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Vol. 17. Issue 1.
Pages 32-36 (January 2021)
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Vol. 17. Issue 1.
Pages 32-36 (January 2021)
Brief Report
DOI: 10.1016/j.reumae.2019.03.005
Neuro-Behçet disease in the Central University Hospital of Asturias
Enfermedad de neuro-Behçet en el Hospital Universitario Central de Asturias
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Lilyan C. Charca-Benaventea,
Corresponding author
lily.charca@gmail.com

Corresponding author.
, Ricardo Gómez de la Torreb, Luis Caminal-Monterob, Rubén Coto-Hernándezb, Dolores Colunga-Argüellesb
a Servicio de Reumatología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Unidad de Enfermedades Autoinmunes y Sistémicas, Unidad de Gestión Clínica de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Spain
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Tables (3)
Table 1. Clinical, imaging, cerebrospinal fluid and anatomopathological characteristics of patients with neuro-Behçet’s disease.
Table 2. Comparison of clinical characteristics between patients with Behçet’s disease without neurological involvement and neuro-Behçet’s.
Table 3. Demographic characteristics and presentation pattern in patients with neuro-Behçet’s.
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Abstract
Objective

To describe the frequency and profile of patients with neuro-Behçet’s disease (NBD) at the Central University Hospital of Asturias between 1981 and June 2018.

Patients and methods

Retrospective study including epidemiological, clinical, neuroimaging, cerebrospinal fluid (CSF) study, histopathology, treatment and evolution characteristics. Clinical characteristics are differentiated between patients with Behçet without neurological affectation and NBD.

Results

We found 10 cases of NBD (25.6%). The mean age was 29.7 years, and it was more frequent in males. Sixty percent had parenchymal involvement. The non-parenchymal involvement included a case with cerebral venous thrombosis and two cases with isolated aseptic meningitis. Findings of vasculitis were found on cerebral magnetic resonance imaging, and alteration in the biochemistry of the CSF. One patient presented a striking motor disability. Ocular involvement was greater in the group of patients without neurological involvement (P = .009).

Conclusions

NBD is a relatively frequent presentation, especially in males and in the parenchymal form. We did not find a systemic clinical marker of neurological involvement.

Keywords:
Behcet’s disease
Neurologic manifestations
Central nervous system
Meningitis
Magnetic resonance imaging
Resumen
Objetivo

Describir frecuencia y perfil de pacientes con neuro-Behçet (NB) del Hospital Universitario Central de Asturias desde 1981 hasta junio del 2018.

Pacientes y métodos

Estudio retrospectivo que incluye características: epidemiológicas, clínicas, neuroimagen, estudio de líquido cefalorraquídeo (LCR), histopatología, tratamiento y evolución. Se diferencian características clínicas entre pacientes con Behçet sin afectación neurológica y NB.

Resultados

Se describen 10 casos de NB (25,6%). La edad media a su diagnóstico: 29,7 años, siendo más frecuente en varones. El 60% tienen afectación parenquimatosa. En la afectación no parenquimatosa se incluyen un caso con trombosis venosa cerebral y dos con meningitis aséptica aislada. Se encontraron hallazgos de vasculitis en la Resonancia Magnética Cerebral, y alteración en la bioquímica del LCR. Un paciente presentó discapacidad motora llamativa. La afectación ocular ha sido mayor en el grupo de los pacientes sin afectación neurológica (p = 0,009).

Conclusiones

El NB es relativamente frecuente, sobre todo en varones y en la forma parenquimatosa. No se encuentra un marcador clínico propio de la afectación neurológica.

Palabras clave:
Enfermedad de Behçet
Afectación neurológica
Sistema nervioso central
Meningitis
Resonancia magnética

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