#46; Kumanovics"
                            1 => "M&#46; Pentek"
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                            3 => "D&#46; Opris"
                            4 => "D&#46; Khanna"
                            5 => "D&#46;E&#46; Furst"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/kex202"
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                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2017"
                        "volumen" => "56"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "v53"
                        "paginaFinal" => "v66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28992173"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Assessment of disease severity and prognosis"
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                        0 => array:2 [
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                            0 => "T&#46;A&#46; Medsger Jr&#46;"
                            1 => "S&#46; Bombardieri"
                            2 => "L&#46; Czirjak"
                            3 => "R&#46; Scorza"
                            4 => "A&#46; Della Rossa"
                            5 => "W&#46; Bencivelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "numero" => "Suppl&#46; 29"
                        "paginaInicial" => "S42"
                        "paginaFinal" => "S46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14969049"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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              "identificador" => "bib0175"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nailfold capillaroscopy within and beyond the scope of connective tissue diseases"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;N&#46; Lambova"
                            1 => "U&#46; Muller-Ladner"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/1573397113666170615093600"
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                        "tituloSerie" => "Curr Rheumatol Rev"
                        "fecha" => "2018"
                        "volumen" => "14"
                        "paginaInicial" => "12"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28641551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0180"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between fluorescent antinuclear antibodies&#44; capillary patterns&#44; and clinical features in scleroderma spectrum disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Z&#46;Y&#46; Chen"
                            1 => "R&#46;M&#46; Silver"
                            2 => "S&#46;K&#46; Ainsworth"
                            3 => "R&#46;L&#46; Dobson"
                            4 => "P&#46; Rust"
                            5 => "H&#46;R&#46; Maricq"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0002-9343(84)90517-5"
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                        "tituloSerie" => "Am J Med"
                        "fecha" => "1984"
                        "volumen" => "77"
                        "paginaInicial" => "812"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6333815"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scleroderma patients nailfold videocapillaroscopic patterns are associated with disease subset and disease severity"
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                          "etal" => true
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                            2 => "N&#46; Martinelli"
                            3 => "A&#46; Volpe"
                            4 => "S&#46; Pieropan"
                            5 => "M&#46; Ferrari"
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                      "doi" => "10.1093/rheumatology/kem190"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17693443"
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                          ]
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                  ]
                ]
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                    0 => array:2 [
                      "titulo" => "Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement&#63; A pilot study"
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                            2 => "A&#46; Sulli"
                            3 => "C&#46; Bonroy"
                            4 => "Y&#46; Piettte"
                            5 => "E&#46; Deschepper"
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                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2011-200780"
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                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2012"
                        "volumen" => "71"
                        "paginaInicial" => "1636"
                        "paginaFinal" => "1639"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22402146"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sequential nailfold videocapillaroscopy examinations have responsiveness to detect organ progression in systemic sclerosis"
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                            3 => "E&#46; Toniolo"
                            4 => "C&#46; Hurabielle"
                            5 => "A&#46; Vallet"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Semin Arthritis Rheum"
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                        "volumen" => "47"
                        "paginaInicial" => "86"
                        "paginaFinal" => "94"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28291582"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nailfold capillaroscopy in systemic sclerosis&#58; data from the EULAR scleroderma trials and research &#40;EUSTAR&#41; database"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "P&#46; Boracchi"
                            3 => "M&#46; Cutolo"
                            4 => "EUSTAR co-authors"
                          ]
                        ]
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                    ]
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                        "tituloSerie" => "Microvasc Res"
                        "fecha" => "2013"
                        "volumen" => "89"
                        "paginaInicial" => "122"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23792167"
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                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Correlation between capillaroscopic classifications and severity in systemic sclerosis&#58; results from SCLEROCAP study at inclusion"
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                          "etal" => true
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                            1 => "S&#46; Aiouaz"
                            2 => "S&#46; Blaise"
                            3 => "M&#46; Mangin"
                            4 => "J&#46; Decamps-Le Chevoir"
                            5 => "P&#46; Senet"
                          ]
                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
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                        "numero" => "Suppl&#46; 119"
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                        "paginaFinal" => "68"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31172926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Capillaroscopic skin ulcer risk index&#58; a new prognostic tool for digital skin ulcer development in systemic sclerosis patients"
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                            3 => "R&#46; D&#8217;Amico"
                            4 => "V&#46; Malagoli"
                            5 => "D&#46; Giuggioli"
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                        "tituloSerie" => "Arthritis Rheum"
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                        "volumen" => "61"
                        "paginaInicial" => "688"
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                  ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Late nailfold videocapillaroscopy pattern associated with hand calcinosis and acro-osteolysis in systemic sclerosis"
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                        0 => array:2 [
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                            3 => "M&#46; Baron"
                            4 => "A&#46; Kahan"
                            5 => "A&#46; Feydy"
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                        "tituloSerie" => "Arthritis Care Res &#40;Hoboken&#41;"
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                        "volumen" => "68"
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                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26223810"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Calcinosis is associated with digital ischaemia in systemic sclerosis &#8211; a longitudinal study"
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                            1 => "J&#46; Pope"
                            2 => "D&#46; Robinson"
                            3 => "N&#46; Jones"
                            4 => "N&#46; Khalidi"
                            5 => "P&#46; Docherty"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
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                        "volumen" => "55"
                        "paginaInicial" => "2148"
                        "paginaFinal" => "2155"
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                ]
              ]
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              "identificador" => "bib0225"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nailfold videocapillaroscopy changes are associated with the presence and severity of systemic sclerosis-related interstitial lung disease"
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                          "etal" => false
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                            2 => "M&#46; Amaral"
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                            4 => "J&#46;D&#46; Alves"
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                        "tituloSerie" => "J Clin Rheumatol"
                        "fecha" => "2019"
                        "volumen" => "25"
                        "paginaInicial" => "e12"
                        "paginaFinal" => "e15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29782426"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
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              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis"
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                            3 => "B&#46;A&#46; Dijkmans"
                            4 => "P&#46;E&#46; Postmus"
                            5 => "Y&#46;M&#46; Smulders"
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                    0 => array:2 [
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                        "tituloSerie" => "Ann Rheum Dis"
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                        "volumen" => "68"
                        "paginaInicial" => "191"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18375538"
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                    ]
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                ]
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