array:23 [
  "pii" => "S1699258X05727054"
  "issn" => "1699258X"
  "doi" => "10.1016/S1699-258X(05)72705-4"
  "estado" => "S300"
  "fechaPublicacion" => "2005-05-01"
  "aid" => "72705"
  "copyright" => "Elsevier España S.L. Barcelona"
  "copyrightAnyo" => "2005"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Reumatol Clin. 2005;1:3-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3993
    "formatos" => array:3 [
      "EPUB" => 109
      "HTML" => 2649
      "PDF" => 1235
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1699258X05727066"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(05)72706-6"
    "estado" => "S300"
    "fechaPublicacion" => "2005-05-01"
    "aid" => "72706"
    "copyright" => "Elsevier España S.L. Barcelona"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2005;1:7-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4235
      "formatos" => array:3 [
        "EPUB" => 117
        "HTML" => 2983
        "PDF" => 1135
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>"
      "titulo" => "Osteoporosis en el var&#243;n con enfermedad pulmonar obstructiva cr&#243;nica&#46; Utilidad de la densitometr&#237;a de falange &#40;AccuDEXA&#41; como m&#233;todo de cribado diagn&#243;stico"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "7"
          "paginaFinal" => "11"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Osteoporosis in men with chronic obstructive pulmonary disease&#46; Utility of phalangeal densitometry &#40;AccuDEXA&#41; as a screening method"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Casado, M&#46; Larrosa, E&#46; Naval, M&#46; Gallego, A&#46; G&#243;mez, C&#46; Domingo, J&#46; Gratac&#243;s"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Casado"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Larrosa"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Naval"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Gallego"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "G&#243;mez"
            ]
            5 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Domingo"
            ]
            6 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Gratac&#243;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727066?idApp=UINPBA00004M"
    "url" => "/1699258X/0000000100000001/v1_201305061714/S1699258X05727066/v1_201305061714/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1699258X05727042"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(05)72704-2"
    "estado" => "S300"
    "fechaPublicacion" => "2005-05-01"
    "aid" => "72704"
    "copyright" => "Elsevier Espa&#241;a S&#46;L&#46; Barcelona"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Reumatol Clin. 2005;1:1"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3456
      "formatos" => array:3 [
        "EPUB" => 87
        "HTML" => 2182
        "PDF" => 1187
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Nota editorial</span>"
      "titulo" => "Reumatolog&#237;a cl&#237;nica&#46; Nuestra revista"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "1"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Laff&#243;n, J&#46; V&#225;zquez-Mellado"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Laff&#243;n"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "V&#225;zquez-Mellado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727042?idApp=UINPBA00004M"
    "url" => "/1699258X/0000000100000001/v1_201305061714/S1699258X05727042/v1_201305061714/es/main.assets"
  ]
  "es" => array:11 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> y gastroprotecci&#243;n"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "3"
        "paginaFinal" => "6"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "X&#46; Calvet, A&#46; Lanas"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "X&#46;"
            "apellidos" => "Calvet"
            "email" => array:1 [
              0 => "xcalvet&#64;cspt&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Lanas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unitat de Malalties Digestives&#46; Hospital de Sabadell&#46; Institut Universitari Parc Taul&#237;&#46; Universitat Aut&#242;noma de Barcelona&#46; Sabadell&#46; Barcelona&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Aparato Digestivo&#46; Hospital Cl&#237;nico Universitario&#46; Zaragoza&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Dr&#46; X&#46; Calvet&#46; Unitat de Malalties Digestives&#46; Hospital de Sabadell&#46; Institut Universitari Parc Taul&#237;&#44; UAB&#46; Parc Taul&#237;&#44; s&#47;n&#46; 08208 Sabadell&#46; Barcelona&#46; Espa&#241;a&#46;"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2004-05-26"
    "fechaAceptado" => "2004-05-30"
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:38 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent considerations in nonsteroidal anti-inflammatory drug gastropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Singh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1998"
                        "volumen" => "105"
                        "paginaInicial" => "31S"
                        "paginaFinal" => "38S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9715832"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gastrointestinal health care resource use and costs associated with nonsteroidal antiinflammatory drugs versus acetaminophen&#58; retrospective cohort study of an elderly population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Rahme"
                            1 => "L&#46; Joseph"
                            2 => "S&#46;X&#46; Kong"
                            3 => "D&#46;J&#46; Watson"
                            4 => "J&#46; LeLorier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200004)43:4<917::AID-ANR25>3.0.CO;2-F"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "43"
                        "paginaInicial" => "917"
                        "paginaFinal" => "924"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10765939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Excess costs from gastrointestinal disease associated with nonsteroidal anti-inflammatory drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;E&#46; Smalley"
                            1 => "M&#46;R&#46; Griffin"
                            2 => "R&#46;L&#46; Fought"
                            3 => "W&#46;A&#46; Ray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gen Intern Med"
                        "fecha" => "1996"
                        "volumen" => "11"
                        "paginaInicial" => "461"
                        "paginaFinal" => "469"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8872783"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio nacional sobre la mortalidad debida a complicaciones gastrointestinales asociadas al consumo de AINE"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Lanas"
                            1 => "M&#46; Andreu"
                            2 => "E&#46; Bajador"
                            3 => "L&#46; Rodrigo"
                            4 => "S&#46; Lorente"
                            5 => "A&#46; L&#243;pez-Morante"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Gastroenterol Hepatol"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "185"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cost stratification of nonsteroidal anti-inflammatory drug-associated gastrointestinal side effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Lanas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2000"
                        "volumen" => "114"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "46"
                        "paginaFinal" => "53"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical strategy to prevent the gastrointestinal adverse effects of nonsteroidal anti-inflammatory agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Lanas"
                            1 => "E&#46; Mart&#237;n-Mola"
                            2 => "J&#46; Ponce"
                            3 => "F&#46; Navarro"
                            4 => "J&#46;M&#46; Pique"
                            5 => "F&#46;J&#46; Blanco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterol Hepatol"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "485"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14534022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span>&#58; a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Heresbach"
                            1 => "J&#46;L&#46; Raoul"
                            2 => "J&#46;F&#46; Bretagne"
                            3 => "J&#46; Minet"
                            4 => "P&#46;Y&#46; Donnio"
                            5 => "M&#46;P&#46; Ramee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "1992"
                        "volumen" => "33"
                        "paginaInicial" => "1608"
                        "paginaFinal" => "1611"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1487160"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe gastric mucosal damage induced by NSAIDs in healthy subjects is associated with <span class="elsevierStyleItalic">Helicobacter pylori</span> infection and high levels of serum pepsinogens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Santucci"
                            1 => "S&#46; Fiorucci"
                            2 => "L&#46; Patoia"
                            3 => "F&#46;M&#46; Di Matteo"
                            4 => "P&#46;M&#46; Brunori"
                            5 => "A&#46; Morelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1995"
                        "volumen" => "40"
                        "paginaInicial" => "2074"
                        "paginaFinal" => "2080"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7555467"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term nonsteroidal antiinflammatory drug use and <span class="elsevierStyleItalic">Helicobacter pylori</span> infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;Y&#46; Graham"
                            1 => "M&#46;D&#46; Lidsky"
                            2 => "A&#46;M&#46; Cox"
                            3 => "D&#46;J&#46; Evans Jr"
                            4 => "D&#46;G&#46; Evans"
                            5 => "L&#46; Alpert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1991"
                        "volumen" => "100"
                        "paginaInicial" => "1653"
                        "paginaFinal" => "1657"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2019371"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term nonsteroidal anti-inflammatory drug use and gastroduodenal injury&#58; the role of <span class="elsevierStyleItalic">Helicobacter pylori</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;S&#46; Loeb"
                            1 => "N&#46;J&#46; Talley"
                            2 => "D&#46;A&#46; Ahlquist"
                            3 => "H&#46;A&#46; Carpenter"
                            4 => "A&#46;R&#46; Zinsmeister"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1992"
                        "volumen" => "102"
                        "paginaInicial" => "1899"
                        "paginaFinal" => "1905"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1587409"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Santolaria"
                            1 => "A&#46; Lanas"
                            2 => "R&#46; Benito"
                            3 => "M&#46; P&#233;rez-Aisa"
                            4 => "M&#46; Montoro"
                            5 => "R&#46; Sainz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aliment Pharmacol Ther"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "1511"
                        "paginaFinal" => "1518"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10571609"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> and risk of ulcer bleeding among users of nonsteroidal anti-inflammatory drugs&#58; a case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Aalykke"
                            1 => "J&#46;M&#46; Lauritsen"
                            2 => "J&#46; Hallas"
                            3 => "S&#46; Reinholdt"
                            4 => "K&#46; Krogfelt"
                            5 => "K&#46; Lauritsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "1305"
                        "paginaFinal" => "1309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10348813"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease&#58; a metaanalysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;Q&#46; Huang"
                            1 => "S&#46; Sridhar"
                            2 => "R&#46;H&#46; Hunt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(02)07273-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2002"
                        "volumen" => "359"
                        "paginaInicial" => "14"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11809181"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomised trial of eradication of <span class="elsevierStyleItalic">Helicobacter pylori</span> before non-steroidal antiinflammatory drug therapy to prevent peptic ulcers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Chan"
                            1 => "J&#46;J&#46; Sung"
                            2 => "S&#46;C&#46; Chung"
                            3 => "K&#46;F&#46; To"
                            4 => "M&#46;Y&#46; Yung"
                            5 => "V&#46;K&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1997"
                        "volumen" => "350"
                        "paginaInicial" => "975"
                        "paginaFinal" => "979"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9329511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eradication of <span class="elsevierStyleItalic">Helicobacter pylori</span> and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs&#58; a randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Chan"
                            1 => "K&#46;F&#46; To"
                            2 => "J&#46;C&#46; Wu"
                            3 => "M&#46;Y&#46; Yung"
                            4 => "W&#46;K&#46; Leung"
                            5 => "T&#46; Kwok"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2002"
                        "volumen" => "359"
                        "paginaInicial" => "9"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11809180"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in <span class="elsevierStyleItalic">Helicobacter pylori</span> positive patients&#58; a randomised&#44; double blind&#44; placebo controlled&#44; clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Labenz"
                            1 => "A&#46;L&#46; Blum"
                            2 => "W&#46;W&#46; Bolten"
                            3 => "B&#46; Dragosics"
                            4 => "W&#46; Rosch"
                            5 => "M&#46; Stolte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "329"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12171952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomised controlled trial of <span class="elsevierStyleItalic">Helicobacter pylori</span> eradication in patients on non-steroidal anti-inflammatory drugs&#58; HELP NSAIDs study&#46; <span class="elsevierStyleItalic">Helicobacter</span> Eradication for Lesion Prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;J&#46; Hawkey"
                            1 => "Z&#46; Tulassay"
                            2 => "L&#46; Szczepanski"
                            3 => "C&#46;J&#46; Van Rensburg"
                            4 => "A&#46; Filipowicz- Sosnowska"
                            5 => "A&#46; Lanas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1998"
                        "volumen" => "352"
                        "paginaInicial" => "1016"
                        "paginaFinal" => "1021"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9759744"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of treatment of <span class="elsevierStyleItalic">Helicobacter pylori</span> on the prevention of gastroduodenal ulcers in patients receiving long-term NSAIDs&#58; a double-blind&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Lai"
                            1 => "C&#46;S&#46; Lau"
                            2 => "W&#46;Y&#46; Ip"
                            3 => "B&#46;C&#46; Wong"
                            4 => "W&#46;M&#46; Hui"
                            5 => "W&#46;H&#46; Hu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aliment Pharmacol Ther"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "799"
                        "paginaFinal" => "805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12641502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Vergara M&#44; Catal&#225;n M&#44; Gisbert JP&#44; Calvet X&#46; Meta-analysis&#58; role of <span class="elsevierStyleItalic">Heliobacter pylori</span> eradication in the prevention of peptic ulcer in NSAID Users&#46; Aliment Pharmacol Ther&#46; 2005 &#40;En prensa&#41;&#46;"
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preventing recurrent upper gastrointestinal bleeding in patients with <span class="elsevierStyleItalic">Helicobacter pylori</span> infection who are taking low-dose aspirin or naproxen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Chan"
                            1 => "S&#46;C&#46; Chung"
                            2 => "B&#46;Y&#46; Suen"
                            3 => "Y&#46;T&#46; Lee"
                            4 => "W&#46;K&#46; Leung"
                            5 => "V&#46;K&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200103293441304"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "344"
                        "paginaInicial" => "967"
                        "paginaFinal" => "973"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11274623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lansoprazole reduces ulcer relapse after eradication of <span class="elsevierStyleItalic">Helicobacter pylori</span> in nonsteroidal anti&#8211;inflammatory drug users&#8211;a randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Lai"
                            1 => "S&#46;K&#46; Lam"
                            2 => "K&#46;M&#46; Chu"
                            3 => "W&#46;M&#46; Hui"
                            4 => "K&#46;F&#46; Kwok"
                            5 => "B&#46;C&#46; Wong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aliment Pharmacol Ther"
                        "fecha" => "2003"
                        "volumen" => "18"
                        "paginaInicial" => "829"
                        "paginaFinal" => "836"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14535877"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lansoprazole for the prevention of recurrences of ulcer complications from longterm low-dose aspirin use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Lai"
                            1 => "S&#46;K&#46; Lam"
                            2 => "K&#46;M&#46; Chu"
                            3 => "B&#46;C&#46; Wong"
                            4 => "W&#46;M&#46; Hui"
                            5 => "W&#46;H&#46; Hu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa012877"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "346"
                        "paginaInicial" => "2033"
                        "paginaFinal" => "2038"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12087138"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intragastric pH during treatment with omeprazole&#58; role of <span class="elsevierStyleItalic">Helicobacter pylori</span> and <span class="elsevierStyleItalic">H&#46; pylori</span>-associated gastritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;F&#46; Verdu"
                            1 => "D&#46; Armstrong"
                            2 => "J&#46;P&#46; Idstrom"
                            3 => "J&#46; Labenz"
                            4 => "M&#46; Stolte"
                            5 => "G&#46; Borsch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "1996"
                        "volumen" => "31"
                        "paginaInicial" => "1151"
                        "paginaFinal" => "1156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8976005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of curing <span class="elsevierStyleItalic">Helicobacter pylori</span> infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Labenz"
                            1 => "B&#46; Tillenburg"
                            2 => "U&#46; Peitz"
                            3 => "E&#46; Verdu"
                            4 => "M&#46; Stolte"
                            5 => "G&#46; Borsch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "1997"
                        "volumen" => "41"
                        "paginaInicial" => "33"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9274468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of omeprazole one year after cure of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection in duodenal ulcer patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Labenz"
                            1 => "B&#46; Tillenburg"
                            2 => "U&#46; Peitz"
                            3 => "G&#46; Borsch"
                            4 => "J&#46;P&#46; Idstrom"
                            5 => "E&#46; Verdu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1997"
                        "volumen" => "92"
                        "paginaInicial" => "576"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9128302"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs&#46; Omeprazole versus Misoprostol for NSAID-induced Ulcer Management &#40;OMNIUM&#41; Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;J&#46; Hawkey"
                            1 => "J&#46;A&#46; Karrasch"
                            2 => "L&#46; Szczepanski"
                            3 => "D&#46;G&#46; Walker"
                            4 => "A&#46; Barkun"
                            5 => "A&#46;J&#46; Swannell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803123381105"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "727"
                        "paginaFinal" => "734"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9494149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs&#46; Acid Suppression Trial&#58; Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment &#40;ASTRONAUT&#41; Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;D&#46; Yeomans"
                            1 => "Z&#46; Tulassay"
                            2 => "L&#46; Juhasz"
                            3 => "I&#46; Racz"
                            4 => "J&#46;M&#46; Howard"
                            5 => "C&#46;J&#46; Van Rensburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803123381104"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "719"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9494148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relative contribution of mucosal injury and <span class="elsevierStyleItalic">Helicobacter pylori</span> in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;J&#46; Hawkey"
                            1 => "J&#46; Naesdal"
                            2 => "I&#46; Wilson"
                            3 => "G&#46; Langstrom"
                            4 => "A&#46;J&#46; Swannell"
                            5 => "R&#46;A&#46; Peacock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "336"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12171953"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Critical effect of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection on the effectiveness of omeprazole for prevention of gastric or duodenal ulcers among chronic NSAID users"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;Y&#46; Graham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Helicobacter"
                        "fecha" => "2002"
                        "volumen" => "7"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12197903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acid inhibitory potency of twice a day omeprazole is not affected by eradication of <span class="elsevierStyleItalic">Helicobacter pylori</span> in healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Thomson"
                            1 => "M&#46; Keelan"
                            2 => "R&#46; Lastiwka"
                            3 => "S&#46; Appelman-Eszcuck"
                            4 => "L&#46; Zuk"
                            5 => "L&#46; Drozdowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Helicobacter"
                        "fecha" => "2003"
                        "volumen" => "8"
                        "paginaInicial" => "46"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12603616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esomeprazole prevents gastric and duodenal ulcers in at-risk patients on continuous non-selective or Cox-2 selective NSAID therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Scheiman"
                            1 => "N&#46; Vakil"
                            2 => "C&#46;J&#46; Hawkey"
                            3 => "N&#46;D&#46; Yeomans"
                            4 => "N&#46;J&#46; Talley"
                            5 => "F&#46;K&#46; Chan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "A"
                        "paginaFinal" => "82"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stratifying the risk of NSAID-related upper gastrointestinal clinical events&#58; results of a double-blind outcomes study in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Laine"
                            1 => "C&#46; Bombardier"
                            2 => "C&#46;J&#46; Hawkey"
                            3 => "B&#46; Davis"
                            4 => "D&#46; Shapiro"
                            5 => "C&#46; Brett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2002"
                        "volumen" => "123"
                        "paginaInicial" => "1006"
                        "paginaFinal" => "1012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12360461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;K&#46; Chan"
                            1 => "L&#46;C&#46; Hung"
                            2 => "B&#46;Y&#46; Suen"
                            3 => "J&#46;C&#46; Wu"
                            4 => "K&#46;C&#46; Lee"
                            5 => "V&#46;K&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021907"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "2104"
                        "paginaFinal" => "2110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12501222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eradication therapy for peptic ulcer disease in <span class="elsevierStyleItalic">Helicobacter pylori</span> positive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Ford"
                            1 => "B&#46; Delaney"
                            2 => "D&#46; Forman"
                            3 => "P&#46; Moayyedi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2003"
                        "paginaInicial" => "CD003840"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">H&#46; pylori</span> eradication therapy vs&#46; antisecretory non-eradication therapy &#40;with or without long-term maintenance antisecretory therapy&#41; for the prevention of recurrent bleeding from peptic ulcer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Gisbert"
                            1 => "S&#46; Khorrami"
                            2 => "F&#46; Carballo"
                            3 => "X&#46; Calvet"
                            4 => "E&#46; Gen&#233;"
                            5 => "J&#46; Dom&#237;nguez-Mu&#241;oz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/14651858.CD004062"
                      "Revista" => array:5 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2003"
                        "volumen" => "4"
                        "paginaInicial" => "CD004062"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14584003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Lanas"
                            1 => "L&#46; Rodrigo"
                            2 => "J&#46;L&#46; M&#225;rquez"
                            3 => "E&#46; Bajador"
                            4 => "F&#46; P&#233;rez-Roldan"
                            5 => "J&#46; Cabrol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "2003"
                        "volumen" => "38"
                        "paginaInicial" => "693"
                        "paginaFinal" => "700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12889553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Laine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "594"
                        "paginaFinal" => "606"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> and nonsteroidal anti-inflammatory drugs&#58; interaction with proton pump inhibitor therapy for prevention of nonsteroidal anti-inflammatory drug ulcers and ulcer complications &#8211;future research needs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;Y&#46; Graham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2001"
                        "volumen" => "110"
                        "paginaInicial" => "58S"
                        "paginaFinal" => "61S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11166000"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/1699258X/0000000100000001/v1_201305061714/S1699258X05727054/v1_201305061714/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17498"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000000100000001/v1_201305061714/S1699258X05727054/v1_201305061714/es/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727054?idApp=UINPBA00004M"
]
Compartir
Información de la revista
Vol. 1. Núm. 1.
Páginas 3-6 (mayo - junio 2005)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 1. Núm. 1.
Páginas 3-6 (mayo - junio 2005)
Editorial
Acceso a texto completo
Helicobacter pylori y gastroprotección
Visitas
7352
X. Calveta,
Autor para correspondencia
xcalvet@cspt.es

Correspondencia: Dr. X. Calvet. Unitat de Malalties Digestives. Hospital de Sabadell. Institut Universitari Parc Taulí, UAB. Parc Taulí, s/n. 08208 Sabadell. Barcelona. España.
, A. Lanasb
a Unitat de Malalties Digestives. Hospital de Sabadell. Institut Universitari Parc Taulí. Universitat Autònoma de Barcelona. Sabadell. Barcelona. España
b Servicio de Aparato Digestivo. Hospital Clínico Universitario. Zaragoza. España
Este artículo ha recibido
Información del artículo
El Texto completo está disponible en PDF
Bibliografía
[1.]
G. Singh.
Recent considerations in nonsteroidal anti-inflammatory drug gastropathy.
Am J Med, 105 (1998), pp. 31S-38S
[2.]
E. Rahme, L. Joseph, S.X. Kong, D.J. Watson, J. LeLorier.
Gastrointestinal health care resource use and costs associated with nonsteroidal antiinflammatory drugs versus acetaminophen: retrospective cohort study of an elderly population.
[3.]
W.E. Smalley, M.R. Griffin, R.L. Fought, W.A. Ray.
Excess costs from gastrointestinal disease associated with nonsteroidal anti-inflammatory drugs.
J Gen Intern Med, 11 (1996), pp. 461-469
[4.]
A. Lanas, M. Andreu, E. Bajador, L. Rodrigo, S. Lorente, A. López-Morante, et al.
Estudio nacional sobre la mortalidad debida a complicaciones gastrointestinales asociadas al consumo de AINE.
Gastroenterol Hepatol, 27 (2004), pp. 185
[5.]
A. Lanas.
Cost stratification of nonsteroidal anti-inflammatory drug-associated gastrointestinal side effects.
Med Clin (Barc), 114 (2000), pp. 46-53
[6.]
A. Lanas, E. Martín-Mola, J. Ponce, F. Navarro, J.M. Pique, F.J. Blanco.
Clinical strategy to prevent the gastrointestinal adverse effects of nonsteroidal anti-inflammatory agents.
Gastroenterol Hepatol, 26 (2003), pp. 485-502
[7.]
D. Heresbach, J.L. Raoul, J.F. Bretagne, J. Minet, P.Y. Donnio, M.P. Ramee, et al.
Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.
Gut, 33 (1992), pp. 1608-1611
[8.]
L. Santucci, S. Fiorucci, L. Patoia, F.M. Di Matteo, P.M. Brunori, A. Morelli.
Severe gastric mucosal damage induced by NSAIDs in healthy subjects is associated with Helicobacter pylori infection and high levels of serum pepsinogens.
Dig Dis Sci, 40 (1995), pp. 2074-2080
[9.]
D.Y. Graham, M.D. Lidsky, A.M. Cox, D.J. Evans Jr, D.G. Evans, L. Alpert, et al.
Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection.
Gastroenterology, 100 (1991), pp. 1653-1657
[10.]
D.S. Loeb, N.J. Talley, D.A. Ahlquist, H.A. Carpenter, A.R. Zinsmeister.
Long-term nonsteroidal anti-inflammatory drug use and gastroduodenal injury: the role of Helicobacter pylori.
Gastroenterology, 102 (1992), pp. 1899-1905
[11.]
S. Santolaria, A. Lanas, R. Benito, M. Pérez-Aisa, M. Montoro, R. Sainz.
Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users.
Aliment Pharmacol Ther, 13 (1999), pp. 1511-1518
[12.]
C. Aalykke, J.M. Lauritsen, J. Hallas, S. Reinholdt, K. Krogfelt, K. Lauritsen.
Helicobacter pylori and risk of ulcer bleeding among users of nonsteroidal anti-inflammatory drugs: a case-control study.
Gastroenterology, 116 (1999), pp. 1305-1309
[13.]
J.Q. Huang, S. Sridhar, R.H. Hunt.
Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a metaanalysis.
[14.]
F.K. Chan, J.J. Sung, S.C. Chung, K.F. To, M.Y. Yung, V.K. Leung, et al.
Randomised trial of eradication of Helicobacter pylori before non-steroidal antiinflammatory drug therapy to prevent peptic ulcers.
Lancet, 350 (1997), pp. 975-979
[15.]
F.K. Chan, K.F. To, J.C. Wu, M.Y. Yung, W.K. Leung, T. Kwok, et al.
Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial.
Lancet, 359 (2002), pp. 9-13
[16.]
J. Labenz, A.L. Blum, W.W. Bolten, B. Dragosics, W. Rosch, M. Stolte, et al.
Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients: a randomised, double blind, placebo controlled, clinical trial.
Gut, 51 (2002), pp. 329-335
[17.]
C.J. Hawkey, Z. Tulassay, L. Szczepanski, C.J. Van Rensburg, A. Filipowicz- Sosnowska, A. Lanas, et al.
Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention.
Lancet, 352 (1998), pp. 1016-1021
[18.]
K.C. Lai, C.S. Lau, W.Y. Ip, B.C. Wong, W.M. Hui, W.H. Hu, et al.
Effect of treatment of Helicobacter pylori on the prevention of gastroduodenal ulcers in patients receiving long-term NSAIDs: a double-blind, placebo-controlled trial.
Aliment Pharmacol Ther, 17 (2003), pp. 799-805
[19.]
Vergara M, Catalán M, Gisbert JP, Calvet X. Meta-analysis: role of Heliobacter pylori eradication in the prevention of peptic ulcer in NSAID Users. Aliment Pharmacol Ther. 2005 (En prensa).
[20.]
F.K. Chan, S.C. Chung, B.Y. Suen, Y.T. Lee, W.K. Leung, V.K. Leung, et al.
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.
N Engl J Med, 344 (2001), pp. 967-973
[21.]
K.C. Lai, S.K. Lam, K.M. Chu, W.M. Hui, K.F. Kwok, B.C. Wong, et al.
Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti–inflammatory drug users–a randomized trial.
Aliment Pharmacol Ther, 18 (2003), pp. 829-836
[22.]
K.C. Lai, S.K. Lam, K.M. Chu, B.C. Wong, W.M. Hui, W.H. Hu, et al.
Lansoprazole for the prevention of recurrences of ulcer complications from longterm low-dose aspirin use.
N Engl J Med, 346 (2002), pp. 2033-2038
[23.]
E.F. Verdu, D. Armstrong, J.P. Idstrom, J. Labenz, M. Stolte, G. Borsch, et al.
Intragastric pH during treatment with omeprazole: role of Helicobacter pylori and H. pylori-associated gastritis.
Scand J Gastroenterol, 31 (1996), pp. 1151-1156
[24.]
J. Labenz, B. Tillenburg, U. Peitz, E. Verdu, M. Stolte, G. Borsch, et al.
Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer.
Gut, 41 (1997), pp. 33-36
[25.]
J. Labenz, B. Tillenburg, U. Peitz, G. Borsch, J.P. Idstrom, E. Verdu, et al.
Efficacy of omeprazole one year after cure of Helicobacter pylori infection in duodenal ulcer patients.
Am J Gastroenterol, 92 (1997), pp. 576-581
[26.]
C.J. Hawkey, J.A. Karrasch, L. Szczepanski, D.G. Walker, A. Barkun, A.J. Swannell, et al.
Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group.
N Engl J Med, 338 (1998), pp. 727-734
[27.]
N.D. Yeomans, Z. Tulassay, L. Juhasz, I. Racz, J.M. Howard, C.J. Van Rensburg, et al.
A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group.
N Engl J Med, 338 (1998), pp. 719-726
[28.]
C.J. Hawkey, J. Naesdal, I. Wilson, G. Langstrom, A.J. Swannell, R.A. Peacock, et al.
Relative contribution of mucosal injury and Helicobacter pylori in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs.
Gut, 51 (2002), pp. 336-343
[29.]
D.Y. Graham.
Critical effect of Helicobacter pylori infection on the effectiveness of omeprazole for prevention of gastric or duodenal ulcers among chronic NSAID users.
Helicobacter, 7 (2002), pp. 1-8
[30.]
A.B. Thomson, M. Keelan, R. Lastiwka, S. Appelman-Eszcuck, L. Zuk, L. Drozdowski, et al.
Acid inhibitory potency of twice a day omeprazole is not affected by eradication of Helicobacter pylori in healthy volunteers.
Helicobacter, 8 (2003), pp. 46-58
[31.]
J.M. Scheiman, N. Vakil, C.J. Hawkey, N.D. Yeomans, N.J. Talley, F.K. Chan, et al.
Esomeprazole prevents gastric and duodenal ulcers in at-risk patients on continuous non-selective or Cox-2 selective NSAID therapy.
Gastroenterology, 126 (2004), pp. A-82
[32.]
L. Laine, C. Bombardier, C.J. Hawkey, B. Davis, D. Shapiro, C. Brett, et al.
Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis.
Gastroenterology, 123 (2002), pp. 1006-1012
[33.]
F.K. Chan, L.C. Hung, B.Y. Suen, J.C. Wu, K.C. Lee, V.K. Leung, et al.
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis.
N Engl J Med, 347 (2002), pp. 2104-2110
[34.]
A. Ford, B. Delaney, D. Forman, P. Moayyedi.
Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients.
Cochrane Database Syst Rev, (2003), pp. CD003840
[35.]
J. Gisbert, S. Khorrami, F. Carballo, X. Calvet, E. Gené, J. Domínguez-Muñoz.
H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.
Cochrane Database Syst Rev, 4 (2003), pp. CD004062
[36.]
A. Lanas, L. Rodrigo, J.L. Márquez, E. Bajador, F. Pérez-Roldan, J. Cabrol, et al.
Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole.
Scand J Gastroenterol, 38 (2003), pp. 693-700
[37.]
L. Laine.
Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient.
Gastroenterology, 120 (2001), pp. 594-606
[38.]
D.Y. Graham.
Helicobacter pylori and nonsteroidal anti-inflammatory drugs: interaction with proton pump inhibitor therapy for prevention of nonsteroidal anti-inflammatory drug ulcers and ulcer complications –future research needs.
Am J Med, 110 (2001), pp. 58S-61S
Copyright © 2005. Elsevier España S.L. Barcelona
Idiomas
Reumatología Clínica
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?