Afección cardíaca en la esclerosis sistémica

array:23 ["pii" => "S1699258X06731059" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73105-9" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73105" "copyright" => "Elsevier España S.L. Barcelona" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2006;2 Supl 3:S31-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7864 "formatos" => array:3 [ "EPUB" => 145 "HTML" => 5047 "PDF" => 2672 ] ] "itemSiguiente" => array:18 [ "pii" => "S1699258X06731060" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73106-0" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73106" "copyright" => "Elsevier España S.L. Barcelona" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2006;2 Supl 3:S37-41" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5740 "formatos" => array:3 [ "EPUB" => 114 "HTML" => 4355 "PDF" => 1271 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Alteraciones endocrinas en la esclerosis sistémica" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S37" "paginaFinal" => "S41" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Endocrinological alterations in systemic sclerosis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Olga Lidia Vera-Lastra, Luis J. Jara" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Olga Lidia" "apellidos" => "Vera-Lastra" ] 1 => array:2 [ "nombre" => "Luis J." "apellidos" => "Jara" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731060?idApp=UINPBA00004M" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731060/v1_201305061741/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699258X06731047" "issn" => "1699258X" "doi" => "10.1016/S1699-258X(06)73104-7" "estado" => "S300" "fechaPublicacion" => "2006-11-01" "aid" => "73104" "copyright" => "Elsevier España S.L. Barcelona" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2006;2 Supl 3:S24-30" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 11280 "formatos" => array:3 [ "EPUB" => 129 "HTML" => 8147 "PDF" => 3004 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "Esclerosis sistémica" "titulo" => "Esclerosis sistémica y tracto gastrointestinal. Abordaje diagnóstico y terapéutico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S24" "paginaFinal" => "S30" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Systemic sclerosis and the gastrointestinal tract. Diagnostic and therapeutic approach" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Olga Lidia Vera-Lastra" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Olga" "apellidos" => "Lidia Vera-Lastra" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731047?idApp=UINPBA00004M" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731047/v1_201305061741/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Esclerosis sistémica" "titulo" => "Afección cardíaca en la esclerosis sistémica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S31" "paginaFinal" => "S36" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luis H. Silveira-Torre" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Luis H." "apellidos" => "Silveira-Torre" "email" => array:1 [ 0 => "luis_hsil@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Bioquímica. Instituto Nacional de Cardiología Ignacio Chávez. México DF. México" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. L.H. Silveira-Torre. Departamento de Bioquímica. Instituto Nacional de Cardiología Ignacio Chávez. Juan Badiano, 1. Colonia Sección XVI. 14080 México DF. México." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cardiac involvement in systemic sclerosis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112014" "palabras" => array:6 [ 0 => "Corazón" 1 => "Esclerosis sistémica" 2 => "Pericardio" 3 => "Miocardio" 4 => "Válvulas cardíacas" 5 => "Cardiopatía isquémica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec112015" "palabras" => array:6 [ 0 => "Heart" 1 => "Systemic sclerosis" 2 => "Pericardium" 3 => "Myocardium" 4 => "Cardiac valves" 5 => "Ischemic cardiopathy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La esclerosis sistémica (ES) puede afectar al pericardio, el miocardio, las arterias coronarias, el sistema de conducción y las válvulas cardíacas. La presencia de síntomas y signos es de mal pronóstico. Las manifestaciones incluyen disnea, palpitaciones, dolor precordial, síncope y datos de insuficiencia cardíaca derecha.La prevalencia de la enfermedad pericárdica con manifestaciones clínicas varía entre el 5 y el 16%; con ecocardiografía, es del 5,4-41% y en estudios de necropsia, es del 33-77,5%. La afección miocárdica característica de la ES es la fibrosis en parches. El hallazgo patológico típico es la “necrosis en banda de contracción”. Las consecuencias importantes de la fibrosis incluyen hipertrofia ventricular izquierda, así como disfunción tanto sistólica como diastólica en ambos ventrículos. La detección en fases tempranas de estas alteraciones es muy importante, sobre todo de la disfunción diastólica, que ocurre mucho antes que la sistólica, por lo que podría predecir el desarrollo de daño cardíaco importante. Se ha descrito la asociación de miositis esquelética y cardíaca. La miopatía esquelética aumenta el riesgo de insuficiencia cardíaca congestiva, arritmias sintomáticas sostenidas y muerte súbita de origen cardíaco. Los vasos pequeños miocárdicos están afectados en la ES; las arterias coronarias epicárdicas no se afectan. Se presentan arritmias, principalmente extrasístoles auriculares y ventriculares, así como alteraciones de la conducción. La afección de las válvulas cardíacas es mínima, y la mitral es la que se afecta con mayor frecuencia. Otras alteraciones que se ha comunicado en relación con la ES son la rigidez de las arterias periféricas de gran calibre y la afección secundaria del corazón por hipertensión arterial pulmonar y sistémica. La afección cardíaca es causa importante de morbimortalidad en la ES." ] "en" => array:1 [ "resumen" => "Systemic sclerosis (SS) can involve the pericardium, myocardium, conduction system, and cardiac valves. The presence of overt clinical signs of cardiac disease is a poor prognostic sign. Clinical manifestations include dyspnea, palpitations, chest pain, syncope, and symptoms of right heart failure.Prevalence of clinically symptomatic pericardial disease is 5-16%. However, ecocardiographic prevalence is 5.4- 41% and at autopsy is 33-77.5%. Patchy fibrosis is the characteristic myocardial finding in SS. Contraction band necrosis is the typical pathological finding. Important complications of fibrosis include left ventricular hypertrophy, as well as systolic and diastolic dysfunction of both ventricles. Early detection of these abnormalities is very important, mainly of the diastolic dysfunction, since it occurs before the systolic dysfunction and can predict important cardiac damage. Association of skeletal myositis with myocardial disease has been described. Patients with skeletal myositis are more likely to develop congestive heart failure, sustained symptomatic arrythmias, and cardiac sudden death. Coronary arteries are normal in systemic sclerosis, but there is no endomyocardial vessel involvement. There is an increased prevalence of arrhytmias, mainly premature atrial and ventricular contractions, as well as conduction system disease. Cardiac valvular involvement is minor in systemic sclerosis; mitral valve is the most frequently affected. Other abnormalities described in this disease include peripheral large vessels stiffness and secondary cardiac involvement due to pulmonary and systemic arterial hypertension. Cardiac involvement confers a high morbi-mortality risk in systemic sclerosis." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:62 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The heart in slceroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Oram" 1 => "W. Stokes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br Heart J" "fecha" => "1961" "volumen" => "23" "paginaInicial" => "243" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13731087" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac involvement in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Deswal" 1 => "W.P. Follansbee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "1996" "volumen" => "22" "paginaInicial" => "841" "paginaFinal" => "860" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8923599" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac score. A semiquantitative measure of cardiac involvement that improves prediction of prognosis in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.J. Clements" 1 => "P.A. Lachenbruch" 2 => "D.E. Furst" 3 => "H.E. Paulus" 4 => "M.G. Sterz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1991" "volumen" => "34" "paginaInicial" => "1371" "paginaFinal" => "1380" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1835389" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.M. Wigley" 1 => "L.K. Hummers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Rheumatology" "paginaInicial" => "1463" "paginaFinal" => "1479" "edicion" => "3.ª ed." "serieFecha" => "2003" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship of arrhytmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis (PSS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.J. Clements" 1 => "D.E. Furst" 2 => "W. Cabeen" 3 => "D. Tashkin" 4 => "H.E. Paulus" 5 => "N. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1981" "volumen" => "71" "paginaInicial" => "38" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7246582" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Ferri" 1 => "L. Bernini" 2 => "M.G. Bongiorni" 3 => "D. Levorato" 4 => "G. Viegi" 5 => "P. Bravi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1985" "volumen" => "28" "paginaInicial" => "259" "paginaFinal" => "266" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angina pectoris, myocardial infarction, and sudden cardiac death with normal coronary arteries: a clinicopathologic study of nine patients with progressive systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.H. Bulkley" 1 => "P.G. Klacsmann" 2 => "G.M. Hutchins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1978" "volumen" => "95" "paginaInicial" => "563" "paginaFinal" => "569" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/636997" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of the frequency of pericardial and pleural effusions in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.E. Thompson" 1 => "J.E. Pope" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Rheumatol" "fecha" => "1998" "volumen" => "37" "paginaInicial" => "1320" "paginaFinal" => "1323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9973157" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pericardial tamponade in systemic sclerosis (scleroderma)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.S. Uhl" 1 => "G.M. Koppes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br Heart J" "fecha" => "1979" "volumen" => "42" "paginaInicial" => "345" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/508457" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Massive pericardial effusion in scleroderma: a review of five cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Satoh" 1 => "M. Tokuhira" 2 => "N. Hama" 3 => "M. Hirakata" 4 => "M. Kuwana" 5 => "M. Akizuki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Rheumatol" "fecha" => "1995" "volumen" => "34" "paginaInicial" => "564" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7633799" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac tamponade revealing systemic scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Bouraui" 1 => "B. Trimeche" 2 => "A. Mahdhaoui" 3 => "S. Ernez-Hajri" 4 => "G. Jeridi" 5 => "H. Ammar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Med Suisse Romande" "fecha" => "2003" "volumen" => "123" "paginaInicial" => "713" "paginaFinal" => "714" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15095640" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma pericardial disease presented with a large pericardial effusion -a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.M. Gowda" 1 => "I.A. Khan" 2 => "T.J. Sacchi" 3 => "B.C. Vasavada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Angiology" "fecha" => "2001" "volumen" => "52" "paginaInicial" => "59" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11205932" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac tamponade preceding skin involvement in progressive systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Peronato" 1 => "P. De Sandre" 2 => "M. Podswiadek" 3 => "S. Arfiero" 4 => "L. Bozzola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Reumatismo" "fecha" => "2002" "volumen" => "54" "paginaInicial" => "257" "paginaFinal" => "260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12404035" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma with cardiac tamponade, hyperthyroidism and incidental papillary thyroid carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.M. Gokula" 1 => "A.K. Gupta" 2 => "S.E. Shirley" 3 => "K. Coard" 4 => "P.S. Ramphal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "West Indian Med J" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "188" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12501551" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma complicated with tamponade during pregnancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Allali" 1 => "M. Alami" 2 => "N. Doghmi" 3 => "A. Mohatane" 4 => "M. Benomar" 5 => "N. Hajjaj-Hassounni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jbspin.2004.10.005" "Revista" => array:6 [ "tituloSerie" => "Joint Bone Spine" "fecha" => "2005" "volumen" => "72" "paginaInicial" => "341" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16038849" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pericardial involvement in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Byers" 1 => "D.A.S. Marshall" 2 => "A.J. Freemont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "1997" "volumen" => "56" "paginaInicial" => "393" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9227172" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.A. D’Angelo" 1 => "J.F. Fries" 2 => "A.T. Masi" 3 => "L.E. Shulman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Med" "fecha" => "1969" "volumen" => "46" "paginaInicial" => "428" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5780367" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0212656712001643" "estado" => "S300" "issn" => "02126567" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A controlled clinicopathologic study of myocardial fibrosis in systemic sclerosis (scleroderma)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.P. Follansbee" 1 => "T.R. Miller" 2 => "E.I. Curtiss" 3 => "J.E. Orie" 4 => "R.L. Bernestein" 5 => "J.M. Kiernan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1990" "volumen" => "17" "paginaInicial" => "656" "paginaFinal" => "662" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2359076" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.H. Bulkley" 1 => "R.L. Ridolfi" 2 => "W.R. Salyer" 3 => "G.M. Hutchins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1976" "volumen" => "53" "paginaInicial" => "483" "paginaFinal" => "490" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1248080" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphologic changes in the digital arteries of patients with progressive systemic sclerosis (scleroderma) and Raynaud phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.P. Rodnan" 1 => "R.L. Myerowitz" 2 => "G.O. Justh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1980" "volumen" => "59" "paginaInicial" => "393" "paginaFinal" => "408" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arteries of the hand in patients with scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Janevski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Diag Imaging Clin Med" "fecha" => "1986" "volumen" => "55" "paginaInicial" => "262" "paginaFinal" => "265" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic identification of cardiac abnormality in scleroderma and related disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.S. Gottdiener" 1 => "H.M. Moutsopoulos" 2 => "J.L. Decker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1979" "volumen" => "66" "paginaInicial" => "391" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/155400" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular function at rest and during Raynaud’s phenomenon in patients with scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Siegel" 1 => "B. O’Connor" 2 => "I. Mena" 3 => "J.M. Criley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1984" "volumen" => "108" "paginaInicial" => "1469" "paginaFinal" => "1476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6507243" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular wall motion abnormalities in 80 patients with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Hegedus" 1 => "L. Czirjak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "161" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789056" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.P. Follansbee" 1 => "E.I. Curtiss" 2 => "T.A. Medsger Jr" 3 => "V.D. Steen" 4 => "B.F. Uretsky" 5 => "G.R. Owens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1984" "volumen" => "310" "paginaInicial" => "142" "paginaFinal" => "148" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diastolic abnormalities in systemic sclerosis: evidence for associated defective cardiac functional reserve" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Valentini" 1 => "D.F. Vitale" 2 => "A. Giunta" 3 => "S. Maione" 4 => "G. Gerundo" 5 => "M. Arnese" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "1996" "volumen" => "55" "paginaInicial" => "455" "paginaFinal" => "460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8774164" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular function in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.P. Armstrong" 1 => "G.A. Whalley" 2 => "R.N. Doughty" 3 => "G.D. Gamble" 4 => "S.M. Flett" 5 => "P.L. Tan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Rheumatol" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "983" "paginaFinal" => "988" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8883437" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular diastolic function in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Aguglia" 1 => "A. Sgreccia" 2 => "M.L. Bernardo" 3 => "E. Carmenini" 4 => "M. Giusti De Marle" 5 => "A. Reali" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2001" "volumen" => "28" "paginaInicial" => "1563" "paginaFinal" => "1567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11469462" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diastolic dysfunction in patients with systemic sclerosis detected by gated myocardial perfusion SPECT: an early sign of cardiac involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Nakajima" 1 => "J. Taki" 2 => "M. Kawano" 3 => "T. Higuchi" 4 => "S. Sato" 5 => "J. Nishijima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "2001" "volumen" => "42" "paginaInicial" => "183" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11216514" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic alterations in systemic sclerosis: A longitudinal study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Maione" 1 => "G. Cuomo" 2 => "A. Giunta" 3 => "L. Tanturri de Horatio" 4 => "G. La Montagna" 5 => "F. Manguso" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.semarthrit.2004.11.001" "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "2005" "volumen" => "34" "paginaInicial" => "721" "paginaFinal" => "727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15846587" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of right ventricular systolic dysfunction in early systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Meune" 1 => "Y. Allanore" 2 => "J.Y. Devaux" 3 => "O. Dessault" 4 => "D. Duboc" 5 => "S. Weber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "1941" "paginaFinal" => "1945" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15468357" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Right ventricular diastolic abnormalities in systemic sclerosis. Relation to left ventricular involvement and pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Giunta" 1 => "E. Tirri" 2 => "S. Maione" 3 => "S. Canganiello" 4 => "A. Mele" 5 => "A. De Luca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2000" "volumen" => "59" "paginaInicial" => "94" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10666162" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disturbed right ventricular diastolic function in patients with systemic sclerosis: A Doppler tissue imaging study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Lindquist" 1 => "K. Caidahl" 2 => "G. Neuman-Andersen" 3 => "C. Ozolins" 4 => "S. Rantapää-Dahlquist" 5 => "A. Waldenström" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.2.755" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "755" "paginaFinal" => "763" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16100164" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of myositis and myocarditis in progressive systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.G. West" 1 => "P.J. Killian" 2 => "D.J. Lawless" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1981" "volumen" => "24" "paginaInicial" => "662" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7236323" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe myositis and myocarditis in progressive systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Carette" 1 => "J. Turcotte" 2 => "G. Matho" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1985" "volumen" => "12" "paginaInicial" => "997" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4087278" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac and skeletal muscle disease in systemic sclerosis (scleroderma): a righ risk association" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.P. Follansbee" 1 => "T.R. Zerbe" 2 => "T.A. Medsger Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "1993" "volumen" => "125" "paginaInicial" => "194" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8417518" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversible myocardial perfusion defects during cold challenge in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Long" 1 => "G. Duffy" 2 => "B. Bresnihan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Rheumatol" "fecha" => "1986" "volumen" => "25" "paginaInicial" => "158" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3708232" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cold-induced reversible myocardial ischaemia in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Gustafsson" 1 => "F. Mannting" 2 => "E. Kazzam" 3 => "A. Waldenstrom" 4 => "R. Hallgren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1989" "volumen" => "2" "paginaInicial" => "475" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2570187" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.L. Alexander" 1 => "G.S. Firestein" 2 => "J.L. Weiss" 3 => "R.R. Heuser" 4 => "G. Leitl" 5 => "H.N. Wagner Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1986" "volumen" => "105" "paginaInicial" => "661" "paginaFinal" => "668" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3767147" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular dysfunction induced by cold exposure in patients with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.W. Ellis" 1 => "A.N. Baer" 2 => "R.M. Robertson" 3 => "T. Pincus" 4 => "M.W. Kronenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1986" "volumen" => "80" "paginaInicial" => "385" "paginaFinal" => "392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3953616" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of cold stress on coronary sinus blood flow in patients with scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.T. Colfer" 1 => "S.K. Das" 2 => "L. Dabich" 3 => "O.S. Randall" 4 => "B. Pitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Assoc Acad Minor Phys" "fecha" => "1993" "volumen" => "4" "paginaInicial" => "62" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8490289" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of captopril on thallium 201 myocardial perfusion in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kahan" 1 => "J.Y. Devaux" 2 => "B. Amor" 3 => "C.J. Menkes" 4 => "S. Weber" 5 => "A. Venot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther" "fecha" => "1990" "volumen" => "47" "paginaInicial" => "483" "paginaFinal" => "489" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183960" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased coronary reserve in primary scleroderma myocardial disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kahan" 1 => "A. Nitenberg" 2 => "J. Foult" 3 => "B. Amor" 4 => "C.J. Menkes" 5 => "J.Y. Devaux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1985" "volumen" => "28" "paginaInicial" => "637" "paginaFinal" => "646" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4004974" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of early impairment of coronary flow reserve in patients with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Montisci" 1 => "A. Vacca" 2 => "P. Garau" 3 => "P. Colonna" 4 => "M. Ruscazio" 5 => "G. Passiu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2003" "volumen" => "62" "paginaInicial" => "890" "paginaFinal" => "893" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12922965" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Absence of epicardial coronary stenosis in patients with systemic sclerosis with severe impairment of coronary flow reserve" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Vacca" 1 => "P. Siotto" 2 => "A. Cauli" 3 => "R. Montisci" 4 => "P. Garau" 5 => "V. Ibba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2005.040154" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2006" "volumen" => "65" "paginaInicial" => "274" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16410537" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive assessment of myocardial involvement in patients with systemic sclerosis: role of signal averaged electrocardiography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Morelli" 1 => "A. Sgreccia" 2 => "P. De Marzio" 3 => "C. Perrone" 4 => "L. Ferrante" 5 => "A.M. Gurgo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "2358" "paginaFinal" => "2363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9415642" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventricular late potentials in systemic sclerosis: relationship with skin involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Paradiso" 1 => "M. Di Franco" 2 => "A. Musca" 3 => "S. Basili" 4 => "V. Riccieri" 5 => "V. Paoletti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "1388" "paginaFinal" => "1392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12136893" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The heart in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Steen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Rheumatol Rep" "fecha" => "2004" "volumen" => "6" "paginaInicial" => "137" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15016344" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of sustained monomorphic ventricular tachycardia in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.C. Rankin" 1 => "S. Osswald" 2 => "B.A. McGovern" 3 => "J.N. Ruskin" 4 => "H. Garan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1999" "volumen" => "83" "paginaInicial" => "633" "paginaFinal" => "636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10073883" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Electroanatomic mapping and ablation of ventricular tachycardia associated with systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Lacroix" 1 => "F. Brigadeau" 2 => "C. Marquie" 3 => "D. Klug" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eupc.2004.03.012" "Revista" => array:6 [ "tituloSerie" => "Europace" "fecha" => "2004" "volumen" => "6" "paginaInicial" => "336" "paginaFinal" => "342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172658" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cardiac conduction system in progressive systemic sclerosis: clinical and pathologic features of 35 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.L. Ridolfi" 1 => "B.H. Bulkley" 2 => "G.M. Hutchins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1976" "volumen" => "61" "paginaInicial" => "361" "paginaFinal" => "366" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/961700" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atrioventricular nodal function in progressive systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.K. Roberts" 1 => "W.R. Cabeen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "1983" "volumen" => "13" "paginaInicial" => "174" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6673113" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The heart in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Sackner" 1 => "E.R. Heinz" 2 => "A.J. Steinberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1966" "volumen" => "17" "paginaInicial" => "542" "paginaFinal" => "559" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5929661" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The echocardiogram in slceroderma endocarditis of the mitral valve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Kinney" 1 => "W. Reeves" 2 => "R. Zellis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1979" "volumen" => "139" "paginaInicial" => "1179" "paginaFinal" => "1180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/485753" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency of mitral valve prolapse in systemic lupus erythematosus, progressive systemic sclerosis, and mixed connective tissue disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Comens" 1 => "M.A. Alpert" 2 => "G.C. Sharp" 3 => "T.A. Pressly" 4 => "D.L. Kelly" 5 => "S.E. Hazelwood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1989" "volumen" => "63" "paginaInicial" => "369" "paginaFinal" => "370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2913742" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac valvular disease and systemic lupus erythematosus/scleroderma overlap associated with antiphospholipid antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Penmetcha" 1 => "S.W. Rosenbush" 2 => "C.A. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1996" "volumen" => "23" "paginaInicial" => "2171" "paginaFinal" => "2174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8970061" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ulnar artery involvement in systemic sclerosis (scleroderma)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Taylor" 1 => "J.A. McFadden" 2 => "M.B. Bolster" 3 => "R.M. Silver" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "102" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11824945" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alteration of arterial distensibility in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Constans" 1 => "P. Gosse" 2 => "J.L. Pellegrin" 3 => "P. Ansorborlo" 4 => "B. Leng" 5 => "J. Clementy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Intern Med" "fecha" => "1997" "volumen" => "241" "paginaInicial" => "115" "paginaFinal" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9077367" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macrovascular disease and systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Ho" 1 => "D. Veale" 2 => "C. Eastmond" 3 => "G. Nuki" 4 => "J. Belch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2000" "volumen" => "59" "paginaInicial" => "39" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10627425" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carotid and femoral arterial wall mechanics in slceroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.S. Cheng" 1 => "A. Tiwari" 2 => "A. Boutin" 3 => "C.P. Denton" 4 => "C.M. Black" 5 => "R. Morris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/keg371" "Revista" => array:6 [ "tituloSerie" => "Rheumatology" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "1299" "paginaFinal" => "1305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12777634" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aortic stiffness in systemic sclerosis is increased independently of the extent of skin involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Moyssakis" 1 => "E. Gialafos" 2 => "V. Vassiliou" 3 => "E. Taktikou" 4 => "C. Katsiari" 5 => "D.P. Papadopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/keh478" "Revista" => array:6 [ "tituloSerie" => "Rheumatology" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "251" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15546962" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortality in systemic sclerosis: an international meta-analysis of individual patient data" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P.A. Ioannidis" 1 => "P.G. Vlachoyiannopoulos" 2 => "A.-B. Haidich" 3 => "T.A. Medsger Jr" 4 => "M. Lucas" 5 => "C.J. Michet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2004.04.031" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2005" "volumen" => "118" "paginaInicial" => "2" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15639201" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731059/v1_201305061741/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/1699258X/00000002000000S3/v1_201305061741/S1699258X06731059/v1_201305061741/es/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731059?idApp=UINPBA00004M"]

Estadísticas

Esclerosis sistémica

Afección cardíaca en la esclerosis sistémica

Cardiac involvement in systemic sclerosis

Luis H. Silveira-Torre

Autor para correspondencia

luis_hsil@yahoo.com

Correspondencia: Dr. L.H. Silveira-Torre. Departamento de Bioquímica. Instituto Nacional de Cardiología Ignacio Chávez. Juan Badiano, 1. Colonia Sección XVI. 14080 México DF. México.

Departamento de Bioquímica. Instituto Nacional de Cardiología Ignacio Chávez. México DF. México

Leído

17932

Veces
se ha leído el artículo

11306

Total PDF

6626

Total HTML

Compartir estadísticas

 array:23 [
  "pii" => "S1699258X06731059"
  "issn" => "1699258X"
  "doi" => "10.1016/S1699-258X(06)73105-9"
  "estado" => "S300"
  "fechaPublicacion" => "2006-11-01"
  "aid" => "73105"
  "copyright" => "Elsevier Espa&#241;a S&#46;L&#46; Barcelona"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Reumatol Clin. 2006;2 Supl 3:S31-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7864
    "formatos" => array:3 [
      "EPUB" => 145
      "HTML" => 5047
      "PDF" => 2672
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1699258X06731060"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(06)73106-0"
    "estado" => "S300"
    "fechaPublicacion" => "2006-11-01"
    "aid" => "73106"
    "copyright" => "Elsevier Espa&#241;a S&#46;L&#46; Barcelona"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2006;2 Supl 3:S37-41"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5740
      "formatos" => array:3 [
        "EPUB" => 114
        "HTML" => 4355
        "PDF" => 1271
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Alteraciones endocrinas en la esclerosis sist&#233;mica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "S37"
          "paginaFinal" => "S41"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Endocrinological alterations in systemic sclerosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Olga Lidia Vera-Lastra, Luis J&#46; Jara"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Olga Lidia"
              "apellidos" => "Vera-Lastra"
            ]
            1 => array:2 [
              "nombre" => "Luis J&#46;"
              "apellidos" => "Jara"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731060?idApp=UINPBA00004M"
    "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731060/v1_201305061741/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1699258X06731047"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(06)73104-7"
    "estado" => "S300"
    "fechaPublicacion" => "2006-11-01"
    "aid" => "73104"
    "copyright" => "Elsevier Espa&#241;a S&#46;L&#46; Barcelona"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2006;2 Supl 3:S24-30"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 11280
      "formatos" => array:3 [
        "EPUB" => 129
        "HTML" => 8147
        "PDF" => 3004
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Esclerosis sist&#233;mica</span>"
      "titulo" => "Esclerosis sist&#233;mica y tracto gastrointestinal&#46; Abordaje diagn&#243;stico y terap&#233;utico"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "S24"
          "paginaFinal" => "S30"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Systemic sclerosis and the gastrointestinal tract&#46; Diagnostic and therapeutic approach"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Olga Lidia Vera-Lastra"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Lidia Vera-Lastra"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731047?idApp=UINPBA00004M"
    "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731047/v1_201305061741/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Esclerosis sist&#233;mica</span>"
    "titulo" => "Afecci&#243;n card&#237;aca en la esclerosis sist&#233;mica"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "S31"
        "paginaFinal" => "S36"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Luis H&#46; Silveira-Torre"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Luis H&#46;"
            "apellidos" => "Silveira-Torre"
            "email" => array:1 [
              0 => "luis&#95;hsil&#64;yahoo&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Departamento de Bioqu&#237;mica&#46; Instituto Nacional de Cardiolog&#237;a Ignacio Ch&#225;vez&#46; M&#233;xico DF&#46; M&#233;xico"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Dr&#46; L&#46;H&#46; Silveira-Torre&#46; Departamento de Bioqu&#237;mica&#46; Instituto Nacional de Cardiolog&#237;a Ignacio Ch&#225;vez&#46; Juan Badiano&#44; 1&#46; Colonia Secci&#243;n XVI&#46; 14080 M&#233;xico DF&#46; M&#233;xico&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Cardiac involvement in systemic sclerosis"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec112014"
          "palabras" => array:6 [
            0 => "Coraz&#243;n"
            1 => "Esclerosis sist&#233;mica"
            2 => "Pericardio"
            3 => "Miocardio"
            4 => "V&#225;lvulas card&#237;acas"
            5 => "Cardiopat&#237;a isqu&#233;mica"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec112015"
          "palabras" => array:6 [
            0 => "Heart"
            1 => "Systemic sclerosis"
            2 => "Pericardium"
            3 => "Myocardium"
            4 => "Cardiac valves"
            5 => "Ischemic cardiopathy"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La esclerosis sist&#233;mica &#40;ES&#41; puede afectar al pericardio&#44; el miocardio&#44; las arterias coronarias&#44; el sistema de conducci&#243;n y las v&#225;lvulas card&#237;acas&#46; La presencia de s&#237;ntomas y signos es de mal pron&#243;stico&#46; Las manifestaciones incluyen disnea&#44; palpitaciones&#44; dolor precordial&#44; s&#237;ncope y datos de insuficiencia card&#237;aca derecha&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de la enfermedad peric&#225;rdica con manifestaciones cl&#237;nicas var&#237;a entre el 5 y el 16&#37;&#59; con ecocardiograf&#237;a&#44; es del 5&#44;4-41&#37; y en estudios de necropsia&#44; es del 33-77&#44;5&#37;&#46; La afecci&#243;n mioc&#225;rdica caracter&#237;stica de la ES es la fibrosis en parches&#46; El hallazgo patol&#243;gico t&#237;pico es la &#8220;necrosis en banda de contracci&#243;n&#8221;&#46; Las consecuencias importantes de la fibrosis incluyen hipertrofia ventricular izquierda&#44; as&#237; como disfunci&#243;n tanto sist&#243;lica como diast&#243;lica en ambos ventr&#237;culos&#46; La detecci&#243;n en fases tempranas de estas alteraciones es muy importante&#44; sobre todo de la disfunci&#243;n diast&#243;lica&#44; que ocurre mucho antes que la sist&#243;lica&#44; por lo que podr&#237;a predecir el desarrollo de da&#241;o card&#237;aco importante&#46; Se ha descrito la asociaci&#243;n de miositis esquel&#233;tica y card&#237;aca&#46; La miopat&#237;a esquel&#233;tica aumenta el riesgo de insuficiencia card&#237;aca congestiva&#44; arritmias sintom&#225;ticas sostenidas y muerte s&#250;bita de origen card&#237;aco&#46; Los vasos peque&#241;os mioc&#225;rdicos est&#225;n afectados en la ES&#59; las arterias coronarias epic&#225;rdicas no se afectan&#46; Se presentan arritmias&#44; principalmente extras&#237;stoles auriculares y ventriculares&#44; as&#237; como alteraciones de la conducci&#243;n&#46; La afecci&#243;n de las v&#225;lvulas card&#237;acas es m&#237;nima&#44; y la mitral es la que se afecta con mayor frecuencia&#46; Otras alteraciones que se ha comunicado en relaci&#243;n con la ES son la rigidez de las arterias perif&#233;ricas de gran calibre y la afecci&#243;n secundaria del coraz&#243;n por hipertensi&#243;n arterial pulmonar y sist&#233;mica&#46; La afecci&#243;n card&#237;aca es causa importante de morbimortalidad en la ES&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Systemic sclerosis &#40;SS&#41; can involve the pericardium&#44; myocardium&#44; conduction system&#44; and cardiac valves&#46; The presence of overt clinical signs of cardiac disease is a poor prognostic sign&#46; Clinical manifestations include dyspnea&#44; palpitations&#44; chest pain&#44; syncope&#44; and symptoms of right heart failure&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Prevalence of clinically symptomatic pericardial disease is 5-16&#37;&#46; However&#44; ecocardiographic prevalence is 5&#46;4- 41&#37; and at autopsy is 33-77&#46;5&#37;&#46; Patchy fibrosis is the characteristic myocardial finding in SS&#46; Contraction band necrosis is the typical pathological finding&#46; Important complications of fibrosis include left ventricular hypertrophy&#44; as well as systolic and diastolic dysfunction of both ventricles&#46; Early detection of these abnormalities is very important&#44; mainly of the diastolic dysfunction&#44; since it occurs before the systolic dysfunction and can predict important cardiac damage&#46; Association of skeletal myositis with myocardial disease has been described&#46; Patients with skeletal myositis are more likely to develop congestive heart failure&#44; sustained symptomatic arrythmias&#44; and cardiac sudden death&#46; Coronary arteries are normal in systemic sclerosis&#44; but there is no endomyocardial vessel involvement&#46; There is an increased prevalence of arrhytmias&#44; mainly premature atrial and ventricular contractions&#44; as well as conduction system disease&#46; Cardiac valvular involvement is minor in systemic sclerosis&#59; mitral valve is the most frequently affected&#46; Other abnormalities described in this disease include peripheral large vessels stiffness and secondary cardiac involvement due to pulmonary and systemic arterial hypertension&#46; Cardiac involvement confers a high morbi-mortality risk in systemic sclerosis&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:62 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The heart in slceroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Oram"
                            1 => "W&#46; Stokes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Heart J"
                        "fecha" => "1961"
                        "volumen" => "23"
                        "paginaInicial" => "243"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13731087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac involvement in scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Deswal"
                            1 => "W&#46;P&#46; Follansbee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheum Dis Clin North Am"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "841"
                        "paginaFinal" => "860"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8923599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac score&#46; A semiquantitative measure of cardiac involvement that improves prediction of prognosis in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;J&#46; Clements"
                            1 => "P&#46;A&#46; Lachenbruch"
                            2 => "D&#46;E&#46; Furst"
                            3 => "H&#46;E&#46; Paulus"
                            4 => "M&#46;G&#46; Sterz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "1371"
                        "paginaFinal" => "1380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1835389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features of systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46;M&#46; Wigley"
                            1 => "L&#46;K&#46; Hummers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Rheumatology"
                        "paginaInicial" => "1463"
                        "paginaFinal" => "1479"
                        "edicion" => "3&#46;&#170; ed&#46;"
                        "serieFecha" => "2003"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship of arrhytmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis &#40;PSS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;J&#46; Clements"
                            1 => "D&#46;E&#46; Furst"
                            2 => "W&#46; Cabeen"
                            3 => "D&#46; Tashkin"
                            4 => "H&#46;E&#46; Paulus"
                            5 => "N&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1981"
                        "volumen" => "71"
                        "paginaInicial" => "38"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7246582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive evaluation of cardiac dysrhythmias&#44; and their relationship with multisystemic symptoms&#44; in progressive systemic sclerosis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Ferri"
                            1 => "L&#46; Bernini"
                            2 => "M&#46;G&#46; Bongiorni"
                            3 => "D&#46; Levorato"
                            4 => "G&#46; Viegi"
                            5 => "P&#46; Bravi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1985"
                        "volumen" => "28"
                        "paginaInicial" => "259"
                        "paginaFinal" => "266"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angina pectoris&#44; myocardial infarction&#44; and sudden cardiac death with normal coronary arteries&#58; a clinicopathologic study of nine patients with progressive systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;H&#46; Bulkley"
                            1 => "P&#46;G&#46; Klacsmann"
                            2 => "G&#46;M&#46; Hutchins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1978"
                        "volumen" => "95"
                        "paginaInicial" => "563"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/636997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A study of the frequency of pericardial and pleural effusions in scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;E&#46; Thompson"
                            1 => "J&#46;E&#46; Pope"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1998"
                        "volumen" => "37"
                        "paginaInicial" => "1320"
                        "paginaFinal" => "1323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9973157"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pericardial tamponade in systemic sclerosis &#40;scleroderma&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;S&#46; Uhl"
                            1 => "G&#46;M&#46; Koppes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Heart J"
                        "fecha" => "1979"
                        "volumen" => "42"
                        "paginaInicial" => "345"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/508457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Massive pericardial effusion in scleroderma&#58; a review of five cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Satoh"
                            1 => "M&#46; Tokuhira"
                            2 => "N&#46; Hama"
                            3 => "M&#46; Hirakata"
                            4 => "M&#46; Kuwana"
                            5 => "M&#46; Akizuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1995"
                        "volumen" => "34"
                        "paginaInicial" => "564"
                        "paginaFinal" => "567"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7633799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac tamponade revealing systemic scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Bouraui"
                            1 => "B&#46; Trimeche"
                            2 => "A&#46; Mahdhaoui"
                            3 => "S&#46; Ernez-Hajri"
                            4 => "G&#46; Jeridi"
                            5 => "H&#46; Ammar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Suisse Romande"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "713"
                        "paginaFinal" => "714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15095640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scleroderma pericardial disease presented with a large pericardial effusion -a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;M&#46; Gowda"
                            1 => "I&#46;A&#46; Khan"
                            2 => "T&#46;J&#46; Sacchi"
                            3 => "B&#46;C&#46; Vasavada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Angiology"
                        "fecha" => "2001"
                        "volumen" => "52"
                        "paginaInicial" => "59"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11205932"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac tamponade preceding skin involvement in progressive systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46; Peronato"
                            1 => "P&#46; De Sandre"
                            2 => "M&#46; Podswiadek"
                            3 => "S&#46; Arfiero"
                            4 => "L&#46; Bozzola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatismo"
                        "fecha" => "2002"
                        "volumen" => "54"
                        "paginaInicial" => "257"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12404035"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scleroderma with cardiac tamponade&#44; hyperthyroidism and incidental papillary thyroid carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;M&#46; Gokula"
                            1 => "A&#46;K&#46; Gupta"
                            2 => "S&#46;E&#46; Shirley"
                            3 => "K&#46; Coard"
                            4 => "P&#46;S&#46; Ramphal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "West Indian Med J"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "188"
                        "paginaFinal" => "190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12501551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scleroderma complicated with tamponade during pregnancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Allali"
                            1 => "M&#46; Alami"
                            2 => "N&#46; Doghmi"
                            3 => "A&#46; Mohatane"
                            4 => "M&#46; Benomar"
                            5 => "N&#46; Hajjaj-Hassounni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jbspin.2004.10.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Joint Bone Spine"
                        "fecha" => "2005"
                        "volumen" => "72"
                        "paginaInicial" => "341"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16038849"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pericardial involvement in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Byers"
                            1 => "D&#46;A&#46;S&#46; Marshall"
                            2 => "A&#46;J&#46; Freemont"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1997"
                        "volumen" => "56"
                        "paginaInicial" => "393"
                        "paginaFinal" => "394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9227172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathologic observations in systemic sclerosis &#40;scleroderma&#41;&#46; A study of fifty-eight autopsy cases and fifty-eight matched controls"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;A&#46; D&#8217;Angelo"
                            1 => "J&#46;F&#46; Fries"
                            2 => "A&#46;T&#46; Masi"
                            3 => "L&#46;E&#46; Shulman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1969"
                        "volumen" => "46"
                        "paginaInicial" => "428"
                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5780367"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0212656712001643"
                          "estado" => "S300"
                          "issn" => "02126567"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A controlled clinicopathologic study of myocardial fibrosis in systemic sclerosis &#40;scleroderma&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;P&#46; Follansbee"
                            1 => "T&#46;R&#46; Miller"
                            2 => "E&#46;I&#46; Curtiss"
                            3 => "J&#46;E&#46; Orie"
                            4 => "R&#46;L&#46; Bernestein"
                            5 => "J&#46;M&#46; Kiernan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1990"
                        "volumen" => "17"
                        "paginaInicial" => "656"
                        "paginaFinal" => "662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2359076"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial lesions of progressive systemic sclerosis&#46; A cause of cardiac dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;H&#46; Bulkley"
                            1 => "R&#46;L&#46; Ridolfi"
                            2 => "W&#46;R&#46; Salyer"
                            3 => "G&#46;M&#46; Hutchins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1976"
                        "volumen" => "53"
                        "paginaInicial" => "483"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1248080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morphologic changes in the digital arteries of patients with progressive systemic sclerosis &#40;scleroderma&#41; and Raynaud phenomenon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;P&#46; Rodnan"
                            1 => "R&#46;L&#46; Myerowitz"
                            2 => "G&#46;O&#46; Justh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "1980"
                        "volumen" => "59"
                        "paginaInicial" => "393"
                        "paginaFinal" => "408"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arteries of the hand in patients with scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46; Janevski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Diag Imaging Clin Med"
                        "fecha" => "1986"
                        "volumen" => "55"
                        "paginaInicial" => "262"
                        "paginaFinal" => "265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic identification of cardiac abnormality in scleroderma and related disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;S&#46; Gottdiener"
                            1 => "H&#46;M&#46; Moutsopoulos"
                            2 => "J&#46;L&#46; Decker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1979"
                        "volumen" => "66"
                        "paginaInicial" => "391"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/155400"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular function at rest and during Raynaud&#8217;s phenomenon in patients with scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Siegel"
                            1 => "B&#46; O&#8217;Connor"
                            2 => "I&#46; Mena"
                            3 => "J&#46;M&#46; Criley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1984"
                        "volumen" => "108"
                        "paginaInicial" => "1469"
                        "paginaFinal" => "1476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6507243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular wall motion abnormalities in 80 patients with systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Hegedus"
                            1 => "L&#46; Czirjak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "1995"
                        "volumen" => "14"
                        "paginaInicial" => "161"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;P&#46; Follansbee"
                            1 => "E&#46;I&#46; Curtiss"
                            2 => "T&#46;A&#46; Medsger Jr"
                            3 => "V&#46;D&#46; Steen"
                            4 => "B&#46;F&#46; Uretsky"
                            5 => "G&#46;R&#46; Owens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Eng J Med"
                        "fecha" => "1984"
                        "volumen" => "310"
                        "paginaInicial" => "142"
                        "paginaFinal" => "148"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic abnormalities in systemic sclerosis&#58; evidence for associated defective cardiac functional reserve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Valentini"
                            1 => "D&#46;F&#46; Vitale"
                            2 => "A&#46; Giunta"
                            3 => "S&#46; Maione"
                            4 => "G&#46; Gerundo"
                            5 => "M&#46; Arnese"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1996"
                        "volumen" => "55"
                        "paginaInicial" => "455"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8774164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular function in scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;P&#46; Armstrong"
                            1 => "G&#46;A&#46; Whalley"
                            2 => "R&#46;N&#46; Doughty"
                            3 => "G&#46;D&#46; Gamble"
                            4 => "S&#46;M&#46; Flett"
                            5 => "P&#46;L&#46; Tan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "983"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8883437"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular diastolic function in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Aguglia"
                            1 => "A&#46; Sgreccia"
                            2 => "M&#46;L&#46; Bernardo"
                            3 => "E&#46; Carmenini"
                            4 => "M&#46; Giusti De Marle"
                            5 => "A&#46; Reali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "1563"
                        "paginaFinal" => "1567"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11469462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic dysfunction in patients with systemic sclerosis detected by gated myocardial perfusion SPECT&#58; an early sign of cardiac involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Nakajima"
                            1 => "J&#46; Taki"
                            2 => "M&#46; Kawano"
                            3 => "T&#46; Higuchi"
                            4 => "S&#46; Sato"
                            5 => "J&#46; Nishijima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "2001"
                        "volumen" => "42"
                        "paginaInicial" => "183"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11216514"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic alterations in systemic sclerosis&#58; A longitudinal study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Maione"
                            1 => "G&#46; Cuomo"
                            2 => "A&#46; Giunta"
                            3 => "L&#46; Tanturri de Horatio"
                            4 => "G&#46; La Montagna"
                            5 => "F&#46; Manguso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2004.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2005"
                        "volumen" => "34"
                        "paginaInicial" => "721"
                        "paginaFinal" => "727"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15846587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of right ventricular systolic dysfunction in early systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Meune"
                            1 => "Y&#46; Allanore"
                            2 => "J&#46;Y&#46; Devaux"
                            3 => "O&#46; Dessault"
                            4 => "D&#46; Duboc"
                            5 => "S&#46; Weber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "1941"
                        "paginaFinal" => "1945"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15468357"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Right ventricular diastolic abnormalities in systemic sclerosis&#46; Relation to left ventricular involvement and pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Giunta"
                            1 => "E&#46; Tirri"
                            2 => "S&#46; Maione"
                            3 => "S&#46; Canganiello"
                            4 => "A&#46; Mele"
                            5 => "A&#46; De Luca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "paginaInicial" => "94"
                        "paginaFinal" => "98"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10666162"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disturbed right ventricular diastolic function in patients with systemic sclerosis&#58; A Doppler tissue imaging study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Lindquist"
                            1 => "K&#46; Caidahl"
                            2 => "G&#46; Neuman-Andersen"
                            3 => "C&#46; Ozolins"
                            4 => "S&#46; Rantap&#228;&#228;-Dahlquist"
                            5 => "A&#46; Waldenstr&#246;m"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.2.755"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "755"
                        "paginaFinal" => "763"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16100164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of myositis and myocarditis in progressive systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;G&#46; West"
                            1 => "P&#46;J&#46; Killian"
                            2 => "D&#46;J&#46; Lawless"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1981"
                        "volumen" => "24"
                        "paginaInicial" => "662"
                        "paginaFinal" => "667"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7236323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe myositis and myocarditis in progressive systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Carette"
                            1 => "J&#46; Turcotte"
                            2 => "G&#46; Matho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1985"
                        "volumen" => "12"
                        "paginaInicial" => "997"
                        "paginaFinal" => "999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4087278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac and skeletal muscle disease in systemic sclerosis &#40;scleroderma&#41;&#58; a righ risk association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;P&#46; Follansbee"
                            1 => "T&#46;R&#46; Zerbe"
                            2 => "T&#46;A&#46; Medsger Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1993"
                        "volumen" => "125"
                        "paginaInicial" => "194"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8417518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversible myocardial perfusion defects during cold challenge in scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Long"
                            1 => "G&#46; Duffy"
                            2 => "B&#46; Bresnihan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1986"
                        "volumen" => "25"
                        "paginaInicial" => "158"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3708232"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cold-induced reversible myocardial ischaemia in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Gustafsson"
                            1 => "F&#46; Mannting"
                            2 => "E&#46; Kazzam"
                            3 => "A&#46; Waldenstrom"
                            4 => "R&#46; Hallgren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1989"
                        "volumen" => "2"
                        "paginaInicial" => "475"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2570187"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;L&#46; Alexander"
                            1 => "G&#46;S&#46; Firestein"
                            2 => "J&#46;L&#46; Weiss"
                            3 => "R&#46;R&#46; Heuser"
                            4 => "G&#46; Leitl"
                            5 => "H&#46;N&#46; Wagner Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1986"
                        "volumen" => "105"
                        "paginaInicial" => "661"
                        "paginaFinal" => "668"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3767147"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular dysfunction induced by cold exposure in patients with systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46;W&#46; Ellis"
                            1 => "A&#46;N&#46; Baer"
                            2 => "R&#46;M&#46; Robertson"
                            3 => "T&#46; Pincus"
                            4 => "M&#46;W&#46; Kronenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1986"
                        "volumen" => "80"
                        "paginaInicial" => "385"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3953616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of cold stress on coronary sinus blood flow in patients with scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;T&#46; Colfer"
                            1 => "S&#46;K&#46; Das"
                            2 => "L&#46; Dabich"
                            3 => "O&#46;S&#46; Randall"
                            4 => "B&#46; Pitt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Assoc Acad Minor Phys"
                        "fecha" => "1993"
                        "volumen" => "4"
                        "paginaInicial" => "62"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8490289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of captopril on thallium 201 myocardial perfusion in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Kahan"
                            1 => "J&#46;Y&#46; Devaux"
                            2 => "B&#46; Amor"
                            3 => "C&#46;J&#46; Menkes"
                            4 => "S&#46; Weber"
                            5 => "A&#46; Venot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther"
                        "fecha" => "1990"
                        "volumen" => "47"
                        "paginaInicial" => "483"
                        "paginaFinal" => "489"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2183960"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decreased coronary reserve in primary scleroderma myocardial disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Kahan"
                            1 => "A&#46; Nitenberg"
                            2 => "J&#46; Foult"
                            3 => "B&#46; Amor"
                            4 => "C&#46;J&#46; Menkes"
                            5 => "J&#46;Y&#46; Devaux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1985"
                        "volumen" => "28"
                        "paginaInicial" => "637"
                        "paginaFinal" => "646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4004974"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of early impairment of coronary flow reserve in patients with systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Montisci"
                            1 => "A&#46; Vacca"
                            2 => "P&#46; Garau"
                            3 => "P&#46; Colonna"
                            4 => "M&#46; Ruscazio"
                            5 => "G&#46; Passiu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2003"
                        "volumen" => "62"
                        "paginaInicial" => "890"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12922965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Absence of epicardial coronary stenosis in patients with systemic sclerosis with severe impairment of coronary flow reserve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Vacca"
                            1 => "P&#46; Siotto"
                            2 => "A&#46; Cauli"
                            3 => "R&#46; Montisci"
                            4 => "P&#46; Garau"
                            5 => "V&#46; Ibba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2005.040154"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "paginaInicial" => "274"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16410537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive assessment of myocardial involvement in patients with systemic sclerosis&#58; role of signal averaged electrocardiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Morelli"
                            1 => "A&#46; Sgreccia"
                            2 => "P&#46; De Marzio"
                            3 => "C&#46; Perrone"
                            4 => "L&#46; Ferrante"
                            5 => "A&#46;M&#46; Gurgo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1997"
                        "volumen" => "24"
                        "paginaInicial" => "2358"
                        "paginaFinal" => "2363"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9415642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventricular late potentials in systemic sclerosis&#58; relationship with skin involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Paradiso"
                            1 => "M&#46; Di Franco"
                            2 => "A&#46; Musca"
                            3 => "S&#46; Basili"
                            4 => "V&#46; Riccieri"
                            5 => "V&#46; Paoletti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "1388"
                        "paginaFinal" => "1392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12136893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The heart in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46; Steen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Rheumatol Rep"
                        "fecha" => "2004"
                        "volumen" => "6"
                        "paginaInicial" => "137"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15016344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of sustained monomorphic ventricular tachycardia in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;C&#46; Rankin"
                            1 => "S&#46; Osswald"
                            2 => "B&#46;A&#46; McGovern"
                            3 => "J&#46;N&#46; Ruskin"
                            4 => "H&#46; Garan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1999"
                        "volumen" => "83"
                        "paginaInicial" => "633"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10073883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Electroanatomic mapping and ablation of ventricular tachycardia associated with systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Lacroix"
                            1 => "F&#46; Brigadeau"
                            2 => "C&#46; Marquie"
                            3 => "D&#46; Klug"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eupc.2004.03.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Europace"
                        "fecha" => "2004"
                        "volumen" => "6"
                        "paginaInicial" => "336"
                        "paginaFinal" => "342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172658"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cardiac conduction system in progressive systemic sclerosis&#58; clinical and pathologic features of 35 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;L&#46; Ridolfi"
                            1 => "B&#46;H&#46; Bulkley"
                            2 => "G&#46;M&#46; Hutchins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1976"
                        "volumen" => "61"
                        "paginaInicial" => "361"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/961700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrioventricular nodal function in progressive systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;K&#46; Roberts"
                            1 => "W&#46;R&#46; Cabeen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "1983"
                        "volumen" => "13"
                        "paginaInicial" => "174"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6673113"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The heart in scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;A&#46; Sackner"
                            1 => "E&#46;R&#46; Heinz"
                            2 => "A&#46;J&#46; Steinberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1966"
                        "volumen" => "17"
                        "paginaInicial" => "542"
                        "paginaFinal" => "559"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5929661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The echocardiogram in slceroderma endocarditis of the mitral valve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Kinney"
                            1 => "W&#46; Reeves"
                            2 => "R&#46; Zellis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1979"
                        "volumen" => "139"
                        "paginaInicial" => "1179"
                        "paginaFinal" => "1180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/485753"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequency of mitral valve prolapse in systemic lupus erythematosus&#44; progressive systemic sclerosis&#44; and mixed connective tissue disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Comens"
                            1 => "M&#46;A&#46; Alpert"
                            2 => "G&#46;C&#46; Sharp"
                            3 => "T&#46;A&#46; Pressly"
                            4 => "D&#46;L&#46; Kelly"
                            5 => "S&#46;E&#46; Hazelwood"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "369"
                        "paginaFinal" => "370"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2913742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac valvular disease and systemic lupus erythematosus&#47;scleroderma overlap associated with antiphospholipid antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Penmetcha"
                            1 => "S&#46;W&#46; Rosenbush"
                            2 => "C&#46;A&#46; Harris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1996"
                        "volumen" => "23"
                        "paginaInicial" => "2171"
                        "paginaFinal" => "2174"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8970061"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ulnar artery involvement in systemic sclerosis &#40;scleroderma&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;H&#46; Taylor"
                            1 => "J&#46;A&#46; McFadden"
                            2 => "M&#46;B&#46; Bolster"
                            3 => "R&#46;M&#46; Silver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "102"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11824945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alteration of arterial distensibility in systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Constans"
                            1 => "P&#46; Gosse"
                            2 => "J&#46;L&#46; Pellegrin"
                            3 => "P&#46; Ansorborlo"
                            4 => "B&#46; Leng"
                            5 => "J&#46; Clementy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "1997"
                        "volumen" => "241"
                        "paginaInicial" => "115"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9077367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macrovascular disease and systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ho"
                            1 => "D&#46; Veale"
                            2 => "C&#46; Eastmond"
                            3 => "G&#46; Nuki"
                            4 => "J&#46; Belch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "paginaInicial" => "39"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10627425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib60"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carotid and femoral arterial wall mechanics in slceroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;S&#46; Cheng"
                            1 => "A&#46; Tiwari"
                            2 => "A&#46; Boutin"
                            3 => "C&#46;P&#46; Denton"
                            4 => "C&#46;M&#46; Black"
                            5 => "R&#46; Morris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/keg371"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "1299"
                        "paginaFinal" => "1305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12777634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib61"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aortic stiffness in systemic sclerosis is increased independently of the extent of skin involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Moyssakis"
                            1 => "E&#46; Gialafos"
                            2 => "V&#46; Vassiliou"
                            3 => "E&#46; Taktikou"
                            4 => "C&#46; Katsiari"
                            5 => "D&#46;P&#46; Papadopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/keh478"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology"
                        "fecha" => "2005"
                        "volumen" => "44"
                        "paginaInicial" => "251"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15546962"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib62"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in systemic sclerosis&#58; an international meta-analysis of individual patient data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46;A&#46; Ioannidis"
                            1 => "P&#46;G&#46; Vlachoyiannopoulos"
                            2 => "A&#46;-B&#46; Haidich"
                            3 => "T&#46;A&#46; Medsger Jr"
                            4 => "M&#46; Lucas"
                            5 => "C&#46;J&#46; Michet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjmed.2004.04.031"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2005"
                        "volumen" => "118"
                        "paginaInicial" => "2"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15639201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/1699258X/00000002000000S3/v1_201305061741/S1699258X06731059/v1_201305061741/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/1699258X/00000002000000S3/v1_201305061741/S1699258X06731059/v1_201305061741/es/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06731059?idApp=UINPBA00004M"
]

Información del artículo

ISSN: 1699258X
Idioma original: Español

DOI:10.1016/S1699-258X(06)73105-9

Datos actualizados diariamente

año/Mes	Html	Pdf	Total

2024 Noviembre	8	33	41
2024 Octubre	28	226	254
2024 Septiembre	28	126	154
2024 Agosto	45	177	222
2024 Julio	35	196	231
2024 Junio	29	213	242
2024 Mayo	43	232	275
2024 Abril	34	237	271
2024 Marzo	33	153	186
2024 Febrero	27	139	166
2024 Enero	26	167	193
2023 Diciembre	32	165	197
2023 Noviembre	39	181	220
2023 Octubre	23	210	233
2023 Septiembre	28	148	176
2023 Agosto	23	100	123
2023 Julio	27	179	206
2023 Junio	31	111	142
2023 Mayo	23	166	189
2023 Abril	19	93	112
2023 Marzo	25	160	185
2023 Febrero	31	126	157
2023 Enero	15	104	119
2022 Diciembre	26	126	152
2022 Noviembre	31	107	138
2022 Octubre	20	151	171
2022 Septiembre	27	97	124
2022 Agosto	26	156	182
2022 Julio	20	132	152
2022 Junio	24	143	167
2022 Mayo	32	130	162
2022 Abril	27	132	159
2022 Marzo	42	98	140
2022 Febrero	15	155	170
2022 Enero	15	161	176
2021 Diciembre	34	115	149
2021 Noviembre	25	143	168
2021 Octubre	38	190	228
2021 Septiembre	31	151	182
2021 Agosto	26	231	257
2021 Julio	22	188	210
2021 Junio	20	220	240
2021 Mayo	31	236	267
2021 Abril	41	610	651
2021 Marzo	44	119	163
2021 Febrero	51	75	126
2021 Enero	24	66	90
2020 Diciembre	22	111	133
2020 Noviembre	23	122	145
2020 Octubre	18	96	114
2020 Septiembre	21	90	111
2020 Agosto	20	93	113
2020 Julio	12	102	114
2020 Junio	21	95	116
2020 Mayo	24	102	126
2020 Abril	27	70	97
2020 Marzo	27	131	158
2020 Febrero	39	121	160
2020 Enero	36	130	166
2019 Diciembre	22	106	128
2019 Noviembre	16	293	309
2019 Octubre	20	198	218
2019 Septiembre	28	68	96
2019 Agosto	17	71	88
2019 Julio	69	62	131
2019 Junio	62	74	136
2019 Mayo	57	137	194
2019 Abril	15	83	98
2019 Marzo	16	75	91
2019 Febrero	13	59	72
2019 Enero	17	74	91
2018 Diciembre	37	91	128
2018 Noviembre	21	21	42
2018 Octubre	14	26	40
2018 Septiembre	20	20	40
2018 Agosto	14	19	33
2018 Julio	3	5	8
2018 Mayo	0	2	2
2018 Abril	12	17	29
2018 Marzo	24	29	53
2018 Febrero	8	9	17
2018 Enero	9	15	24
2017 Diciembre	10	15	25
2017 Noviembre	10	21	31
2017 Octubre	11	15	26
2017 Septiembre	12	12	24
2017 Agosto	9	19	28
2017 Julio	12	22	34
2017 Junio	14	10	24
2017 Mayo	33	20	53
2017 Abril	16	6	22
2017 Marzo	11	40	51
2017 Febrero	4	11	15
2017 Enero	15	8	23
2016 Diciembre	30	19	49
2016 Noviembre	17	9	26
2016 Octubre	25	10	35
2016 Septiembre	25	12	37
2016 Agosto	21	8	29
2016 Julio	12	10	22
2016 Abril	1	0	1
2015 Octubre	1	0	1
2015 Septiembre	2	0	2
2015 Agosto	6	6	12
2015 Julio	116	7	123
2015 Junio	148	31	179
2015 Mayo	192	54	246
2015 Abril	176	30	206
2015 Marzo	196	29	225
2015 Febrero	160	21	181
2015 Enero	150	16	166
2014 Diciembre	180	17	197
2014 Noviembre	127	17	144
2014 Octubre	188	32	220
2014 Septiembre	146	31	177
2014 Agosto	159	24	183
2014 Julio	85	25	110
2014 Junio	118	21	139
2014 Mayo	103	30	133
2014 Abril	56	26	82
2014 Marzo	66	29	95
2014 Febrero	37	10	47
2014 Enero	46	24	70
2013 Diciembre	44	18	62
2013 Noviembre	51	34	85
2013 Octubre	49	24	73
2013 Septiembre	34	16	50
2013 Agosto	51	7	58
2013 Julio	43	8	51
2013 Junio	28	9	37
2013 Mayo	26	13	39
2013 Abril	26	10	36
2013 Marzo	35	9	44
2013 Febrero	21	2	23
2013 Enero	20	3	23
2012 Diciembre	18	2	20
2012 Noviembre	17	6	23
2012 Octubre	5	6	11
2012 Septiembre	4	1	5
2011 Mayo	8	0	8
2011 Abril	10	0	10
2011 Marzo	25	0	25
2011 Febrero	28	0	28
2011 Enero	40	0	40
2010 Diciembre	24	0	24
2010 Noviembre	20	0	20
2010 Octubre	32	0	32
2010 Septiembre	41	0	41
2010 Agosto	23	0	23
2010 Julio	34	0	34
2010 Junio	25	0	25
2010 Mayo	55	0	55
2010 Abril	60	0	60
2010 Marzo	53	0	53
2010 Febrero	12	0	12
2010 Enero	27	0	27
2009 Diciembre	9	0	9
2009 Noviembre	26	0	26
2009 Octubre	8	0	8
2009 Septiembre	17	0	17
2009 Agosto	10	0	10
2009 Julio	20	0	20
2009 Junio	18	0	18
2009 Mayo	20	0	20
2009 Abril	21	0	21
2009 Marzo	7	0	7
2009 Enero	1	0	1
2008 Diciembre	20	0	20
2008 Noviembre	18	0	18
2008 Octubre	21	0	21
2008 Septiembre	16	0	16
2008 Agosto	18	0	18
2008 Julio	17	0	17
2008 Junio	19	0	19
2008 Mayo	23	0	23
2008 Abril	38	0	38
2008 Marzo	25	0	25
2008 Febrero	25	0	25
2008 Enero	25	0	25
2007 Diciembre	21	0	21
2007 Noviembre	46	0	46
2007 Octubre	28	0	28
2007 Septiembre	34	0	34
2007 Agosto	13	0	13
2007 Julio	22	0	22
2007 Junio	25	0	25
2007 Mayo	37	0	37
2007 Abril	11	0	11
2007 Marzo	57	0	57
2007 Febrero	26	0	26
2007 Enero	1	0	1

Mostrar todo

Indexada en:

Síguenos:

Suscribirse:

Estadísticas

Indexada en:

Síguenos:

Suscribirse:

Estadísticas

Suscríbase a la newsletter