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    "titulo" => "Growth factors&#58; Do they play a role in entheseal involvement in psoriatic arthritis and undifferentiated spondyloarthritis patients&#63;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The role of growth factors &#40;GFs&#41; in arthritis is rarely investigated&#44; reporting controversial results&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; the serum levels of IGF-1&#44; FGF-1&#44; TGF&#946; in patients &#40;pts&#41; with undifferentiated spondyloarthritis &#40;SpA&#41; or psoriatic arthritis &#40;PsA&#41; have never been described in literature&#46; Partsch et al&#46; described a higher titer of GH in the sera of PsA pts compared to psoriatic pts&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We describe a study designed to evaluate the serum levels of GFs&#44; IGF-1&#44; FGF-1&#44; GH and TGF&#946;&#44; in PsA pts and SpA pts&#44; with particular focus on the entheseal involvement&#46; Our goal was to assess any differences in the concentration of these GFs between pts with different clinical and instrumental features&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Preliminary data were obtained on 15 pts &#40;all female&#41;&#58; 6 with a new diagnosis of PsA&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> 9 with a new diagnosis of SpA&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> The control group was formed by 5 age-matched healthy females &#40;HC&#41;&#46; The exclusion criteria were intestinal bowel disease&#44; diabetes mellitus&#44; body mass index &#62;30&#44; systemic hypertension&#44; dyslipidemia&#44; alteration of thyroid function&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Serum levels of IGF-1&#44; FGF-1&#44; GH and TGF&#946; were measured using enzyme-linked immunosorbent assay &#40;ELISA&#41;&#46; Moreover&#44; an imaging evaluation was conducted on all pts&#58; the presence of calcific enthesopathy &#40;CE&#41; was assessed using standard radiology&#59; the ultrasound evaluation was conducted according to the Madrid Sonographic Enthesis Index &#40;MASEI&#41; score&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Disease activity was assessed by means of Disease Activity Score &#40;DAS28&#41;&#44; Disease Activity in PSoriatic Arthritis &#40;DAPSA&#41; and Leeds Enthesitis Index &#40;LEI&#41;&#46; Comparisons between groups were made with one-way analysis of variance &#40;ANOVA&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">We found that serum levels of IGF-1 and TGF&#946; were remarkably but not significantly higher in SpA pts compared to PsA pts and HC&#46; In particular&#44; there was a tendency toward higher serum concentrations of TGF&#946; in pts with CE compared to those pts without and HC &#40;1003&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>208&#46;5 vs&#46; 999&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>156&#46;9 vs&#46; 975&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>61&#46;7&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;965&#41;&#46; Furthermore&#44; a statistically significant negative correlation between TGF&#946; levels and symptoms duration both in SpA and PsA pts was observed &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;582&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;029&#41;&#46; In addition&#44; subjects with moderate &#40;MA&#41; or high disease activity &#40;HA&#41; according to DAPSA score showed a tendency toward higher GH &#40;low activity &#40;LA&#41;&#58; 310&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>449&#46;4&#44; MA&#58; 533&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>967&#46;4&#44; HA&#58; 630<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1074&#46;4&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;903&#41; and IGF-1 &#40;LA&#58; 389&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>532&#46;8&#44; MA&#58; 467&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>825&#46;2&#44; HA&#58; 491&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>585&#46;6&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;908&#41; levels&#44; while TGF&#946; levels were higher only in DAPSA HA &#40;LA&#58; 954&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>257&#46;3&#44; MA&#58; 910&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>170&#46;5&#44; HA&#58; 1049&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44&#46;1&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;653&#41;&#46; Interestingly&#44; this tendency was not observed when assessing the disease activity using the DAS28 score&#44; except for the HA group &#40;LA&#58; 954&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>257&#46;3&#44; MA&#58; 903&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>207&#46;7&#44; HA&#58; 974&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>124&#46;2&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;91&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The differences we found were not statistically significant most presumably given the small sample size&#46; Since no statistically significant differences in age and BMI were observed between the groups&#44; a difference in the GFs concentration due to physiological hormonal variations can be excluded&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The evidences about DAS28 may be owed to the focus of this score on joint involvement&#44; while enthesitis is not evaluated&#44; as in DAPSA&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The most remarkable result is the significant higher TGF&#946; serum levels in pts with shorter symptoms duration&#44; suggestive for a potential role of TGF&#946; as an early biomarker of disease&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This preliminary study&#44; although lacking statistically significant results&#44; support the hypothesis of an important role played by GFs IGF-1&#44; GH and TGF&#946; rather in the pathogenesis of enthesitis than of joint inflammation&#46; In particular&#44; TGF&#946; should have a key role in earlier phases of SpA and PsA&#46; Further studies&#44; with a larger sample size&#44; are necessary to clarify the role of GFs in the pathogenesis of enthesopathy&#44; and more broadly of spondylarthritis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">No funding was received for this study&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparison of demographic&#44; clinical characteristics and serum levels of growth factors between groups in study&#46;</p>"
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      "titulo" => "References"
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          "identificador" => "bibs0015"
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        "texto" => "<p id="par0065" class="elsevierStylePara elsevierViewall">We would like to thank Prof&#46; Addolorata Corrado and Dr&#46; Giovanni Bellantuono for their contribution in this study&#46;</p>"
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Letter to the Editor
Growth factors: Do they play a role in entheseal involvement in psoriatic arthritis and undifferentiated spondyloarthritis patients?
Factores de crecimiento: ¿desempeñan un papel en el compromiso enteseal en pacientes de artritis psoriásica y espondiloartritis indiferenciada?
Cinzia Rotondo, Daniela Cici
Autor para correspondencia
daniela.cici@gmail.com

Corresponding author.
, Francesco Paolo Cantatore
Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Ospedali Riuniti Foggia, Viale Pinto 1, 71121 Foggia, Italy
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        "titulo" => "Factores de crecimiento&#58; &#191;desempe&#241;an un papel en el compromiso enteseal en pacientes de artritis psori&#225;sica y espondiloartritis indiferenciada&#63;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The role of growth factors &#40;GFs&#41; in arthritis is rarely investigated&#44; reporting controversial results&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; the serum levels of IGF-1&#44; FGF-1&#44; TGF&#946; in patients &#40;pts&#41; with undifferentiated spondyloarthritis &#40;SpA&#41; or psoriatic arthritis &#40;PsA&#41; have never been described in literature&#46; Partsch et al&#46; described a higher titer of GH in the sera of PsA pts compared to psoriatic pts&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We describe a study designed to evaluate the serum levels of GFs&#44; IGF-1&#44; FGF-1&#44; GH and TGF&#946;&#44; in PsA pts and SpA pts&#44; with particular focus on the entheseal involvement&#46; Our goal was to assess any differences in the concentration of these GFs between pts with different clinical and instrumental features&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Preliminary data were obtained on 15 pts &#40;all female&#41;&#58; 6 with a new diagnosis of PsA&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> 9 with a new diagnosis of SpA&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> The control group was formed by 5 age-matched healthy females &#40;HC&#41;&#46; The exclusion criteria were intestinal bowel disease&#44; diabetes mellitus&#44; body mass index &#62;30&#44; systemic hypertension&#44; dyslipidemia&#44; alteration of thyroid function&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Serum levels of IGF-1&#44; FGF-1&#44; GH and TGF&#946; were measured using enzyme-linked immunosorbent assay &#40;ELISA&#41;&#46; Moreover&#44; an imaging evaluation was conducted on all pts&#58; the presence of calcific enthesopathy &#40;CE&#41; was assessed using standard radiology&#59; the ultrasound evaluation was conducted according to the Madrid Sonographic Enthesis Index &#40;MASEI&#41; score&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Disease activity was assessed by means of Disease Activity Score &#40;DAS28&#41;&#44; Disease Activity in PSoriatic Arthritis &#40;DAPSA&#41; and Leeds Enthesitis Index &#40;LEI&#41;&#46; Comparisons between groups were made with one-way analysis of variance &#40;ANOVA&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">We found that serum levels of IGF-1 and TGF&#946; were remarkably but not significantly higher in SpA pts compared to PsA pts and HC&#46; In particular&#44; there was a tendency toward higher serum concentrations of TGF&#946; in pts with CE compared to those pts without and HC &#40;1003&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>208&#46;5 vs&#46; 999&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>156&#46;9 vs&#46; 975&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>61&#46;7&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;965&#41;&#46; Furthermore&#44; a statistically significant negative correlation between TGF&#946; levels and symptoms duration both in SpA and PsA pts was observed &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;582&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;029&#41;&#46; In addition&#44; subjects with moderate &#40;MA&#41; or high disease activity &#40;HA&#41; according to DAPSA score showed a tendency toward higher GH &#40;low activity &#40;LA&#41;&#58; 310&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>449&#46;4&#44; MA&#58; 533&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>967&#46;4&#44; HA&#58; 630<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1074&#46;4&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;903&#41; and IGF-1 &#40;LA&#58; 389&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>532&#46;8&#44; MA&#58; 467&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>825&#46;2&#44; HA&#58; 491&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>585&#46;6&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;908&#41; levels&#44; while TGF&#946; levels were higher only in DAPSA HA &#40;LA&#58; 954&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>257&#46;3&#44; MA&#58; 910&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>170&#46;5&#44; HA&#58; 1049&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44&#46;1&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;653&#41;&#46; Interestingly&#44; this tendency was not observed when assessing the disease activity using the DAS28 score&#44; except for the HA group &#40;LA&#58; 954&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>257&#46;3&#44; MA&#58; 903&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>207&#46;7&#44; HA&#58; 974&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>124&#46;2&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;91&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The differences we found were not statistically significant most presumably given the small sample size&#46; Since no statistically significant differences in age and BMI were observed between the groups&#44; a difference in the GFs concentration due to physiological hormonal variations can be excluded&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The evidences about DAS28 may be owed to the focus of this score on joint involvement&#44; while enthesitis is not evaluated&#44; as in DAPSA&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The most remarkable result is the significant higher TGF&#946; serum levels in pts with shorter symptoms duration&#44; suggestive for a potential role of TGF&#946; as an early biomarker of disease&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This preliminary study&#44; although lacking statistically significant results&#44; support the hypothesis of an important role played by GFs IGF-1&#44; GH and TGF&#946; rather in the pathogenesis of enthesitis than of joint inflammation&#46; In particular&#44; TGF&#946; should have a key role in earlier phases of SpA and PsA&#46; Further studies&#44; with a larger sample size&#44; are necessary to clarify the role of GFs in the pathogenesis of enthesopathy&#44; and more broadly of spondylarthritis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">No funding was received for this study&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Data are expressed as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#59; significant <span class="elsevierStyleItalic">P</span> value was set to &#8804; &#46;05&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; BODY MASS INdex&#59; CRP&#58; C Reactive Protein&#59; DAPSA&#58; Disease Activity in PSoriatic Arthritis&#59; DAS28&#58; Disease Activity Score&#59; ESR&#58; Erythrocytes Sedimentation Rate&#59; HC&#58; Healthy Controls&#59; LEI&#58; Leeds Enthesitis Index&#59; MASEI&#58; MAdrid Sonographic Enthesitis Index&#59; PARS&#58; Psoriatic Arthritis Ratingen Score&#59; PsA&#58; Psoriatic Arthritis&#59; SpA&#58; undifferentiated Spondyloarthritis&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PsA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SpA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">43&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;691&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">22&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;233&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Symptoms duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">4&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;00<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;424&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;688&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CRP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;813&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LEI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DAS28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;287&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DAPSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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ISSN: 1699258X
Idioma original: Inglés
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