Al final del manuscrito se ofrece la relación de miembros del Panel de Expertos de la SER.
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Vol. 1. Núm. 1.
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Vol. 1. Núm. 1.
Páginas 38-48 (mayo - junio 2005)
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Primer documento de consenso de la Sociedad Española de Reumatología sobre el tratamiento farmacológico de la artrosis de rodilla
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F.J. Blanco
, Panel de Expertos de la Sociedad Española de Reumatología (SER) *
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francisco_blanco@canalejo.org
Correspondencia: Dr. F.J. Blanco. Servicio de Reumatología. CH. Universitario Juan Canalejo. Xubias, P4. 15006 A Coruña. España.
Correspondencia: Dr. F.J. Blanco. Servicio de Reumatología. CH. Universitario Juan Canalejo. Xubias, P4. 15006 A Coruña. España.
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Bibliografía
[1.]
M.C. Hochberg, R.D. Altman, K. Brandt, B. Clark, P. Dieppe, M. Griffin, et al.
Guidelines for the medical management of osteoarthritis.
Arthritis and Rheumatism, 38 (1995), pp. 1541-1546
[2.]
R.D. Altman, M.C. Hochberg, R.V. Moskowitz, T.J. Schnitzer.
American College of Rheumatology subcommittee on osteoarthritis guidelines.
Arthritis Rheumatism, 43 (2000), pp. 1905-1915
[3.]
A. Pendleton, N. Arden, M. Dougados, M. Doherty, B. Bannwarth, J.W. Bijlsma, et al.
EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT).
Ann Rheum Dis, 59 (2000), pp. 936-944
[4.]
K.M. Jordan, K.M. Arden, M. Doherthy, B. Bannwarth, J.W. Bijlsma, P. Dieppe, et al.
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT).
Ann Rheum Dis, 62 (2003), pp. 1145-1155
[5.]
A.R. Jadad, H.J. McQuay.
Meta-analyses to evaluate analgesic interventions: a systematic qualitative review of their methodology.
J Clin Epidemiol, 49 (1996), pp. 235-243
[6.]
A.D. Oxman, D.J. Cook, G.H. Guyatt.
Users’ guides to the medical literature. VI. How to use an overview. Evidence-Based Medicine Working Group.
JAMA, 272 (1994), pp. 1367-1371
[7.]
A. Laupacis, G. Wells, W.S. Richardson, P. Tugwell.
Users’ guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group.
JAMA, 272 (1994), pp. 234-237
[8.]
M. Levine, S. Walter, H. Lee, T. Haines, A. Holbrook, V. Moyer.
Users’ guides to the medical literature. IV. How to use an article about harm. Evidence-Based Medicine Working Group.
JAMA, 271 (1994), pp. 1615-1619
[9.]
G.H. Guyatt, D.L. Sackett, D.J. Cook.
Users’ guides to the medical literature. II. How to use an article about therapy or prevention. B. What were the results and will they help me in caring for my patients? Evidence-Based Medicine Working Group.
JAMA, 271 (1994), pp. 59-63
[10.]
G.H. Guyatt, D.L. Sackett, D.J. Cook.
Users’ guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group.
JAMA, 270 (1993), pp. 2598-2601
[11.]
T.E. Towheed, M.J. Judd, M.C. Hochberg, G. Wells.
Acetaminophen for osteoarthritis.
The Cochrane database of systematic reviews, 2 (2004),
[12.]
A. Wegman, D. Van der Windt, M. Van Tulder, W. Stalman, T. De Vries.
Nonsteroidal anti-inflammatory drugs or acetaminophen for osteoarthritis of the hip or knee? A systematic review of evidence and guidelines.
J Rheumatol, 31 (2004), pp. 344-354
[13.]
E. Eccles.
Non-steroidal anti-inflammatory drug guideline development Group.
BMJ, 317 (1998), pp. 526-530
[14.]
J.D. Bradley, B.P. Katz, K.D. Brandt.
Severity of knee pain does not predict a better response to an anti-inflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.
J Rheumatol, 28 (2001), pp. 1073-1076
[15.]
T. Pincus, C. Swearingen, P. Cummings, L.F. Callahan.
Preference for no steroidal ant inflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis.
J Rheumatol, 27 (2000), pp. 1020-1027
[16.]
F. Wolfe, D. Zhao, N. Lane.
Preference for no steroidal anti-inflammatory drugs over acetominophen by rheumatic disease patients: a survey of 1799 patients with osteoarthritis, rheumatoid arthritis and fibromyalgia.
Arthritis Rheum, 43 (2000), pp. 378-385
[17.]
H.J. Williams, J.R. Ward, M.J. Egger, R. Neuner, R.H. Brooks, D.O. Clegg, et al.
Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee.
Arthritis Rheum, 36 (1993), pp. 1196-1206
[18.]
G.P. Geba, A.L. Weaver, A.B. Polis, M.E. Dixon, T.J. Schnitzer.
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
JAMA, 287 (2002), pp. 64-71
[19.]
W. Zhang, A. Jones, M. Doherty.
Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials.
Ann Rheum Dis, 63 (2004), pp. 901-907
[20.]
R. Neame, W. Zhang, M. Doherty.
A historic issue of the Annals: three papers examine paracetamol in osteoarthritis.
Ann Rheum Dis, 63 (2004), pp. 897-900
[21.]
J.P. Case, A.J. Baliunas, J.A. Block.
Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium.
Arch Intern Med, 163 (2003), pp. 169-178
[22.]
T. Pincus, G. Koch, H. Lei, B. Mangal, T. Sokka, R. Moskowitz, et al.
Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis.
Ann Rheum Dis, 63 (2004), pp. 931-939
[23.]
F. Boureau, H. Schneid, N. Zeghari, R. Wall, P. Bourgeois, The IPSO study: ibuprofen, paracetamol study in osteoarthritis.
A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip.
Ann Rheum Dis, 63 (2004), pp. 1028-1034
[24.]
T.E. Towheed, M.J. Judd, M.C. Hochberg, G. Wells.
Acetaminophen for osteoarthritis.
The Cochrane database of systematic reviews, 2 (2004),
[25.]
A.A. Bookman, K.S. Williams, J.Z. Shainhouse.
Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial.
CMAJ, 171 (2004), pp. 333-338
[26.]
P. Bruhlmann, B.A. Michel.
Topical diclofenac patch in patients with knee osteoarthritis: a randomized, double-blind, controlled clinical trial.
Clin Exp Rheumatol, 21 (2003), pp. 193-198
[27.]
D.J. Dickson.
A double-blind evaluation of topical piroxicam gel with oral ibuprofen in osteoarthritis of th knee.
Curr Ther Res, 49 (1991), pp. 199-207
[28.]
R.L. Dreiser, M. Tisne-Camus.
DHEP plasters as a topical treatment of knee osteoarthritis–a double-blind placebo-controlled study.
Drugs Exp Clin Res, 19 (1993), pp. 117-123
[29.]
D. Grace, J. Rogers, K. Skeith, K. Anderson.
Topical diclofenac versus placebo: a double blind, randomized clinical trial in patients with osteoarthritis of the knee.
J Rheumatol, 26 (1999), pp. 2659-2663
[30.]
C.A. Heyneman, C. Lawless-Liday, G.C. Wall.
Oral versus topical NSAIDs in rheumatic diseases: a comparison.
Drugs, 60 (2000), pp. 555-574
[31.]
S.G. Kilminster, G.P. Mould.
Comparison of diclofenac spray and gel on knee joints of patients with osteoarthritic pain.
Clinical Drug Investigation, 18 (1999), pp. 345-354
[32.]
N.J. Koenen, R.F. Haag, P. Bias, P. R.ose.
Percutaneous therapy of activated osteoarthritis of the knee - comparison between DMSO and diclofenac.
Munchener Medizinische Wochenschrift, 138 (1996), pp. 534-538
[33.]
E. Kozanoglu, S. Basaran, R. Guzel, F. Guler-Uysal.
Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis.
Swiss Med Wkly, 133 (2003), pp. 333-338
[34.]
J. Lin, W. Zhang, A. Jones, M. Doherty.
Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials.
BMJ, 329 (2004), pp. 324
[35.]
R.A. Moore, M.R. Tramer, D. Carroll, P.J. Wiffen, H.J. McQuay.
Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs.
BMJ, 316 (1998), pp. 333-338
[36.]
E.D. Rosenstein.
Topical agents in the treatment of rheumatic disorders.
Rheum Dis Clin North Am, 25 (1999), pp. 899-918
[37.]
S.H. Roth.
A controlled clinical investigation of 3% diclofenac/2.5% sodium hyaluronate topical gel in the treatment of uncontrolled pain in chronic oral NSAID users with osteoarthritis.
Int J Tissue React, 17 (1995), pp. 129-132
[38.]
J. Rovensky, D. Micekova, Z. Gubzova, R. Fimmers, G. Lenhard, U. Vogtle-Jumkert, et al.
Treatment of knee osteoarthritis with a topical non-steroidal anti-inflammatory drug. Results of a randomized, double blind, placebo-controlled study on the efficacy and safety of a 5% ibuprofen cream.
Drugs Exp Clin Res, 27 (2001), pp. 209-221
[39.]
H. Shimojo, M. Kaneko, H. Saito, Y. Onuma, K. Yamashita.
Clinical evaluation of felbinac patch (SELSPOT) on osteoarthritis of the knee: clinical comparative study versus commercially available patch.
Japanese Pharmacology & Therapeutics, 27 (1999), pp. 63-74
[40.]
K. Trnavsky, M. Fischer, U. Vogtle-Junkert, F. Schreyger.
Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double blind, placebo-controlled study.
J Rheumatol, 31 (2004), pp. 565-572
[41.]
R.A. Van Haselen, P.A. Fisher.
A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee.
Rheumatology (Oxford), 39 (2000), pp. 714-719
[42.]
S. Waikakul, P. Penkitti, K. Soparat, W. Boonsanong.
Topical analgesics for knee arthrosis: a parallel study of ketoprofen gel and diclofenac emulgel.
J Med Assoc Thai, 80 (1997), pp. 593-597
[43.]
G.J. Algozzine, G.H. Stein, P.L. Doering, O.E. Araujo, K.C. Akin.
Trolamine salicylate cream in osteoarthritis of the knee.
JAMA, 247 (1982), pp. 1311-1313
[44.]
B. Ottillinger, B. Gomor, B.A. Michel, K. Pavelka, W. Beck, U. Elsasser.
Efficacy and safety of eltenac gel in the treatment of knee osteoarthritis.
Osteoarthritis Cartilage, 9 (2001), pp. 273-280
[45.]
J. Sandelin, A. Harilainen, H. Crone, P. Hamberg, B. Forsskahl, G. Tamelander.
Local NSAID gel (eltenac) in the treatment of osteoarthritis of the knee. A double blind study comparing eltenac with oral diclofenac and placebo gel.
Scand J Rheumatol, 26 (1997), pp. 287-292
[46.]
L. Long, K. Soeken, E. Ernst.
Herbal medicines for the treatment of osteoarthritis: a systematic review.
Rheumatology (Oxford), 40 (2001), pp. 779-793
[47.]
R.D. Altman, K.C. Marcussen.
Effects of a ginger extract on knee pain in patients with osteoarthritis.
Arthritis Rheum, 44 (2001), pp. 2531-2538
[48.]
C.V. Little, T. Parsons, S. Logan.
Tratamiento a base de hierbas para la osteoarthritis.
La Cochrane Library plus en español, Update Software, (2005),
[49.]
R. Emkey, N. Rosenthal, W. Shu-Chen, D. Jordan, M. Kamin, For the CAPPS-114 Study Group.
Efficacy and safety of Tramadol/Acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjetsreceiving a COX-2 nonsteroidal anti-inflammatory drug: a multicenter, randomized, double blind, placebo-controlled trial.
J Rheumatol, 31 (2004), pp. 150-156
[50.]
W.S. Mullican, J.R. Lacy.
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
Clin Ther, 23 (2001), pp. 1429-1445
[51.]
J.C. Silverfield, M. Kamin, W. Shu-Chen, N. Rosenthal, For the CAPPS-105 Study Group.
Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomised, double blind, placebo-controlled, parallel group, add-on study.
Clin Ther, 24 (2002), pp. 282-297
[52.]
L. Adler, C. McDonald, C. O’Brien, M. Wilson.
A comparison of oncedaily tramadol with normal release tramadol in the treatment of pain in osteoarthritis.
J Rheumatol, 29 (2002), pp. 2196-2199
[53.]
B. Bodalia, C.J. McDonald, K.J. Smith, C. O’Brien, L. Cousens.
A comparison of the pharmacokinetics, clinical efficacy, and tolerability of once-daily tramadol tablets with normal release tramadol capsules.
J Pain Symptom Manage, 25 (2003), pp. 142-149
[54.]
S.H. Roth.
Efficacy and safety of tramadol HC1 in breakthrough musculoskeletal pain attributed to osteoarthritis.
J Rheumatol, 25 (1998), pp. 1358-1363
[55.]
T.J. Schnitzer, M. Kamin, W.H. Olson.
Tramadol allows reduction of naproxen dose among patients with naproxen-responsive osteoarthritis pain. A randomised, double blind, placebo-controlled study.
Arthritis Rheum, 42 (1999), pp. 1370-1377
[56.]
J.R. Caldwell, R.J. Rapoport, J.C. Davis, H.L. Offenberg, H.W. Moober, S.H. Roth, et al.
Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomised, placebo-controlled, double-blind trial and an open-label extension trial.
J Pain Symptom Manage, 23 (2002), pp. 278-291
[57.]
J.Y. Reginster, R. Deroisy, L.C. Rovati, R.L. Lee, E. Lejeune, O. Bruyere, et al.
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.
Lancet, 357 (2001), pp. 251-256
[58.]
K. Pavelka, J. Gatterova, M. Olejarova, S. Machacek, G. Giacovelli, L.C. Rovati.
Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomised, placebo-controlled, double-blind study.
Arch Intern Med, 162 (2002), pp. 2113-2123
[59.]
R. Hughes, A. Carr.
A randomised, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.
Rheumatology (Oxford), 41 (2002), pp. 279-284
[60.]
J.P. Rindone, D. Hiller, E. Collacott, N. Nordhaugen, G. Arriola.
Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee.
West J Med, 172 (2000), pp. 91-94
[61.]
T.E. Towheed, T.P. Anastassiades, B. Shea, J. Houpt, V. Welch, M.C. Hochberg.
Glucosamine therapy for treating osteoarthritis.
Cochrane Database Syst Rev, 1 (2001),
[62.]
F. Richy, O. Bruyere, O. Ethgen, M. Cucherat, Y. Henrotin, J.Y. Reginster.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
Arch Intern Med, 163 (2003), pp. 1514-1522
[63.]
O. Bruyere, S. Compere, L.C. Rovati, G. Giacovelli, R. Deroisy, J.Y. Reginster.
Five-year follow-up of patients from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis.
ACR, 48 (2003), pp. S80
[64.]
T.E. Towheed.
Published meta-analyses of pharmacological therapies for osteoarthritis.
Osteoarthritis Cartilage, 11 (2002), pp. 836-837
[65.]
T.E. McAlindon, M.P. LaValley, J.P. Gulin, D.T. Felson.
Glucosamine and chondroitin for treatment of osteoarthritis: a quality systematic quality assessment and meta-analysis.
JAMA, 283 (2000), pp. 1469-1475
[66.]
B.F. Leeb, H. Schweitzer, K. Montag, J.S. Smolen.
A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis.
J Rheumatol, 27 (2000), pp. 205-211
[67.]
D. Uebelhart, M. Mabise, R. Marcolengo, F. De Vathaire, M. Piperno, E. Mailleux, et al.
Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year randomised, double-blind, multicenter study versus placebo.
Osteoarthritis Cartilage, 12 (2004), pp. 269-276
[68.]
D. Uebelhart, E.J. Thonar, P.D. Delmas, A. Chantraine, E. Vignon.
Effects of oral chondroitin sulfate on the progression of knee osteoarthritis a pilot study.
Osteoarthritis Cartilage, 6 (1998), pp. 39-46
[69.]
B.A. Michel, G. Stucki, H. Haenselmann, D. Frey, F. De Vathaire, E. Vignon, et al.
Retardation of knee joint space narrowing through chondroitin 4&6 sulphate.
ACR, (2003),
[70.]
J.P. Pelletier, M. Yaron, B. Haraoui, P. Cohen, M. Nahir, D. Choquette, et al.
Efficacy and safety of diacerein in the osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.
Arthritis Rheum, 43 (2000), pp. 2339-2348
[71.]
T. Pham, A. Le Henanff, P. Ravaud, P. Dieppe, L. Paolozzi, M. Dougados.
Evaluation of symptomatic and structural efficacy of a new hyaluronic acid (HA) compound, (NRD101), compared to diacerein and placebo in a one-year randomized controlled study in symptomatic knee osteoarthritis.
Ann Rheum Dis, 26 (2004), pp. 1611-1617
[72.]
R.J. Petrella, M.D. DiSilvestro, C. Hildebrand.
Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial.
Archives of Internal Medicine, 162 (2002), pp. 292-298
[73.]
M.E. Adams, M.H. Atkinson, A.J. Lussier, J. Schulz, K.A. Siminovitch, J.P. Wade, et al.
The role of viscosupplementation with hylan g-f 20 (synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan g-f 20 alone, hylan g-f 20 with non-steroidal anti-inflammatory drugs (nsaids) and nsaids alone.
Osteoarthritis Cartilage, 3 (1995), pp. 213-225
[74.]
R. Day, P. Brooks, P.G. Conaghan, M. Petersen, Multicenter Trial Group.
A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee.
J Rheumatol, 31 (2004), pp. 775-782
[75.]
D. Caborn, J. Rush, W. Lanzer, D. Parenti, C. Murray, Synvisc 901 Study Group.
A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee.
J Rheumatol, 31 (2004), pp. 333-343
[76.]
J.P. Raynauld, G.W. Torrance, P.A. Band, C.H. Goldsmith, P. Tugwell, V. Walker, Canadian Knee OA Study Group, et al.
A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with knee osteoarthritis (Part 1 of 2): clinical results.
Osteoarthritis Cartilage, 10 (2002), pp. 506-517
[77.]
C.T. Wang, J. Lin, C.J. Chang, Y.T. Lin, S.M. Hou.
Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials.
J Bone Joint Surg Am, 86-A (2004), pp. 538-545
[78.]
G.H. Lo, M. LaValley, T. McAlindon, D.T. Felson.
Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis.
JAMA, 290 (2003), pp. 3115-3121
[79.]
E. Maheu, X. Ayral, M. Dougados.
A hyaluronan preparation (500-730 kDa) in the treatment of osteoarthritis: a review of clinical trials with Hyalgan.
Int J Clin Pract, 56 (2002), pp. 804-813
[80.]
M. Espallergues, J.M. Pons.
Efficacy and Safety of viscosupplementation with Hylan G-F 20 for the treatment of knee osteoarthritis: a systematic review.
Int J Technol Assess Health Care, 19 (2003), pp. 41-56
[81.]
N. Bellamy, J. Campbell, G. Wells, R. Bourne.
Viscosupplementation for osteoarthritis of the knee (Protocol for a Cochrane Review).
The Cochrane Library, Issue 3, John Willey & Sons, Ltd, (2004),
[82.]
J.R. Kirwan, E. Rankin.
Intra-articular therapy in osteoarthritis.
Baillieres Clin Rheumatol, 11 (1997), pp. 769-794
[83.]
J.P. Raynauld, C. Buckland-Wright, R. Ward, D. Choquette, B. Haraoui, J. Martel-Pelletier, et al.
Safety and efficacy of long-term intra-articular steroid injections in osteoarthritis of the knee.
Arthritis Rheum, 48 (2003), pp. 370-377
[84.]
S.S. Leopold, B.B. Redd, W.J. Warme, P.A. Wehrle, P.D. Pettis, S. Shott.
Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee.
J Bone Joint Surg, 85-A (2003), pp. 1197-1203
[85.]
J.M. Williams, K.D. Brandt.
Trimacinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage.
Arthritis Rheum, 11 (1985), pp. 1267-1274
[86.]
J.P. Pelletier, F. Mineau, J.P. Raylnaud, J.F. Woessner, R. Gunja-Smith, J. Martel-Pelletier.
Intra-articular injection with methylprednisolone acetate reduced osteoarthritis lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis.
Arthritis Rheum, 37 (1994), pp. 414-423
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