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Vol. 17. Issue 6.
Pages 309-312 (June - July 2021)
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Vol. 17. Issue 6.
Pages 309-312 (June - July 2021)
Special Article
DOI: 10.1016/j.reumae.2020.04.012
Proposal for the use of anakinra in acute respiratory distress secondary to COVID-19
Propuesta de uso de anakinra en el distrés respiratorio agudo secundario a COVID-19
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Alejandro Muñoz-Jiméneza,
Corresponding author
amj@ser.es

Corresponding author.
, Esteban Rubio-Romeroa, José Luis Marenco de la Fuenteb
a Servicio de Reumatología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Servicio de Reumatología, Hospital Universitario Virgen de Valme, Sevilla, Spain
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Abstract

The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS). This process is an inflammatory picture, involving an NLRP3 INFLAMOSOME-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. ANAKINRA is a potent biological drug, capable of blocking this IL 1 beta. We propose its use in controlling ARDS secondary to COVID-19 infection.

Keywords:
Anakinra
Covid-19
Acute respiratory distress syndrome
Inflamosome
IL-1β
Resumen

El desenlace de la infección por SARS-CoV-2 (COVID-19) afecta fundamentalmente al campo pulmonar, ocasionando un cuadro de SÍNDROME DE DISTRÉS RESPIRATORIO AGUDO (SDRA). Este proceso es un cuadro inflamatorio, protagonizado por una cascada de citocinas bajo el amparo del INFLAMOSOMA NLRP3, responsable principal de la destrucción alveolar. De entre todas las citocinas que se desencadenan en este cuadro destaca la IL beta. ANAKINRA es un potente fármaco biológico, capaz de bloquear esta IL 1 beta. Proponemos su uso, de cara a controlar el SDRA secundario a la infección por COVID-19.

Palabras clave:
Anakinra
Covid-19
Síndrome de distres respiratorio agudo
Inflamasoma
IL-1β

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