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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Elaborar recomendaciones para el uso apropiado de AINE en reumatolog&#237;a&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se utiliz&#243; una metodolog&#237;a modificada de RAND&#47;UCLA&#46; Se seleccionaron dos grupos de panelistas&#44; uno por el CMR y otro por la SER&#46; A partir de grupos nominales&#44; se obtuvieron propuestas de recomendaciones&#44; que fueron sometidas a la prueba de acuerdo entre los reumat&#243;logos de ambas sociedades mediante encuesta Delphi a dos rondas&#46; Del an&#225;lisis de la segunda ronda Delphi&#44; se extrajeron las recomendaciones finales y posteriormente se revis&#243; el nivel de evidencia y el grado de acuerdo de la recomendaci&#243;n seg&#250;n el Centro de Medicina Basada en la Evidencia de Oxford&#46; Finalmente&#44; se efectu&#243; revisi&#243;n sistem&#225;tica de cinco recomendaciones sin acuerdo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se presentan recomendaciones sobre el uso seguro de los AINE en las enfermedades reum&#225;ticas&#44; con base en la mejor evidencia disponible&#44; la opini&#243;n de expertos&#44; el acuerdo entre reumat&#243;logos y la revisi&#243;n de la literatura&#46; La tendencia es disminuir la frecuencia&#44; la duraci&#243;n y la dosis de AINE en favor de medidas no farmacol&#243;gicas&#44; analg&#233;sicos o f&#225;rmacos modificadores de los s&#237;ntomas o del curso de la enfermedad&#46; Adem&#225;s&#44; es obligado identificar perfiles de mayor riesgo de toxicidad&#44; en especial gastrointestinal y cardiovascular&#46; Se recomiendan pautas de actuaci&#243;n y monitorizaci&#243;n en los diferentes grupos de riesgo y en pacientes con empleo de antiagregantes plaquetarios&#44; anticoagulaci&#243;n o con terapias concomitantes&#46; El porcentaje de acuerdo es elevado en la mayor&#237;a de los casos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los AINE son medicamentos seguros y eficaces en el tratamiento de las afecciones reum&#225;ticas&#46; No obstante&#44; dado su perfil de riesgo&#44; es necesario individualizar su uso&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To develop guidelines for the appropriate use of NSAIDs in rheumatology&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We used a methodology modified from the one developed by RAND&#47;UCLA&#46; Two groups of panellists were selected&#44; one by the CMR and another by the SER&#46; Recommendations were proposed from nominal groups and the agreement to them was tested among rheumatologists from both societies by a tworound Delphi survey&#46; The analysis of the second Delphi round supported the generation of the final set of recommendations and the assignment of a level of agreement to each of them&#46; Systematic reviews of five recommendations in which the agreement was low or was divided were also carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Here we present recommendations for the safe use of NSAIDs in rheumatic diseases&#44; based on the best available evidence&#44; expert opinion&#44; the agreement among rheumatologists&#44; and literature review&#46; The trend is to reduce the frequency&#44; duration and dose of NSAIDs in favour of non-pharmacological measures&#44; analgesic drugs or disease modifying drugs&#46; In addition&#44; the recommendations help to identify profiles for increased toxicity&#44; with an emphasis on gastrointestinal and cardiovascular risks&#46; The recommendations deal with the course of action and monitoring in different risk groups and in patients using antiplatelet or anticoagulant drugs&#46; The overall level of agreement is high&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The NSAIDs are safe and effective drugs for the treatment of rheumatic diseases&#46; However&#44; it is necessary to individualize its use according to their risk profile&#46;</p>"
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Uso apropiado de los antiinflamatorios no esteroideos en reumatología: documento de consenso de la Sociedad Española de Reumatología y el Colegio Mexicano de Reumatología
Appropriate use of non-steroidal anti-inflammatory drugs in rheumatology: guidelines from the Spanish Society of Rheumatology and the Mexican College of Rheumatology
Gerardo Bori Seguraa, Blanca Hernández Cruzb, Milena Gobboc,
Autor para correspondencia
milena.gobbo@ser.es

Autor para correspondencia.
, Ángel Lanas Arbeload, Mario Salazar Páramoe, Leobardo Terán Estradaf, José Federico Díaz Gonzálezg, Rolando Espinosa Moralesh, Federico Galván Villegasi, Luis Alberto García Rodríguezj, José María Álvaro-Gracia Álvarok, Hilario Ávila Armengoll, Loreto Carmonac, Javier Rivera Redondom, Lucio Ventura Ríosn
a Servicio de Reumatología, Hospital General de Zona 32 (Villa Coapa), Instituto Mexicano del Seguro Social, México DF, México
b Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, España
c Unidad de Investigación, Fundación Española de Reumatología, Madrid, España
d Servicio de Digestivo, Hospital Clínico Universitario, Universidad de Zaragoza, IACS, CIBERehd, Zaragoza, España
e División de Investigación, Hospital de Especialidades CMNO, IMSS y CUCS, Universidad de Guadalajara, Guadalajara, México
f Departamento de Medicina Interna, HGR n.o 1. IMSS, Morelia, Michoacán, México
g Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, España
h Servicio de Reumatología, Instituto Nacional de Rehabilitación, México DF, México
i Colegio Mexicano de Reumatología, México DF, México
j Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, España
k Servicio de Reumatología, Hospital de La Princesa, Madrid, España
l Departamento de Medicina Interna, Hospital Civil de Guadalajara, Guadalajara, México
m Servicio de Reumatología, Instituto Provincial de Rehabilitación, Madrid, España
n Servicio de Reumatología, Hospital Central Sur de Alta Especialidad, PEMEX, México DF, México
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Elaborar recomendaciones para el uso apropiado de AINE en reumatolog&#237;a&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se utiliz&#243; una metodolog&#237;a modificada de RAND&#47;UCLA&#46; Se seleccionaron dos grupos de panelistas&#44; uno por el CMR y otro por la SER&#46; A partir de grupos nominales&#44; se obtuvieron propuestas de recomendaciones&#44; que fueron sometidas a la prueba de acuerdo entre los reumat&#243;logos de ambas sociedades mediante encuesta Delphi a dos rondas&#46; Del an&#225;lisis de la segunda ronda Delphi&#44; se extrajeron las recomendaciones finales y posteriormente se revis&#243; el nivel de evidencia y el grado de acuerdo de la recomendaci&#243;n seg&#250;n el Centro de Medicina Basada en la Evidencia de Oxford&#46; Finalmente&#44; se efectu&#243; revisi&#243;n sistem&#225;tica de cinco recomendaciones sin acuerdo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se presentan recomendaciones sobre el uso seguro de los AINE en las enfermedades reum&#225;ticas&#44; con base en la mejor evidencia disponible&#44; la opini&#243;n de expertos&#44; el acuerdo entre reumat&#243;logos y la revisi&#243;n de la literatura&#46; La tendencia es disminuir la frecuencia&#44; la duraci&#243;n y la dosis de AINE en favor de medidas no farmacol&#243;gicas&#44; analg&#233;sicos o f&#225;rmacos modificadores de los s&#237;ntomas o del curso de la enfermedad&#46; Adem&#225;s&#44; es obligado identificar perfiles de mayor riesgo de toxicidad&#44; en especial gastrointestinal y cardiovascular&#46; Se recomiendan pautas de actuaci&#243;n y monitorizaci&#243;n en los diferentes grupos de riesgo y en pacientes con empleo de antiagregantes plaquetarios&#44; anticoagulaci&#243;n o con terapias concomitantes&#46; El porcentaje de acuerdo es elevado en la mayor&#237;a de los casos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los AINE son medicamentos seguros y eficaces en el tratamiento de las afecciones reum&#225;ticas&#46; No obstante&#44; dado su perfil de riesgo&#44; es necesario individualizar su uso&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To develop guidelines for the appropriate use of NSAIDs in rheumatology&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We used a methodology modified from the one developed by RAND&#47;UCLA&#46; Two groups of panellists were selected&#44; one by the CMR and another by the SER&#46; Recommendations were proposed from nominal groups and the agreement to them was tested among rheumatologists from both societies by a tworound Delphi survey&#46; The analysis of the second Delphi round supported the generation of the final set of recommendations and the assignment of a level of agreement to each of them&#46; Systematic reviews of five recommendations in which the agreement was low or was divided were also carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Here we present recommendations for the safe use of NSAIDs in rheumatic diseases&#44; based on the best available evidence&#44; expert opinion&#44; the agreement among rheumatologists&#44; and literature review&#46; The trend is to reduce the frequency&#44; duration and dose of NSAIDs in favour of non-pharmacological measures&#44; analgesic drugs or disease modifying drugs&#46; In addition&#44; the recommendations help to identify profiles for increased toxicity&#44; with an emphasis on gastrointestinal and cardiovascular risks&#46; The recommendations deal with the course of action and monitoring in different risk groups and in patients using antiplatelet or anticoagulant drugs&#46; The overall level of agreement is high&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The NSAIDs are safe and effective drugs for the treatment of rheumatic diseases&#46; However&#44; it is necessary to individualize its use according to their risk profile&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:43 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Fosbol EL&#44; Gislason GH&#44; Jacobsen S&#44; Abildstrom SZ&#44; Hansen ML&#44; Schramm TK&#44; et al&#46; The pattern of use of non-steroidal anti-inflammatory drugs &#40;NSAIDs&#41; from 1997 to 2005&#58; a nationwide study on 4&#46;6 million people&#46; Pharmacoepidemiol Drug Saf&#46; 2008&#46; &#91;revista on-line&#59; citado 1 Jul 2008&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www3.interscience.wiley.com/journal/5669/home">http&#58;&#47;&#47;www3&#46;interscience&#46;wiley&#46;com&#47;journal&#47;5669&#47;home</a>"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impacto del consumo de AINE en la poblaci&#243;n general espa&#241;ola&#58; Resultados del estudio EPISER"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Grupo de Estudio EPISER"
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;J&#46; Ballina"
                            1 => "L&#46; Carmona"
                            2 => "A&#46; Laffon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Reumatol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "337"
                        "paginaFinal" => "342"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Grupos terap&#233;uticos y principios activos de mayor consumo por el Sistema Nacional de Salud durante 2004&#46; Informe Farmacoterap&#233;utico del Sistema Nacional de Salud&#46; 2005&#59;28&#58;121-4&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip&#58; face validity of selfreport questionnaire ratings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Pincus"
                            1 => "X&#46; Wang"
                            2 => "C&#46; Chung"
                            3 => "T&#46; Sokka"
                            4 => "G&#46;G&#46; Koch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2005"
                        "volumen" => "32"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15742449"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-inflammatory drugs in the 21st century"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;D&#46; Rainsford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Subcell Biochem"
                        "fecha" => "2007"
                        "volumen" => "42"
                        "paginaInicial" => "3"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17612044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46; Strand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)61909-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "370"
                        "paginaInicial" => "2138"
                        "paginaFinal" => "2151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18156036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs &#40;etodolac&#44; meloxicam&#44; celecoxib&#44; rofecoxib&#44; etoricoxib&#44; valdecoxib and lumiracoxib&#41; for osteoarthritis and rheumatoid arthritis&#58; a systematic review and economic evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46;F&#46; Chen"
                            1 => "P&#46; Jobanputra"
                            2 => "P&#46; Barton"
                            3 => "S&#46; Bryan"
                            4 => "A&#46; Fry-Smith"
                            5 => "G&#46; Harris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Health Technol Assess"
                        "fecha" => "2008"
                        "volumen" => "12"
                        "paginaInicial" => "1"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18796263"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-steroidal antiinflammatory drugs&#46; A review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Winzeler"
                            1 => "B&#46;D&#46; Rosenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AAOHN J"
                        "fecha" => "1998"
                        "volumen" => "46"
                        "paginaInicial" => "253"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9652239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonsteroidal antiinflammatory drugs&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;L&#46; Curry"
                            1 => "S&#46;M&#46; Cogar"
                            2 => "J&#46;L&#46; Cook"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5326/0410298"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Anim Hosp Assoc"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "298"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16141181"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis&#63; Meta-analysis of randomised trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;M&#46; Kearney"
                            1 => "C&#46; Baigent"
                            2 => "J&#46; Godwin"
                            3 => "H&#46; Halls"
                            4 => "J&#46;R&#46; Emberson"
                            5 => "C&#46; Patrono"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.332.7553.1302"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2006"
                        "volumen" => "332"
                        "paginaInicial" => "1302"
                        "paginaFinal" => "1308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16740558"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of serious NSAID-related gastrointestinal events during long-term exposure&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Schaffer"
                            1 => "T&#46; Florin"
                            2 => "C&#46; Eagle"
                            3 => "I&#46; Marschner"
                            4 => "G&#46; Singh"
                            5 => "M&#46; Grobler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med J Aust"
                        "fecha" => "2006"
                        "volumen" => "185"
                        "paginaInicial" => "501"
                        "paginaFinal" => "506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17137455"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of nonsteroidal antiinflammatory drugs&#58; an update for clinicians&#58; a scientific statement from the American Heart Association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;M&#46; Antman"
                            1 => "J&#46;S&#46; Bennett"
                            2 => "A&#46; Daugherty"
                            3 => "C&#46; Furberg"
                            4 => "H&#46; Roberts"
                            5 => "K&#46;A&#46; Taubert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.106.181424"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2007"
                        "volumen" => "115"
                        "paginaInicial" => "1634"
                        "paginaFinal" => "1642"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17325246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Review&#58; nonselective nonsteroidal antiinflammatory drugs do not increase risk for cardiovascular events"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;E&#46; Szmitko"
                            1 => "D&#46; Juurlink"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "ACP J Club"
                        "fecha" => "2007"
                        "volumen" => "146"
                        "paginaInicial" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17203932"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The RAND&#47;UCLA Appropriateness Method User&#39;s Manual"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Fitch"
                            1 => "S&#46;J&#46; Bernstein"
                            2 => "M&#46;D&#46; Aguilar"
                            3 => "B&#46; Burnand"
                            4 => "J&#46;R&#46; LaCalle"
                            5 => "P&#46; L&#225;zaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2001"
                        "editorial" => "RAND"
                        "editorialLocalizacion" => "Santa Monica"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Center for Evidence Based Medicine&#46; Levels of evidence&#46; 2008 &#91;citado 8 Abr 2008&#93;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.cebm.net/index.aspx%3Fo=1025">http&#58;&#47;&#47;www&#46;cebm&#46;net&#47;index&#46;aspx&#63;o&#61;1025</a>"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analgesic&#44; antipyretic and anti-inflammatory agents and drugs used for the treatment of gout"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Roberts"
                            1 => "J&#46; Monroy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "The pharmacologic basis of diseases"
                        "paginaInicial" => "669"
                        "edicion" => "10&#46;<span class="elsevierStyleSup">a</span> ed&#46;"
                        "serieFecha" => "2001"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Concepto y clasificaci&#243;n de las enfermedades reum&#225;ticas&#46; Manual SER de las enfermedades reum&#225;ticas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "1&#46;<span class="elsevierStyleSup">a</span> ed&#46;"
                        "fecha" => "2001"
                        "editorial" => "M&#233;dica Panamericana"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisi&#243;n sistem&#225;tica&#58; &#191;hay alguna raz&#243;n para contraindicar el uso concomitante de antiinflamatorios no esteroideos y esteroides&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Loza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1699-258X(08)75542-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2008"
                        "volumen" => "4"
                        "paginaInicial" => "220"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794538"
                            "web" => "Medline"
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Información del artículo
ISSN: 1699258X
Idioma original: Español
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