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Vol. 13. Issue 2.
Pages 102-106 (March - April 2017)
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Vol. 13. Issue 2.
Pages 102-106 (March - April 2017)
Review article
DOI: 10.1016/j.reumae.2016.04.006
Biological Therapy and Neurological Manifestations. What do We Know?
Terapias biológicas y manifestaciones neurológicas. ¿Qué sabemos?
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Beatriz Tejera-Segura
Corresponding author
btejerasegura@gmail.com

Corresponding author.
, Iván Ferraz-Amaro
Servicio de Reumatología, Hospital Universitario de Canarias, Tenerife, Spain
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Table 1. Summary of the Series of Patients With Rheumatic Diseases Reported Over the Past 10 Years.
Abstract

Biological therapy has changed the course of inflammatory rheumatic diseases. The safety is well documented in national and international studies. Neurological manifestations are uncommon and it is difficult to establish a clear causal relationship. The neurological signs and symptoms that may appear are multiple and sometimes mimic demyelinating neurological diseases and/or neurodegenerative diseases. Knowledge and disclosure of these cases is essential for a comprehensive management of biological therapy in our patients.

Keywords:
Biological therapy
Anti-TNF-alpha
Neurological manifestations
Inflammatory rheumatic diseases
Resumen

La terapia biológica ha cambiado el curso de las enfermedades reumáticas inflamatorias. La seguridad de la misma está más que documentada en diferentes estudios nacionales e internacionales. La baja frecuencia de las manifestaciones neurológicas dificulta en muchas ocasiones el establecer una relación causal clara entre el tratamiento biológico y la clínica neurológica propiamente dicha. Los síntomas y signos neurológicos que pueden aparecer son múltiples, y en ocasiones simulan enfermedades neurológicas desmielinizantes y/o neurodegenerativas. El conocimiento y el reporte de los mismos es fundamental para realizar un manejo exhaustivo de la terapia biológica en nuestros pacientes.

Palabras clave:
Terapia biológica
Anti-TNF alfa
Manifestaciones neurológicas
Enfermedades reumáticas inflamatorias

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