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MTX: metotrexato; LEF: leflunomida; FARMEb: fármacos modificadores de la enfermedad biológicos; Tofa: tofacitinib; Anti-TNF; IL-12/23, IL-17: inhibidores del factor de necrosis tumoral; interleucinas 12,23, o 17; PDE4: apremilast.</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">En el diseño de la estrategia terapéutica es necesario considerar el patrón de afección de cada paciente en cada dominio.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Julio Casasola-Vargas, Diana Flores-Alvarado, Luis H. Silveira, Sandra Sicsik-Ayala, Greta Reyes-Cordero, Guadalupe Villanueva Quintero, Mario Amaya Guerra, Sara G. Reyes Orozco, Beatriz E. Zazueta Montiel, Roberto Hernández-Paz, Angélica Mendoza-Fuentes, Ana G. Bernard-Medina, Alejandra López Rodriguez, Rosa E. Barbosa Cobos, Rubén Burgos-Vargas, César Pacheco-Tena" "autores" => array:16 [ 0 => array:2 [ "nombre" => "Julio" "apellidos" => "Casasola-Vargas" ] 1 => array:2 [ "nombre" => "Diana" "apellidos" => "Flores-Alvarado" ] 2 => array:2 [ "nombre" => "Luis H." "apellidos" => "Silveira" ] 3 => array:2 [ "nombre" => "Sandra" "apellidos" => "Sicsik-Ayala" ] 4 => array:2 [ "nombre" => "Greta" "apellidos" => "Reyes-Cordero" ] 5 => array:2 [ "nombre" => "Guadalupe" "apellidos" => "Villanueva Quintero" ] 6 => array:2 [ "nombre" => "Mario" "apellidos" => "Amaya Guerra" ] 7 => array:2 [ "nombre" => "Sara G." "apellidos" => "Reyes Orozco" ] 8 => array:2 [ "nombre" => "Beatriz E." 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"apellidos" => "Barbosa Cobos" ] 14 => array:2 [ "nombre" => "Rubén" "apellidos" => "Burgos-Vargas" ] 15 => array:2 [ "nombre" => "César" "apellidos" => "Pacheco-Tena" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574321001398" "doi" => "10.1016/j.reumae.2020.12.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001398?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21000292?idApp=UINPBA00004M" "url" => "/1699258X/0000001700000010/v1_202111230834/S1699258X21000292/v1_202111230834/es/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>" "titulo" => "Synovial osteochondromatosis of the knee" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "622" "paginaFinal" => "623" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sreoshy Saha, Latika Gupta" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Sreoshy" "apellidos" => "Saha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Latika" "apellidos" => "Gupta" "email" => array:1 [ 0 => "drlatikagupta@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Mymensingh Medical College, Mymensingh, Bangladesh" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, C block, Rai Bareilley Road, 226014 Lucknow, India" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Osteocondromatosis sinovial de la rodilla" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 756 "Ancho" => 1005 "Tamanyo" => 113718 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior and lateral radiographs of knee. Multiple loose calcified bodies are seen within it (asterisks).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 55-year-old lady presented in the outpatient clinic, with the complaints of mechanical knee pain of three-year duration. Radiographs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) of the knee were suggestive of multiple loose radio-opaque calcified bodies around the knee joint.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The radiographs are pathognomonic of Synovial Osteochondromatosis, an atypical neoplastic disease, with an occurrence rate of 1 in 100,000 people.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> People are likely to get affected by Synovial Osteochondromatosis in their 3rd to 5th decades of life, occurs almost 2 times more frequently in men than women. The pathogenesis includes hyperplastic metaplasia of connective tissue where hyaline cartilage gets calcified into multiple intra-articular loose bodies in synovial tissues, within the joint, bursa or tendon sheaths. Though knee is mostly affected, hip, shoulder, ankle, elbow, and wrist joints can also be affected. Joint swelling and tenderness, locking, pain, restrictions of range of motion in affected joints are some common clinical features. This disease has potential to transform into chondrosarcoma, in very few cases.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> Surgical excision of the chondromal nodules and synovectomy are the mainstay of treatment to prevent late degenerative transformation. Overall with a reported recurrence of 3–60% in primary disease, the recurrence rate goes below 10% after surgery.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">1,2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethics approval and consent to participate</span><p id="par0015" class="elsevierStylePara elsevierViewall">Participant provided informed consent for the photographs included in this paper.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Availability and data sharing</span><p id="par0020" class="elsevierStylePara elsevierViewall">The data used during the current study is available from the corresponding author on reasonable request.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Consent for publication</span><p id="par0025" class="elsevierStylePara elsevierViewall">Consent for publication of pictures was given by the participant.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Disclosure</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have nothing to disclose.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">All authors were involved in manuscript ideation and preparation.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Ethics approval and consent to participate" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Availability and data sharing" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Consent for publication" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Disclosure" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Contributions" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Funding" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflict of interest" ] 7 => array:2 [ "identificador" => "xack569457" "titulo" => "Acknowledgements" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-11-30" "fechaAceptado" => "2020-12-10" "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 756 "Ancho" => 1005 "Tamanyo" => 113718 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior and lateral radiographs of knee. Multiple loose calcified bodies are seen within it (asterisks).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Synovial osteochondromatosis of the shoulder: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.F. Díaz Fernández" 1 => "R.A. Peraza Mc Liberty" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.reumae.2017.09.001" "Revista" => array:6 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2018" "volumen" => "14" "paginaInicial" => "56" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27613313" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Not a typical case of bilateral knee osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Khodaee" 1 => "J. Seyfert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.i39" "Revista" => array:4 [ "tituloSerie" => "BMJ" "fecha" => "2016" "volumen" => "352" "itemHostRev" => array:3 [ "pii" => "S221385871930422X" "estado" => "S300" "issn" => "22138587" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack569457" "titulo" => "Acknowledgements" "texto" => "<p id="par0050" class="elsevierStylePara elsevierViewall">The authors thank Connecting Researchers and Dr Mallke Asaad for their help with this work.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/1699258X/0000001700000010/v1_202111230834/S1699258X21000115/v1_202111230834/en/main.assets" "Apartado" => array:4 [ "identificador" => "42683" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Reumatología clínica en imágenes" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000001700000010/v1_202111230834/S1699258X21000115/v1_202111230834/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21000115?idApp=UINPBA00004M" ]
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