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"textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Eosinophilic fasciitis is an uncommon scleroderma-like disease of unknown etiology. It was first described by Shulman in 1974, and is characterized clinically by a subcutaneous induration and its development predominantly in the limbs.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Eosinophilia is detected in peripheral blood in 80% of the patients, and more than 50% present with hypergammaglobulinemia.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case Report</span><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 45-year-old man, with nothing remarkable in his medical record, who presented with a 6-month history of thickening and induration of upper and lower limbs, which had an important functional impact on his activities of daily living. The patient participated in sports, but recalled no noteworthy injuries or other possible triggering factor.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Aside from the above-mentioned induration, the physical examination revealed furrows along the length of the veins of the superficial plexus, a phenomenon classically referred to as the “groove sign”. On the other hand, the skin on extensor surfaces was shiny, erythematous and edematous, with marked follicular orifices, which gave it the appearance of an “orange peel” or “peau d’orange” (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). Full-thickness skin biopsy disclosed thickening of the muscle fascia, together with a mixed inflammatory infiltrate composed of lymphocytes, plasma cells and scattered eosinophils (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Laboratory tests revealed blood eosinophilia with a count of 1000<span class="elsevierStyleHsp" style=""></span>cells/mm<span class="elsevierStyleSup">3</span>. With a diagnosis of eosinophilic fasciitis, treatment was begun with prednisone at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg/kg/day and, later, with methotrexate. The signs and symptoms improved progressively over the following months.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnosis of eosinophilic fasciitis is based mainly on a histological study, requiring a full-thickness skin biopsy that includes muscle fascia. However, knowledge of the forms of clinical presentation is necessary to establish diagnostic suspicion.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> The groove sign is a highly specific finding, and is often accompanied by “peau d’orange”. It consists of furrowing along the length of the veins of the superficial plexus, which becomes more marked when the limb is raised. It is thought to be due to the fact that, as the epidermis and superficial dermis are not affected, they maintain their elasticity and, thus, they are depressed upon the collapse of the superficial veins, which are surrounded by inflamed, fibrotic tissue.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Ethical Disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Protection of human and animal subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Confidentiality of data</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Right to privacy and informed consent</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest.</p></span></span>"
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