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El bloqueo terapéutico del factor de necrosis tumoral disminuye la concentración sérica de interleucina 15 en pacientes con artritis reumatoide
The therapeutic blockade of TNF reduces serum levels of interleukin 15 in patients with rheumatoid arthritis
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Ortiz, Eva G. Tomero, Alejandro Balsa, Javier Orte, Pedro Sabando Suárez, Rosario García-Vicuña" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Isidoro" "apellidos" => "González-Álvaro" "email" => array:1 [ 0 => "isidoro.ga@ser.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Ana M." "apellidos" => "Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Eva G." "apellidos" => "Tomero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Alejandro" "apellidos" => "Balsa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "Orte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "Pedro" "apellidos" => "Sabando Suárez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "Rosario" "apellidos" => "García-Vicuña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario La Paz, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The therapeutic blockade of TNF reduces serum levels of interleukin 15 in patients with rheumatoid arthritis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-03-12" "fechaAceptado" => "2008-06-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112705" "palabras" => array:4 [ 0 => "Artritis reumatoide" 1 => "Citocinas" 2 => "Antagonistas del TNF" 3 => "Interleucina 15" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112704" "palabras" => array:4 [ 0 => "Rheumatoid Arthritis" 1 => "Cytokines" 2 => "TNF antagonists" 3 => "IL-15" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar el efecto de la terapia con agentes inhibidores del factor de necrosis tumoral (TNF) en la concentración sérica de interleucina 15 (IL-15) y determinar si los valores basales de ésta o su variación con el tratamiento predicen la respuesta clínica a los anti-TNF.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió a 75 pacientes con artritis reumatoide que iban a iniciar tratamiento con anti-TNF. Se recogieron muestras de suero previas y a los 3 meses de tratamiento. La concentración de IL-15 se cuantificó mediante enzimoinmunoanálisis. Tanto en la visita basal como en la final se recogieron parámetros clínicos y analíticos que permitieran calcular el DAS28. También se recogieron variables sociodemográficas y otras relacionadas con la enfermedad, como factor reumatoide, número de fármacos previos, etc. Se definió remisión como un DAS28 < 2,6 y respuesta clínica relevante, como una disminución del DAS28 > 1,2.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La concentración de IL-15 se relacionó de forma significativa con un mayor uso de fármacos modificadores de la enfermedad durante el seguimiento de los pacientes. También se observó una disminución significativa de la IL-15 a los 3 meses de tratamiento con anti-TNF. Sin embargo, los valores basales de IL-15 y su disminución con el tratamiento no se relacionaron con la respuesta a los anti-TNF o la consecución de remisión clínica.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestros datos parecen confirmar los obtenidos in vitro, que indican que el TNF está implicado en la modulación de la expresión de IL-15. No obstante, la medición de la concentración sérica de IL-15 no parece ser de utilidad para seleccionar a los pacientes candidatos a terapia anti-TNF.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze the effect of the TNF blocking agents (aTNF) on the serum levels of interleukin 15 (IL-15). To determine whether baseline IL15 serum levels or their response to aTNF therapy can predict the clinical response to this treatment.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 75 patients suffering from rheumatoid arthritis that were selected to start aTNF therapy. Serum samples were obtained at baseline visit and after three months of aTNF treatment. Measurement of IL-15 serum concentration was performed through immune-enzyme assay. We collected the clinical and analytical parameters needed to calculate DAS28 both at baseline and final visit, as well as sociodemographic variables and other such as rheumatoid factor, previous disease modifying anti-rheumatic drugs (DMARD), etc. We defined remission as a DAS28 < 2.6 and clinical response when the decrease in DAS28 value was higher than 1.2.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There was a significant correlation between IL-15 serum level and the number of previous DMARD. We also detected a significant decrease in the concentration of serum IL-15 after three months of treatment with aTNF. However, neither the baseline IL-15 serum level nor the decrease in the concentration of IL-15 were associated with a specific pattern of response to aTNF.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our data seem to support previous in vitro findings suggesting that TNF is involved in the regulation of IL-15 expression. Nevertheless, the measurement of IL-15 serum levels does not seem to be a useful tool to select those patients that should be treated with aTNF therapy.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 22 | 31 |
| 2024 Octubre | 43 | 34 | 77 |
| 2024 Septiembre | 48 | 26 | 74 |
| 2024 Agosto | 92 | 57 | 149 |
| 2024 Julio | 53 | 43 | 96 |
| 2024 Junio | 57 | 42 | 99 |
| 2024 Mayo | 57 | 41 | 98 |
| 2024 Abril | 51 | 44 | 95 |
| 2024 Marzo | 57 | 45 | 102 |
| 2024 Febrero | 39 | 38 | 77 |
| 2024 Enero | 51 | 22 | 73 |
| 2023 Diciembre | 28 | 23 | 51 |
| 2023 Noviembre | 43 | 25 | 68 |
| 2023 Octubre | 31 | 48 | 79 |
| 2023 Septiembre | 63 | 46 | 109 |
| 2023 Agosto | 34 | 22 | 56 |
| 2023 Julio | 54 | 60 | 114 |
| 2023 Junio | 40 | 41 | 81 |
| 2023 Mayo | 49 | 34 | 83 |
| 2023 Abril | 44 | 18 | 62 |
| 2023 Marzo | 59 | 40 | 99 |
| 2023 Febrero | 39 | 44 | 83 |
| 2023 Enero | 39 | 19 | 58 |
| 2022 Diciembre | 55 | 45 | 100 |
| 2022 Noviembre | 70 | 39 | 109 |
| 2022 Octubre | 63 | 45 | 108 |
| 2022 Septiembre | 61 | 46 | 107 |
| 2022 Agosto | 56 | 55 | 111 |
| 2022 Julio | 55 | 60 | 115 |
| 2022 Junio | 41 | 49 | 90 |
| 2022 Mayo | 68 | 54 | 122 |
| 2022 Abril | 68 | 56 | 124 |
| 2022 Marzo | 69 | 70 | 139 |
| 2022 Febrero | 84 | 42 | 126 |
| 2022 Enero | 68 | 57 | 125 |
| 2021 Diciembre | 51 | 64 | 115 |
| 2021 Noviembre | 52 | 82 | 134 |
| 2021 Octubre | 88 | 65 | 153 |
| 2021 Septiembre | 85 | 68 | 153 |
| 2021 Agosto | 81 | 66 | 147 |
| 2021 Julio | 83 | 53 | 136 |
| 2021 Junio | 92 | 59 | 151 |
| 2021 Mayo | 72 | 48 | 120 |
| 2021 Abril | 106 | 127 | 233 |
| 2021 Marzo | 98 | 49 | 147 |
| 2021 Febrero | 68 | 38 | 106 |
| 2021 Enero | 53 | 35 | 88 |
| 2020 Diciembre | 52 | 15 | 67 |
| 2020 Noviembre | 54 | 24 | 78 |
| 2020 Octubre | 41 | 15 | 56 |
| 2020 Septiembre | 104 | 34 | 138 |
| 2020 Agosto | 105 | 30 | 135 |
| 2020 Julio | 51 | 25 | 76 |
| 2020 Junio | 60 | 28 | 88 |
| 2020 Mayo | 68 | 28 | 96 |
| 2020 Abril | 91 | 18 | 109 |
| 2020 Marzo | 175 | 19 | 194 |
| 2020 Febrero | 150 | 27 | 177 |
| 2020 Enero | 84 | 32 | 116 |
| 2019 Diciembre | 71 | 26 | 97 |
| 2019 Noviembre | 94 | 25 | 119 |
| 2019 Octubre | 119 | 15 | 134 |
| 2019 Septiembre | 105 | 22 | 127 |
| 2019 Agosto | 113 | 24 | 137 |
| 2019 Julio | 101 | 23 | 124 |
| 2019 Junio | 115 | 43 | 158 |
| 2019 Mayo | 121 | 89 | 210 |
| 2019 Abril | 110 | 56 | 166 |
| 2019 Marzo | 59 | 38 | 97 |
| 2019 Febrero | 51 | 35 | 86 |
| 2019 Enero | 60 | 31 | 91 |
| 2018 Diciembre | 72 | 61 | 133 |
| 2018 Noviembre | 73 | 14 | 87 |
| 2018 Octubre | 48 | 14 | 62 |
| 2018 Septiembre | 30 | 11 | 41 |
| 2018 Agosto | 19 | 13 | 32 |
| 2018 Julio | 12 | 6 | 18 |
| 2018 Mayo | 3 | 0 | 3 |
| 2018 Abril | 34 | 11 | 45 |
| 2018 Marzo | 27 | 21 | 48 |
| 2018 Febrero | 23 | 5 | 28 |
| 2018 Enero | 26 | 6 | 32 |
| 2017 Diciembre | 21 | 13 | 34 |
| 2017 Noviembre | 28 | 11 | 39 |
| 2017 Octubre | 29 | 12 | 41 |
| 2017 Septiembre | 24 | 11 | 35 |
| 2017 Agosto | 30 | 4 | 34 |
| 2017 Julio | 20 | 3 | 23 |
| 2017 Junio | 36 | 6 | 42 |
| 2017 Mayo | 38 | 8 | 46 |
| 2017 Abril | 24 | 4 | 28 |
| 2017 Marzo | 30 | 34 | 64 |
| 2017 Febrero | 22 | 4 | 26 |
| 2017 Enero | 39 | 8 | 47 |
| 2016 Diciembre | 38 | 10 | 48 |
| 2016 Noviembre | 50 | 11 | 61 |
| 2016 Octubre | 79 | 15 | 94 |
| 2016 Septiembre | 63 | 4 | 67 |
| 2016 Agosto | 75 | 8 | 83 |
| 2016 Julio | 46 | 5 | 51 |
| 2016 Junio | 2 | 0 | 2 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Septiembre | 2 | 0 | 2 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 31 | 0 | 31 |
| 2015 Junio | 53 | 6 | 59 |
| 2015 Mayo | 69 | 13 | 82 |
| 2015 Abril | 58 | 6 | 64 |
| 2015 Marzo | 31 | 6 | 37 |
| 2015 Febrero | 54 | 4 | 58 |
| 2015 Enero | 37 | 11 | 48 |
| 2014 Diciembre | 53 | 5 | 58 |
| 2014 Noviembre | 40 | 12 | 52 |
| 2014 Octubre | 37 | 7 | 44 |
| 2014 Septiembre | 33 | 5 | 38 |
| 2014 Agosto | 55 | 9 | 64 |
| 2014 Julio | 49 | 13 | 62 |
| 2014 Junio | 56 | 11 | 67 |
| 2014 Mayo | 54 | 15 | 69 |
| 2014 Abril | 59 | 11 | 70 |
| 2014 Marzo | 75 | 15 | 90 |
| 2014 Febrero | 45 | 26 | 71 |
| 2014 Enero | 55 | 17 | 72 |
| 2013 Diciembre | 40 | 9 | 49 |
| 2013 Noviembre | 39 | 9 | 48 |
| 2013 Octubre | 63 | 12 | 75 |
| 2013 Septiembre | 60 | 15 | 75 |
| 2013 Agosto | 44 | 13 | 57 |
| 2013 Julio | 51 | 9 | 60 |
| 2013 Junio | 30 | 11 | 41 |
| 2013 Mayo | 47 | 5 | 52 |
| 2013 Abril | 29 | 11 | 40 |
| 2013 Marzo | 36 | 14 | 50 |
| 2013 Febrero | 24 | 11 | 35 |
| 2013 Enero | 27 | 9 | 36 |
| 2012 Diciembre | 24 | 5 | 29 |
| 2012 Noviembre | 14 | 9 | 23 |
| 2012 Octubre | 13 | 7 | 20 |
| 2012 Septiembre | 15 | 6 | 21 |
| 2011 Mayo | 1 | 0 | 1 |
| 2011 Abril | 5 | 0 | 5 |
| 2011 Marzo | 6 | 0 | 6 |
| 2011 Febrero | 7 | 0 | 7 |
| 2011 Enero | 30 | 0 | 30 |
| 2010 Diciembre | 1 | 0 | 1 |
| 2010 Noviembre | 1 | 0 | 1 |
| 2010 Octubre | 1 | 0 | 1 |
| 2010 Agosto | 3 | 0 | 3 |
| 2010 Julio | 8 | 0 | 8 |
| 2010 Junio | 6 | 0 | 6 |
| 2010 Mayo | 3 | 0 | 3 |
| 2010 Abril | 1 | 0 | 1 |
| 2010 Marzo | 3 | 0 | 3 |
| 2010 Febrero | 7 | 0 | 7 |
| 2010 Enero | 2 | 0 | 2 |
| 2009 Diciembre | 1 | 0 | 1 |
| 2009 Noviembre | 2 | 0 | 2 |
| 2009 Octubre | 1 | 0 | 1 |
| 2009 Septiembre | 1 | 0 | 1 |
| 2009 Agosto | 4 | 0 | 4 |
| 2009 Julio | 11 | 0 | 11 |
| 2009 Junio | 9 | 0 | 9 |
| 2009 Mayo | 12 | 0 | 12 |
| 2009 Abril | 30 | 0 | 30 |
| 2009 Marzo | 12 | 0 | 12 |
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