Journal Information
Vol. 20. Issue 4.
Pages 218-222 (April 2024)
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Vol. 20. Issue 4.
Pages 218-222 (April 2024)
Case Report
Spontaneous pneumomediastinum: An extra muscular manifestation of anti-MDA5 dermatomyositis. Report of 2 cases
Neumomediastino espontáneo: una manifestación extramuscular de la dermatomiositis anti-MDA5. Reporte de dos casos
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Pablo Arango Guerraa,
Corresponding author
pablo828@hotmail.es

Corresponding author.
, Santiago Monsalve Yepesa, Andrés Chavarriaga Restrepob, Carlos Jaime Velasquez Francoc
a Medicina Interna, Clínica CES, Universidad CES, Medellín, Colombia
b Reumatología, Clínica CES, Medellín, Colombia
c Reumatología, Clínica Universitaria Bolivariana, Medellín, Colombia
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Abstract

The use of specific antibodies in inflammatory myopathies has improved the characterization of this disease, identifying different clinical phenotypes. Patients with dermatomyositis (DM) and anti-MDA5 antibodies display typical skin symptoms, lesser muscular involvement, and a prevalence of interstitial lung disease (ILD) of up to 91%. Beyond ILD, spontaneous pneumomediastinum (SN) has been identified as a rare but potentially fatal pulmonary manifestation. Two cases of this complication in patients with anti-MDA5 DM are reported.

Keywords:
Dermatomyositis
Pneumomediastinum
Subcutaneous emphysema
Pneumothorax
Interstitial lung disease
Resumen

El uso de anticuerpos específicos en miopatías inflamatorias ha mejorado la caracterización de esta enfermedad identificando distintos fenotipos clínicos. Los pacientes con dermatomiositis (DM) y anticuerpos anti MDA5 muestran síntomas típicos en piel, menor compromiso muscular y una prevalencia de enfermedad pulmonar intersticial (EPI) de hasta el 91%. Además de la EPI, se ha identificado el neumomediastino espontáneo (NE) como una manifestación pulmonar rara pero potencialmente mortal. Se reportan 2 casos de esta manifestación en pacientes con DM anti MDA5.

Palabras clave:
Dermatomiositis
Neumomediastino
Enfisema subcutáneo
Neumotórax
Enfermedades pulmonares intersticiales

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