Esclerosis sistémica
Epidemiología. Diferencias étnicas en la esclerosis sistémica
Epidemiology. Ethnic differences in systemic sclerosis
Jorge Rojas-Serrano
Autor para correspondencia
jorroser@aol.com
Correspondencia: Dr. J. Rojas-Serrano. Instituto Nacional de Enfermedades Respiratorias. Calzada de Tlalpan 4502. Sección XVI, Tlalpan. 14080 México DF. México.
Correspondencia: Dr. J. Rojas-Serrano. Instituto Nacional de Enfermedades Respiratorias. Calzada de Tlalpan 4502. Sección XVI, Tlalpan. 14080 México DF. México.
Instituto Nacional de Enfermedades Respiratorias. Tlalpan. México
Leído
11882
Vecesse ha leído el artículo
3865
Total PDF
8017
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1699258X06730996" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73099-6" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73099" "copyright" => "Elsevier España S.L. Barcelona" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2006;2 Supl 3:S2-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5656 "formatos" => array:3 [ "EPUB" => 116 "HTML" => 4402 "PDF" => 1138 ] ] "itemSiguiente" => array:18 [ "pii" => "S1699258X0673100X" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73100-X" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73100" "copyright" => "Elsevier España S.L. Barcelona" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2006;2 Supl 3:S6-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5131 "formatos" => array:3 [ "EPUB" => 94 "HTML" => 3868 "PDF" => 1169 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Esclerosis sistémica</span>" "titulo" => "Etiopatogenia. Nuevos conceptos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S6" "paginaFinal" => "S9" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Etiopathogenesis. New concepts" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Navarro, Martha L. Bustos" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Navarro" ] 1 => array:2 [ "nombre" => "Martha L." "apellidos" => "Bustos" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X0673100X?idApp=UINPBA00004M" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X0673100X/v1_201305061741/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699258X06730984" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73098-4" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73098" "copyright" => "Elsevier España S.L. Barcelona" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Reumatol Clin. 2006;2 Supl 3:S1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2758 "formatos" => array:3 [ "EPUB" => 113 "HTML" => 1772 "PDF" => 873 ] ] "es" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Esclerosis sistémica</span>" "titulo" => "Prefacio" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "S1" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Olga Lidia Vera-Lastra, Luis J. Jara Quezada" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Olga" "apellidos" => "Lidia Vera-Lastra" ] 1 => array:2 [ "nombre" => "Luis J." "apellidos" => "Jara Quezada" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06730984?idApp=UINPBA00004M" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06730984/v1_201305061741/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Esclerosis sistémica</span>" "titulo" => "Epidemiología. Diferencias étnicas en la esclerosis sistémica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S2" "paginaFinal" => "S5" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jorge Rojas-Serrano" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Jorge" "apellidos" => "Rojas-Serrano" "email" => array:1 [ 0 => "jorroser@aol.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Instituto Nacional de Enfermedades Respiratorias. Tlalpan. México" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. J. Rojas-Serrano. Instituto Nacional de Enfermedades Respiratorias. Calzada de Tlalpan 4502. Sección XVI, Tlalpan. 14080 México DF. México." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epidemiology. Ethnic differences in systemic sclerosis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111988" "palabras" => array:4 [ 0 => "Esclerosis sistémica difusa y limitada" 1 => "Grupos étnicos" 2 => "Diferencias en epidemiología y expresión clínica" 3 => "Factores genéticos y ambientales" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111987" "palabras" => array:4 [ 0 => "Limited and difuse systemic sclerosis" 1 => "Ethnic groups" 2 => "Differences in epidemiology and clinical manifestations" 3 => "Genetic and environmental factors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El objetivo de esta revisión es analizar las diferencias en la epidemiología, las manifestaciones clínicas y la gravedad de la esclerosis sistémica en los diferentes grupos étnicos. La revisión se limita a la esclerosis sistémica en su variedad difusa y limitada.</p><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionó los artículos más relevantes del tema y se presenta la información en 3 apartados: diferencias en la epidemiología de la esclerodermia entre grupos étnicos diferentes; diferencias en la expresión clínica de la enfermedad entre grupos étnicos diferentes, y factores que pudieran explicar esas diferencias.</p><p class="elsevierStyleSimplePara elsevierViewall">De los grupos étnicos estudiados, los blancos tienen menores incidencia y prevalencia de la enfermedad. Además tienen menor frecuencia de manifestaciones inflamatorias y tienden a presentar con mayor frecuencia la variedad limitada de la esclerosis sistémica. Estas diferencias se ven reflejadas en la mejor supervivencia de los blancos respecto a otros grupos étnicos. Hasta el momento, no se ha logrado identificar el origen de estas diferencias.</p><p class="elsevierStyleSimplePara elsevierViewall">Es probable que factores genéticos y ambientales sean la causa de las diferencias encontradas en la expresión de la enfermedad entre los diferentes grupos étnicos estudiados.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">To review the differences in the epidemiology, clinical manifestations, and severity of systemic sclerosis in different ethnic groups. This review considers only limited and diffuse forms of systemic sclerosis.</p><p class="elsevierStyleSimplePara elsevierViewall">The most relevant articles about ethnic differences in systemic sclerosis were selected. The information is presented in three sections: differences in the epidemiology of systemic sclerosis between ethnic groups; differences in clinical manifestations between ethnic group, and factors that may explain these differences.</p><p class="elsevierStyleSimplePara elsevierViewall">Of the different ethnic groups studied, whites have less incidence and prevalence of systemic sclerosis. Whites also have less frequency of inflammatory manifestations, and have a higher frequency of limited skin disease compared with other ethnic groups. These differences may result in the better survival of whites compared with no whites. The origin of these differences has not been discovered so far.</p><p class="elsevierStyleSimplePara elsevierViewall">Is probable that genetic and environmental factors may play a role in the expression of disease, producing the differences found among the ethnic groups.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic sclerosis (scleroderma): clinical aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Medsger Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Artritis and allied conditions. A textbook of rheumatology" "paginaInicial" => "1590" "paginaFinal" => "1624" "edicion" => "14.ª ed" "serieFecha" => "2002" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.C. LeRoy" 1 => "C. Black" 2 => "R. Fleischmajer" 3 => "S. J.ablonska" 4 => "T. Krieg" 5 => "T.A. Medsger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1988" "volumen" => "15" "paginaInicial" => "202" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3361530" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.D. Mayes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "2003" "volumen" => "29" "paginaInicial" => "239" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12841293" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preliminary criteria for the classification of systemic sclerosis (scleroderma)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1980" "volumen" => "23" "paginaInicial" => "581" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7378088" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of systemic sclerosis (scleroderma)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.A. Medsger" 1 => "A.T. Masi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1971" "volumen" => "74" "paginaInicial" => "714" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5559436" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of systemic sclerosis in Allengheny County, Pennsylvania" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V.D. Steen" 1 => "C.V. Oddis" 2 => "C.G. Conte" 3 => "J. Janoski" 4 => "G. Ziegler" 5 => "T.A. Medsger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1997" "volumen" => "40" "paginaInicial" => "441" "paginaFinal" => "445" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9082931" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial differences in scleroderma among women in Michigan" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.J. Laing" 1 => "B.W. Gillepie" 2 => "M.B. Toth" 3 => "M.D. Mayes" 4 => "R.H. Gallavan" 5 => "C.J. Burns" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(199704)40:4<734::AID-ART20>3.0.CO;2-3" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1997" "volumen" => "40" "paginaInicial" => "734" "paginaFinal" => "742" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9125258" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.D. Mayes" 1 => "J.V. Lacey Jr" 2 => "J. Beebe-Dimmer" 3 => "B.W. Gillespie" 4 => "B. Cooper" 5 => "T.J. Laing" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11073" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "2246" "paginaFinal" => "2255" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12905479" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimates of the prevalence of selected arthritic and musculoskeletal diseases in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.C. Lawrence" 1 => "M.C. Hochberg" 2 => "J.L. Kelsey" 3 => "F.C. McDuffe" 4 => "T.A. Medsger" 5 => "W.R. Felts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1989" "volumen" => "16" "paginaInicial" => "427" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2746583" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased prevalence of systemic sclerosis in a native American tribe in Oklahoma. Association with an Amerindian HLA haplotype" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.C. Arnett" 1 => "R.F. Howard" 2 => "F. Tan" 3 => "J.M. Moulds" 4 => "W.B. Bias" 5 => "E. Durban" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1996" "volumen" => "39" "paginaInicial" => "1362" "paginaFinal" => "1370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8702445" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic sclerosis in 3 US ethnic groups: a comparison of clinical sociodemographic, serologic and immunogenic determinants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Reveille" 1 => "M. Fischbach" 2 => "T. McNearney" 3 => "A.W. Friedman" 4 => "M.B. Aguilar" 5 => "J. Lisse" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/sarh.2001.20268" "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "2001" "volumen" => "30" "paginaInicial" => "332" "paginaFinal" => "346" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11303306" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe restrictive lung disease in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V.D. Steen" 1 => "C. Conte" 2 => "G.R. Owena" 3 => "T.A. Medsger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1994" "volumen" => "37" "paginaInicial" => "1283" "paginaFinal" => "1289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7945490" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial differences in antinuclear antibody patterns and clinical manifestations of scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.J. McNeilage" 1 => "U. Younuchaiyud" 2 => "S. Whittingham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1989" "volumen" => "32" "paginaInicial" => "54" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2783552" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial differences in the frequencies of scleroderma related autoantibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.D. Reveille" 1 => "E. Durban" 2 => "R. Goldstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1992" "volumen" => "35" "paginaInicial" => "216" "paginaFinal" => "218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1734910" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial variation in clinical and immunological manifestations of systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.J. Nietert" 1 => "H.C. Mitchell" 2 => "M.B. Bolster" 3 => "S.R. Shaftman" 4 => "B.C. Tilley" 5 => "R.M. Silver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2006" "volumen" => "33" "paginaInicial" => "263" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16465656" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of ethnic background on clinical and serological features in patients with systemic slcerodid and anti-DNA topoisomerase I antibody" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Kuwana" 1 => "J. Kaburaki" 2 => "F.C. Arnett" 3 => "R.F. Howard" 4 => "T.A. Medsger" 5 => "T.M. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1999" "volumen" => "42" "paginaInicial" => "465" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10088769" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X11003156" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival with systemic sclerosis (scleroderma). A life table analysis of clinical and demographic factors in 309 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.A. Medsger" 1 => "A.T. Masi" 2 => "G.P. Rodnan" 3 => "T.G. Benedek" 4 => "H. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1971" "volumen" => "75" "paginaInicial" => "369" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4105464" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demographic and clinical factors associated with in hospital death among patients with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.J. Nietert" 1 => "R.M. Silver" 2 => "H.C. Mitchell" 3 => "S.R. Shaftman" 4 => "B.C. Tilley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "1888" "paginaFinal" => "1892" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16206342" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Rojas-Serrano J, Codina-Velázquez H, Medrano-Ramírez G, et al. Low frequency of severe organ involvement in Mexican mestizo patients with systemic sclerosis with diffuse scleroderma. [en prensa]." ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe organ involvement in systemic sclerosis with diffuse scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Steen" 1 => "T.A. Medsger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2000" "volumen" => "43" "paginaInicial" => "2437" "paginaFinal" => "2444" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11083266" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial variation in clinical and immunological manifestations of systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.J. Niert" 1 => "H.C. Mitchell" 2 => "M.B. Bolster" 3 => "S.R. Shaftman" 4 => "B. Tilley" 5 => "R.M. Silver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2006" "volumen" => "33" "paginaInicial" => "263" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16465656" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.C. Arnett" 1 => "M. Cho" 2 => "S. Chatterjee" 3 => "M.B. Aguilar" 4 => "J.D. Reveille" 5 => "M.D. Mayes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200106)44:6<1359::AID-ART228>3.0.CO;2-S" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "1359" "paginaFinal" => "1362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11407695" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortality and prognostic factors in Spanish patients with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Simeon" 1 => "L. Armadans" 2 => "V. Fonollosa" 3 => "R. Solans" 4 => "A. Selva" 5 => "M. Villar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "71" "paginaFinal" => "75" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of HLA-DR5 (DR11) with systemic sclerosis (scleroderma) in Mexican patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Vargas-Alarcon" 1 => "J. Granados" 2 => "G. Ibanez de Kasep" 3 => "J. Alcocer-Varela" 4 => "D. Alarcon-Segovia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "1995" "volumen" => "13" "paginaInicial" => "11" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7774089" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Ferghali-Bostwick" 1 => "T.A. Medsger" 2 => "T.M. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11173" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "1956" "paginaFinal" => "1963" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12847690" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic sclerosis: the susceptible host (genetics and enviroment)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.K. Tan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "2003" "volumen" => "29" "paginaInicial" => "211" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12841292" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06730996/v1_201305061741/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/1699258X/00000002000000S3/v1_201305061741/S1699258X06730996/v1_201305061741/es/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06730996?idApp=UINPBA00004M" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 22 | 31 |
| 2024 Octubre | 74 | 55 | 129 |
| 2024 Septiembre | 79 | 27 | 106 |
| 2024 Agosto | 83 | 43 | 126 |
| 2024 Julio | 93 | 46 | 139 |
| 2024 Junio | 84 | 63 | 147 |
| 2024 Mayo | 88 | 49 | 137 |
| 2024 Abril | 66 | 34 | 100 |
| 2024 Marzo | 70 | 69 | 139 |
| 2024 Febrero | 48 | 50 | 98 |
| 2024 Enero | 72 | 32 | 104 |
| 2023 Diciembre | 41 | 41 | 82 |
| 2023 Noviembre | 54 | 53 | 107 |
| 2023 Octubre | 76 | 46 | 122 |
| 2023 Septiembre | 52 | 56 | 108 |
| 2023 Agosto | 56 | 25 | 81 |
| 2023 Julio | 25 | 42 | 67 |
| 2023 Junio | 63 | 58 | 121 |
| 2023 Mayo | 46 | 73 | 119 |
| 2023 Abril | 47 | 32 | 79 |
| 2023 Marzo | 51 | 37 | 88 |
| 2023 Febrero | 37 | 45 | 82 |
| 2023 Enero | 30 | 27 | 57 |
| 2022 Diciembre | 41 | 30 | 71 |
| 2022 Noviembre | 76 | 58 | 134 |
| 2022 Octubre | 75 | 47 | 122 |
| 2022 Septiembre | 94 | 63 | 157 |
| 2022 Agosto | 60 | 55 | 115 |
| 2022 Julio | 52 | 45 | 97 |
| 2022 Junio | 39 | 36 | 75 |
| 2022 Mayo | 38 | 47 | 85 |
| 2022 Abril | 55 | 45 | 100 |
| 2022 Marzo | 37 | 56 | 93 |
| 2022 Febrero | 63 | 54 | 117 |
| 2022 Enero | 64 | 59 | 123 |
| 2021 Diciembre | 64 | 69 | 133 |
| 2021 Noviembre | 68 | 60 | 128 |
| 2021 Octubre | 81 | 83 | 164 |
| 2021 Septiembre | 44 | 81 | 125 |
| 2021 Agosto | 54 | 60 | 114 |
| 2021 Julio | 66 | 47 | 113 |
| 2021 Junio | 64 | 51 | 115 |
| 2021 Mayo | 69 | 71 | 140 |
| 2021 Abril | 154 | 94 | 248 |
| 2021 Marzo | 124 | 41 | 165 |
| 2021 Febrero | 66 | 40 | 106 |
| 2021 Enero | 64 | 60 | 124 |
| 2020 Diciembre | 47 | 41 | 88 |
| 2020 Noviembre | 77 | 39 | 116 |
| 2020 Octubre | 52 | 24 | 76 |
| 2020 Septiembre | 48 | 23 | 71 |
| 2020 Agosto | 47 | 34 | 81 |
| 2020 Julio | 50 | 34 | 84 |
| 2020 Junio | 46 | 29 | 75 |
| 2020 Mayo | 71 | 43 | 114 |
| 2020 Abril | 72 | 39 | 111 |
| 2020 Marzo | 118 | 34 | 152 |
| 2020 Febrero | 74 | 30 | 104 |
| 2020 Enero | 63 | 48 | 111 |
| 2019 Diciembre | 42 | 28 | 70 |
| 2019 Noviembre | 47 | 25 | 72 |
| 2019 Octubre | 45 | 26 | 71 |
| 2019 Septiembre | 25 | 27 | 52 |
| 2019 Agosto | 26 | 23 | 49 |
| 2019 Julio | 59 | 20 | 79 |
| 2019 Junio | 73 | 41 | 114 |
| 2019 Mayo | 49 | 75 | 124 |
| 2019 Abril | 23 | 18 | 41 |
| 2019 Marzo | 31 | 29 | 60 |
| 2019 Febrero | 17 | 25 | 42 |
| 2019 Enero | 11 | 21 | 32 |
| 2018 Diciembre | 51 | 53 | 104 |
| 2018 Noviembre | 32 | 18 | 50 |
| 2018 Octubre | 34 | 11 | 45 |
| 2018 Septiembre | 15 | 5 | 20 |
| 2018 Agosto | 10 | 14 | 24 |
| 2018 Julio | 11 | 4 | 15 |
| 2018 Mayo | 0 | 2 | 2 |
| 2018 Abril | 25 | 12 | 37 |
| 2018 Marzo | 18 | 21 | 39 |
| 2018 Febrero | 10 | 4 | 14 |
| 2018 Enero | 9 | 5 | 14 |
| 2017 Diciembre | 10 | 10 | 20 |
| 2017 Noviembre | 5 | 15 | 20 |
| 2017 Octubre | 13 | 9 | 22 |
| 2017 Septiembre | 8 | 7 | 15 |
| 2017 Agosto | 8 | 6 | 14 |
| 2017 Julio | 10 | 7 | 17 |
| 2017 Junio | 21 | 20 | 41 |
| 2017 Mayo | 25 | 14 | 39 |
| 2017 Abril | 18 | 6 | 24 |
| 2017 Marzo | 22 | 10 | 32 |
| 2017 Febrero | 5 | 6 | 11 |
| 2017 Enero | 8 | 9 | 17 |
| 2016 Diciembre | 28 | 15 | 43 |
| 2016 Noviembre | 17 | 13 | 30 |
| 2016 Octubre | 33 | 10 | 43 |
| 2016 Septiembre | 35 | 13 | 48 |
| 2016 Agosto | 20 | 4 | 24 |
| 2016 Julio | 17 | 10 | 27 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Octubre | 1 | 14 | 15 |
| 2015 Septiembre | 4 | 9 | 13 |
| 2015 Agosto | 1 | 8 | 9 |
| 2015 Julio | 40 | 7 | 47 |
| 2015 Junio | 49 | 13 | 62 |
| 2015 Mayo | 99 | 31 | 130 |
| 2015 Abril | 57 | 7 | 64 |
| 2015 Marzo | 64 | 12 | 76 |
| 2015 Febrero | 56 | 5 | 61 |
| 2015 Enero | 88 | 11 | 99 |
| 2014 Diciembre | 49 | 12 | 61 |
| 2014 Noviembre | 81 | 11 | 92 |
| 2014 Octubre | 86 | 9 | 95 |
| 2014 Septiembre | 78 | 9 | 87 |
| 2014 Agosto | 46 | 6 | 52 |
| 2014 Julio | 46 | 11 | 57 |
| 2014 Junio | 63 | 10 | 73 |
| 2014 Mayo | 73 | 8 | 81 |
| 2014 Abril | 66 | 15 | 81 |
| 2014 Marzo | 52 | 13 | 65 |
| 2014 Febrero | 35 | 8 | 43 |
| 2014 Enero | 40 | 9 | 49 |
| 2013 Diciembre | 32 | 9 | 41 |
| 2013 Noviembre | 79 | 26 | 105 |
| 2013 Octubre | 45 | 17 | 62 |
| 2013 Septiembre | 50 | 9 | 59 |
| 2013 Agosto | 40 | 7 | 47 |
| 2013 Julio | 40 | 11 | 51 |
| 2013 Junio | 37 | 8 | 45 |
| 2013 Mayo | 33 | 8 | 41 |
| 2013 Abril | 49 | 8 | 57 |
| 2013 Marzo | 23 | 11 | 34 |
| 2013 Febrero | 21 | 7 | 28 |
| 2013 Enero | 18 | 6 | 24 |
| 2012 Diciembre | 11 | 3 | 14 |
| 2012 Noviembre | 8 | 5 | 13 |
| 2012 Octubre | 3 | 4 | 7 |
| 2012 Septiembre | 6 | 2 | 8 |
| 2011 Mayo | 8 | 0 | 8 |
| 2011 Abril | 12 | 0 | 12 |
| 2011 Marzo | 25 | 0 | 25 |
| 2011 Febrero | 28 | 0 | 28 |
| 2011 Enero | 25 | 0 | 25 |
| 2010 Diciembre | 21 | 0 | 21 |
| 2010 Noviembre | 20 | 0 | 20 |
| 2010 Octubre | 26 | 0 | 26 |
| 2010 Septiembre | 10 | 0 | 10 |
| 2010 Agosto | 41 | 0 | 41 |
| 2010 Julio | 20 | 0 | 20 |
| 2010 Junio | 42 | 0 | 42 |
| 2010 Mayo | 45 | 0 | 45 |
| 2010 Abril | 29 | 0 | 29 |
| 2010 Marzo | 37 | 0 | 37 |
| 2010 Febrero | 40 | 0 | 40 |
| 2010 Enero | 71 | 0 | 71 |
| 2009 Diciembre | 61 | 0 | 61 |
| 2009 Noviembre | 59 | 0 | 59 |
| 2009 Octubre | 25 | 0 | 25 |
| 2009 Septiembre | 31 | 0 | 31 |
| 2009 Agosto | 18 | 0 | 18 |
| 2009 Julio | 19 | 0 | 19 |
| 2009 Junio | 29 | 0 | 29 |
| 2009 Mayo | 22 | 0 | 22 |
| 2009 Abril | 12 | 0 | 12 |
| 2009 Marzo | 19 | 0 | 19 |
| 2008 Diciembre | 42 | 0 | 42 |
| 2008 Noviembre | 38 | 0 | 38 |
| 2008 Octubre | 26 | 0 | 26 |
| 2008 Septiembre | 31 | 0 | 31 |
| 2008 Agosto | 45 | 0 | 45 |
| 2008 Julio | 40 | 0 | 40 |
| 2008 Junio | 25 | 0 | 25 |
| 2008 Mayo | 49 | 0 | 49 |
| 2008 Abril | 63 | 0 | 63 |
| 2008 Marzo | 29 | 0 | 29 |
| 2008 Febrero | 35 | 0 | 35 |
| 2008 Enero | 42 | 0 | 42 |
| 2007 Diciembre | 22 | 0 | 22 |
| 2007 Noviembre | 51 | 0 | 51 |
| 2007 Octubre | 41 | 0 | 41 |
| 2007 Septiembre | 40 | 0 | 40 |
| 2007 Agosto | 20 | 0 | 20 |
| 2007 Julio | 53 | 0 | 53 |
| 2007 Junio | 50 | 0 | 50 |
| 2007 Mayo | 50 | 0 | 50 |
| 2007 Abril | 10 | 0 | 10 |
| 2007 Marzo | 36 | 0 | 36 |
| 2007 Febrero | 25 | 0 | 25 |
Mostrar todo
