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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">To be able to decide what is relevant in science was never as difficult as today&#46; The proliferation of journals and the Internet are a source of all kinds of new descriptions and interpretations&#44; many of them right&#44; but many others wrong or misleading&#46; Such is the case for rheumatoid arthritis &#40;RA&#41; that&#44; despite all the knowledge and new therapies&#44; still remains an enormous challenge for its understanding&#46; Although RA therapy has reached high levels of reasonability and many new drugs&#44; especially biologicals&#44; are now directed at mediators of inflammation and tissue damage known to participate in RA&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> most of its pathogenesis remains poorly understood&#46; The recent finding that a high percentage of RA patients and mice with inflammatory RA-like arthritis are carriers of particular strains of bacteria in their microbiota<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> could be a major advance in our understanding of the disease&#46; But&#44; without a critical approach&#44; it might lead to additional confusion instead of the much needed clarification&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Historical perspective</span><p id="par0010" class="elsevierStylePara elsevierViewall">Although several hints of familial occurrence of RA had long indicated that the disease affected only genetically susceptible individuals&#44; the major steps in our understanding of RA started with the discovery of rheumatoid factor in 1948&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> This was the first indicator of the autoimmune origin of RA that led to a great deal of research&#44; but did little to our understanding of the pathogenesis of RA&#46; The next major step was the finding of the predominance of T lymphocytes in the rheumatoid synovial membrane&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> later shown to be predominantly CD4&#43;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> leading to the hypothesis that RA was mediated by T cells&#46; This was reinforced with the discovery of the association of the major histocompatibility complex &#40;MHC&#41; class II &#40;MHCII&#41; allele HLA-DR4<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> that led to the definition of the MHCII shared epitope &#40;SE&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> More recently&#44; the advent of systems biology has led to the identification of many &#40;&#62;100&#41; genetic susceptibility loci for RA&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Nevertheless&#44; the single most important one still lies in the MHCII gene HLA-DRB1&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> where DRB1 alleles encoding the shared epitope with the amino acid sequence QKRAA in residues 70&#8211;74 of the HLA-DR&#946; chain&#44; or related sequences are highly susceptible to developing RA with a particular pattern of autoantibodies&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Finally&#44; toward the end of the 20th century&#44; the discovery of antibodies directed at citrullinated proteins<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> reinstated B cells and humoral immunity as part of the RA pathogenesis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With regard to the microbial pathogenesis of RA&#44; early in the 20th century&#44; considering that RA was a form of tuberculosis &#40;the major view at the time in France&#41;&#44; Forestier introduced gold therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Subsequent studies focused in the search of a specific etiologic agent for RA&#44; including Mycoplasma<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and several viruses&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> By the beginning of the 1980s&#44; the hypothesis of a single infectious agent in the etiology of RA was essentially abandoned&#46; However&#44; there is an increased rate of clinical infections in patients with early but not with established RA&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> This is not new&#44; however&#44; as in 1924 Billington and Crabbe already had considered that RA was triggered by hidden infections and the therapeutic approach proposed by them included removal of the infective focus&#44; which in their view was&#44; in decreasing order&#58; dental &#40;periodontal&#41;&#44; throat&#47;nose&#44; gallbladder&#44; and genitourinary&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> It is amazing to see how&#44; nine decades later&#44; our view has not changed much&#33;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Thus&#44; RA can be non-specifically triggered or exacerbated by a number of infections<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> or by external chemical or physical agents&#44; including tobacco smoking and silica&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> Although the mechanism of association is not entirely clear&#44; one possible explanation is activation of the innate immune system leading to costimulation&#44; followed by activation of autoreactive T cells&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">The microbiome</span><p id="par0025" class="elsevierStylePara elsevierViewall">More recently&#44; as in other pathologic states&#44; the role of normal or abnormal microbiome &#40;but not specific pathogens&#41; has attracted a great deal of &#40;probably too much&#41; attention&#46; Undoubtedly&#44; the great loads of bacteria in our bodies&#44; mainly the gut&#44; are of major importance in shaping our physiology&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> but we are still far from understanding many aspects of host&#8211;commensal interactions in normal and pathological states&#46; For instance&#44; males and females have qualitative and quantitative differences in immune competence and susceptibility to autoimmune disease&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> In mice&#44; these appear to be explained by the effects of male androgens on the gut microbiota&#44; which leads to a lower immunoreactivity and decreased susceptibility to autoimmune diabetes&#46; RA is more frequent in females&#44; which could be related to the microbiota&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Recent studies yielded evidence of two possible links between particular Gram-negative anaerobic bacilli and RA development in humans&#46; The first one is periodontal disease caused by <span class="elsevierStyleItalic">Porphyromonas gingivalis</span><a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a> and the second is the prevalence&#44; in the gut microbiota&#44; of <span class="elsevierStyleItalic">Prevotella copri</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">But wait&#33; As interesting and potentially relevant as these findings appear&#44; one must be careful&#46; Let us not forget that through the years&#44; the etiology of RA has been attributed to conditions ranging from infections such as tuberculosis&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> amebiasis&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Epstein Barr virus&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Proteus<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#59; endocrine imbalance&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> to surgical procedures&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> to mention just a few&#46; In some cases it led&#44; mostly by serendipity&#44; to useful therapies &#40;i&#46;e&#46; gold&#41;&#44; but in others to harmful failures &#40;insulin causing hypoglycemia&#41;&#46; Although some of these considerations have been completely wrong&#44; others are of importance because they are clues to identifying some of the predisposing and triggering factors for RA&#46; Indeed it was the notion that RA was caused by hypoadrenalism and not its inflammatory nature that led Hench to the use of cortisone for RA&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015"><span class="elsevierStyleItalic">Porphyromonas gingivalis</span> and periodontal disease</span><p id="par0040" class="elsevierStylePara elsevierViewall">The possible link of particular periodontal pathogens to connective tissue damage&#44; including RA&#44; in the modern era was first proposed by Engel et al&#46; &#40;1978&#41; in studies of human fibroblasts exposed to <span class="elsevierStyleItalic">Actinomyces viscous</span> extracts&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> whereas the relation of rapidly progressing periodontitis to HLA-DR4 was described by Katz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> Over the following years&#44; studies from different groups established a link between <span class="elsevierStyleItalic">Porphyromonas gingivalis</span> and RA&#44; leading some to believe that this bacterium was critical for the development of RA&#44; or even the etiological agent&#44; based on&#58; &#40;1&#41; the high prevalence of <span class="elsevierStyleItalic">P&#46; gingivalis</span> positive periodontal disease &#40;PD&#41; among RA patients and viceversa<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;35</span></a>&#59; &#40;2&#41; the presence of high titers of anti-<span class="elsevierStyleItalic">P&#46; gingivalis</span> antibodies in RA<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#59; &#40;3&#41; <span class="elsevierStyleItalic">P&#46; gingivalis</span> expresses an endogenous peptidyl-arginyl deiminase &#40;PAD&#41; capable of citrullinating human protein substrates<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#59; &#40;4&#41; periodontal treatment leads to amelioration of RA activity&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> However&#44; not all RA patients have PD and&#47;or <span class="elsevierStyleItalic">P&#46; gingivallis</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;35</span></a> Moreover&#44; anti-<span class="elsevierStyleItalic">P&#46; gingivalis</span> antibodies do not predict rheumatoid arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> Finally&#44; native bacterial PAD&#44; which is truncated&#44; lacks enzymatic activity&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> as opposed to previous studies that used recombinant &#40;non truncated&#41; bacterial PAD&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Does it mean that <span class="elsevierStyleItalic">P&#46; gingivalis</span> has no role in the pathogenesis of RA&#63; Probably not&#44; but it is not a specific pathogen&#44; but an incidental infectious agent non-specifically triggering autoimmunity&#46; Thus&#44; <span class="elsevierStyleItalic">P&#46; gingivalis</span> is not the etiologic agent of RA&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">The gut microbiota</span><p id="par0045" class="elsevierStylePara elsevierViewall">Recent studies have brought a new partner that might help the understanding of the relationship between microbes&#44; RA and other autoimmune diseases&#46; Dan Littman and coworkers studied the gut microbiota in patients with new onset RA &#40;NORA&#41;&#44; compared to established &#40;chronic&#41; RA&#44; psoriatic arthritis &#40;PsA&#41; and healthy individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A high proportion of NORA patients had significantly increased ratio of Prevotella over Bacteroides organisms&#46; The Prevotella species in NORA patients was <span class="elsevierStyleItalic">Prevotella copri</span> with statistical significances of <span class="elsevierStyleItalic">P&#46; copri</span> prevalence in NORA vs&#46; healthy individuals&#44; chronic RA or PsA <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;00002612&#44; 0&#46;000001031 and 0&#46;01698&#44; respectively&#44; very significant indeed&#46; However&#44; not all NORA patients had increased <span class="elsevierStyleItalic">P&#46; copri</span>&#44; indicating that it is a very important&#44; but not unique&#44; contributing factor for the development of RA&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Studies in mice have shown that the presence of segmented filamentous bacteria &#40;SFB&#41; in the microbiota contributes significantly to the development of autoimmune disease in genetically susceptible hosts&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It has been shown that the composition of the gut microbiota contributes to shape the immune system into a proinflammatory state through differentiation of CD4&#43; T lymphocytes to the Th17 subset&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> Gut SFB&#44; but not Bacteroides drive Th17 development and enhance arthritis in mice&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Littman and coworkers colonized mice intestines with <span class="elsevierStyleItalic">P&#46; copri</span> to find that it favors Th17 development and experimental dextran sulfate sodium-induced colitis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This suggests that the role of <span class="elsevierStyleItalic">P&#46; copri</span> in human RA could be similar&#44; as Th17 lymphocytes are the major inducers of tissue damage in RA&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> On the other hand&#44; <span class="elsevierStyleItalic">Porphyromonas gingivalis</span> also drives Th17 cell differentiation&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;44</span></a> Thus&#44; Th17 induction represents an important link among at least two of the bacteria associated to RA and suggests that additional microbes will be identified in the future as associated to RA&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">One final observation of potential importance was that the increased prevalence of <span class="elsevierStyleItalic">P&#46; copri</span> in NORA patients was inversely related to positivity for the shared epitope&#46; The authors interpret this finding as an indication that the role of <span class="elsevierStyleItalic">P&#46; copri</span> in RA could be more important in patients with a lower load of genetic susceptibility loci&#44; where exogenous triggers of the disease are critical&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Whatever the mechanism&#44; it deserves further investigation as it is relevant for the understanding of RA and could have therapeutic implications&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; RA is a complex genetically determined inflammatory condition of autoimmune origin&#44; where external agents&#44; mainly microbes&#44; contribute in a variable manner to its onset and to its flares&#46; Analysis of the available information must always be careful and one must not create artificial links to explain apparent contradictions&#46; It usually leads to confusion&#44; and waste of time and money that could be used for rational research&#46; As Casaubon points in Umberto Eco&#39;s novel Focault&#39;s Pendulum &#8220;I believe that you can reach the point where there is no longer any difference between developing the habit of pretending to believe and developing the habit of believing&#46;&#8221; Let us keep science free of this&#46;</p></span></span>"
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Editorial
Prevotella copri and the microbial pathogenesis of rheumatoid arthritis
Prevotella copri y la patogenia microbiana de la artritis reumatoide
José Moreno
Hospital Juárez de México, Dirección de Investigación, Av. Instituto Politécnico Naciona No. 5160, Col. Magdalena de las Salinas, Del. Gustavo A. Madero, C.P. 07760 México, D.F., Mexico
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But&#44; without a critical approach&#44; it might lead to additional confusion instead of the much needed clarification&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Historical perspective</span><p id="par0010" class="elsevierStylePara elsevierViewall">Although several hints of familial occurrence of RA had long indicated that the disease affected only genetically susceptible individuals&#44; the major steps in our understanding of RA started with the discovery of rheumatoid factor in 1948&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> This was the first indicator of the autoimmune origin of RA that led to a great deal of research&#44; but did little to our understanding of the pathogenesis of RA&#46; The next major step was the finding of the predominance of T lymphocytes in the rheumatoid synovial membrane&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> later shown to be predominantly CD4&#43;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> leading to the hypothesis that RA was mediated by T cells&#46; This was reinforced with the discovery of the association of the major histocompatibility complex &#40;MHC&#41; class II &#40;MHCII&#41; allele HLA-DR4<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> that led to the definition of the MHCII shared epitope &#40;SE&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> More recently&#44; the advent of systems biology has led to the identification of many &#40;&#62;100&#41; genetic susceptibility loci for RA&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Nevertheless&#44; the single most important one still lies in the MHCII gene HLA-DRB1&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> where DRB1 alleles encoding the shared epitope with the amino acid sequence QKRAA in residues 70&#8211;74 of the HLA-DR&#946; chain&#44; or related sequences are highly susceptible to developing RA with a particular pattern of autoantibodies&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Finally&#44; toward the end of the 20th century&#44; the discovery of antibodies directed at citrullinated proteins<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> reinstated B cells and humoral immunity as part of the RA pathogenesis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">With regard to the microbial pathogenesis of RA&#44; early in the 20th century&#44; considering that RA was a form of tuberculosis &#40;the major view at the time in France&#41;&#44; Forestier introduced gold therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Subsequent studies focused in the search of a specific etiologic agent for RA&#44; including Mycoplasma<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and several viruses&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> By the beginning of the 1980s&#44; the hypothesis of a single infectious agent in the etiology of RA was essentially abandoned&#46; However&#44; there is an increased rate of clinical infections in patients with early but not with established RA&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> This is not new&#44; however&#44; as in 1924 Billington and Crabbe already had considered that RA was triggered by hidden infections and the therapeutic approach proposed by them included removal of the infective focus&#44; which in their view was&#44; in decreasing order&#58; dental &#40;periodontal&#41;&#44; throat&#47;nose&#44; gallbladder&#44; and genitourinary&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> It is amazing to see how&#44; nine decades later&#44; our view has not changed much&#33;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Thus&#44; RA can be non-specifically triggered or exacerbated by a number of infections<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> or by external chemical or physical agents&#44; including tobacco smoking and silica&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> Although the mechanism of association is not entirely clear&#44; one possible explanation is activation of the innate immune system leading to costimulation&#44; followed by activation of autoreactive T cells&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">The microbiome</span><p id="par0025" class="elsevierStylePara elsevierViewall">More recently&#44; as in other pathologic states&#44; the role of normal or abnormal microbiome &#40;but not specific pathogens&#41; has attracted a great deal of &#40;probably too much&#41; attention&#46; Undoubtedly&#44; the great loads of bacteria in our bodies&#44; mainly the gut&#44; are of major importance in shaping our physiology&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> but we are still far from understanding many aspects of host&#8211;commensal interactions in normal and pathological states&#46; For instance&#44; males and females have qualitative and quantitative differences in immune competence and susceptibility to autoimmune disease&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> In mice&#44; these appear to be explained by the effects of male androgens on the gut microbiota&#44; which leads to a lower immunoreactivity and decreased susceptibility to autoimmune diabetes&#46; RA is more frequent in females&#44; which could be related to the microbiota&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Recent studies yielded evidence of two possible links between particular Gram-negative anaerobic bacilli and RA development in humans&#46; The first one is periodontal disease caused by <span class="elsevierStyleItalic">Porphyromonas gingivalis</span><a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#44;28</span></a> and the second is the prevalence&#44; in the gut microbiota&#44; of <span class="elsevierStyleItalic">Prevotella copri</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">But wait&#33; As interesting and potentially relevant as these findings appear&#44; one must be careful&#46; Let us not forget that through the years&#44; the etiology of RA has been attributed to conditions ranging from infections such as tuberculosis&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> amebiasis&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Epstein Barr virus&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Proteus<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#59; endocrine imbalance&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> to surgical procedures&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> to mention just a few&#46; In some cases it led&#44; mostly by serendipity&#44; to useful therapies &#40;i&#46;e&#46; gold&#41;&#44; but in others to harmful failures &#40;insulin causing hypoglycemia&#41;&#46; Although some of these considerations have been completely wrong&#44; others are of importance because they are clues to identifying some of the predisposing and triggering factors for RA&#46; Indeed it was the notion that RA was caused by hypoadrenalism and not its inflammatory nature that led Hench to the use of cortisone for RA&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015"><span class="elsevierStyleItalic">Porphyromonas gingivalis</span> and periodontal disease</span><p id="par0040" class="elsevierStylePara elsevierViewall">The possible link of particular periodontal pathogens to connective tissue damage&#44; including RA&#44; in the modern era was first proposed by Engel et al&#46; &#40;1978&#41; in studies of human fibroblasts exposed to <span class="elsevierStyleItalic">Actinomyces viscous</span> extracts&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> whereas the relation of rapidly progressing periodontitis to HLA-DR4 was described by Katz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> Over the following years&#44; studies from different groups established a link between <span class="elsevierStyleItalic">Porphyromonas gingivalis</span> and RA&#44; leading some to believe that this bacterium was critical for the development of RA&#44; or even the etiological agent&#44; based on&#58; &#40;1&#41; the high prevalence of <span class="elsevierStyleItalic">P&#46; gingivalis</span> positive periodontal disease &#40;PD&#41; among RA patients and viceversa<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;35</span></a>&#59; &#40;2&#41; the presence of high titers of anti-<span class="elsevierStyleItalic">P&#46; gingivalis</span> antibodies in RA<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#59; &#40;3&#41; <span class="elsevierStyleItalic">P&#46; gingivalis</span> expresses an endogenous peptidyl-arginyl deiminase &#40;PAD&#41; capable of citrullinating human protein substrates<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#59; &#40;4&#41; periodontal treatment leads to amelioration of RA activity&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> However&#44; not all RA patients have PD and&#47;or <span class="elsevierStyleItalic">P&#46; gingivallis</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;35</span></a> Moreover&#44; anti-<span class="elsevierStyleItalic">P&#46; gingivalis</span> antibodies do not predict rheumatoid arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> Finally&#44; native bacterial PAD&#44; which is truncated&#44; lacks enzymatic activity&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> as opposed to previous studies that used recombinant &#40;non truncated&#41; bacterial PAD&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Does it mean that <span class="elsevierStyleItalic">P&#46; gingivalis</span> has no role in the pathogenesis of RA&#63; Probably not&#44; but it is not a specific pathogen&#44; but an incidental infectious agent non-specifically triggering autoimmunity&#46; Thus&#44; <span class="elsevierStyleItalic">P&#46; gingivalis</span> is not the etiologic agent of RA&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">The gut microbiota</span><p id="par0045" class="elsevierStylePara elsevierViewall">Recent studies have brought a new partner that might help the understanding of the relationship between microbes&#44; RA and other autoimmune diseases&#46; Dan Littman and coworkers studied the gut microbiota in patients with new onset RA &#40;NORA&#41;&#44; compared to established &#40;chronic&#41; RA&#44; psoriatic arthritis &#40;PsA&#41; and healthy individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A high proportion of NORA patients had significantly increased ratio of Prevotella over Bacteroides organisms&#46; The Prevotella species in NORA patients was <span class="elsevierStyleItalic">Prevotella copri</span> with statistical significances of <span class="elsevierStyleItalic">P&#46; copri</span> prevalence in NORA vs&#46; healthy individuals&#44; chronic RA or PsA <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;00002612&#44; 0&#46;000001031 and 0&#46;01698&#44; respectively&#44; very significant indeed&#46; However&#44; not all NORA patients had increased <span class="elsevierStyleItalic">P&#46; copri</span>&#44; indicating that it is a very important&#44; but not unique&#44; contributing factor for the development of RA&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Studies in mice have shown that the presence of segmented filamentous bacteria &#40;SFB&#41; in the microbiota contributes significantly to the development of autoimmune disease in genetically susceptible hosts&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It has been shown that the composition of the gut microbiota contributes to shape the immune system into a proinflammatory state through differentiation of CD4&#43; T lymphocytes to the Th17 subset&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> Gut SFB&#44; but not Bacteroides drive Th17 development and enhance arthritis in mice&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Littman and coworkers colonized mice intestines with <span class="elsevierStyleItalic">P&#46; copri</span> to find that it favors Th17 development and experimental dextran sulfate sodium-induced colitis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This suggests that the role of <span class="elsevierStyleItalic">P&#46; copri</span> in human RA could be similar&#44; as Th17 lymphocytes are the major inducers of tissue damage in RA&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> On the other hand&#44; <span class="elsevierStyleItalic">Porphyromonas gingivalis</span> also drives Th17 cell differentiation&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;44</span></a> Thus&#44; Th17 induction represents an important link among at least two of the bacteria associated to RA and suggests that additional microbes will be identified in the future as associated to RA&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">One final observation of potential importance was that the increased prevalence of <span class="elsevierStyleItalic">P&#46; copri</span> in NORA patients was inversely related to positivity for the shared epitope&#46; The authors interpret this finding as an indication that the role of <span class="elsevierStyleItalic">P&#46; copri</span> in RA could be more important in patients with a lower load of genetic susceptibility loci&#44; where exogenous triggers of the disease are critical&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Whatever the mechanism&#44; it deserves further investigation as it is relevant for the understanding of RA and could have therapeutic implications&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; RA is a complex genetically determined inflammatory condition of autoimmune origin&#44; where external agents&#44; mainly microbes&#44; contribute in a variable manner to its onset and to its flares&#46; Analysis of the available information must always be careful and one must not create artificial links to explain apparent contradictions&#46; It usually leads to confusion&#44; and waste of time and money that could be used for rational research&#46; As Casaubon points in Umberto Eco&#39;s novel Focault&#39;s Pendulum &#8220;I believe that you can reach the point where there is no longer any difference between developing the habit of pretending to believe and developing the habit of believing&#46;&#8221; Let us keep science free of this&#46;</p></span></span>"
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Información del artículo
ISSN: 1699258X
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 9 4 13
2024 Octubre 108 57 165
2024 Septiembre 131 24 155
2024 Agosto 129 40 169
2024 Julio 172 40 212
2024 Junio 198 30 228
2024 Mayo 302 53 355
2024 Abril 304 44 348
2024 Marzo 109 32 141
2024 Febrero 78 39 117
2024 Enero 96 40 136
2023 Diciembre 57 35 92
2023 Noviembre 76 44 120
2023 Octubre 105 43 148
2023 Septiembre 157 34 191
2023 Agosto 78 18 96
2023 Julio 102 27 129
2023 Junio 119 28 147
2023 Mayo 142 31 173
2023 Abril 84 24 108
2023 Marzo 195 37 232
2023 Febrero 124 34 158
2023 Enero 104 28 132
2022 Diciembre 187 43 230
2022 Noviembre 183 38 221
2022 Octubre 189 40 229
2022 Septiembre 165 47 212
2022 Agosto 127 73 200
2022 Julio 127 45 172
2022 Junio 100 52 152
2022 Mayo 106 48 154
2022 Abril 102 55 157
2022 Marzo 102 53 155
2022 Febrero 160 47 207
2022 Enero 165 61 226
2021 Diciembre 149 53 202
2021 Noviembre 159 50 209
2021 Octubre 188 61 249
2021 Septiembre 156 56 212
2021 Agosto 150 75 225
2021 Julio 163 48 211
2021 Junio 170 63 233
2021 Mayo 302 67 369
2021 Abril 452 137 589
2021 Marzo 238 52 290
2021 Febrero 194 33 227
2021 Enero 221 55 276
2020 Diciembre 218 51 269
2020 Noviembre 175 55 230
2020 Octubre 166 43 209
2020 Septiembre 208 68 276
2020 Agosto 158 25 183
2020 Julio 123 31 154
2020 Junio 130 39 169
2020 Mayo 218 46 264
2020 Abril 397 40 437
2020 Marzo 165 48 213
2020 Febrero 188 31 219
2020 Enero 175 42 217
2019 Diciembre 164 36 200
2019 Noviembre 184 31 215
2019 Octubre 194 48 242
2019 Septiembre 205 64 269
2019 Agosto 206 62 268
2019 Julio 187 41 228
2019 Junio 238 98 336
2019 Mayo 226 145 371
2019 Abril 204 75 279
2019 Marzo 219 35 254
2019 Febrero 302 41 343
2019 Enero 156 31 187
2018 Diciembre 204 67 271
2018 Noviembre 270 16 286
2018 Octubre 92 13 105
2018 Septiembre 71 8 79
2018 Agosto 57 18 75
2018 Julio 25 11 36
2018 Mayo 6 2 8
2018 Abril 63 17 80
2018 Marzo 72 9 81
2018 Febrero 48 7 55
2018 Enero 38 7 45
2017 Diciembre 54 14 68
2017 Noviembre 48 16 64
2017 Octubre 58 9 67
2017 Septiembre 38 29 67
2017 Agosto 47 16 63
2017 Julio 50 26 76
2017 Junio 71 30 101
2017 Mayo 74 28 102
2017 Abril 118 33 151
2017 Marzo 79 58 137
2017 Febrero 46 15 61
2017 Enero 83 14 97
2016 Diciembre 101 25 126
2016 Noviembre 86 23 109
2016 Octubre 132 30 162
2016 Septiembre 121 39 160
2016 Agosto 53 30 83
2016 Julio 19 21 40
2016 Mayo 1 0 1
2016 Abril 1 0 1
2015 Diciembre 2 0 2
2015 Noviembre 1 41 42
2015 Octubre 2 48 50
2015 Septiembre 2 0 2
2015 Julio 36 7 43
2015 Junio 77 27 104
2015 Mayo 108 55 163
2015 Abril 188 132 320
2015 Marzo 247 166 413
2015 Febrero 129 17 146
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