Correspondencia: Dra. O.L. Vera-Lastra. Departamento de Medicina Interna. Hospital de Especialidades. Centro Médico Nacional La Raza. Seris y Zaachila, s/n. Col. La Raza. CP 02990 México DF. México.
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Jara" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Olga Lidia" "apellidos" => "Vera-Lastra" "email" => array:1 [ 0 => "olgavera62@yahoo.com.mx" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Luis J." "apellidos" => "Jara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Medicina Interna. Hospital de Especialidades Dr. Antonio Fraga Mouret. Universidad Autónoma de México. México. DF. México" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "División de Investigación. Hospital de Especialidades Dr. Antonio Fraga Mouret. Universidad Autónoma de México. México. DF. México" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dra. O.L. Vera-Lastra. Departamento de Medicina Interna. Hospital de Especialidades. Centro Médico Nacional La Raza. Seris y Zaachila, s/n. Col. La Raza. CP 02990 México DF. México." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Endocrinological alterations in systemic sclerosis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112019" "palabras" => array:5 [ 0 => "Esclerosis sistémica" 1 => "Hipotiroidismo" 2 => "Hiperprolactinemia" 3 => "Prolactinomas" 4 => "Osteoporosis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec112018" "palabras" => array:5 [ 0 => "Systemic sclerosis" 1 => "Hypothyroidism" 2 => "Hyperprolactinemia" 3 => "Prolactinomas" 4 => "Osteoporosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">En la esclerosis sistémica, se ha comunicado frecuencias de las alteraciones tiroideas (hipotiroidismo clínico y subclínico) y los anticuerpos antitiroglobulina de hasta el 43 y 73%, respectivamente, y en su patogenia participan mecanismos estructurales, autoinmunitarios y genéticos. Se debe investigar el hipotiroidismo clínico y subclínico e iniciar tratamiento con levotiroxina. La frecuencia de hiperprolactinemia en esta entidad es del 13 al 59% y los mecanismos implicados son la disfunción hipotálamica y los prolactinomas. La frecuencia de los prolactinomas es de hasta el 66%. Las frecuencias de osteopenia y osteoporosis son del 3 al 35% y del 35 al 44%, respectivamente. La osteoporosis en la esclerodermia es multifactorial (isquemia, inmovilización, síndrome de absorción intestinal deficiente, menopausia, esteroides, hiperprolactinemia, entre otros). Es importante realizar densitometría ósea en estos pacientes para identificar los casos de osteoporosis e iniciar un tratamiento oportuno.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">In systemic sclerosis, the frequency of thyroid derangements (clinical and subclinical hypothyroidism) is 43 and 73% respectively; in its pathogenesis participate structural, autoimmune and genetic mechanisms. It is important to run thyroid function test and to investigate the manifestation of clinical and subclinical hypothyroidism and to initiate treatment with levothyroxine.</p><p class="elsevierStyleSimplePara elsevierViewall">The frequency of hyperprolactinemia in SS goes from 13 to 59% and the implied mechanisms are the hypothalamic dysfunction and prolactinomas. The frequency of prolactinomas runs up to 66%. The frequency of osteopenia and osteoporosis is from 3 to 35 and from 35 to 44% respectively. The osteoporosis in escleroderma is multifactorial (ischemia, immobilization, intestinal malabsorption syndrome, steroids, menopause, hyperprolactinemia, among other). It is important to erform bone densitometry in these patients and to identify the cases of osteoporosis and to start opportune treatment.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:76 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.R. Seibold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Textbook of Rheumatology" "paginaInicial" => "1133" "paginaFinal" => "1162" "edicion" => "5.ª ed." "serieFecha" => "1997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 7 | 21 | 28 |
2024 Octubre | 24 | 60 | 84 |
2024 Septiembre | 26 | 58 | 84 |
2024 Agosto | 46 | 66 | 112 |
2024 Julio | 36 | 65 | 101 |
2024 Junio | 28 | 60 | 88 |
2024 Mayo | 39 | 43 | 82 |
2024 Abril | 32 | 39 | 71 |
2024 Marzo | 34 | 61 | 95 |
2024 Febrero | 23 | 29 | 52 |
2024 Enero | 24 | 50 | 74 |
2023 Diciembre | 33 | 47 | 80 |
2023 Noviembre | 31 | 38 | 69 |
2023 Octubre | 32 | 70 | 102 |
2023 Septiembre | 23 | 74 | 97 |
2023 Agosto | 21 | 28 | 49 |
2023 Julio | 23 | 54 | 77 |
2023 Junio | 26 | 33 | 59 |
2023 Mayo | 52 | 38 | 90 |
2023 Abril | 27 | 29 | 56 |
2023 Marzo | 31 | 37 | 68 |
2023 Febrero | 28 | 42 | 70 |
2023 Enero | 32 | 38 | 70 |
2022 Diciembre | 52 | 38 | 90 |
2022 Noviembre | 60 | 42 | 102 |
2022 Octubre | 47 | 58 | 105 |
2022 Septiembre | 29 | 46 | 75 |
2022 Agosto | 38 | 67 | 105 |
2022 Julio | 28 | 47 | 75 |
2022 Junio | 28 | 70 | 98 |
2022 Mayo | 20 | 85 | 105 |
2022 Abril | 37 | 105 | 142 |
2022 Marzo | 38 | 107 | 145 |
2022 Febrero | 23 | 74 | 97 |
2022 Enero | 20 | 91 | 111 |
2021 Diciembre | 26 | 81 | 107 |
2021 Noviembre | 23 | 91 | 114 |
2021 Octubre | 29 | 84 | 113 |
2021 Septiembre | 25 | 67 | 92 |
2021 Agosto | 23 | 67 | 90 |
2021 Julio | 23 | 54 | 77 |
2021 Junio | 13 | 57 | 70 |
2021 Mayo | 26 | 76 | 102 |
2021 Abril | 36 | 153 | 189 |
2021 Marzo | 34 | 41 | 75 |
2021 Febrero | 36 | 37 | 73 |
2021 Enero | 15 | 33 | 48 |
2020 Diciembre | 19 | 29 | 48 |
2020 Noviembre | 26 | 42 | 68 |
2020 Octubre | 11 | 36 | 47 |
2020 Septiembre | 25 | 19 | 44 |
2020 Agosto | 28 | 42 | 70 |
2020 Julio | 18 | 26 | 44 |
2020 Junio | 26 | 20 | 46 |
2020 Mayo | 20 | 47 | 67 |
2020 Abril | 29 | 36 | 65 |
2020 Marzo | 30 | 41 | 71 |
2020 Febrero | 32 | 38 | 70 |
2020 Enero | 47 | 42 | 89 |
2019 Diciembre | 29 | 48 | 77 |
2019 Noviembre | 12 | 52 | 64 |
2019 Octubre | 28 | 72 | 100 |
2019 Septiembre | 33 | 73 | 106 |
2019 Agosto | 22 | 69 | 91 |
2019 Julio | 28 | 47 | 75 |
2019 Junio | 18 | 31 | 49 |
2019 Mayo | 35 | 61 | 96 |
2019 Abril | 26 | 38 | 64 |
2019 Marzo | 17 | 32 | 49 |
2019 Febrero | 17 | 20 | 37 |
2019 Enero | 10 | 31 | 41 |
2018 Diciembre | 41 | 60 | 101 |
2018 Noviembre | 36 | 21 | 57 |
2018 Octubre | 29 | 15 | 44 |
2018 Septiembre | 24 | 12 | 36 |
2018 Agosto | 13 | 13 | 26 |
2018 Julio | 5 | 5 | 10 |
2018 Mayo | 0 | 2 | 2 |
2018 Abril | 11 | 11 | 22 |
2018 Marzo | 25 | 18 | 43 |
2018 Febrero | 9 | 4 | 13 |
2018 Enero | 4 | 10 | 14 |
2017 Diciembre | 12 | 11 | 23 |
2017 Noviembre | 9 | 9 | 18 |
2017 Octubre | 14 | 6 | 20 |
2017 Septiembre | 16 | 7 | 23 |
2017 Agosto | 15 | 7 | 22 |
2017 Julio | 28 | 7 | 35 |
2017 Junio | 30 | 3 | 33 |
2017 Mayo | 24 | 11 | 35 |
2017 Abril | 22 | 6 | 28 |
2017 Marzo | 17 | 5 | 22 |
2017 Febrero | 8 | 7 | 15 |
2017 Enero | 15 | 11 | 26 |
2016 Diciembre | 41 | 18 | 59 |
2016 Noviembre | 29 | 13 | 42 |
2016 Octubre | 40 | 8 | 48 |
2016 Septiembre | 34 | 10 | 44 |
2016 Agosto | 14 | 2 | 16 |
2016 Julio | 18 | 11 | 29 |
2015 Octubre | 1 | 0 | 1 |
2015 Septiembre | 5 | 0 | 5 |
2015 Agosto | 4 | 0 | 4 |
2015 Julio | 46 | 7 | 53 |
2015 Junio | 73 | 8 | 81 |
2015 Mayo | 130 | 17 | 147 |
2015 Abril | 85 | 8 | 93 |
2015 Marzo | 66 | 7 | 73 |
2015 Febrero | 86 | 8 | 94 |
2015 Enero | 68 | 7 | 75 |
2014 Diciembre | 79 | 14 | 93 |
2014 Noviembre | 80 | 7 | 87 |
2014 Octubre | 87 | 7 | 94 |
2014 Septiembre | 55 | 11 | 66 |
2014 Agosto | 63 | 4 | 67 |
2014 Julio | 61 | 14 | 75 |
2014 Junio | 62 | 8 | 70 |
2014 Mayo | 71 | 9 | 80 |
2014 Abril | 46 | 9 | 55 |
2014 Marzo | 41 | 12 | 53 |
2014 Febrero | 36 | 8 | 44 |
2014 Enero | 44 | 7 | 51 |
2013 Diciembre | 28 | 8 | 36 |
2013 Noviembre | 59 | 25 | 84 |
2013 Octubre | 48 | 9 | 57 |
2013 Septiembre | 46 | 8 | 54 |
2013 Agosto | 45 | 8 | 53 |
2013 Julio | 43 | 6 | 49 |
2013 Junio | 39 | 11 | 50 |
2013 Mayo | 33 | 8 | 41 |
2013 Abril | 34 | 14 | 48 |
2013 Marzo | 32 | 12 | 44 |
2013 Febrero | 21 | 7 | 28 |
2013 Enero | 18 | 3 | 21 |
2012 Diciembre | 17 | 5 | 22 |
2012 Noviembre | 10 | 4 | 14 |
2012 Octubre | 9 | 4 | 13 |
2012 Septiembre | 22 | 4 | 26 |
2011 Mayo | 2 | 0 | 2 |
2011 Abril | 6 | 0 | 6 |
2011 Marzo | 32 | 0 | 32 |
2011 Febrero | 32 | 0 | 32 |
2011 Enero | 34 | 0 | 34 |
2010 Diciembre | 28 | 0 | 28 |
2010 Noviembre | 49 | 0 | 49 |
2010 Octubre | 22 | 0 | 22 |
2010 Septiembre | 17 | 0 | 17 |
2010 Agosto | 37 | 0 | 37 |
2010 Julio | 15 | 0 | 15 |
2010 Junio | 17 | 0 | 17 |
2010 Mayo | 41 | 0 | 41 |
2010 Abril | 27 | 0 | 27 |
2010 Marzo | 40 | 0 | 40 |
2010 Febrero | 26 | 0 | 26 |
2010 Enero | 49 | 0 | 49 |
2009 Diciembre | 58 | 0 | 58 |
2009 Noviembre | 91 | 0 | 91 |
2009 Octubre | 34 | 0 | 34 |
2009 Septiembre | 27 | 0 | 27 |
2009 Agosto | 31 | 0 | 31 |
2009 Julio | 28 | 0 | 28 |
2009 Junio | 14 | 0 | 14 |
2009 Mayo | 23 | 0 | 23 |
2009 Abril | 22 | 0 | 22 |
2009 Marzo | 12 | 0 | 12 |
2009 Enero | 1 | 0 | 1 |
2008 Diciembre | 26 | 0 | 26 |
2008 Noviembre | 50 | 0 | 50 |
2008 Octubre | 55 | 0 | 55 |
2008 Septiembre | 46 | 0 | 46 |
2008 Agosto | 25 | 0 | 25 |
2008 Julio | 41 | 0 | 41 |
2008 Junio | 25 | 0 | 25 |
2008 Mayo | 38 | 0 | 38 |
2008 Abril | 39 | 0 | 39 |
2008 Marzo | 35 | 0 | 35 |
2008 Febrero | 23 | 0 | 23 |
2008 Enero | 25 | 0 | 25 |
2007 Diciembre | 37 | 0 | 37 |
2007 Noviembre | 53 | 0 | 53 |
2007 Octubre | 51 | 0 | 51 |
2007 Septiembre | 47 | 0 | 47 |
2007 Agosto | 22 | 0 | 22 |
2007 Julio | 40 | 0 | 40 |
2007 Junio | 23 | 0 | 23 |
2007 Mayo | 38 | 0 | 38 |
2007 Abril | 23 | 0 | 23 |
2007 Marzo | 34 | 0 | 34 |
2007 Febrero | 26 | 0 | 26 |
2007 Enero | 1 | 0 | 1 |