array:23 [
  "pii" => "S1699258X2200047X"
  "issn" => "1699258X"
  "doi" => "10.1016/j.reuma.2022.02.001"
  "estado" => "S300"
  "fechaPublicacion" => "2022-10-01"
  "aid" => "1600"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2022;18:495-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1699258X21000930"
    "issn" => "1699258X"
    "doi" => "10.1016/j.reuma.2021.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2022-10-01"
    "aid" => "1526"
    "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2022;18:497-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
      "titulo" => "Estudios m&#233;tricos del <span class="elsevierStyleItalic">Compliance Questionnaire on Rheumatology</span> &#40;CQR&#41;&#58; &#191;Un caso de inducci&#243;n de la validez&#63;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "497"
          "paginaFinal" => "498"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Metric Studies of the Compliance Questionnaire on Rheumatology &#40;CQR&#41;&#58; A Case of Validity Induction&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#233;sar Merino-Soto, Marisol Angulo-Ramos"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Merino-Soto"
            ]
            1 => array:2 [
              "nombre" => "Marisol"
              "apellidos" => "Angulo-Ramos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173574321001660"
        "doi" => "10.1016/j.reumae.2021.03.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001660?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21000930?idApp=UINPBA00004M"
    "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X21000930/v1_202210010847/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1699258X21001674"
    "issn" => "1699258X"
    "doi" => "10.1016/j.reuma.2021.06.003"
    "estado" => "S300"
    "fechaPublicacion" => "2022-10-01"
    "aid" => "1558"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2022;18:493-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Takotsubo Syndrome in a Rheumatoid Arthritis Patient Under Tofacitinib&#58; A Case Report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "493"
          "paginaFinal" => "494"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "S&#237;ndrome de takotsubo en un paciente con artritis reumatoide tomando tofacitinib&#58; reporte de un caso"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Salom&#233; Garcia, Georgina Terroso, Elisabete Martins, Sofia Pimenta, L&#250;cia Costa, Miguel Bernardes"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Salom&#233;"
              "apellidos" => "Garcia"
            ]
            1 => array:2 [
              "nombre" => "Georgina"
              "apellidos" => "Terroso"
            ]
            2 => array:2 [
              "nombre" => "Elisabete"
              "apellidos" => "Martins"
            ]
            3 => array:2 [
              "nombre" => "Sofia"
              "apellidos" => "Pimenta"
            ]
            4 => array:2 [
              "nombre" => "L&#250;cia"
              "apellidos" => "Costa"
            ]
            5 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Bernardes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21001674?idApp=UINPBA00004M"
    "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X21001674/v1_202210010847/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Reumatolog&#237;a Cl&#237;nica en im&#225;genes</span>"
    "titulo" => "Crowned dens syndrome as a rare cause of severe cervical pain"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "495"
        "paginaFinal" => "496"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Daniela Oliveira, Carlos Vaz"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Daniela"
            "apellidos" => "Oliveira"
            "email" => array:1 [
              0 => "danielasoff@gmail.com"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "Vaz"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Rheumatology Department&#44; University Hospital Center of S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Medicine of Faculty of Medicine&#44; University of Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Center for Health Technology and Services Research &#40;CINTESIS&#41;&#44; Faculty of Medicine&#44; University of Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome de Crowned Dens como causa rara de dolor cervical severo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 591
            "Ancho" => 1305
            "Tamanyo" => 74450
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial &#40;A&#41; and sagittal &#40;B&#41; CT images of the patient&#39;s cervical spine&#44; representing calcium pyrophosphate dihydrate crystals deposition around the odontoid process of C2 &#40;red arrows&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cervico-occipital computed tomography &#40;CT&#41; demonstrated deposition of calcium pyrophosphate dihydrate crystals around the odontoid process of axis in a 87-year-old female patient with initial diagnosis of polymyalgia rheumatica &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#44; B&#41;&#46; Patient had an acute severe cervico-occipital pain and markable neck stiffness&#46; The patient had no shoulder or pelvic girdle pain and no jaw claudication&#46; There is no history of trauma&#46; There was a long personal history of knee pain due to calcium pyrophosphate dehydrate crystal deposition disease&#46; Physical examination revealed limited passive cervical rotation without focal neurologic deficit&#46; Laboratory results revealed elevation of erythrocyte sedimentation rate of 54<span class="elsevierStyleHsp" style=""></span>mm&#47;h and a normal C-reactive protein &#40;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; A knee radiography confirmed peripheral calcium pyrophosphate deposition disease&#46; CT images showed atlantoaxial synovial calcifications in a crown around the odontoid process&#46; A diagnosis of crowned dens syndrome &#40;CDS&#41; or periodontoid calcium pyrophosphate dehydrate crystal deposition disease was made&#46; The patient was improved with a combination of prednisolone and nonsteroidal anti-inflammatory drug &#40;NSAID&#41; in a week&#46; CDS is a rare clinical and radiological entity described firstly in 1985 and which pathophysiologic is not completely clear&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This condition is accompanied by acute cervico-occipital pain and stiffness with severe limitation of neck rotation&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> The elevation of inflammatory markers is common&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> CDS can be misdiagnosed as various rheumatic diseases namely rheumatoid arthritis&#44; spondyloarthritis&#44; giant cell arthritis and PMR&#44; as in our case&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> For diagnosis&#44; cervico-occipital CT&#44; showing calcification around the odontoid process&#44; is the gold standard and should be done as soon as symptoms appear&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Patients respond well to corticosteroids&#44; NSAIDs and colchicine&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Surgical procedure is performed rarely&#46; CDS is a rare disease entity with various differential diagnosis&#46; Thus&#44; a high index of clinical suspicion is needed to obtain an early accurate diagnosis avoiding unnecessary exams or treatments&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0010" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-12-20"
    "fechaAceptado" => "2022-02-10"
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 591
            "Ancho" => 1305
            "Tamanyo" => 74450
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial &#40;A&#41; and sagittal &#40;B&#41; CT images of the patient&#39;s cervical spine&#44; representing calcium pyrophosphate dihydrate crystals deposition around the odontoid process of C2 &#40;red arrows&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute neck pain due to calcifications surrounding the odontoid process&#58; the crowned dens syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Bouvet"
                            1 => "J&#46;M&#46; le Parc"
                            2 => "B&#46; Michalski"
                            3 => "C&#46; Benlahrache"
                            4 => "L&#46; Auquier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.1780281215"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1985"
                        "volumen" => "28"
                        "paginaInicial" => "1417"
                        "paginaFinal" => "1420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4084331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The crowned dens syndrome&#58; a rare form of calcium pyrophosphate deposition disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Baysal"
                            1 => "O&#46; Baysal"
                            2 => "R&#46; Kutlu"
                            3 => "I&#46; Karaman"
                            4 => "B&#46; Mizrak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s003300051052"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2000"
                        "volumen" => "10"
                        "paginaInicial" => "1003"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10879718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and quantitative analysis of patients with crowned dens syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Takahashi"
                            1 => "M&#46; Tamura"
                            2 => "T&#46; Takasu"
                            3 => "S&#46; Kamei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2017.02.050"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2017"
                        "volumen" => "376"
                        "paginaInicial" => "52"
                        "paginaFinal" => "59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28431628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Crowned dens syndrome misdiagnosed as polymyalgia rheumatica&#44; giant cell arteritis&#44; meningitis or spondylitis&#58; an analysis of eight cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Aouba"
                            1 => "V&#46; Vuillemin-Bodaghi"
                            2 => "C&#46; Mutschler"
                            3 => "M&#46; De Bandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/keh370"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1508"
                        "paginaFinal" => "1512"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The crowned dens syndrome as a cause of neck pain&#58; clinical and computed tomography study in patients with calcium pyrophosphate dihydrate deposition disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Salaffi"
                            1 => "M&#46; Carotti"
                            2 => "G&#46; Guglielmi"
                            3 => "G&#46; Passarini"
                            4 => "W&#46; Grassi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "1040"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19210868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute suboccipital neck pain of calcifying origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Ziza"
                            1 => "J&#46;P&#46; Bouvet"
                            2 => "L&#46; Auquier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Rhum Mal Osteoartic"
                        "fecha" => "1982"
                        "volumen" => "49"
                        "paginaInicial" => "549"
                        "paginaFinal" => "551"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7123130"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1873994612004564"
                          "estado" => "S300"
                          "issn" => "18739946"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X2200047X/v1_202210010847/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93550"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reumatolog&#237;a Cl&#237;nica en im&#225;genes"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000001800000008/v1_202210010847/S1699258X2200047X/v1_202210010847/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X2200047X?idApp=UINPBA00004M"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Reumatología Clínica en imágenes
Crowned dens syndrome as a rare cause of severe cervical pain
Síndrome de Crowned Dens como causa rara de dolor cervical severo
Daniela Oliveiraa,b,c,
Autor para correspondencia
danielasoff@gmail.com

Corresponding author.
, Carlos Vaza,b
a Rheumatology Department, University Hospital Center of São João, Porto, Portugal
b Department of Medicine of Faculty of Medicine, University of Porto, Porto, Portugal
c Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, Porto, Portugal
Leído
1151
Veces
se ha leído el artículo
513
Total PDF
638
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1699258X2200047X"
  "issn" => "1699258X"
  "doi" => "10.1016/j.reuma.2022.02.001"
  "estado" => "S300"
  "fechaPublicacion" => "2022-10-01"
  "aid" => "1600"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2022;18:495-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1699258X21000930"
    "issn" => "1699258X"
    "doi" => "10.1016/j.reuma.2021.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2022-10-01"
    "aid" => "1526"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2022;18:497-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
      "titulo" => "Estudios m&#233;tricos del <span class="elsevierStyleItalic">Compliance Questionnaire on Rheumatology</span> &#40;CQR&#41;&#58; &#191;Un caso de inducci&#243;n de la validez&#63;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "497"
          "paginaFinal" => "498"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Metric Studies of the Compliance Questionnaire on Rheumatology &#40;CQR&#41;&#58; A Case of Validity Induction&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#233;sar Merino-Soto, Marisol Angulo-Ramos"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Merino-Soto"
            ]
            1 => array:2 [
              "nombre" => "Marisol"
              "apellidos" => "Angulo-Ramos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2173574321001660"
        "doi" => "10.1016/j.reumae.2021.03.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001660?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21000930?idApp=UINPBA00004M"
    "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X21000930/v1_202210010847/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1699258X21001674"
    "issn" => "1699258X"
    "doi" => "10.1016/j.reuma.2021.06.003"
    "estado" => "S300"
    "fechaPublicacion" => "2022-10-01"
    "aid" => "1558"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2022;18:493-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Takotsubo Syndrome in a Rheumatoid Arthritis Patient Under Tofacitinib&#58; A Case Report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "493"
          "paginaFinal" => "494"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "S&#237;ndrome de takotsubo en un paciente con artritis reumatoide tomando tofacitinib&#58; reporte de un caso"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Salom&#233; Garcia, Georgina Terroso, Elisabete Martins, Sofia Pimenta, L&#250;cia Costa, Miguel Bernardes"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Salom&#233;"
              "apellidos" => "Garcia"
            ]
            1 => array:2 [
              "nombre" => "Georgina"
              "apellidos" => "Terroso"
            ]
            2 => array:2 [
              "nombre" => "Elisabete"
              "apellidos" => "Martins"
            ]
            3 => array:2 [
              "nombre" => "Sofia"
              "apellidos" => "Pimenta"
            ]
            4 => array:2 [
              "nombre" => "L&#250;cia"
              "apellidos" => "Costa"
            ]
            5 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Bernardes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X21001674?idApp=UINPBA00004M"
    "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X21001674/v1_202210010847/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Reumatolog&#237;a Cl&#237;nica en im&#225;genes</span>"
    "titulo" => "Crowned dens syndrome as a rare cause of severe cervical pain"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "495"
        "paginaFinal" => "496"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Daniela Oliveira, Carlos Vaz"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Daniela"
            "apellidos" => "Oliveira"
            "email" => array:1 [
              0 => "danielasoff@gmail.com"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "Vaz"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Rheumatology Department&#44; University Hospital Center of S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Medicine of Faculty of Medicine&#44; University of Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Center for Health Technology and Services Research &#40;CINTESIS&#41;&#44; Faculty of Medicine&#44; University of Porto&#44; Porto&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome de Crowned Dens como causa rara de dolor cervical severo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 591
            "Ancho" => 1305
            "Tamanyo" => 74450
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial &#40;A&#41; and sagittal &#40;B&#41; CT images of the patient&#39;s cervical spine&#44; representing calcium pyrophosphate dihydrate crystals deposition around the odontoid process of C2 &#40;red arrows&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cervico-occipital computed tomography &#40;CT&#41; demonstrated deposition of calcium pyrophosphate dihydrate crystals around the odontoid process of axis in a 87-year-old female patient with initial diagnosis of polymyalgia rheumatica &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#44; B&#41;&#46; Patient had an acute severe cervico-occipital pain and markable neck stiffness&#46; The patient had no shoulder or pelvic girdle pain and no jaw claudication&#46; There is no history of trauma&#46; There was a long personal history of knee pain due to calcium pyrophosphate dehydrate crystal deposition disease&#46; Physical examination revealed limited passive cervical rotation without focal neurologic deficit&#46; Laboratory results revealed elevation of erythrocyte sedimentation rate of 54<span class="elsevierStyleHsp" style=""></span>mm&#47;h and a normal C-reactive protein &#40;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; A knee radiography confirmed peripheral calcium pyrophosphate deposition disease&#46; CT images showed atlantoaxial synovial calcifications in a crown around the odontoid process&#46; A diagnosis of crowned dens syndrome &#40;CDS&#41; or periodontoid calcium pyrophosphate dehydrate crystal deposition disease was made&#46; The patient was improved with a combination of prednisolone and nonsteroidal anti-inflammatory drug &#40;NSAID&#41; in a week&#46; CDS is a rare clinical and radiological entity described firstly in 1985 and which pathophysiologic is not completely clear&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This condition is accompanied by acute cervico-occipital pain and stiffness with severe limitation of neck rotation&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> The elevation of inflammatory markers is common&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> CDS can be misdiagnosed as various rheumatic diseases namely rheumatoid arthritis&#44; spondyloarthritis&#44; giant cell arthritis and PMR&#44; as in our case&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;5</span></a> For diagnosis&#44; cervico-occipital CT&#44; showing calcification around the odontoid process&#44; is the gold standard and should be done as soon as symptoms appear&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Patients respond well to corticosteroids&#44; NSAIDs and colchicine&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Surgical procedure is performed rarely&#46; CDS is a rare disease entity with various differential diagnosis&#46; Thus&#44; a high index of clinical suspicion is needed to obtain an early accurate diagnosis avoiding unnecessary exams or treatments&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0010" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-12-20"
    "fechaAceptado" => "2022-02-10"
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 591
            "Ancho" => 1305
            "Tamanyo" => 74450
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial &#40;A&#41; and sagittal &#40;B&#41; CT images of the patient&#39;s cervical spine&#44; representing calcium pyrophosphate dihydrate crystals deposition around the odontoid process of C2 &#40;red arrows&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute neck pain due to calcifications surrounding the odontoid process&#58; the crowned dens syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Bouvet"
                            1 => "J&#46;M&#46; le Parc"
                            2 => "B&#46; Michalski"
                            3 => "C&#46; Benlahrache"
                            4 => "L&#46; Auquier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.1780281215"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1985"
                        "volumen" => "28"
                        "paginaInicial" => "1417"
                        "paginaFinal" => "1420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4084331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The crowned dens syndrome&#58; a rare form of calcium pyrophosphate deposition disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Baysal"
                            1 => "O&#46; Baysal"
                            2 => "R&#46; Kutlu"
                            3 => "I&#46; Karaman"
                            4 => "B&#46; Mizrak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s003300051052"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2000"
                        "volumen" => "10"
                        "paginaInicial" => "1003"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10879718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and quantitative analysis of patients with crowned dens syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Takahashi"
                            1 => "M&#46; Tamura"
                            2 => "T&#46; Takasu"
                            3 => "S&#46; Kamei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2017.02.050"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2017"
                        "volumen" => "376"
                        "paginaInicial" => "52"
                        "paginaFinal" => "59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28431628"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Crowned dens syndrome misdiagnosed as polymyalgia rheumatica&#44; giant cell arteritis&#44; meningitis or spondylitis&#58; an analysis of eight cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Aouba"
                            1 => "V&#46; Vuillemin-Bodaghi"
                            2 => "C&#46; Mutschler"
                            3 => "M&#46; De Bandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/keh370"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1508"
                        "paginaFinal" => "1512"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The crowned dens syndrome as a cause of neck pain&#58; clinical and computed tomography study in patients with calcium pyrophosphate dihydrate deposition disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Salaffi"
                            1 => "M&#46; Carotti"
                            2 => "G&#46; Guglielmi"
                            3 => "G&#46; Passarini"
                            4 => "W&#46; Grassi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "1040"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19210868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute suboccipital neck pain of calcifying origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Ziza"
                            1 => "J&#46;P&#46; Bouvet"
                            2 => "L&#46; Auquier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Rhum Mal Osteoartic"
                        "fecha" => "1982"
                        "volumen" => "49"
                        "paginaInicial" => "549"
                        "paginaFinal" => "551"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7123130"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1873994612004564"
                          "estado" => "S300"
                          "issn" => "18739946"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/1699258X/0000001800000008/v1_202210010847/S1699258X2200047X/v1_202210010847/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93550"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reumatolog&#237;a Cl&#237;nica en im&#225;genes"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000001800000008/v1_202210010847/S1699258X2200047X/v1_202210010847/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X2200047X?idApp=UINPBA00004M"
]
Información del artículo
ISSN: 1699258X
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 9 12 21
2024 Octubre 26 35 61
2024 Septiembre 37 25 62
2024 Agosto 38 36 74
2024 Julio 30 18 48
2024 Junio 45 20 65
2024 Mayo 35 42 77
2024 Abril 49 24 73
2024 Marzo 42 28 70
2024 Febrero 27 20 47
2024 Enero 26 21 47
2023 Diciembre 25 31 56
2023 Noviembre 38 33 71
2023 Octubre 25 28 53
2023 Septiembre 47 36 83
2023 Agosto 27 10 37
2023 Julio 26 23 49
2023 Junio 21 20 41
2023 Mayo 33 20 53
2023 Abril 18 15 33
2023 Marzo 3 7 10
2023 Febrero 1 0 1
2023 Enero 1 2 3
2022 Octubre 7 7 14
2022 Julio 1 0 1
2022 Marzo 1 0 1
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Reumatología Clínica
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?