Estadísticas

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      "titulo" => "Implicaciones terapéuticas de la interleucina-17 en otras enfermedades y comorbilidades"
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      "titulo" => "Eficacia y seguridad de los fármacos inhibidores de la interleucina-17 en la artritis psoriásica"
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          "autoresLista" => "José Antonio Pinto Tasende"
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        "resumen" => "La interleucina 17A &#40;IL&#45;17A&#41; es una citocina producida por linfocitos T colaboradores &#40;Th17&#41; y otras c&#233;lulas del sistema inmune&#44; con efectos pleiotr&#243;picos sobre m&#250;ltiples estirpes celulares&#46; Mientras que su deficiencia produce una reducci&#243;n en el control de ciertas infecciones extracelulares y f&#250;ngicas&#44; su sobreproducci&#243;n puede constituir la base patog&#233;nica de varias enfermedades mediadas por el sistema inmune&#46; Aunque la eficacia del bloqueo terap&#233;utico de esta citocina es un hecho probado en varias enfermedades&#44; tambi&#233;n es importante conocer el rol de esta citocina en otras circunstancias cl&#237;nicas&#46; En este art&#237;culo de revisi&#243;n se describe el papel que desempe&#241;a la IL&#45;17A en la patogenia de algunas de las enfermedades con las que est&#225; relacionada&#44; como la psoriasis&#44; la enfermedad inflamatoria intestinal y la uve&#237;tis&#44; as&#237; como el riesgo de infecciones asociado al bloqueo o al d&#233;ficit gen&#233;tico de esta&#46;"
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        "resumen" => "Interleukin-17A &#40;IL&#45;17A&#41; is a cytokine produced by T helper lymphocytes &#40;Th17&#41; and other cells of the immune system&#44; with pleiotropic effects on a number of cell lines&#46; Whereas its deficiency reduces the control of certain extracellular and fungal infections&#44; its overproduction can constitute the pathogenic basis of a number of immune-mediated diseases&#46; Although the efficacy of the therapeutic blockade of this cytokine has been confirmed in several diseases&#44; it is also important to be aware of its involvement in other clinical circumstances&#46; In this review article&#44; we describe the role of IL&#45;17A in the pathogenesis of some of the diseases with which it is linked&#44; such as psoriasis&#44; inflammatory bowel disease and uveitis&#44; as well as the risk of infections associated with its blockade or its genetic deficiency&#46;"
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