Publish in this journal
Journal Information
Vol. 14. Issue 4.
Pages 239-241 (July - August 2018)
Vol. 14. Issue 4.
Pages 239-241 (July - August 2018)
Images in Clinical Rheumatology
DOI: 10.1016/j.reumae.2017.01.006
Full text access
Another Gouty Tophus? The Many Faces of the Enchondroma
¿Otro tofo gotoso? Las múltiples caras del encondroma
Visits
...
Ismael Calero-Paniaguaa,b,
Corresponding author
ismaelcaleropaniagua@yahoo.es

Corresponding author.
, Julio Alberto Vicente-Rodrigoa, Daniel Soliva-Martínezc, Francisco Torrecillas-Fernándezd
a Servicio de Medicina Interna, Hospital General Virgen de la Luz, Cuenca, Spain
b Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
c Servicio de Radiodiagnóstico, Hospital General Virgen de la Luz, Cuenca, Spain
d Servicio de Anatomía Patológica, Hospital General Virgen de la Luz, Cuenca, Spain
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Full Text

Primary bone tumors of the hands are rare (2%–5%), the most common of them is the enchondroma.1,2 Enchondromas usually develop in the second decade of life, but can occur at any age. In all, 50% are located in the proximal phalanges, followed in frequency by the metacarpal bones and middle phalanges. Patients usually remain asymptomatic, although, on occasion, there may be an enlargement or deformity of the fingers, pain and pathological fractures secondary to the expansion and remodeling of the lesion. The development of multiple enchondromas is known as Ollier disease.3,4

The patient was an 82-year-old man diagnosed with gout. He presented with a tumor-like lesion on the second phalanx of the third finger of the left hand that had developed months earlier (Fig. 1A and B). Since a gouty tophus at that site is rare, he underwent plain radiography (Fig. 1C and D), which showed an expansile lytic lesion. The findings in magnetic resonance imaging (MRI) were suggestive of malignancy (Fig. 2A–C). Ultimately, biopsy was performed, leading to a diagnosis of enchondroma (Fig. 2D).

Fig. 1.

(A and B) Multilobulated tumor in the second phalange of the third finger of the left hand. (C and D) Anteroposterior and lateral radiographs of the third finger of the left hand, showing a large expansile lytic lesion, that undergoes inflation, deflation and destroys the cortical.

(0.14MB).
Fig. 2.

(A–C) Magnetic resonance images; multilobulated expansile lesion, with endosteal scalloping and substantial cortical thinning, which is hypointense in T1 (axial plane) and hyperintense in the T2-weighted sequence with fat suppression (sagittal plane) and in a short tau inversion recovery (STIR) sequence (coronal plane). (D) Biopsy of the tumor showing mature hyaline cartilage (arrows), with areas of myxoid degeneration (arrowheads), compatible with enchondroma.

(0.2MB).

The differential diagnosis of a lesion affecting the hand like the one we present includes, in addition to intraosseous gouty tophus (reported in up to 13.3% of patients with advanced gouty arthropathy)5,6 and enchondroma, other bone tumors such as chondrosarcoma,7 low-grade chondroblastoma, myxoid fibroma, epidermoid cysts, nonossifying fibromas, fibrous dysplasia and giant cell tumor.8 Other conditions to be ruled out would be bone infarction, brown tumors associated with hyperparathyroidism,9 xanthomas, rheumatoid nodules and sarcoid granulomas10 and those related to infections (syphilis, Borrelia, mycobacteria).8

In radiographs, enchondromas are characterized as round, well-defined lesions with central radiolucency in the diaphysis or the metaphysis. It may have a lobulated contour, punctate calcifications and even endosteal scalloping, cortical thinning and pathological fractures in the case of substantial enlargement.2

Ethical DisclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflicts of Interest

The authors declare they have no conflicts of interest.

References
[1]
M. Figl, M. Leixnering.
Retrospective review of outcome after surgical treatment of enchondromas in the hand.
Arch Orthop Trauma Surg, 129 (2009), pp. 729-734
[2]
M.I. O’Connor, L.W. Bancroft.
Benign and malignant cartilage tumors of the hand.
Hand Clin, 20 (2004), pp. 317-323
[3]
D.N. Hakim, T. Pelly, M. Kulendran, J.A. Caris.
Benign tumours of the bone: a review.
J Bone Oncol, 4 (2015), pp. 37-41
[4]
T.C. Pansuriya, H.M. Kroon, J.V. Bovee.
Enchondromatosis: insights on the different subtypes.
Int J Clin Exp Pathol, 3 (2010), pp. 557-569
[5]
J.U. Monu, T.L. Pope Jr..
Gout: a clinical and radiologic review.
Radiol Clin North Am, 42 (2004), pp. 169-184
[6]
K.H. Ko, Y.C. Hsu, H.S. Lee, C.H. Lee, G.S. Huang.
Tophaceous gout of the knee: revisiting MRI patterns in 30 patients.
J Clin Rheumatol, 16 (2010), pp. 209-214
[7]
M.D. Murphey, D.J. Flemming, S.R. Boyea, J.A. Bojescul, D.E. Sweet, H.T. Temple.
Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features.
Radiographics, 18 (1998), pp. 1213-1237
[8]
K. Melamud, J.L. Drape, D. Hayashi, F.W. Roemer, J. Zentner, A. Guermazi.
Diagnostic imaging of benign and malignant osseous tumors of the fingers.
Radiographics, 34 (2014), pp. 1954-1967
[9]
H.C. Chavin, A.A. Pisarevsky, C. Chavin, L. Koll, E.A. Petrucci.
Brown tumor as the initial manifestation of primary hyperparathyroidism.
Medicina (B Aires), 68 (2008), pp. 219-221
[10]
S.L. Moore, A.E. Teirstein.
Musculoskeletal sarcoidosis: spectrum of appearances at MR imaging.
Radiographics, 23 (2003), pp. 1389-1399

Please cite this article as: Calero-Paniagua I, Vicente-Rodrigo JA, Soliva-Martínez D, Torrecillas-Fernández F. ¿Otro tofo gotoso? Las múltiples caras del encondroma. Reumatol Clin. 2018;14:239–241.

Copyright © 2017. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Idiomas
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.