Publish in this journal
Journal Information
Vol. 13. Issue 2.
Pages 122 (March - April 2017)
Vol. 13. Issue 2.
Pages 122 (March - April 2017)
Letter to the Editor
DOI: 10.1016/j.reumae.2016.05.004
Full text access
Similarities Between Takayasu Arteritis and Giant Cell Arteritis
Similitudes entre la arteritis de Takayasu y la arteritis de células gigantes
Visits
...
Maria Noelia Antoniol, Carlos Edgardo Perandones
Corresponding author
perandones0@gmail.com

Corresponding author.
Sección Reumatología, Departamento de Medicina Interna, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
Dear Editor,

We were very interested in the letter to the editor published in this journal in March of this year, by Drs. Martín Guillén, Álvarez de Cienfuegos and Hurtado García.1

The case they mention brought us to make certain reflections. Our patient is a 59-year-old woman at the onset of the disease, with occipital headaches accompanied by an increase in levels of acute-phase reactants. Physical examination revealed asymmetric peripheral pulses and the same was observed in temporal pulses.

Both Takayasu arteritis (TA) and giant cell arteritis (GCA) are vasculitides that predominantly affect large-sized vessels.2

There are significant differences between these 2 disorders. Takayasu arteritis is generally found in patients under 40 years of age. It mostly involves the aorta and its major branches, whereas GCA mainly affects patients over 50 years of age, and is detected in branches of the external carotid artery. Both diseases predominantly affect women, they share pathogenic mechanisms and pathological findings, and have a similar response to treatment.

The typical symptoms of GCA are headache, loss of vision, jaw claudication and symptoms of polymyalgia. However, approximately 40% of the patients have manifestations considered atypical. Within this group, clinical involvement of the aorta and its major branches is found in 10%–15% of the patients as an initial manifestation.3 A study performed by Ostberg in autopsies of patients with GCA revealed the involvement of the aorta in 12 of 13 cases.4 In their cohort of 168 patients with GCA, Nuenninghoff et al. found that 27% had complications affecting the large vessels. In all, 18% had aortic aneurysm/dissection and 13% had stenosis.5 The majority of the cases are asymptomatic and it is underdiagnosed and, thus, its true prevalence is unknown. Patients with stenosis of the large vessels generally have fewer cranial symptoms, are found to have fewer changes in the temporal arteries on biopsies and a less marked increase in the levels of acute-phase reactants.5

The detection of the involvement of the aorta its branches increases notably when ancillary tests like ultrasound, computed tomography angiography, positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) or angiography are utilized.3,6–8

The study evaluated 35 GCA patients who had not been treated with corticosteroids because of FDG-PET and found that 83% had increased FDG uptake in the large arteries. The involvement of the subclavian artery and aorta was observed in 74% and 54% of the cases, respectively. The uptake of FDG had increased after 3 months of treatment with corticosteroids.6 In another study, computed tomography angiography showed involvement of the large vessels in 67.5% of 40 patients with GCA. Those most widely affected were the aorta (65%), brachiocephalic trunk (47.5%), carotid arteries (35%) and subclavian arteries (42.5%).7

In short, their patient, at the age of 64 years, has headaches but no Doppler evidence or temporal artery biopsy, and the predominating signs are arterial stenoses. She may have TA, as was suggested, or could have GCA, with stenoses involving the large vessels.

References
[1]
S. Martín Guillén, A. Álvarez de Cienfuegos, R. Hurtado García.
Nuevos fármacos en la arteritis de Takayasu, papel del tocilizumab.
[2]
J.C. Jennette, R.J. Falk, P.A. Bacon, N. Basu, M.C. Cid, F. Ferrario, et al.
2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides.
Arthritis Rheum, 65 (2013), pp. 1-11
[3]
M.C. Cid, S. Prieto-González, P. Arguis, G. Espígol-Frigolé, M. Butjosa, J. Hernández-Rodríguez, et al.
The spectrum of vascular involvement in giant-cell arteritis: clinical consequences of detrimental vascular remodeling at different sites.
APMIS, (2009), pp. 10-20
[4]
G. Ostberg.
Morphological changes in the large arteries in polymyalgia arteritica.
Acta Med Scand Suppl, 533 (1972), pp. 135-159
[5]
D.M. Nuenninghoff, G.G. Hunder, T.J. Christianson, R.L. McClelland, E.L. Matteson.
Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years.
Arthritis Rheum, 48 (2003), pp. 3522-3531
[6]
D. Blockmans, L. de Ceuninck, S. Vanderschueren, D. Knockaert, L. Mortelmans, H. Bobbaers.
Repetitive 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients.
Arthritis Rheum, 55 (2006), pp. 131-137
[7]
S. Prieto-González, P. Arguis, A. García-Martínez, G. Espígol-Frigolé, I. Tavera-Bahillo, M. Butjosa, et al.
Large vessel involvement in biopsy-proven giant cell arteritis: prospective study in 40 newly diagnosed patients using CT angiography.
Ann Rheum Dis, 71 (2012), pp. 1170-1176
[8]
W.A. Schmidt, A. Seifert, E. Gromnica-Ihle, A. Krause, A. Natusch.
Ultrasound of proximal upper extremity arteries to increase the diagnostic yield in large-vessel giant cell arteritis.
Rheumatology (Oxford), 47 (2008), pp. 96-101

Please cite this article as: Antoniol MN, Perandones CE. Similitudes entre la arteritis de Takayasu y la arteritis de células gigantes. Reumatol Clin. 2017;13:122.

Copyright © 2016. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Idiomas
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.