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anterior uveitis&#44; enthesitis&#44; bilateral sacroiliitis and positive HLA-B27&#46; He was first treated with infliximab &#40;2004&#8211;2009&#41; and was after changed to adalimumab because of recurrent uveitis&#46; Before infliximab&#44; he had been treated with isoniazid for latent tuberculosis&#44; following a positive tuberculin skin test&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On December 2013&#44; he referred asthenia and new onset of left axillar nodules lasting for two weeks without fever or other complaints&#46; He had nodules around 30<span class="elsevierStyleHsp" style=""></span>mm limited to left axillar region&#44; without skin lesions&#46; The cardiopulmonary&#44; abdominal and neurological examinations were unremarkable&#46; He denied known contacts with tuberculosis patients&#46; He was owner of a cat which frequently scratched him but he did not recall any special lesion&#46; Adalimumab treatment was stopped and diagnostic workup was performed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Except for Erythrocyte sedimentation rate &#40;38<span class="elsevierStyleHsp" style=""></span>mm&#47;1st hour&#41; and C Reactive Protein &#40;9&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; no others relevant analytical findings were found&#46; Quantiferon&#8211;Gold in Tube was negative and thoracic X-ray was normal&#46; Axillar ultrasound examination revealed multiple hypoechoic nodules sized between 20&#8211;30<span class="elsevierStyleHsp" style=""></span>mm&#46; After fine needle aspiration procedure&#44; the cytology revealed granulomatous inflammation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; being Ziehl Neelsen stain&#44; culture for mycobacteria and PCR for&#58; <span class="elsevierStyleItalic">Mycobacterium &#40;tuberculosis&#44; avium and intracellulare</span>&#41;&#44; <span class="elsevierStyleItalic">Borrelia Burgdorferi</span> and <span class="elsevierStyleItalic">Nocardia</span> all negative&#46; The PCR for <span class="elsevierStyleItalic">Bartonella</span> spp&#46; was positive as were blood antibodies for <span class="elsevierStyleItalic">Bartonella henselae</span> &#40;IgG titer 1&#58;256&#59; 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to our knowledge&#44; the second case of CSD on adalimumab treatment&#46; Splenic nodules raised the concern of splenic dissemination of the disease that we cannot certainly attribute to <span class="elsevierStyleItalic">Bartonella</span> infection since biopsy was not undertaken&#46; Tuberculosis&#44; being our first concern&#44; was completely excluded&#46; In a retrospective study of adverse event reports on TNF&#945; blockers users&#44; an increased risk of granulomatous infections&#44; particularly tuberculosis&#44; was documented&#44; but only one case was caused by <span class="elsevierStyleItalic">Bartonella</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Later on&#44; 10 CSD reports were described&#58; seven patients were under TNF&#945; blockers &#40;one case on adalimumab&#41;&#44; one case on abatacept and two on tocilizumab&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#8211;11</span></a> The majority presented regional lymphadenopathy and had good therapeutic response&#44; restarting biologics 2&#8211;3 months after&#46; However&#44; in three published cases&#44; visceral infection presenting with mesenteric panniculitis&#44; splenic nodules and&#44; one of those&#44; with liver granulomatosis&#44; were documented&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;8&#44;11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">It should be stressed that new onset lymphadenopathy and granulomatosis in patients under biological therapies should raise the suspicion of CSD&#44; particularly in the field of epidemiologic risk&#46; The possibility of systemic dissemination should be kept in mind due to underlying immunosuppression&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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Letter to the Editor
Cat Scratch Disease During Adalimumab Therapy: A Case Report
Enfermedad por arañazo de gato durante el tratamiento con adalimumab: a propósito de un caso
Teresa Martins-Rochaa,
Autor para correspondencia
teresa.asmr@gmail.com

Corresponding author.
, Cândida Abreub, Alexandra Bernardoa, Miguel Bernardesa,c, Joanne Lopesd
a Rheumatology Department, Centro Hospitalar de São João, Porto, Portugal
b Infectious Diseases Department, Centro Hospitalar de São João, Porto, Portugal
c Rheumatology Department, Faculty of Medicine of the University of Porto, Portugal
d Department of Anatomic Pathology, Centro Hospitalar de São João, Porto, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cat scratch disease &#40;CSD&#41; is an infection caused by <span class="elsevierStyleItalic">Bartonella henselae</span> after exposure to infected fleas from cats&#46; Commonly occurs in children and young adults with regional lymphadenopathy and presents a self-limited course&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> In patients under biological drugs the disease may be severe and disseminated&#46; A differential diagnosis with more common granulomatous infections&#44; like tuberculosis&#44; should be considered in the field of immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors report the case of a 38 year-old man diagnosed with Ankylosing Spondylitis &#40;AS&#41; in 2000&#46; He presented inflammatory back pain&#44; anterior uveitis&#44; enthesitis&#44; bilateral sacroiliitis and positive HLA-B27&#46; He was first treated with infliximab &#40;2004&#8211;2009&#41; and was after changed to adalimumab because of recurrent uveitis&#46; Before infliximab&#44; he had been treated with isoniazid for latent tuberculosis&#44; following a positive tuberculin skin test&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On December 2013&#44; he referred asthenia and new onset of left axillar nodules lasting for two weeks without fever or other complaints&#46; He had nodules around 30<span class="elsevierStyleHsp" style=""></span>mm limited to left axillar region&#44; without skin lesions&#46; The cardiopulmonary&#44; abdominal and neurological examinations were unremarkable&#46; He denied known contacts with tuberculosis patients&#46; He was owner of a cat which frequently scratched him but he did not recall any special lesion&#46; Adalimumab treatment was stopped and diagnostic workup was performed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Except for Erythrocyte sedimentation rate &#40;38<span class="elsevierStyleHsp" style=""></span>mm&#47;1st hour&#41; and C Reactive Protein &#40;9&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#44; no others relevant analytical findings were found&#46; Quantiferon&#8211;Gold in Tube was negative and thoracic X-ray was normal&#46; Axillar ultrasound examination revealed multiple hypoechoic nodules sized between 20&#8211;30<span class="elsevierStyleHsp" style=""></span>mm&#46; After fine needle aspiration procedure&#44; the cytology revealed granulomatous inflammation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; being Ziehl Neelsen stain&#44; culture for mycobacteria and PCR for&#58; <span class="elsevierStyleItalic">Mycobacterium &#40;tuberculosis&#44; avium and intracellulare</span>&#41;&#44; <span class="elsevierStyleItalic">Borrelia Burgdorferi</span> and <span class="elsevierStyleItalic">Nocardia</span> all negative&#46; The PCR for <span class="elsevierStyleItalic">Bartonella</span> spp&#46; was positive as were blood antibodies for <span class="elsevierStyleItalic">Bartonella henselae</span> &#40;IgG titer 1&#58;256&#59; IgM &#60;1&#58;32&#41;&#46; Due to CSD diagnosis&#44; azithromycin was prescribed for 5 days&#46; After one month&#44; he presented complete regression of lymphadenopathies&#46; Abdominal CT revealed splenic hypodense millimetric nodules and abdominal ultrasound showed two splenic nodules &#40;11 and 8<span class="elsevierStyleHsp" style=""></span>mm&#41;&#59; there was no previous exam to compare &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Regarding procedure risks&#44; it was decided by a multidisciplinary team to avoid splenic biopsy and ciprofloxacin during 3 weeks was prescribed&#46; Regular ultrasound examinations revealed stability of the splenic lesions&#46; Adalimumab was re-started on September 2014 because of exacerbation of AS activity&#46; After more than three years&#44; he remains asymptomatic and abdominal ultrasound revealed slight reduction of splenic nodules &#40;8 and 5<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">We herein report&#44; to our knowledge&#44; the second case of CSD on adalimumab treatment&#46; Splenic nodules raised the concern of splenic dissemination of the disease that we cannot certainly attribute to <span class="elsevierStyleItalic">Bartonella</span> infection since biopsy was not undertaken&#46; Tuberculosis&#44; being our first concern&#44; was completely excluded&#46; In a retrospective study of adverse event reports on TNF&#945; blockers users&#44; an increased risk of granulomatous infections&#44; particularly tuberculosis&#44; was documented&#44; but only one case was caused by <span class="elsevierStyleItalic">Bartonella</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> Later on&#44; 10 CSD reports were described&#58; seven patients were under TNF&#945; blockers &#40;one case on adalimumab&#41;&#44; one case on abatacept and two on tocilizumab&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#8211;11</span></a> The majority presented regional lymphadenopathy and had good therapeutic response&#44; restarting biologics 2&#8211;3 months after&#46; However&#44; in three published cases&#44; visceral infection presenting with mesenteric panniculitis&#44; splenic nodules and&#44; one of those&#44; with liver granulomatosis&#44; were documented&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;8&#44;11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">It should be stressed that new onset lymphadenopathy and granulomatosis in patients under biological therapies should raise the suspicion of CSD&#44; particularly in the field of epidemiologic risk&#46; The possibility of systemic dissemination should be kept in mind due to underlying immunosuppression&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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2023 Marzo 63 30 93
2023 Febrero 55 23 78
2023 Enero 58 18 76
2022 Diciembre 71 38 109
2022 Noviembre 44 20 64
2022 Octubre 68 38 106
2022 Septiembre 59 38 97
2022 Agosto 49 60 109
2022 Julio 40 44 84
2022 Junio 40 36 76
2022 Mayo 48 39 87
2022 Abril 77 44 121
2022 Marzo 90 42 132
2022 Febrero 97 31 128
2022 Enero 71 32 103
2021 Diciembre 53 36 89
2021 Noviembre 40 36 76
2021 Octubre 55 48 103
2021 Septiembre 60 37 97
2021 Agosto 35 40 75
2021 Julio 34 27 61
2021 Junio 39 41 80
2021 Mayo 52 57 109
2021 Abril 114 92 206
2021 Marzo 77 30 107
2021 Febrero 51 17 68
2021 Enero 53 28 81
2020 Diciembre 51 26 77
2020 Noviembre 41 25 66
2020 Octubre 34 14 48
2020 Septiembre 83 40 123
2020 Agosto 85 28 113
2020 Julio 30 16 46
2020 Junio 29 15 44
2020 Mayo 76 29 105
2020 Abril 43 23 66
2020 Marzo 63 24 87
2020 Febrero 1 0 1
2019 Diciembre 1 2 3
2019 Noviembre 1 0 1
2019 Octubre 2 0 2
2019 Junio 0 1 1
2019 Mayo 49 31 80
2019 Abril 75 23 98
2019 Marzo 57 24 81
2019 Febrero 28 14 42
2019 Enero 40 25 65
2018 Diciembre 53 52 105
2018 Noviembre 0 15 15
2018 Octubre 0 7 7
2018 Septiembre 0 6 6
2018 Agosto 0 11 11
2018 Julio 0 7 7
2018 Marzo 0 16 16
2018 Febrero 0 25 25
2018 Enero 0 11 11
2017 Diciembre 0 21 21
2017 Noviembre 0 30 30
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