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"apellidos" => "de Miguel" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X09701962?idApp=UINPBA00004M" "url" => "/1699258X/0000000500000001/v1_201305061810/S1699258X09701962/v1_201305061810/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Uso apropiado de los antiinflamatorios no esteroideos en reumatología: documento de consenso de la Sociedad Española de Reumatología y el Colegio Mexicano de Reumatología" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "12" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gerardo Bori Segura, Blanca Hernández Cruz, Milena Gobbo, Ángel Lanas Arbeloa, Mario Salazar Páramo, Leobardo Terán Estrada, José Federico Díaz González, Rolando Espinosa Morales, Federico Galván Villegas, Luis Alberto García Rodríguez, José María 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IMSS, Morelia, Michoacán, México" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] 6 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] 7 => array:3 [ "entidad" => "Servicio de Reumatología, Instituto Nacional de Rehabilitación, México DF, México" "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] 8 => array:3 [ "entidad" => "Colegio Mexicano de Reumatología, México DF, México" "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff9" ] 9 => array:3 [ "entidad" => "Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">j</span>" "identificador" => "aff10" ] 10 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital de La Princesa, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">k</span>" "identificador" => "aff11" ] 11 => array:3 [ "entidad" => "Departamento de Medicina Interna, Hospital Civil de Guadalajara, Guadalajara, México" "etiqueta" => "<span class="elsevierStyleSup">l</span>" "identificador" => "aff12" ] 12 => array:3 [ "entidad" => "Servicio de Reumatología, Instituto Provincial de Rehabilitación, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">m</span>" "identificador" => "aff13" ] 13 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Central Sur de Alta Especialidad, PEMEX, México DF, México" "etiqueta" => "<span class="elsevierStyleSup">n</span>" "identificador" => "aff14" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Appropriate use of non-steroidal anti-inflammatory drugs in rheumatology: guidelines from the Spanish Society of Rheumatology and the Mexican College of Rheumatology" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-30" "fechaAceptado" => "2008-07-04" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112699" "palabras" => array:4 [ 0 => "Antiinflamatorios" 1 => "Recomendaciones" 2 => "Técnica Delphi" 3 => "Revisión" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112698" "palabras" => array:4 [ 0 => "Anti-inflammatory agents" 1 => "Guideline" 2 => "Delphi technique" 3 => "Review" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Elaborar recomendaciones para el uso apropiado de AINE en reumatología.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se utilizó una metodología modificada de RAND/UCLA. Se seleccionaron dos grupos de panelistas, uno por el CMR y otro por la SER. A partir de grupos nominales, se obtuvieron propuestas de recomendaciones, que fueron sometidas a la prueba de acuerdo entre los reumatólogos de ambas sociedades mediante encuesta Delphi a dos rondas. Del análisis de la segunda ronda Delphi, se extrajeron las recomendaciones finales y posteriormente se revisó el nivel de evidencia y el grado de acuerdo de la recomendación según el Centro de Medicina Basada en la Evidencia de Oxford. Finalmente, se efectuó revisión sistemática de cinco recomendaciones sin acuerdo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se presentan recomendaciones sobre el uso seguro de los AINE en las enfermedades reumáticas, con base en la mejor evidencia disponible, la opinión de expertos, el acuerdo entre reumatólogos y la revisión de la literatura. La tendencia es disminuir la frecuencia, la duración y la dosis de AINE en favor de medidas no farmacológicas, analgésicos o fármacos modificadores de los síntomas o del curso de la enfermedad. Además, es obligado identificar perfiles de mayor riesgo de toxicidad, en especial gastrointestinal y cardiovascular. Se recomiendan pautas de actuación y monitorización en los diferentes grupos de riesgo y en pacientes con empleo de antiagregantes plaquetarios, anticoagulación o con terapias concomitantes. El porcentaje de acuerdo es elevado en la mayoría de los casos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los AINE son medicamentos seguros y eficaces en el tratamiento de las afecciones reumáticas. No obstante, dado su perfil de riesgo, es necesario individualizar su uso.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To develop guidelines for the appropriate use of NSAIDs in rheumatology.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We used a methodology modified from the one developed by RAND/UCLA. Two groups of panellists were selected, one by the CMR and another by the SER. Recommendations were proposed from nominal groups and the agreement to them was tested among rheumatologists from both societies by a tworound Delphi survey. The analysis of the second Delphi round supported the generation of the final set of recommendations and the assignment of a level of agreement to each of them. Systematic reviews of five recommendations in which the agreement was low or was divided were also carried out.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Here we present recommendations for the safe use of NSAIDs in rheumatic diseases, based on the best available evidence, expert opinion, the agreement among rheumatologists, and literature review. The trend is to reduce the frequency, duration and dose of NSAIDs in favour of non-pharmacological measures, analgesic drugs or disease modifying drugs. In addition, the recommendations help to identify profiles for increased toxicity, with an emphasis on gastrointestinal and cardiovascular risks. The recommendations deal with the course of action and monitoring in different risk groups and in patients using antiplatelet or anticoagulant drugs. The overall level of agreement is high.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The NSAIDs are safe and effective drugs for the treatment of rheumatic diseases. However, it is necessary to individualize its use according to their risk profile.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Fosbol EL, Gislason GH, Jacobsen S, Abildstrom SZ, Hansen ML, Schramm TK, et al. The pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) from 1997 to 2005: a nationwide study on 4.6 million people. Pharmacoepidemiol Drug Saf. 2008. [revista on-line; citado 1 Jul 2008]. 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año/Mes | Html | Total | |
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2024 Noviembre | 71 | 27 | 98 |
2024 Octubre | 346 | 71 | 417 |
2024 Septiembre | 347 | 56 | 403 |
2024 Agosto | 625 | 67 | 692 |
2024 Julio | 483 | 65 | 548 |
2024 Junio | 572 | 126 | 698 |
2024 Mayo | 541 | 78 | 619 |
2024 Abril | 596 | 86 | 682 |
2024 Marzo | 557 | 79 | 636 |
2024 Febrero | 610 | 63 | 673 |
2024 Enero | 481 | 50 | 531 |
2023 Diciembre | 307 | 73 | 380 |
2023 Noviembre | 342 | 60 | 402 |
2023 Octubre | 338 | 66 | 404 |
2023 Septiembre | 326 | 72 | 398 |
2023 Agosto | 477 | 59 | 536 |
2023 Julio | 426 | 46 | 472 |
2023 Junio | 386 | 84 | 470 |
2023 Mayo | 471 | 94 | 565 |
2023 Abril | 300 | 37 | 337 |
2023 Marzo | 391 | 85 | 476 |
2023 Febrero | 349 | 73 | 422 |
2023 Enero | 404 | 54 | 458 |
2022 Diciembre | 493 | 61 | 554 |
2022 Noviembre | 511 | 133 | 644 |
2022 Octubre | 443 | 79 | 522 |
2022 Septiembre | 451 | 71 | 522 |
2022 Agosto | 310 | 101 | 411 |
2022 Julio | 268 | 82 | 350 |
2022 Junio | 211 | 70 | 281 |
2022 Mayo | 277 | 90 | 367 |
2022 Abril | 400 | 80 | 480 |
2022 Marzo | 360 | 154 | 514 |
2022 Febrero | 223 | 112 | 335 |
2022 Enero | 210 | 91 | 301 |
2021 Diciembre | 183 | 87 | 270 |
2021 Noviembre | 191 | 101 | 292 |
2021 Octubre | 203 | 96 | 299 |
2021 Septiembre | 165 | 105 | 270 |
2021 Agosto | 176 | 140 | 316 |
2021 Julio | 167 | 111 | 278 |
2021 Junio | 206 | 98 | 304 |
2021 Mayo | 169 | 125 | 294 |
2021 Abril | 256 | 209 | 465 |
2021 Marzo | 232 | 168 | 400 |
2021 Febrero | 155 | 67 | 222 |
2021 Enero | 226 | 69 | 295 |
2020 Diciembre | 169 | 76 | 245 |
2020 Noviembre | 134 | 135 | 269 |
2020 Octubre | 137 | 82 | 219 |
2020 Septiembre | 126 | 116 | 242 |
2020 Agosto | 104 | 81 | 185 |
2020 Julio | 134 | 104 | 238 |
2020 Junio | 129 | 123 | 252 |
2020 Mayo | 126 | 100 | 226 |
2020 Abril | 76 | 105 | 181 |
2020 Marzo | 88 | 113 | 201 |
2020 Febrero | 78 | 129 | 207 |
2020 Enero | 80 | 94 | 174 |
2019 Diciembre | 183 | 192 | 375 |
2019 Noviembre | 111 | 205 | 316 |
2019 Octubre | 116 | 370 | 486 |
2019 Septiembre | 122 | 309 | 431 |
2019 Agosto | 76 | 405 | 481 |
2019 Julio | 83 | 324 | 407 |
2019 Junio | 108 | 187 | 295 |
2019 Mayo | 245 | 320 | 565 |
2019 Abril | 262 | 292 | 554 |
2019 Marzo | 70 | 187 | 257 |
2019 Febrero | 63 | 161 | 224 |
2019 Enero | 81 | 151 | 232 |
2018 Diciembre | 96 | 99 | 195 |
2018 Noviembre | 71 | 54 | 125 |
2018 Octubre | 81 | 39 | 120 |
2018 Septiembre | 36 | 54 | 90 |
2018 Agosto | 52 | 102 | 154 |
2018 Julio | 20 | 28 | 48 |
2018 Mayo | 1 | 13 | 14 |
2018 Abril | 36 | 124 | 160 |
2018 Marzo | 46 | 79 | 125 |
2018 Febrero | 41 | 37 | 78 |
2018 Enero | 31 | 31 | 62 |
2017 Diciembre | 46 | 44 | 90 |
2017 Noviembre | 45 | 71 | 116 |
2017 Octubre | 51 | 51 | 102 |
2017 Septiembre | 34 | 57 | 91 |
2017 Agosto | 42 | 44 | 86 |
2017 Julio | 42 | 54 | 96 |
2017 Junio | 43 | 69 | 112 |
2017 Mayo | 52 | 63 | 115 |
2017 Abril | 35 | 62 | 97 |
2017 Marzo | 62 | 146 | 208 |
2017 Febrero | 113 | 109 | 222 |
2017 Enero | 49 | 39 | 88 |
2016 Diciembre | 85 | 28 | 113 |
2016 Noviembre | 114 | 33 | 147 |
2016 Octubre | 114 | 53 | 167 |
2016 Septiembre | 149 | 72 | 221 |
2016 Agosto | 138 | 36 | 174 |
2016 Julio | 89 | 51 | 140 |
2016 Abril | 3 | 0 | 3 |
2016 Enero | 2 | 0 | 2 |
2015 Diciembre | 4 | 0 | 4 |
2015 Octubre | 1 | 0 | 1 |
2015 Septiembre | 3 | 0 | 3 |
2015 Agosto | 5 | 0 | 5 |
2015 Julio | 136 | 10 | 146 |
2015 Junio | 243 | 23 | 266 |
2015 Mayo | 272 | 33 | 305 |
2015 Abril | 200 | 16 | 216 |
2015 Marzo | 235 | 10 | 245 |
2015 Febrero | 220 | 13 | 233 |
2015 Enero | 122 | 22 | 144 |
2014 Diciembre | 111 | 14 | 125 |
2014 Noviembre | 178 | 22 | 200 |
2014 Octubre | 176 | 18 | 194 |
2014 Septiembre | 166 | 13 | 179 |
2014 Agosto | 172 | 19 | 191 |
2014 Julio | 194 | 15 | 209 |
2014 Junio | 226 | 21 | 247 |
2014 Mayo | 257 | 24 | 281 |
2014 Abril | 190 | 20 | 210 |
2014 Marzo | 169 | 18 | 187 |
2014 Febrero | 142 | 15 | 157 |
2014 Enero | 120 | 23 | 143 |
2013 Diciembre | 122 | 10 | 132 |
2013 Noviembre | 99 | 15 | 114 |
2013 Octubre | 145 | 22 | 167 |
2013 Septiembre | 142 | 26 | 168 |
2013 Agosto | 113 | 18 | 131 |
2013 Julio | 95 | 19 | 114 |
2013 Junio | 76 | 27 | 103 |
2013 Mayo | 98 | 18 | 116 |
2013 Abril | 78 | 17 | 95 |
2013 Marzo | 68 | 35 | 103 |
2013 Febrero | 114 | 25 | 139 |
2013 Enero | 104 | 11 | 115 |
2012 Diciembre | 43 | 11 | 54 |
2012 Noviembre | 39 | 17 | 56 |
2012 Octubre | 34 | 21 | 55 |
2012 Septiembre | 23 | 14 | 37 |
2011 Mayo | 5 | 0 | 5 |
2011 Abril | 5 | 0 | 5 |
2011 Marzo | 15 | 0 | 15 |
2011 Febrero | 30 | 0 | 30 |
2011 Enero | 19 | 0 | 19 |
2010 Diciembre | 4 | 0 | 4 |
2010 Noviembre | 18 | 0 | 18 |
2010 Octubre | 7 | 0 | 7 |
2010 Septiembre | 6 | 0 | 6 |
2010 Agosto | 25 | 0 | 25 |
2010 Julio | 13 | 0 | 13 |
2010 Junio | 5 | 0 | 5 |
2010 Mayo | 11 | 0 | 11 |
2010 Marzo | 10 | 0 | 10 |
2010 Febrero | 4 | 0 | 4 |
2010 Enero | 7 | 0 | 7 |
2009 Diciembre | 2 | 0 | 2 |
2009 Noviembre | 8 | 0 | 8 |
2009 Octubre | 9 | 0 | 9 |
2009 Septiembre | 13 | 0 | 13 |
2009 Agosto | 12 | 0 | 12 |
2009 Julio | 19 | 0 | 19 |
2009 Junio | 17 | 0 | 17 |
2009 Mayo | 22 | 0 | 22 |
2009 Abril | 24 | 0 | 24 |
2009 Marzo | 30 | 0 | 30 |
2009 Febrero | 7 | 0 | 7 |