array:24 [
  "pii" => "S217357431300138X"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2013.12.007"
  "estado" => "S300"
  "fechaPublicacion" => "2014-05-01"
  "aid" => "598"
  "copyright" => "Elsevier España, S.L.. All rights reserved"
  "copyrightAnyo" => "2013"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2014;10:196-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1742
    "formatos" => array:3 [
      "EPUB" => 54
      "HTML" => 1382
      "PDF" => 306
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X13001812"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2013.05.011"
      "estado" => "S300"
      "fechaPublicacion" => "2014-05-01"
      "aid" => "598"
      "copyright" => "Elsevier España, S.L."
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2014;10:196-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5259
        "formatos" => array:3 [
          "EPUB" => 196
          "HTML" => 3994
          "PDF" => 1069
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Reactivaci&#243;n del virus de la hepatitis B en un paciente con artritis reumatoide tras el tratamiento con rituximab"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "196"
            "paginaFinal" => "197"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Reactivation of hepatitis virus B infection in a patient with rheumatoid arthritis after treatment with rituximab"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Tarek Carlos Salman-Monte, Mar&#237;a Pilar Lisbona, Montserrat Garc&#237;a-Retortillo, Joan Maym&#243;"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Tarek Carlos"
                "apellidos" => "Salman-Monte"
              ]
              1 => array:2 [
                "nombre" => "Mar&#237;a Pilar"
                "apellidos" => "Lisbona"
              ]
              2 => array:2 [
                "nombre" => "Montserrat"
                "apellidos" => "Garc&#237;a-Retortillo"
              ]
              3 => array:2 [
                "nombre" => "Joan"
                "apellidos" => "Maym&#243;"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S217357431300138X"
          "doi" => "10.1016/j.reumae.2013.12.007"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431300138X?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13001812?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001000000003/v1_201405040016/S1699258X13001812/v1_201405040016/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574313001366"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2013.12.005"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "595"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2014;10:197-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2064
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 1452
        "PDF" => 562
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Frequency of Gout According to the Perception of Physicians in M&#233;xico"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "197"
          "paginaFinal" => "198"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Frecuencia de la gota seg&#250;n la percepci&#243;n de los m&#233;dicos en M&#233;xico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 854
              "Ancho" => 1641
              "Tamanyo" => 60019
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Frequency of rheumatic diseases as perceived by physicians&#46; OA &#40;osteoarthritis&#41;&#44; RA &#40;rheumatoid arthritis&#41;&#44; FM &#40;fibromyalgia&#41;&#44; SLE &#40;systemic lupus erythematosus&#41; and AS &#40;ankylosing spondylitis&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sergio Garc&#237;a-M&#233;ndez, Roberto Arregu&#237;n-Reyes, Omar L&#243;pez-L&#243;pez, Janitzia V&#225;zquez-Mellado"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Garc&#237;a-M&#233;ndez"
            ]
            1 => array:2 [
              "nombre" => "Roberto"
              "apellidos" => "Arregu&#237;n-Reyes"
            ]
            2 => array:2 [
              "nombre" => "Omar"
              "apellidos" => "L&#243;pez-L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Janitzia"
              "apellidos" => "V&#225;zquez-Mellado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X13001782"
        "doi" => "10.1016/j.reuma.2013.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13001782?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313001366?idApp=UINPBA00004M"
    "url" => "/21735743/0000001000000003/v2_201406190029/S2173574313001366/v2_201406190029/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574314000148"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2013.09.001"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "604"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2014;10:194-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2344
      "formatos" => array:3 [
        "EPUB" => 52
        "HTML" => 1814
        "PDF" => 478
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Nodular Regenerative Hyperplasia of the Liver as a Complication of Long-standing Systemic-onset Juvenile Idiopathic Arthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "194"
          "paginaFinal" => "195"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Hiperplasia nodular regenerativa hep&#225;tica como complicaci&#243;n tard&#237;a de la artritis idiop&#225;tica juvenil de inicio sist&#233;mico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 345
              "Ancho" => 1400
              "Tamanyo" => 160504
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Liver biopsy in which a hyperplastic nodular zone &#40;arrowheads&#41; partially surrounded by dilated sinusoids &#40;arrow&#41; and absence of fibrosis &#40;hematoxylin&#8211;eosin 2&#215;&#41; &#40;A&#41; is observed&#46; At higher magnification&#44; the sinusoids are compressed by the thickened hepatocyte plaques &#40;hematoxylin&#8211;eosin 40&#215;&#41; &#40;B&#41;&#46; An abdominal CT scan shows dilation of the portal vein and its branches &#40;arrow&#41; &#40;C&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Walter Alberto Sifuentes Giraldo, Ana Burdaspal Moratilla, Alberto Moreno Caparr&#243;s, Mar&#237;a Luz G&#225;mir G&#225;mir"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Walter Alberto"
              "apellidos" => "Sifuentes Giraldo"
            ]
            1 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Burdaspal Moratilla"
            ]
            2 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Moreno Caparr&#243;s"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Luz"
              "apellidos" => "G&#225;mir G&#225;mir"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X1300199X"
        "doi" => "10.1016/j.reuma.2013.09.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1300199X?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000148?idApp=UINPBA00004M"
    "url" => "/21735743/0000001000000003/v2_201406190029/S2173574314000148/v2_201406190029/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Reactivation of Hepatitis Virus B Infection in a Patient With Rheumatoid Arthritis After Treatment With Rituximab"
    "tieneTextoCompleto" => true
    "saludo" => "To the editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "196"
        "paginaFinal" => "197"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Tarek Carlos Salman-Monte, Mar&#237;a Pilar Lisbona, Montserrat Garc&#237;a-Retortillo, Joan Maym&#243;"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Tarek Carlos"
            "apellidos" => "Salman-Monte"
            "email" => array:2 [
              0 => "tareto4&#64;gmail&#46;com"
              1 => "98383&#64;parcdesalutmar&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Mar&#237;a Pilar"
            "apellidos" => "Lisbona"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Montserrat"
            "apellidos" => "Garc&#237;a-Retortillo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Joan"
            "apellidos" => "Maym&#243;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Parc de Salut Mar&#44; Hospital del Mar&#44; IMIM&#44; Universidad Aut&#243;noma de Barcelona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Secci&#243;n de Hepatolog&#237;a&#44; Parc de Salut Mar&#44; Hospital del Mar&#44; IMIM&#44; Universidad Aut&#243;noma de Barcelona&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Reactivaci&#243;n del virus de la hepatitis B en un paciente con artritis reumatoide tras el tratamiento con rituximab"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The reactivation of hepatitis B virus &#40;HBV&#41; infection is defined as an increase in HBV replication in a patient with an inactive or resolved hepatitis &#40;usually accompanied by increased serum transaminase levels&#41;&#46; Most reported cases have occurred in patients with hematologic malignancies after chemotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Recently&#44; there have been reports of HBV reactivation in patients with rheumatoid arthritis after treatment with biological therapies such as rituximab &#40;RTX&#41;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Although most cases of HBV reactivation have occurred in patients with serology indicating chronic HBV infection&#44; patients with resolved HBV infection can develop this complication&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 77 year old patient with a history of seropositive and erosive rheumatoid arthritis of 12 years of evolution&#44; receiving the first cycle of RTX in February 2008&#46; Serology for HBV in 2001 was HBsAg negative and anti-HBc positive&#44; compatible with resolved hepatitis B&#46; The patient received methotrexate from 2002 to 2004 and the treatment was stopped by the appearance of oral ulcers&#46; In 2005&#44; treatment was started with infliximab 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg every 8 weeks with good response&#59; after one year of treatment&#44; the patient presented a lack of response in March 2006 and it was suspended due to multiple episodes of lung infections and switched to etanercept 50<span class="elsevierStyleHsp" style=""></span>mg weekly&#46; From 2005 to 2008&#44; serum levels of ALT transaminase &#40;GPT&#41; ansd AST &#40;GOT&#41;&#44; remained stable&#44; but new virus serology was not requested&#46; Due to poor control of symptoms &#40;disease activity score &#91;DAS&#93; 28 joints 6&#46;43&#41; the patient was treated with RTX &#40;2&#215;1000&#41; in February 2008&#46; He received the second cycle of RTX in August 2008&#46; After treatment&#44; the DAS 28 was 3&#46;79&#44; but in July 2009 the patient had anicteric hepatitis with ALT &#40;GPT&#41; 555<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; AST &#40;GOT&#41; 349<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; GGT 81<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; total bilirubin 0&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and HBsAg&#43;&#44; HBeAg&#43;&#44; albumin<span class="elsevierStyleHsp" style=""></span>35<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; 70&#37; TP&#44; 99<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>platelets&#47;mm<span class="elsevierStyleSup">3</span> and HBV DNA was &#62;8<span class="elsevierStyleHsp" style=""></span>log<span class="elsevierStyleHsp" style=""></span>U&#47;ml &#40;virus genotype was A&#41;&#46; This data indicated the presence of a reactivation of chronic hepatitis B with a moderate degree of hepatocellular failure&#46; At this point the patient quickly was sent to the hepatologist and began treatment with entecavir&#46; After one month of therapy&#44; HBV was DNA down to 5&#46;4<span class="elsevierStyleHsp" style=""></span>log<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#46; Five months later HBV-DNA was only 1&#46;74<span class="elsevierStyleHsp" style=""></span>U&#47;ml &#40;3&#46;24<span class="elsevierStyleHsp" style=""></span>log<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41;&#44; but remained positive until February 2011&#46; The biochemical response was faster&#44; with normalization of transaminases after only 8 months of therapy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">HBV reactivation after immunosuppressive treatment is a serious adverse effect which can be identified and prevented&#46; There have been various guidelines and recommendations but the management of HBV occult infection with only anti-HBc positivity remains unclear today&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The consensus on RTX use in rheumatoid arthritis recommends monitoring of transaminases and&#47;or HBV DNA<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> in patients without active HBV with HBsAg negative but anti-HBc-positive antibodies&#44; as in our patient&#46; In patients who had increased levels of HBV DNA during therapy with RTX&#44; one should consider associating antiretroviral therapy&#46; The exact mechanism of HBV reactivation is unknown and although it is not a very common complication&#44; there have been cases of fulminant hepatitis that were seen even after 6 months of cessation of therapy with RTX&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Prophylactic treatment with antiretroviral therapy significantly reduces the incidence of HBV reactivation after treatment with RTX&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In conclusion&#44; strict monitoring should follow liver biochemistry&#44; HBsAg&#44; HBV-DNA in the anti-HBc positive and HBsAg negative patients during and 6 months after treatment with RTX&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salman-Monte TC&#44; Lisbona MP&#44; Garc&#237;a-Retortillo M&#44; Maym&#243; J&#46; Reactivaci&#243;n del virus de la hepatitis B en un paciente con artritis reumatoide tras el tratamiento con rituximab&#46; Reumatol Clin&#46; 2014&#59;10&#58;196&#8211;197&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">F&#58; female&#44; M&#58; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">No&#46; cycles RTX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HBV serology before RTX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HBV serology after RTX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Antiretroviral therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Evolution&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pyrpasopoulou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F 56 RA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Only RTX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg&#43; HBeAg&#43; HBeAb&#8722; HBV DNA&#62;9&#46;6&#215;10<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>U&#47;ml Normal serum transaminases treatment with lamivudine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg&#43; HBeAg&#43; HBV DNA&#62;1&#46;1&#215;10<span class="elsevierStyleSup">8</span><span class="elsevierStyleHsp" style=""></span>U&#47;ml ASAT 110<span class="elsevierStyleHsp" style=""></span>U&#47;l ALT 150<span class="elsevierStyleHsp" style=""></span>U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tenofovir and lamivudine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 months later HBV load was 46<span class="elsevierStyleHsp" style=""></span>U&#47;ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ghr&#233;nassia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M 78 RA and mantle cell lymphoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RTX&#43;prednisone 10<span class="elsevierStyleHsp" style=""></span>mg&#47;day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg HBcAb&#43;normal serum transaminases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg &#43;HBeAg&#43; HBV DNA<span class="elsevierStyleMonospace">&#62;</span>7<span class="elsevierStyleHsp" style=""></span>log<span class="elsevierStyleHsp" style=""></span>U&#47;ml ASAT 177<span class="elsevierStyleHsp" style=""></span>U&#47;l ALT 421<span class="elsevierStyleHsp" style=""></span>U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Entecavir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 months later HBV load was undetectable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M 77 RA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RTX&#43;prednisone<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mg&#47;day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg HBcAb&#43;normal serum transaminases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HBsAg&#43; HBeAg&#43; HBV DNA&#62;8<span class="elsevierStyleHsp" style=""></span>log<span class="elsevierStyleHsp" style=""></span>U&#47;ml ASAT 349<span class="elsevierStyleHsp" style=""></span>U&#47;l ALT 555<span class="elsevierStyleHsp" style=""></span>U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Entecavir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 months later HBV load was undetectable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab517346.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Previous Cases of HBV Reactivation in RA Patients Following Treatment With RTX&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:5 [
                            0 => "W&#46; Yeo"
                            1 => "T&#46;C&#46; Chan"
                            2 => "N&#46;W&#46;Y&#46; Leung"
                            3 => "F&#46;K&#46;F&#46; Lam WY&#44; Mo"
                            4 => "M&#46;T&#46; Chu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2008.18.0182"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2008"
                        "volumen" => "27"
                        "paginaInicial" => "605"
                        "paginaFinal" => "611"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19075267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactivation of hepatitis B virus during RTX treatment of a patient with follucilar limphoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; Yang"
                            1 => "S&#46;H&#46; Kuo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Haematol"
                        "fecha" => "2008"
                        "volumen" => "87"
                        "paginaInicial" => "325"
                        "paginaFinal" => "327"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactivation of hepatitis B virus following rituximab-based regimens&#58; a serious complication in both HBsAg-positive and HBsAg-negative patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Pei"
                            1 => "C&#46; Chen"
                            2 => "C&#46; Lee"
                            3 => "M&#46; Wang"
                            4 => "M&#46; Ma"
                            5 => "T&#46;H&#46; Hu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00277-009-0806-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Hematol"
                        "fecha" => "2010"
                        "volumen" => "89"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19697028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactivation of chronic hepatitis B virus infection following rituximab administration for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Pyrpasoppoulou"
                            1 => "S&#46; Douma"
                            2 => "T&#46; Vassiliadis"
                            3 => "S&#46; Chatzimichailidou"
                            4 => "A&#46; Triantafyllou"
                            5 => "S&#46; Aslanidis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00296-009-1202-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatol Int"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "paginaInicial" => "403"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19830433"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactivation of resolved hepatitis B during rituximab therapy for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Ghr&#233;nassia"
                            1 => "A&#46; M&#233;knian"
                            2 => "S&#46; Rouaghe"
                            3 => "N&#46; Granne"
                            4 => "O&#46; Fain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jbspin.2011.07.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Joint Bone Spine"
                        "fecha" => "2012"
                        "volumen" => "79"
                        "paginaInicial" => "100"
                        "paginaFinal" => "101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21944979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatitis B virus infections and anti-tumor necrosis factor-alpha therapy&#58; guidelines for clinical approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;M&#46; Nathan"
                            1 => "P&#46;W&#46; Angus"
                            2 => "P&#46;R&#46; Gibson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1746.2006.04559.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastroenterol Hepatol"
                        "fecha" => "2006"
                        "volumen" => "21"
                        "paginaInicial" => "1366"
                        "paginaFinal" => "2137"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16911678"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preventing hepatitis B reactivation in immunosuppressed patients&#58; is it time to revisit the guidelines&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Yazdany"
                            1 => "L&#46; Calabrese"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res &#40;Hoboken&#41;"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "585"
                        "paginaFinal" => "589"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;H&#46; Buch"
                            1 => "J&#46;S&#46; Smolen"
                            2 => "N&#46; Betteridge"
                            3 => "F&#46;C&#46; Breedveld"
                            4 => "G&#46; Burmester"
                            5 => "T&#46; D&#246;rner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2010.144998"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2011"
                        "volumen" => "70"
                        "paginaInicial" => "909"
                        "paginaFinal" => "920"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21378402"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rituximab administration and reactivation of HBV"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Tsutsumi"
                            1 => "R&#46; Ogasawara"
                            2 => "Y&#46; Kamihara"
                            3 => "S&#46; Ito"
                            4 => "Y&#46; Yamamoto"
                            5 => "J&#46; Tanaka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Hepatitis Res Treat"
                        "fecha" => "2010"
                        "volumen" => "2010"
                        "paginaInicial" => "182067"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of hepatitis B virus reactivation in patients who are hepatitis B surface antigen negative&#47;antibody to hepatitis B core antigen positive and the role of routine antiviral prophylaxis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46;X&#46; Koo"
                            1 => "D&#46;S&#46; Tan"
                            2 => "B&#46;H&#46; Tan"
                            3 => "R&#46; Quek"
                            4 => "M&#46; Tao"
                            5 => "S&#46;T&#46; Lim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2009.21.9352"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "2570"
                        "paginaFinal" => "2571"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19364951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001000000003/v2_201406190029/S217357431300138X/v2_201406190029/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001000000003/v2_201406190029/S217357431300138X/v2_201406190029/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431300138X?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 10. Issue 3.
Pages 196-197 (May - June 2014)
Vol. 10. Issue 3.
Pages 196-197 (May - June 2014)
Letter to the Editor
Full text access
Reactivation of Hepatitis Virus B Infection in a Patient With Rheumatoid Arthritis After Treatment With Rituximab
Reactivación del virus de la hepatitis B en un paciente con artritis reumatoide tras el tratamiento con rituximab
Visits
5359
Tarek Carlos Salman-Montea,
Corresponding author
, María Pilar Lisbonaa, Montserrat García-Retortillob, Joan Maymóa
a Servicio de Reumatología, Parc de Salut Mar, Hospital del Mar, IMIM, Universidad Autónoma de Barcelona, Barcelona, Spain
b Sección de Hepatología, Parc de Salut Mar, Hospital del Mar, IMIM, Universidad Autónoma de Barcelona, Barcelona, Spain
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Tables (1)
Table 1. Previous Cases of HBV Reactivation in RA Patients Following Treatment With RTX.
Full Text
To the editor:

The reactivation of hepatitis B virus (HBV) infection is defined as an increase in HBV replication in a patient with an inactive or resolved hepatitis (usually accompanied by increased serum transaminase levels). Most reported cases have occurred in patients with hematologic malignancies after chemotherapy.1–3 Recently, there have been reports of HBV reactivation in patients with rheumatoid arthritis after treatment with biological therapies such as rituximab (RTX)4,5 (Table 1). Although most cases of HBV reactivation have occurred in patients with serology indicating chronic HBV infection, patients with resolved HBV infection can develop this complication.5

Table 1.

Previous Cases of HBV Reactivation in RA Patients Following Treatment With RTX.

Reference  Patient  Treatment  No. cycles RTX  HBV serology before RTX  HBV serology after RTX  Antiretroviral therapy  Evolution 
Pyrpasopoulou et al.1  F 56 RA  Only RTX  HBsAg+ HBeAg+ HBeAb− HBV DNA>9.6×102U/ml Normal serum transaminases treatment with lamivudine  HBsAg+ HBeAg+ HBV DNA>1.1×108U/ml ASAT 110U/l ALT 150U/l  Tenofovir and lamivudine  10 months later HBV load was 46U/ml 
Ghrénassia et al.5  M 78 RA and mantle cell lymphoma  RTX+prednisone 10mg/day  HBsAg HBcAb+normal serum transaminases  HBsAg +HBeAg+ HBV DNA>7logU/ml ASAT 177U/l ALT 421U/l  Entecavir  6 months later HBV load was undetectable 
Case  M 77 RA  RTX+prednisone15mg/day  HBsAg HBcAb+normal serum transaminases  HBsAg+ HBeAg+ HBV DNA>8logU/ml ASAT 349U/l ALT 555U/l  Entecavir  18 months later HBV load was undetectable 

F: female, M: male.

We report the case of a 77 year old patient with a history of seropositive and erosive rheumatoid arthritis of 12 years of evolution, receiving the first cycle of RTX in February 2008. Serology for HBV in 2001 was HBsAg negative and anti-HBc positive, compatible with resolved hepatitis B. The patient received methotrexate from 2002 to 2004 and the treatment was stopped by the appearance of oral ulcers. In 2005, treatment was started with infliximab 3mg/kg every 8 weeks with good response; after one year of treatment, the patient presented a lack of response in March 2006 and it was suspended due to multiple episodes of lung infections and switched to etanercept 50mg weekly. From 2005 to 2008, serum levels of ALT transaminase (GPT) ansd AST (GOT), remained stable, but new virus serology was not requested. Due to poor control of symptoms (disease activity score [DAS] 28 joints 6.43) the patient was treated with RTX (2×1000) in February 2008. He received the second cycle of RTX in August 2008. After treatment, the DAS 28 was 3.79, but in July 2009 the patient had anicteric hepatitis with ALT (GPT) 555U/L, AST (GOT) 349U/l, GGT 81U/l, total bilirubin 0.7mg/dl and HBsAg+, HBeAg+, albumin35mg/dl, 70% TP, 99000platelets/mm3 and HBV DNA was >8logU/ml (virus genotype was A). This data indicated the presence of a reactivation of chronic hepatitis B with a moderate degree of hepatocellular failure. At this point the patient quickly was sent to the hepatologist and began treatment with entecavir. After one month of therapy, HBV was DNA down to 5.4logU/ml. Five months later HBV-DNA was only 1.74U/ml (3.24logU/ml), but remained positive until February 2011. The biochemical response was faster, with normalization of transaminases after only 8 months of therapy.

HBV reactivation after immunosuppressive treatment is a serious adverse effect which can be identified and prevented. There have been various guidelines and recommendations but the management of HBV occult infection with only anti-HBc positivity remains unclear today.6,7 The consensus on RTX use in rheumatoid arthritis recommends monitoring of transaminases and/or HBV DNA8 in patients without active HBV with HBsAg negative but anti-HBc-positive antibodies, as in our patient. In patients who had increased levels of HBV DNA during therapy with RTX, one should consider associating antiretroviral therapy. The exact mechanism of HBV reactivation is unknown and although it is not a very common complication, there have been cases of fulminant hepatitis that were seen even after 6 months of cessation of therapy with RTX.9 Prophylactic treatment with antiretroviral therapy significantly reduces the incidence of HBV reactivation after treatment with RTX.10 In conclusion, strict monitoring should follow liver biochemistry, HBsAg, HBV-DNA in the anti-HBc positive and HBsAg negative patients during and 6 months after treatment with RTX.

References
[1]
W. Yeo, T.C. Chan, N.W.Y. Leung, F.K.F. Lam WY, Mo, M.T. Chu, et al.
Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab.
J Clin Oncol, 27 (2008), pp. 605-611
[2]
S.H. Yang, S.H. Kuo.
Reactivation of hepatitis B virus during RTX treatment of a patient with follucilar limphoma.
Ann Haematol, 87 (2008), pp. 325-327
[3]
S. Pei, C. Chen, C. Lee, M. Wang, M. Ma, T.H. Hu, et al.
Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients.
Ann Hematol, 89 (2010), pp. 255-262
[4]
A. Pyrpasoppoulou, S. Douma, T. Vassiliadis, S. Chatzimichailidou, A. Triantafyllou, S. Aslanidis.
Reactivation of chronic hepatitis B virus infection following rituximab administration for rheumatoid arthritis.
Rheumatol Int, 31 (2011), pp. 403-404
[5]
E. Ghrénassia, A. Méknian, S. Rouaghe, N. Granne, O. Fain.
Reactivation of resolved hepatitis B during rituximab therapy for rheumatoid arthritis.
Joint Bone Spine, 79 (2012), pp. 100-101
[6]
D.M. Nathan, P.W. Angus, P.R. Gibson.
Hepatitis B virus infections and anti-tumor necrosis factor-alpha therapy: guidelines for clinical approach.
J Gastroenterol Hepatol, 21 (2006), pp. 1366-2137
[7]
J. Yazdany, L. Calabrese.
Preventing hepatitis B reactivation in immunosuppressed patients: is it time to revisit the guidelines?.
Arthritis Care Res (Hoboken), 62 (2010), pp. 585-589
[8]
M.H. Buch, J.S. Smolen, N. Betteridge, F.C. Breedveld, G. Burmester, T. Dörner, et al.
Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis.
Ann Rheum Dis, 70 (2011), pp. 909-920
[9]
Y. Tsutsumi, R. Ogasawara, Y. Kamihara, S. Ito, Y. Yamamoto, J. Tanaka, et al.
Rituximab administration and reactivation of HBV.
Hepatitis Res Treat, 2010 (2010), pp. 182067
[10]
Y.X. Koo, D.S. Tan, B.H. Tan, R. Quek, M. Tao, S.T. Lim.
Risk of hepatitis B virus reactivation in patients who are hepatitis B surface antigen negative/antibody to hepatitis B core antigen positive and the role of routine antiviral prophylaxis.
J Clin Oncol, 27 (2009), pp. 2570-2571

Please cite this article as: Salman-Monte TC, Lisbona MP, García-Retortillo M, Maymó J. Reactivación del virus de la hepatitis B en un paciente con artritis reumatoide tras el tratamiento con rituximab. Reumatol Clin. 2014;10:196–197.

Copyright © 2013. Elsevier España, S.L.. All rights reserved
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?