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high AST and ALT &#40;98 and 81<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; respectively&#41;&#44; high ferritin &#40;5075<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; and hypertriglyceridemia &#40;357<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; High lactate dehydrogenase &#40;LDH 1095<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#44; low haptoglobin &#40;&#60;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; positive direct coombs test&#44; absence of schistocytes on the peripheral blood smear and reticulocytopenia were also observed&#46; Coagulation tests showed normal prothrombin and activated partial thromboplastin time and hypofibrinogenemia &#40;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; Urine analysis was normal&#46; Blood cultures and serological tests for infectious diseases&#44; namely for cytomegalovirus and epstein barr virus&#44; were negative&#46; Autoimmune workup showed positive ANA &#40;1&#58;1280&#44; 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associated with MAS was diagnosed&#46; MAS was diagnosed according to the HLH-2004 criteria and the <span class="elsevierStyleItalic">H</span>-score&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> The patient started hydroxychloroquine 400<span class="elsevierStyleHsp" style=""></span>mg daily&#44; intravenous methylprednisolone pulse &#40;1<span class="elsevierStyleHsp" style=""></span>g daily for 3 days&#41;&#44; followed by 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily of oral prednisolone and cyclosporine 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily&#46; <span class="elsevierStyleItalic">Prophylaxis</span> for <span class="elsevierStyleItalic">Pneumocystis jiroveci</span>&#44; calcium and vitamin D supplementation were also started&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A significant clinical and laboratory improvement was noticed with resolution of fever and constitutional symptoms&#44; improvement of pancytopenia&#44; hyperferritinemia&#44; hypertriglyceridemia and hypofibrinogenemia&#46; The patient was discharged after 3 weeks&#44; with steroid tapering&#46; At one year follow-up&#44; a sustained remission was observed&#46; Steroid was stopped and hydroxychloroquine 400<span class="elsevierStyleHsp" style=""></span>mg daily and cyclosporine 2&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily were maintained&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">MAS is rarely associated with SLE and the incidence is 0&#46;9&#8211;4&#46;6&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;6</span></a> The mainstay of treatment is steroids&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;7</span></a> Concomitant use of other agents&#44; such as etoposide&#44; cyclosporine&#44; high-dose IV immunoglobulin and anakinra is useful in patients with severe&#44; corticosteroid-resistant or refractory MAS&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Cyclosporine is a cyclic polypeptide immunosuppressant that suppresses the production of IL-2&#44; IFN-&#947; TNF-<span class="elsevierStyleItalic">&#945;</span>&#44; IL-1 and IL-6&#44; and also inhibits T lymphocyte activation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> This agent is effective for the induction and maintenance of remission in patients with MAS associated with rheumatic diseases&#44; even in the cases of severe and corticosteroid-resistant disease&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Early diagnosis is crucial since mortality remains high&#44; even in patients undergoing treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Here&#44; we present an unusual&#44; severe and life-threatening onset manifestation of SLE&#44; MAS&#46; Remission of the disease was achieved with corticosteroids and ciclosporine&#44; with no adverse events reported&#44; which corroborate the effectiveness&#44; and also the safety&#44; of this therapy&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Fever with constitutional symptoms and cytopenia can be clues to MAS and the level of suspicion should be high&#44; to guarantee an early diagnosis&#46; Looking for secondary causes of MAS&#44; such as rheumatic diseases&#44; is essential to ensure an accurate diagnosis and to select the appropriate treatment&#46; However&#44; a genetic predisposition can also exist and be related to dysregulated inflammasome activity &#40;e&#46;g&#46;&#44; NLRC4 gene&#41;&#44; and especially in situations with a positive family history of MAS&#44; this should be investigated&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare they have no conflict of interest&#46;</p></span></span>"
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Case report
Severe and life-threatening onset of systemic lupus erythematosus
Una presentación grave y potencialmente fatal de lupus eritematoso sistémico
Ana Martinsa,b,
Autor para correspondencia
anaigmartins.med@gmail.com

Corresponding author.
, Sofia Pimentaa,b, Daniela Oliveiraa,b, Frederico Martinsc, Beatriz Samõesd, Lúcia Costaa
a Department of Rheumatology, Centro Hospitalar Universitário de São João, Porto, Portugal
b Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
c Department of Rheumatology, Hospital de Faro, CHA, Faro, Portugal
d Department of Rheumatology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
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fatigue&#44; anorexia&#44; weight loss&#44; polyarthralgia of the hands and dry mouth&#46; She denied symptoms suggestive of infection&#44; night sweats or swelling of the lymph nodes&#46; No family history for rheumatic disease&#46; Physical examination revealed normal vital signs except high temperature &#40;38&#46;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; pallor of the skin&#44; mild tenderness at proximal interphalangeal joints without swelling or deformities&#46; Cardiopulmonary&#44; abdominal and neurological examination was normal&#46; Small red and painful patches were observed on her fingers&#46; No axillary&#44; cervical and inguinal adenopathy or peripheral edema were noticed&#46; Laboratory workup showed pancytopenia &#40;Hb 8&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; WBC 1630&#47;&#956;L&#44; platelet 108&#44;000&#47;&#956;L&#41;&#44; normal ESR and CRP&#44; normal renal function&#44; mild hypoalbuminemia &#40;36&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; high AST and ALT &#40;98 and 81<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; respectively&#41;&#44; high ferritin &#40;5075<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; and hypertriglyceridemia &#40;357<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; High lactate dehydrogenase &#40;LDH 1095<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#44; low haptoglobin &#40;&#60;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; positive direct coombs test&#44; absence of schistocytes on the peripheral blood smear and reticulocytopenia were also observed&#46; Coagulation tests showed normal prothrombin and activated partial thromboplastin time and hypofibrinogenemia &#40;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; Urine analysis was normal&#46; Blood cultures and serological tests for infectious diseases&#44; namely for cytomegalovirus and epstein barr virus&#44; were negative&#46; Autoimmune workup showed positive ANA &#40;1&#58;1280&#44; homogenous pattern&#41;&#44; anti-dsDNA &#40;&#62;800<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#41;&#44; anti-Sm&#44; anti-SS-A and anti-nucleosome antibodies and low complement levels &#40;C3 54<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; C4 8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; CT of chest&#44; abdomen and pelvis showed cervical&#44; axillary and retroperitoneal lymphadenopathy&#44; hepatosplenomegaly with no focal lesions&#46; No signs of infection or malignancy&#46; Biopsy of axillary node showed <span class="elsevierStyleItalic">non-specific reactive lymphadenitis&#46;</span> Bone marrow aspiration and biopsy were performed but the sample was inappropriate&#46; Soluble CD25 in serum was only collected after 10 days of therapy&#46; Even though&#44; the level remained high &#40;1187<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#44; <span class="elsevierStyleItalic">N</span> 158&#8211;623&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">New-onset of systemic lupus erythematosus &#40;SLE&#41; associated with MAS was diagnosed&#46; MAS was diagnosed according to the HLH-2004 criteria and the <span class="elsevierStyleItalic">H</span>-score&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> The patient started hydroxychloroquine 400<span class="elsevierStyleHsp" style=""></span>mg daily&#44; intravenous methylprednisolone pulse &#40;1<span class="elsevierStyleHsp" style=""></span>g daily for 3 days&#41;&#44; followed by 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily of oral prednisolone and cyclosporine 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily&#46; <span class="elsevierStyleItalic">Prophylaxis</span> for <span class="elsevierStyleItalic">Pneumocystis jiroveci</span>&#44; calcium and vitamin D supplementation were also started&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A significant clinical and laboratory improvement was noticed with resolution of fever and constitutional symptoms&#44; improvement of pancytopenia&#44; hyperferritinemia&#44; hypertriglyceridemia and hypofibrinogenemia&#46; The patient was discharged after 3 weeks&#44; with steroid tapering&#46; At one year follow-up&#44; a sustained remission was observed&#46; Steroid was stopped and hydroxychloroquine 400<span class="elsevierStyleHsp" style=""></span>mg daily and cyclosporine 2&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg daily were maintained&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">MAS is rarely associated with SLE and the incidence is 0&#46;9&#8211;4&#46;6&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;6</span></a> The mainstay of treatment is steroids&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;7</span></a> Concomitant use of other agents&#44; such as etoposide&#44; cyclosporine&#44; high-dose IV immunoglobulin and anakinra is useful in patients with severe&#44; corticosteroid-resistant or refractory MAS&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Cyclosporine is a cyclic polypeptide immunosuppressant that suppresses the production of IL-2&#44; IFN-&#947; TNF-<span class="elsevierStyleItalic">&#945;</span>&#44; IL-1 and IL-6&#44; and also inhibits T lymphocyte activation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> This agent is effective for the induction and maintenance of remission in patients with MAS associated with rheumatic diseases&#44; even in the cases of severe and corticosteroid-resistant disease&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Early diagnosis is crucial since mortality remains high&#44; even in patients undergoing treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Here&#44; we present an unusual&#44; severe and life-threatening onset manifestation of SLE&#44; MAS&#46; Remission of the disease was achieved with corticosteroids and ciclosporine&#44; with no adverse events reported&#44; which corroborate the effectiveness&#44; and also the safety&#44; of this therapy&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Fever with constitutional symptoms and cytopenia can be clues to MAS and the level of suspicion should be high&#44; to guarantee an early diagnosis&#46; Looking for secondary causes of MAS&#44; such as rheumatic diseases&#44; is essential to ensure an accurate diagnosis and to select the appropriate treatment&#46; However&#44; a genetic predisposition can also exist and be related to dysregulated inflammasome activity &#40;e&#46;g&#46;&#44; NLRC4 gene&#41;&#44; and especially in situations with a positive family history of MAS&#44; this should be investigated&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare they have no conflict of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macrophage activation syndrome &#40;MAS&#41; is a potentially life-threatening complication of rheumatic diseases&#46; We report a unique case of a previously healthy 20-year-old female presenting with MAS as first presentation of systemic lupus erythematosus&#46; Remission was achieved with hydroxychloroquine&#44; intravenous methylprednisolone pulse followed by oral prednisolone and cyclosporine&#46; However&#44; the management of MAS is still challenging&#44; and the mortality rate remains high&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de activaci&#243;n macrof&#225;gica &#40;SAM&#41; es una complicaci&#243;n potencialmente letal de algunas enfermedades reum&#225;ticas&#46; Presentamos un caso &#250;nico de una mujer de 20 a&#241;os previamente sana que se present&#243; con SAM como primera manifestaci&#243;n de lupus eritematoso sist&#233;mico&#46; Se logr&#243; una remisi&#243;n completa con hidroxicloroquina&#44; pulsos intravenosos de metilprednisolona seguido de prednisolona oral y ciclosporina&#46; Sin embargo&#44; el manejo del SAM sigue siendo un desaf&#237;o y la tasa de mortalidad sigue siendo alta&#46;</p></span>"
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                      "titulo" => "Cyclosporine &#40;CsA&#41; in lupus nephritis&#58; assessing the evidence"
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                      "titulo" => "Efficacy of cyclosporine in the induction and maintenance of remission in a systemic lupus erythematosus patient presenting with macrophage-activating syndrome"
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ISSN: 1699258X
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