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Vol. 17. Issue 10.
Pages 575-581 (December 2021)
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Vol. 17. Issue 10.
Pages 575-581 (December 2021)
Original Article
Serum immunoglobulin levels, complement components 3 and 4, HLA-B27 allele and spondyloarthropathy in patients with non-infectious anterior uveites
Niveles séricos de inmunoglobulinas, componentes 3 y 4 del complemento, alelo HLA-B27 y espondiloartropatía en pacientes con uveítis anterior no infecciosa
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Bárbara Torres Rivesa,
Corresponding author
barbara.torres@infomed.sld.cu

Corresponding author.
, Goitybell Martínez Télleza, Minerva Mataran Valdésa, Teresa Collazo Mesab, Rosa Colás Gonzálezb, Isabel Frutos Ambouc
a Laboratorio de Inmunología, Centro Nacional de Genética Médica, La Habana, Cuba
b Laboratorio de Biología Molecular, Centro Nacional de Genética Médica, La Habana, Cuba
c Departamento de Uveítis, Instituto Cubano de Oftalmología Ramón Pando Ferrer, La Habana, Cuba
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Tables (4)
Table 1. Demographic variables, clinical, serum levels of immunoglobulins and the complement components 3 and 4 according to the presence of the HLA-B27 allele and diagnosis of spondyloarthropathies in patients with non-infectious anterior uveites.
Table 2. Association of the decrease of IgG e IgM with sex, ophthalmic complications, arthalgias and personal histories of a suspicion of immunodeficiencies in patients with non-infectious anterior uveites.
Table 3. Immunoglobulin alterations in patients with diagnosis of non-infectious anterior uveitis.
Table 4. Association of drop in C3 and C4 with sex, ophthalmologic complications, arthralgias and personal backgorund of suspicion of immunodeficiency in patients with non-infectious anterior uveitis.
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Abstract
Objective

To identify the relationship between serum immunoglobulin levels, complement components 3 and 4, the presence of the HLA-B27 allele and diagnosis of spondyloarthropathies in patients with non-infectious anterior uveitis.

Materials and methods

The participants were 197 patients with a non-infectious anterior uveitis. The concentrations of serum immunoglobulins, C3 and C4 proteins of the complement were determined by turbidimetry. The personal history of suspected immunodeficiency, ophthalmological complications, arthralgia, family history of spondyloarthropathies and the presence of the HLA-B27 allele were collected.

Results

A family history of spondyloarthropathy, axial arthralgias, and ophthalmological complications were more frequent in HLA-B27 positive patients (P=.0005, P.0001, P.0001 respectively) and in patients with spondyloarthropathy diagnoses (P.0001, P.0001, P.0001 respectively). A personal history of recurrent sepsis, and gastrointestinal abnormalities was associated with the presence of the HLA-B27 allele (P.0001, P=.0240 respectively) and with the diagnosis of spondyloarthropathy (P=.0492, P=.0017 respectively). IgG decrease was observed (χ2=18.5, OR=5.03, 95% CI=2.32–10.89, P=.0001) and M (OR=7.13, 95% CI=1.40−36.4; P=.0128) in patients positive for the HLA-B27 allele and in patients with a diagnosis of SpA (P=.0364 and P=.0028 respectively). The decrease of C3 proteins (OR=4.82; CI 95%=1.35–17.11; P=.0328) and C4 (OR=9.09; CI 95%=2.13–38.88; P=.0074) were associated with a spondyloarthropathies diagnosis.

Conclusions

Patients with non-infectious anterior uveitis, positive for the HLA-B27 allele and diagnosed with spondyloarthropathies have alterations in serum immunoglobulin levels and complement components 3 and 4, which could contribute to the perpetuation and worse clinical course of this disease.

Keywords:
Non-infectious anterior uveitis
HLA- B27
Immunoglobulins
Serum complement
Immunodeficiency
Resumen
Objetivo

Identificar la relación entre los niveles séricos de inmunoglobulinas, los componentes 3 y 4 del complemento, la presencia del alelo HLA-B27 y el diagnóstico de espondiloartropatía en pacientes con uveítis anterior no infecciosa.

Materiales y métodos

Se incluyeron 197 pacientes con diagnóstico de uveítis anterior no infecciosa. Se determinaron las concentraciones de inmunoglobulinas séricas y proteínas C3 y C4 del complemento mediante turbidimetría. Se recogieron los antecedentes personales de sospecha de inmunodeficiencia, complicaciones oftalmológicas, de artralgias, antecedentes familiares de espondiloartropatías y la presencia del alelo HLA-B27.

Resultados

Los antecedentes familiares de espondiloartropatías, de artralgias axiales y complicaciones oftalmológicas fueron más frecuentes en los pacientes positivos de HLA-B27 (p=0,0005, p0,0001, p0,0001 respectivamente) y en los pacientes con diagnósticos de espondiloartropatías (p0,0001, p0,0001, p0,0001 respectivamente). Los antecedentes personales de sospecha de inmunodeficiencia, sepsis recurrentes y alteraciones gastrointestinales, se asociaron a la presencia del alelo HLA-B27 (p0,0001, y p=0,0240 respectivamente) y al diagnóstico de espondiloartropatía (p=0,0492 y p=0,0017 respectivamente). Se observó disminución de las IgG (χ2=18,5; OR=5,03; IC 95%=2,32−10,89; p=0,0001) y M (OR=7,13; IC 95%=1,40−36,4; p=0,0128) en pacientes positivos del alelo HLA-B27 y en los pacientes con diagnóstico de EspA (p=0,0364 y p=0,0028 respectivamente). La disminución de las proteínas C3 (OR=4,82; IC=1,35−17,11; p=0,0328) y C4 (OR=9,09; IC=2,13–38,88; p=0,0074) se asociaron al diagnóstico de espondiloartropatías.

Conclusiones

Los pacientes con uveítis anterior no infecciosa, positivos del alelo HLA-B27 y con diagnóstico de espondiloartropatías tienen alteraciones de los niveles séricos de inmunoglobulinas, los componentes 3 y 4 del complemento, las cuales pudieran contribuir a la perpetuación y peor curso clínico de esta enfermedad.

Palabras clave:
Uveítis anterior no infecciosa
HLA-B27
Inmunoglobulinas
Complemento sérico
Inmunodeficiencia

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