array:24 [
  "pii" => "S2173574320301167"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.08.013"
  "estado" => "S300"
  "fechaPublicacion" => "2020-11-01"
  "aid" => "1272"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2020;16:506-7"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S1699258X18301906"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2018.08.010"
      "estado" => "S300"
      "fechaPublicacion" => "2020-11-01"
      "aid" => "1272"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Reumatol Clin. 2020;16:506-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 20
        "formatos" => array:2 [
          "HTML" => 14
          "PDF" => 6
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Reumatolog&#237;a Cl&#237;nica en im&#225;genes</span>"
        "titulo" => "Gota tof&#225;cea en una mujer"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "506"
            "paginaFinal" => "507"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Tophaceous Gout in a Woman"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 597
                "Ancho" => 900
                "Tamanyo" => 53453
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Radiograf&#237;a de manos&#58; aumento de partes blandas y erosiones&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Jos&#233; P&#233;rez Gal&#225;n, Celia Garc&#237;a Jim&#233;nez"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Jos&#233;"
                "apellidos" => "P&#233;rez Gal&#225;n"
              ]
              1 => array:2 [
                "nombre" => "Celia"
                "apellidos" => "Garc&#237;a Jim&#233;nez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574320301167"
          "doi" => "10.1016/j.reumae.2018.08.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301167?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18301906?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001600000006/v1_202010290752/S1699258X18301906/v1_202010290752/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S217357431930187X"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.11.017"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "1309"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2020;16:508-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Anemia and eosinophilia secondary to <span class="elsevierStyleItalic">Strongyloides</span> in a patient treated with anti-TNF-alpha"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "508"
          "paginaFinal" => "509"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Anemia y eosinofilia secundaria a Strongyloides en un paciente tratado con anti-TNF alfa"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "&#193;gueda Prior-Espa&#241;ol, Silvia Roure, Lourdes Mateo, Melania Mart&#237;nez-Morillo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "&#193;gueda"
              "apellidos" => "Prior-Espa&#241;ol"
            ]
            1 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Roure"
            ]
            2 => array:2 [
              "nombre" => "Lourdes"
              "apellidos" => "Mateo"
            ]
            3 => array:2 [
              "nombre" => "Melania"
              "apellidos" => "Mart&#237;nez-Morillo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X18302638"
        "doi" => "10.1016/j.reuma.2018.11.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18302638?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431930187X?idApp=UINPBA00004M"
    "url" => "/21735743/0000001600000006/v1_202011251719/S217357431930187X/v1_202011251719/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574320301179"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.08.014"
    "estado" => "S300"
    "fechaPublicacion" => "2020-11-01"
    "aid" => "1275"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2020;16:502-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Coexistence of systemic lupus erythematosus and myasthenia gravis&#58; an unusual case of polyautoimmunity"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "502"
          "paginaFinal" => "505"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Coexistencia de lupus eritematoso sist&#233;mico y miastenia gravis&#46; Una expresi&#243;n infrecuente de poliautoinmunidad"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1205
              "Ancho" => 905
              "Tamanyo" => 120606
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0015"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Palpebral ptosis in the initial evaluation of the patient and herpes lesions&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carolina Garc&#237;a-Alfonso, Santiago Bernal-Mac&#237;as, Yulieth Garc&#237;a-Pardo, Sonia Patricia Mill&#225;n, Mar&#237;a-Claudia D&#237;az"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Carolina"
              "apellidos" => "Garc&#237;a-Alfonso"
            ]
            1 => array:2 [
              "nombre" => "Santiago"
              "apellidos" => "Bernal-Mac&#237;as"
            ]
            2 => array:2 [
              "nombre" => "Yulieth"
              "apellidos" => "Garc&#237;a-Pardo"
            ]
            3 => array:2 [
              "nombre" => "Sonia"
              "apellidos" => "Patricia Mill&#225;n"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a-Claudia"
              "apellidos" => "D&#237;az"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X18301931"
        "doi" => "10.1016/j.reuma.2018.08.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18301931?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301179?idApp=UINPBA00004M"
    "url" => "/21735743/0000001600000006/v1_202011251719/S2173574320301179/v1_202011251719/en/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
    "titulo" => "Tophaceous gout in a woman"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "506"
        "paginaFinal" => "507"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Jos&#233; P&#233;rez Gal&#225;n, Celia Garc&#237;a Jim&#233;nez"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Mar&#237;a Jos&#233;"
            "apellidos" => "P&#233;rez Gal&#225;n"
            "email" => array:1 [
              0 => "mjpg77@hotmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Celia"
            "apellidos" => "Garc&#237;a Jim&#233;nez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Unidad de Reumatolog&#237;a&#44; Complejo Hospitalario de Ja&#233;n&#44; Ja&#233;n&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Gota tof&#225;cea en una mujer"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 927
            "Ancho" => 905
            "Tamanyo" => 84527
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">X-ray image of feet&#58; erosion in the first metatarsophalangeal joints&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical case</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 76 year-old woman&#44; with a history of anaemia and hyperuricemia treated with ferrous sulphate and 100&#8239;mg allopurinol per day&#46; She states that she has consumed half a litre of alcohol-free beer per day for 15 years&#46; She states that she has no history of arterial hypertension&#44; no chronic disease and that she does not consume diuretics&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">She visited our surgery due to arthralgia in the hands and feet with a crisis of pain and functional impotency in multiple joints that has evolved over more than 15 years&#46; Physical examination found major tophaceous deposits in the hands and feet&#44; most strikingly in the right hand &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with incapacity of grasping&#44; above all in the right hand&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Analysis detected 7&#46;7&#8239;mg&#47;dl uricaemia&#44; while the rest of basic biochemistry was normal&#46; The haemogram&#44; acute phase reagents&#44; rheumatoid factor and anti-citrulline antibodies were normal or negative&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Bone X-ray imaging showed an important increase in the soft parts&#44; with trapping and erosion in the metacarpophalangeal&#44; proximal and distal interphalangeal joints of both hands &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; as well as erosion on the first metatarsal joints and luxation of the 5th left metatarsal joint &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Tophaceous gout&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Evol&#8239;ution</span><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment with hygienic and dietary methods was prescribed&#44; with colchicine and an increased dose of allopurinol to maintain uricaemia below 5&#8239;mg&#47;dl&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Gout arthropathy is more common in men<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> than it is in women&#44; although it is the most frequent inflammatory disease of the joints in post-menopausal women&#46; The first manifestation of the disease is typically acute arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Tophi are sodium urate monohydrate deposits surrounded by a granulomatous inflammatory reaction&#46; They are a pathognomic characteristic of gout and can be detected by physical examination and&#47;or imaging techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">We present the case of a woman with tophaceous arthropathy&#46; We recall the importance of maintaining suitable levels of uricaemia&#44; as this disease is potentially disabling&#46; We underline that although it occurs more frequently in men&#44; it is the most common inflammatory arthropathy in post-menopausal women&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:6 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Clinical case"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Diagnosis"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Evol&#8239;ution"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interests"
        ]
        5 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-05-27"
    "fechaAceptado" => "2018-08-02"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez Gal&#225;n MJ&#44; Garc&#237;a Jim&#233;nez C&#46; Gota tof&#225;cea en una mujer&#46; Reumatol Clin&#46; 2020&#59;16&#58;506&#8211;507&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 680
            "Ancho" => 905
            "Tamanyo" => 61701
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tophaceous deposits in the hands&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 602
            "Ancho" => 905
            "Tamanyo" => 53310
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">X-ray image of hands&#58; increased soft parts and erosion&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 927
            "Ancho" => 905
            "Tamanyo" => 84527
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">X-ray image of feet&#58; erosion in the first metatarsophalangeal joints&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of gout in women&#58; Fifty-two-year followup of a prospective cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Bhole"
                            1 => "Rahman M&#46;M&#46; de VM"
                            2 => "E&#46; Krishnan"
                            3 => "H&#46; Choi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.27338"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "1069"
                        "paginaFinal" => "1076"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20131266"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46; Neogi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gout N Engl J Med"
                        "fecha" => "2011"
                        "volumen" => "364"
                        "paginaInicial" => "443"
                        "paginaFinal" => "452"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Tophi&#44; mainly in articular&#44; periarticular&#44; bursal&#44; bone&#44; auricular&#44; and cutaneous tissues are a pathognomonic feature of gout&#44; and are detectable by physical exam&#44; and&#47;or by imaging approaches and pathology examination&#46;"
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001600000006/v1_202011251719/S2173574320301167/v1_202011251719/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5795"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Images in Clinical Rheumatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001600000006/v1_202011251719/S2173574320301167/v1_202011251719/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301167?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 16. Issue 6.
Pages 506-507 (November - December 2020)
Visits
4208
Vol. 16. Issue 6.
Pages 506-507 (November - December 2020)
Images in Clinical Rheumatology
Full text access
Tophaceous gout in a woman
Gota tofácea en una mujer
Visits
4208
María José Pérez Galán
Corresponding author
mjpg77@hotmail.com

Corresponding author.
, Celia García Jiménez
Unidad de Reumatología, Complejo Hospitalario de Jaén, Jaén, Spain
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Full Text
Clinical case

A 76 year-old woman, with a history of anaemia and hyperuricemia treated with ferrous sulphate and 100 mg allopurinol per day. She states that she has consumed half a litre of alcohol-free beer per day for 15 years. She states that she has no history of arterial hypertension, no chronic disease and that she does not consume diuretics.

She visited our surgery due to arthralgia in the hands and feet with a crisis of pain and functional impotency in multiple joints that has evolved over more than 15 years. Physical examination found major tophaceous deposits in the hands and feet, most strikingly in the right hand (Fig. 1), with incapacity of grasping, above all in the right hand.

Figure 1.

Tophaceous deposits in the hands.

(0.06MB).

Analysis detected 7.7 mg/dl uricaemia, while the rest of basic biochemistry was normal. The haemogram, acute phase reagents, rheumatoid factor and anti-citrulline antibodies were normal or negative.

Bone X-ray imaging showed an important increase in the soft parts, with trapping and erosion in the metacarpophalangeal, proximal and distal interphalangeal joints of both hands (Fig. 2), as well as erosion on the first metatarsal joints and luxation of the 5th left metatarsal joint (Fig. 3).

Figure 2.

X-ray image of hands: increased soft parts and erosion.

(0.05MB).
Figure 3.

X-ray image of feet: erosion in the first metatarsophalangeal joints.

(0.08MB).
Diagnosis

Tophaceous gout.

Evol ution

Treatment with hygienic and dietary methods was prescribed, with colchicine and an increased dose of allopurinol to maintain uricaemia below 5 mg/dl.

Discussion

Gout arthropathy is more common in men1 than it is in women, although it is the most frequent inflammatory disease of the joints in post-menopausal women. The first manifestation of the disease is typically acute arthritis.2 Tophi are sodium urate monohydrate deposits surrounded by a granulomatous inflammatory reaction. They are a pathognomic characteristic of gout and can be detected by physical examination and/or imaging techniques.3

We present the case of a woman with tophaceous arthropathy. We recall the importance of maintaining suitable levels of uricaemia, as this disease is potentially disabling. We underline that although it occurs more frequently in men, it is the most common inflammatory arthropathy in post-menopausal women.

Conflict of interests

The authors have no conflict of interests to declare.

References
[1]
V. Bhole, Rahman M.M. de VM, E. Krishnan, H. Choi.
Epidemiology of gout in women: Fifty-two-year followup of a prospective cohort.
Arthritis Rheum, 62 (2010), pp. 1069-1076
[2]
T. Neogi.
Clinical practice.
Gout N Engl J Med, 364 (2011), pp. 443-452
[3]
Tophi, mainly in articular, periarticular, bursal, bone, auricular, and cutaneous tissues are a pathognomonic feature of gout, and are detectable by physical exam, and/or by imaging approaches and pathology examination.

Please cite this article as: Pérez Galán MJ, García Jiménez C. Gota tofácea en una mujer. Reumatol Clin. 2020;16:506–507.

Copyright © 2018. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?