array:23 [
  "pii" => "S1699258X05727698"
  "issn" => "1699258X"
  "doi" => "10.1016/S1699-258X(05)72769-8"
  "estado" => "S300"
  "fechaPublicacion" => "2005-12-01"
  "aid" => "72769"
  "copyright" => "Elsevier España S.L. Barcelona"
  "copyrightAnyo" => "2005"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Reumatol Clin. 2005;1 Supl 2:S16-23"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 7658
    "formatos" => array:3 [
      "EPUB" => 86
      "HTML" => 4745
      "PDF" => 2827
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1699258X05727704"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(05)72770-4"
    "estado" => "S300"
    "fechaPublicacion" => "2005-12-01"
    "aid" => "72770"
    "copyright" => "Elsevier España S.L. Barcelona"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2005;1 Supl 2:S24-41"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9038
      "formatos" => array:3 [
        "EPUB" => 95
        "HTML" => 7614
        "PDF" => 1329
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Novedades terap&#233;uticas en reumatolog&#237;a</span>"
      "titulo" => "Eficacia de los agentes biol&#243;gicos en la espondilitis anquilosante"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "S24"
          "paginaFinal" => "S41"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Burgos-Vargas, J&#46; Braun, J&#46;C&#46; Casasola-Vargas, J&#46; Sieper"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Burgos-Vargas"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Braun"
            ]
            2 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Casasola-Vargas"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Sieper"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727704?idApp=UINPBA00004M"
    "url" => "/1699258X/00000001000000S2/v1_201305061724/S1699258X05727704/v1_201305061724/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1699258X05727686"
    "issn" => "1699258X"
    "doi" => "10.1016/S1699-258X(05)72768-6"
    "estado" => "S300"
    "fechaPublicacion" => "2005-12-01"
    "aid" => "72768"
    "copyright" => "Elsevier Espa&#241;a S&#46;L&#46; Barcelona"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2005;1 Supl 2:S8-S15"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 20791
      "formatos" => array:3 [
        "EPUB" => 98
        "HTML" => 7837
        "PDF" => 12856
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Novedades terap&#233;uticas en reumatolog&#237;a</span>"
      "titulo" => "Enfoque terap&#233;utico actual de la osteoartritis"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "S8"
          "paginaFinal" => "S15"
        ]
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Espinoza-Morales, M&#46;E&#46; P&#233;rez-Bastidas"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Espinoza-Morales"
            ]
            1 => array:2 [
              "nombre" => "M&#46;E&#46;"
              "apellidos" => "P&#233;rez-Bastidas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727686?idApp=UINPBA00004M"
    "url" => "/1699258X/00000001000000S2/v1_201305061724/S1699258X05727686/v1_201305061724/es/main.assets"
  ]
  "es" => array:9 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Novedades terap&#233;uticas en reumatolog&#237;a</span>"
    "titulo" => "Tratamiento de la artritis de inicio reciente"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "S16"
        "paginaFinal" => "S23"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; V&#225;zquez-Mellado, J&#46; Rojas-Serrano"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "V&#225;zquez-Mellado"
            "email" => array:1 [
              0 => "jvazquezmellado&#64;prodigy&#46;net&#46;mx"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Rojas-Serrano"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Reumatolog&#237;a&#46; Hospital General de M&#233;xico&#46; M&#233;xico DF&#46; M&#233;xico"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia&#58; Dra&#46; J&#46; V&#225;zquez-Mellado&#46; Unidad 404-B&#46; Hospital General de M&#233;xico&#46; Dr&#46; Balmis&#44; 148&#46; Colonia Doctores&#46; 06726 M&#233;xico DF&#46; M&#233;xico&#46;"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:39 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The no man&#39;s land of undifferentiated inflammatory polyarthritis &#91;editorial&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;A&#46; Paget"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "1673"
                        "paginaFinal" => "1679"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15338481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;C&#46; Arnett"
                            1 => "S&#46;M&#46; Edworthy"
                            2 => "D&#46;A&#46; Bloch"
                            3 => "D&#46;J&#46; McShane"
                            4 => "J&#46;F&#46; Fries"
                            5 => "N&#46;S&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1988"
                        "volumen" => "31"
                        "paginaInicial" => "315"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3358796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How do you diagnose rheumatoid arthritis early&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Quinn"
                            1 => "M&#46;J&#46; Green"
                            2 => "P&#46; Conaghan"
                            3 => "P&#46; Emery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/berh.2000.0125"
                      "Revista" => array:6 [
                        "tituloSerie" => "Best Pract Res Clin Rheumatol"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "49"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11358414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early referral recommendation for newly diagnosed rheumatoid arthritis&#58; evidence based development of a clinical guide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Emery"
                            1 => "F&#46;C&#46; Breedveld"
                            2 => "M&#46; Dougados"
                            3 => "J&#46;R&#46; Kalden"
                            4 => "M&#46;H&#46; Schiff"
                            5 => "J&#46;S&#46; Smolen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2002"
                        "volumen" => "61"
                        "paginaInicial" => "290"
                        "paginaFinal" => "297"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11874828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rheumatoid artritis&#46; Treatment of early disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Boers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheum Dis Clin North Am"
                        "fecha" => "2001"
                        "volumen" => "27"
                        "paginaInicial" => "405"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11396100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;M&#46; Lee"
                            1 => "M&#46;E&#46; Weinblatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(01)06075-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "358"
                        "paginaInicial" => "903"
                        "paginaFinal" => "911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11567728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The nosologytaxonomy of recent-onset arthritis&#58; the experience of early arthritis clinics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Berthelot"
                            1 => "A&#46; Saraux"
                            2 => "Y&#46; Maugars"
                            3 => "A&#46; Prost"
                            4 => "P&#46; Le Goff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/sarh.2001.19820"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2001"
                        "volumen" => "30"
                        "paginaInicial" => "354"
                        "paginaFinal" => "365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11303308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint erosions and patients with early rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;M&#46;F&#46;M&#46; Van der Heijde"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1995"
                        "volumen" => "34"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "74"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8535653"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "F&#46;M&#46; McQueen"
                            1 => "N&#46; Stewart"
                            2 => "J&#46; Crabbe"
                            3 => "E&#46; Robinson"
                            4 => "S&#46; Yeoman"
                            5 => "P&#46;L&#46;J&#46; Tan"
                            6 => "L&#46; et al"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1998"
                        "volumen" => "57"
                        "paginaInicial" => "350"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9771209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomised comparison of combined stepdown prednisolone&#44; methotrexate and sulphasalazine alone in early rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Boers"
                            1 => "A&#46;C&#46; Verhoeven"
                            2 => "H&#46;M&#46; Markusse"
                            3 => "M&#46;A&#46; Van de Laar"
                            4 => "R&#46; Westhovens"
                            5 => "J&#46;C&#46; Van Denderen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(97)01300-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1997"
                        "volumen" => "350"
                        "paginaInicial" => "309"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9251634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis&#58; a randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; M&#246;tt&#246;nen"
                            1 => "P&#46; Hannonen"
                            2 => "M&#46; Leirisalo-Repo"
                            3 => "M&#46; Nissil&#228;"
                            4 => "H&#46; Kautiainen"
                            5 => "M&#46; Korpela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "353"
                        "paginaInicial" => "1568"
                        "paginaFinal" => "1573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10334255"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Concomitant leflunamide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate&#58; a randomized&#44; double blind&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Kremer"
                            1 => "M&#46;C&#46; Genovese"
                            2 => "G&#46;W&#46; Cannon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2002"
                        "volumen" => "137"
                        "paginaInicial" => "726"
                        "paginaFinal" => "733"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12416946"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and radiographic outcomes of rheumatoid arthritis patients not treated with disease modifying drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Abu-Shakra"
                            1 => "R&#46; Toker"
                            2 => "D&#46; Flusser"
                            3 => "G&#46; Flusser"
                            4 => "M&#46; Friger"
                            5 => "S&#46; Sukenik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(199807)41:7<1190::AID-ART7>3.0.CO;2-B"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1998"
                        "volumen" => "41"
                        "paginaInicial" => "1190"
                        "paginaFinal" => "1195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9663474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a treatment strategy of tigh control for rheumatoid arthritis &#40;the TICORA study&#41;&#58; a single-blind randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Grigor"
                            1 => "H&#46; Capell"
                            2 => "A&#46; Stirling"
                            3 => "A&#46;D&#46; McMahon"
                            4 => "P&#46; Lock"
                            5 => "R&#46; Vallance"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)16676-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "364"
                        "paginaInicial" => "263"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15262104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methotrexate and mortality in patients with rheumatoid arthritis&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;K&#46; Choi"
                            1 => "M&#46;A&#46; Hern&#225;n"
                            2 => "J&#46;D&#46; Seeger"
                            3 => "J&#46;M&#46; Robins"
                            4 => "F&#46; Wolfe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(02)08213-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2002"
                        "volumen" => "359"
                        "paginaInicial" => "1173"
                        "paginaFinal" => "1177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11955534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Krause"
                            1 => "B&#46; Schleusser"
                            2 => "G&#46; Herborn"
                            3 => "R&#46; Rau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200001)43:1<14::AID-ANR3>3.0.CO;2-7"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "43"
                        "paginaInicial" => "14"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10643695"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0009739X1000521X"
                          "estado" => "S300"
                          "issn" => "0009739X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors predicting response to treatment in rheumatoid arthritis&#46; The importance of disease duration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;J&#46; Anderson"
                            1 => "G&#46; Wells"
                            2 => "A&#46;C&#46; Verhoeven"
                            3 => "D&#46;T&#46; Felson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200001)43:1<22::AID-ANR4>3.0.CO;2-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "43"
                        "paginaInicial" => "22"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10643696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic effect of the combination of etarnecept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis&#58; double-blind randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Klareskog"
                            1 => "D&#46; Van der Heijde"
                            2 => "J&#46;P&#46; De Jager"
                            3 => "A&#46; Gough"
                            4 => "J&#46; Kalden"
                            5 => "M&#46; Malaise"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)15640-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "363"
                        "paginaInicial" => "675"
                        "paginaFinal" => "681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15001324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COBRA combination therapy in patients with early rheumatoid arthritis&#46; Long-term structural benefits of a brief intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;B&#46;M&#46; Landew&#233;"
                            1 => "M&#46; Boers"
                            2 => "A&#46;C&#46; Verhoeven"
                            3 => "R&#46; Westhovens"
                            4 => "M&#46;A&#46;F&#46;J&#46; Van de Laar"
                            5 => "H&#46;M&#46; Markusse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "347"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11840436"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Norfolk Arthritis register &#40;NOAR&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;P&#46;M&#46; Symmons"
                            1 => "A&#46;J&#46; Silman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "S94"
                        "paginaFinal" => "S99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14969058"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Leiden early arthritis clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Van Aken"
                            1 => "J&#46;H&#46;M&#46; Van Bilsen"
                            2 => "C&#46;F&#46; Allaart"
                            3 => "T&#46;W&#46;J&#46; Huizinga"
                            4 => "F&#46;C&#46; Breedveld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "S100"
                        "paginaFinal" => "S105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14969059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Austrian early arthritis register"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;P&#46; Machold"
                            1 => "V&#46;P&#46;K&#46; Nell"
                            2 => "T&#46;A&#46; Stamm"
                            3 => "G&#46; Eberl"
                            4 => "G&#46; Steiner"
                            5 => "J&#46;S&#46; Smolen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "S113"
                        "paginaFinal" => "S117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14969061"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The performance of the 1987 ARA classification criteria for rheumatoid arthritis in a population based cohort of patients with early inflammatory polyarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;J&#46; Harrison"
                            1 => "D&#46;P&#46;M&#46; Symmons"
                            2 => "E&#46;M&#46; Barret"
                            3 => "A&#46;J&#46; Silman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1998"
                        "volumen" => "25"
                        "paginaInicial" => "2324"
                        "paginaFinal" => "2330"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9858425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and course of early-onset arthritis&#58; results of a special arthritis clinic compared to routine patient care&#46; Br"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46;E&#46; Van der Horst Bruinsma"
                            1 => "I&#46; Speyer"
                            2 => "H&#46; Visser"
                            3 => "F&#46;C&#46; Breedveld"
                            4 => "J&#46;M&#46;W&#46; Hazes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1998"
                        "volumen" => "37"
                        "paginaInicial" => "1084"
                        "paginaFinal" => "1088"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Quinn"
                            1 => "M&#46;J&#46; Green"
                            2 => "H&#46; Marzo-Ortega"
                            3 => "S&#46; Proudman"
                            4 => "Z&#46; Karim"
                            5 => "R&#46; Wakefield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11269"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "3039"
                        "paginaFinal" => "3045"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14613264"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Very recent onset arthritis-clinical&#44; laboratory&#44; and radiological findings during the first year of disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;P&#46; Machold"
                            1 => "T&#46;A&#46; Stamm"
                            2 => "G&#46;J&#46;M&#46; Eberl"
                            3 => "V&#46;K&#46;P&#46; Nell"
                            4 => "A&#46; Dunky"
                            5 => "M&#46;U&#46; Ufmman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2002"
                        "volumen" => "29"
                        "paginaInicial" => "2278"
                        "paginaFinal" => "2287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12415582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognosis of rheumatoid arthritis and undifferentiated polyarthritis syndrome in the clinic&#58; A study of 1141 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Wolfe"
                            1 => "K&#46; Ross"
                            2 => "D&#46;J&#46; Hawley"
                            3 => "F&#46;K&#46; Roberts"
                            4 => "M&#46;A&#46; Cathey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1993"
                        "volumen" => "20"
                        "paginaInicial" => "2005"
                        "paginaFinal" => "2009"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8014925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistological features in the synovium obtained from clinically uninvolved knee Joints of patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Soden"
                            1 => "M&#46; Rooney"
                            2 => "A&#46; Cullen"
                            3 => "A&#46; Whelan"
                            4 => "C&#46; Feighery"
                            5 => "B&#46; Brensnihan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Rheumatol"
                        "fecha" => "1989"
                        "volumen" => "28"
                        "paginaInicial" => "287"
                        "paginaFinal" => "292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2787183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonante imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Ejberg"
                            1 => "E&#46; Narvestad"
                            2 => "E&#46; Rostrup"
                            3 => "M&#46; Szkudlarek"
                            4 => "S&#46; Jacobsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20135"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "1097"
                        "paginaFinal" => "1106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15077291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dating the &#8220;window of therapeutic opportunity&#8221; in early rheumatoid arthritis&#58; accuracy of patient recall of arthritis symptom onset"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Amjadi-Begvand"
                            1 => "D&#46; Khanna"
                            2 => "G&#46;S&#46; Park"
                            3 => "K&#46;J&#46; Bulpitt"
                            4 => "W&#46;K&#46; Wong"
                            5 => "H&#46;E&#46; Paulus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "1686"
                        "paginaFinal" => "1692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15338485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Specific autoantibodies precede the symptoms of rheumatoid arthritis&#46; A study of serial measurements in blood donors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46;J&#46; Nielen"
                            1 => "D&#46; Van Schaardenburg"
                            2 => "H&#46;W&#46; Reesink"
                            3 => "R&#46;J&#46; Van de Stadt"
                            4 => "I&#46;E&#46; Van der Horst-Bruinsma"
                            5 => "M&#46;H&#46;M&#46;T&#46; De Koning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "380"
                        "paginaFinal" => "386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14872479"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Rantap&#228;&#228;-Dahlqvist"
                            1 => "B&#46;A&#46;W&#46; De Jong"
                            2 => "E&#46; Berglin"
                            3 => "G&#46; Hallmans"
                            4 => "G&#46; Wadell"
                            5 => "H&#46; Stenlund"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11223"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "2741"
                        "paginaFinal" => "2749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14558078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased levels of C reactive protein in serum from blood donors before the onset of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46;J&#46; Nielen"
                            1 => "D&#46; Van Schaardenburg"
                            2 => "H&#46;W&#46; Reesink"
                            3 => "J&#46;W&#46;R&#46; Twisk"
                            4 => "R&#46;J&#46; Van de Stadt"
                            5 => "I&#46;E&#46; Van der Horst-Bruinsma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "38"
                        "paginaInicial" => "2423"
                        "paginaFinal" => "2427"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of a combination of DMRD in patients with recent onset arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; V&#225;zquez Mellado"
                            1 => "C&#46; Garc&#237;a-Garc&#237;a"
                            2 => "J&#46;F&#46; Moctezuma"
                            3 => "L&#46; Lino P&#233;rez"
                            4 => "E&#46; &#193;lvarez"
                            5 => "M&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2003.011130"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2004"
                        "volumen" => "63"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15082483"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive factors in early arthritis&#58; long-term follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;R&#46; Schumacher"
                            1 => "W&#46; Habre"
                            2 => "R&#46; Miador"
                            3 => "E&#46;C&#46; Hsia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "33"
                        "paginaInicial" => "264"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14978664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Criteria for early rheumatoid arthritis&#46; From Bayes&#8217; law revisited to new thoughts on pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;W&#46;J&#46; Huizinga"
                            1 => "K&#46;P&#46; Machold"
                            2 => "F&#46;C&#46; Breedveld"
                            3 => "P&#46;E&#46; Lipsky"
                            4 => "J&#46;S&#46; Smolen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.10195"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "1155"
                        "paginaFinal" => "1159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12115216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cases of early inflammatory polyarthritis should not be classified as having rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;P&#46;M&#46; Symmons"
                            1 => "J&#46;M&#46;W&#46; Hazes"
                            2 => "A&#46;J&#46; Silman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "902"
                        "paginaFinal" => "904"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinate peptide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Schellekens"
                            1 => "H&#46; Visser"
                            2 => "B&#46; De Jong"
                            3 => "F&#46;H&#46;J&#46; Van den Hoogen"
                            4 => "J&#46;M&#46;W&#46; Hazes"
                            5 => "F&#46;C&#46; Breedveld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "43"
                        "paginaInicial" => "155"
                        "paginaFinal" => "163"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10643712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of disease-modifying therapy on radiographic outcome in inflammatory polyarthritis at five years&#58; results from a large observational inception study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Bukhari"
                            1 => "N&#46;J&#46; Wiles"
                            2 => "M&#46; Lunt"
                            3 => "B&#46;J&#46; Harrison"
                            4 => "D&#46;G&#46; Scott"
                            5 => "D&#46;P&#46; Symmons"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.10727"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "46"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12528102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/1699258X/00000001000000S2/v1_201305061724/S1699258X05727698/v1_201305061724/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/1699258X/00000001000000S2/v1_201305061724/S1699258X05727698/v1_201305061724/es/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X05727698?idApp=UINPBA00004M"
]
Compartir
Información de la revista
Vol. 1. Núm. S2.
Novedades terapéuticas en reumatología+J1:J72
Páginas S16-S23 (diciembre 2005)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 1. Núm. S2.
Novedades terapéuticas en reumatología+J1:J72
Páginas S16-S23 (diciembre 2005)
Novedades terapéuticas en reumatología
Acceso a texto completo
Tratamiento de la artritis de inicio reciente
Visitas
12971
J. Vázquez-Mellado
Autor para correspondencia
jvazquezmellado@prodigy.net.mx

Correspondencia: Dra. J. Vázquez-Mellado. Unidad 404-B. Hospital General de México. Dr. Balmis, 148. Colonia Doctores. 06726 México DF. México.
, J. Rojas-Serrano
Servicio de Reumatología. Hospital General de México. México DF. México
Este artículo ha recibido
Información del artículo
El Texto completo está disponible en PDF
Bibliografía
[1.]
S.A. Paget.
The no man's land of undifferentiated inflammatory polyarthritis [editorial].
J Rheumatol, 31 (2004), pp. 1673-1679
[2.]
F.C. Arnett, S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, et al.
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
Arthritis Rheum, 31 (1988), pp. 315-324
[3.]
M.A. Quinn, M.J. Green, P. Conaghan, P. Emery.
How do you diagnose rheumatoid arthritis early?.
Best Pract Res Clin Rheumatol, 15 (2000), pp. 49-66
[4.]
P. Emery, F.C. Breedveld, M. Dougados, J.R. Kalden, M.H. Schiff, J.S. Smolen.
Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide.
Ann Rheum Dis, 61 (2002), pp. 290-297
[5.]
M. Boers.
Rheumatoid artritis. Treatment of early disease.
Rheum Dis Clin North Am, 27 (2001), pp. 405-416
[6.]
D.M. Lee, M.E. Weinblatt.
Rheumatoid arthritis.
[7.]
J.M. Berthelot, A. Saraux, Y. Maugars, A. Prost, P. Le Goff.
The nosologytaxonomy of recent-onset arthritis: the experience of early arthritis clinics.
Semin Arthritis Rheum, 30 (2001), pp. 354-365
[8.]
D.M.F.M. Van der Heijde.
Joint erosions and patients with early rheumatoid arthritis.
Br J Rheumatol, 34 (1995), pp. 74-78
[9.]
F.M. McQueen, N. Stewart, J. Crabbe, E. Robinson, S. Yeoman, P.L.J. Tan, L. et al.
Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset.
Ann Rheum Dis, 57 (1998), pp. 350-356
[10.]
M. Boers, A.C. Verhoeven, H.M. Markusse, M.A. Van de Laar, R. Westhovens, J.C. Van Denderen, et al.
Randomised comparison of combined stepdown prednisolone, methotrexate and sulphasalazine alone in early rheumatoid arthritis.
[11.]
T. Möttönen, P. Hannonen, M. Leirisalo-Repo, M. Nissilä, H. Kautiainen, M. Korpela, et al.
Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomized trial.
Lancet, 353 (1999), pp. 1568-1573
[12.]
J.M. Kremer, M.C. Genovese, G.W. Cannon.
Concomitant leflunamide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double blind, placebo-controlled trial.
Ann Intern Med, 137 (2002), pp. 726-733
[13.]
M. Abu-Shakra, R. Toker, D. Flusser, G. Flusser, M. Friger, S. Sukenik, et al.
Clinical and radiographic outcomes of rheumatoid arthritis patients not treated with disease modifying drugs.
[14.]
C. Grigor, H. Capell, A. Stirling, A.D. McMahon, P. Lock, R. Vallance.
Effect of a treatment strategy of tigh control for rheumatoid arthritis (the TICORA study): a single-blind randomized controlled trial.
[15.]
H.K. Choi, M.A. Hernán, J.D. Seeger, J.M. Robins, F. Wolfe.
Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study.
Lancet, 359 (2002), pp. 1173-1177
[16.]
D. Krause, B. Schleusser, G. Herborn, R. Rau.
Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis.
[17.]
J.J. Anderson, G. Wells, A.C. Verhoeven, D.T. Felson.
Factors predicting response to treatment in rheumatoid arthritis. The importance of disease duration.
[18.]
L. Klareskog, D. Van der Heijde, J.P. De Jager, A. Gough, J. Kalden, M. Malaise.
Therapeutic effect of the combination of etarnecept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomized controlled trial.
[19.]
R.B.M. Landewé, M. Boers, A.C. Verhoeven, R. Westhovens, M.A.F.J. Van de Laar, H.M. Markusse, et al.
COBRA combination therapy in patients with early rheumatoid arthritis. Long-term structural benefits of a brief intervention.
Arthritis Rheum, 46 (2002), pp. 347-356
[20.]
D.P.M. Symmons, A.J. Silman.
The Norfolk Arthritis register (NOAR).
Clin Exp Rheumatol, 21 (2003), pp. S94-S99
[21.]
J. Van Aken, J.H.M. Van Bilsen, C.F. Allaart, T.W.J. Huizinga, F.C. Breedveld.
The Leiden early arthritis clinic.
Clin Exp Rheumatol, 21 (2003), pp. S100-S105
[22.]
K.P. Machold, V.P.K. Nell, T.A. Stamm, G. Eberl, G. Steiner, J.S. Smolen.
The Austrian early arthritis register.
Clin Exp Rheumatol, 21 (2003), pp. S113-S117
[23.]
B.J. Harrison, D.P.M. Symmons, E.M. Barret, A.J. Silman.
The performance of the 1987 ARA classification criteria for rheumatoid arthritis in a population based cohort of patients with early inflammatory polyarthritis.
J Rheumatol, 25 (1998), pp. 2324-2330
[24.]
I.E. Van der Horst Bruinsma, I. Speyer, H. Visser, F.C. Breedveld, J.M.W. Hazes.
Diagnosis and course of early-onset arthritis: results of a special arthritis clinic compared to routine patient care. Br.
J Rheumatol, 37 (1998), pp. 1084-1088
[25.]
M.A. Quinn, M.J. Green, H. Marzo-Ortega, S. Proudman, Z. Karim, R. Wakefield, et al.
Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol.
Arthritis Rheum, 48 (2003), pp. 3039-3045
[26.]
K.P. Machold, T.A. Stamm, G.J.M. Eberl, V.K.P. Nell, A. Dunky, M.U. Ufmman, et al.
Very recent onset arthritis-clinical, laboratory, and radiological findings during the first year of disease.
J Rheumatol, 29 (2002), pp. 2278-2287
[27.]
F. Wolfe, K. Ross, D.J. Hawley, F.K. Roberts, M.A. Cathey.
The prognosis of rheumatoid arthritis and undifferentiated polyarthritis syndrome in the clinic: A study of 1141 patients.
J Rheumatol, 20 (1993), pp. 2005-2009
[28.]
M. Soden, M. Rooney, A. Cullen, A. Whelan, C. Feighery, B. Brensnihan.
Immunohistological features in the synovium obtained from clinically uninvolved knee Joints of patients with rheumatoid arthritis.
Br J Rheumatol, 28 (1989), pp. 287-292
[29.]
B. Ejberg, E. Narvestad, E. Rostrup, M. Szkudlarek, S. Jacobsen.
Magnetic resonante imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis.
Arthritis Rheum, 50 (2004), pp. 1097-1106
[30.]
S. Amjadi-Begvand, D. Khanna, G.S. Park, K.J. Bulpitt, W.K. Wong, H.E. Paulus.
Dating the “window of therapeutic opportunity” in early rheumatoid arthritis: accuracy of patient recall of arthritis symptom onset.
J Rheumatol, 31 (2004), pp. 1686-1692
[31.]
M.M.J. Nielen, D. Van Schaardenburg, H.W. Reesink, R.J. Van de Stadt, I.E. Van der Horst-Bruinsma, M.H.M.T. De Koning, et al.
Specific autoantibodies precede the symptoms of rheumatoid arthritis. A study of serial measurements in blood donors.
Arthritis Rheum, 50 (2004), pp. 380-386
[32.]
S. Rantapää-Dahlqvist, B.A.W. De Jong, E. Berglin, G. Hallmans, G. Wadell, H. Stenlund, et al.
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
Arthritis Rheum, 48 (2003), pp. 2741-2749
[33.]
M.M.J. Nielen, D. Van Schaardenburg, H.W. Reesink, J.W.R. Twisk, R.J. Van de Stadt, I.E. Van der Horst-Bruinsma, et al.
Increased levels of C reactive protein in serum from blood donors before the onset of rheumatoid arthritis.
Arthritis Rheum, 38 (2004), pp. 2423-2427
[34.]
J. Vázquez Mellado, C. García-García, J.F. Moctezuma, L. Lino Pérez, E. Álvarez, M. González, et al.
The effect of a combination of DMRD in patients with recent onset arthritis.
Ann Rheum Dis, 63 (2004), pp. 530
[35.]
H.R. Schumacher, W. Habre, R. Miador, E.C. Hsia.
Predictive factors in early arthritis: long-term follow-up.
Semin Arthritis Rheum, 33 (2004), pp. 264-272
[36.]
T.W.J. Huizinga, K.P. Machold, F.C. Breedveld, P.E. Lipsky, J.S. Smolen.
Criteria for early rheumatoid arthritis. From Bayes’ law revisited to new thoughts on pathogenesis.
Arthritis Rheum, 46 (2002), pp. 1155-1159
[37.]
D.P.M. Symmons, J.M.W. Hazes, A.J. Silman.
Cases of early inflammatory polyarthritis should not be classified as having rheumatoid arthritis.
J Rheumatol, 30 (2003), pp. 902-904
[38.]
G.A. Schellekens, H. Visser, B. De Jong, F.H.J. Van den Hoogen, J.M.W. Hazes, F.C. Breedveld, et al.
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinate peptide.
[39.]
M.A. Bukhari, N.J. Wiles, M. Lunt, B.J. Harrison, D.G. Scott, D.P. Symmons, et al.
Influence of disease-modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: results from a large observational inception study.
Arthritis Rheum, 48 (2003), pp. 46-53
Copyright © 2005. Elsevier España S.L. Barcelona
Descargar PDF
Idiomas
Reumatología Clínica
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?