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Vol. 12. Issue 1.
Pages 22-26 (January - February 2016)
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Vol. 12. Issue 1.
Pages 22-26 (January - February 2016)
Original Article
DOI: 10.1016/j.reumae.2015.03.011
Two-year Incidence of Psoriasis, Uveitis and Inflammatory Bowel Disease in Patients With Spondyloarthritis: A Study in the AQUILES Cohort
Incidencia a los 2 años de psoriasis, uveítis y enfermedad inflamatoria intestinal en la cohorte de pacientes con espondiloartritis del estudio AQUILES
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Rosario García-Vicuñaa,
Corresponding author
vicuna111@gmail.com

Corresponding author.
, Pedro Zarcob, Carlos M. Gonzálezc, Francisco Vanaclochad, Ignacio Marín-Jiméneze, Luis Cea-Calvof
a Departamento de Reumatología, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain
b Departamento de Reumatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
c Departamento de Reumatología, Hospital Universitario Gregorio Marañón, Madrid, Spain
d Departamento de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain
e Departamento de Gastroenterología, Hospital Universitario Gregorio Marañón, Madrid, Spain
f Departamento de Medical Affairs, Merck Sharp & Dohme de España, S.A., Madrid, Spain
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Tables (4)
Table 1. Characteristics of the Patients Followed up During 2 Years and Those Lost.
Table 2. Accumulated Incidence at 2-Year Follow-up of New Extra-articular Manifestations in the Cohort of Patients With Spondyloarthritis From the AQUILES Study.
Table 3. Accumulated Incidence at 2 Years of Follow-up of New Extra-articular Manifestations in the Cohort of Patients With Spondyloarthritis From the AQUILES Study Based on the Base Spondyloarthritis.a
Table 4. Incidence After 2 Years of New Extra-articular Manifestations in Subgroups of Patients.
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Abstract
Objectives

To describe the 2-year incidence of new extra-articular manifestations (uveitis, psoriasis, inflammatory bowel disease) in a cohort of patients with spondyloarthritis included in the AQUILES study.

Patients

Over a period of 2 years, 513 patients with spondyloarthritis (62.5% males, mean age 48 years) diagnosed with ankylosing spondylitis (AS) (55.6%), psoriatic arthritis (25.3%), undifferentiated spondyloarthritis (16.2%), enteropathic arthritis (2.5%), and other diseases (0.4%) were followed. New diagnoses were based on reports of the corresponding specialists (ophthalmologists, dermatologists, gastroenterologists).

Results

During the 2-year follow-up, 22 new diagnoses of the extra-articular manifestations were established, with a cumulative incidence of 4.3% (95% confidence interval 2.4–6.1) and an incidence rate of 17 cases per 10,000 patient-year. Uveitis was the most frequent diagnosis (cumulative incidence 3.1%), predominantly in patients with AS. In the multivariate analysis, the diagnosis of AS was the only predictive variable associated to the development of new extra-articular disease.

Conclusions

In patients with spondyloarthritis, the 2-year global incidence of uveitis, psoriasis and inflammatory bowel disease (IMID) was 4.3%, particularly due to new diagnoses of uveitis in patients with AS.

Keywords:
Psoriatic arthritis
Inflammatory bowel disease
Ankylosing spondylitis
Spondyloarthritis
Observational study
Prospective study
Uveitis
Resumen
Objetivos

Describir la incidencia a los 2 años de nuevas manifestaciones extraarticulares (uveítis, psoriasis, enfermedad inflamatoria intestinal) en la cohorte de pacientes con espondiloartritis del estudio AQUILES.

Pacientes

Durante 2 años se siguieron 513 pacientes con espondiloartritis (62,5% varones, edad media 48 años) diagnosticados de espondilitis anquilosante (EA) (55,6%), artritis psoriásica (25,3%), espondiloartritis indiferenciada (16,2%), artritis enteropática (2,5%) y otros diagnósticos (0,4%). Los nuevos diagnósticos se basaron en los informes de los respectivos especialistas (oftalmólogos, dermatólogos y gastroenterólogos).

Resultados

Se establecieron 22 nuevos diagnósticos de las manifestaciones extraarticulares estudiadas (incidencia acumulada: 4,3% [intervalo de confianza del 95% 2,4-6,1]; tasa de incidencia: 17 casos por 10.000 pacientes-año). La uveítis fue el diagnóstico más frecuente (incidencia acumulada del 3,1%), predominantemente en pacientes con EA. En el análisis multivariable, el diagnóstico de EA fue el único predictor de aparición de nueva manifestación extraarticular.

Conclusiones

En pacientes con espondiloartritis, la incidencia de uveítis, psoriasis y enfermedad inflamatoria intestinal a los 2 años fue globalmente del 4,3%, principalmente por nuevos diagnósticos de uveítis en pacientes con EA.

Palabras clave:
Artritis psoriásica
Enfermedad inflamatoria intestinal
Espondilitis anquilosante
Espondiloartritis
Estudio observacional
Estudio prospectivo
Uveítis

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