Información de la revista
Vol. 7. Núm. 4.
Páginas 258-261 (julio - agosto 2011)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 7. Núm. 4.
Páginas 258-261 (julio - agosto 2011)
Acceso a texto completo
Efficacy of adalimumab in Behçet's disease. Description of 6 cases
Eficacia del adalimumab en la enfermedad de Behçet: descripción de 6 casos
Visitas
5767
Javier Calvo Cataláa,
Autor para correspondencia
calvo_jav@gva.es

Corresponding author.
, Cristina Campos Fernandeza, Amalia Rueda Cida, Maria Isabel Gonzalez-Cruz Cervelleraa, Aurelio Baixauli Rubiob, Maria Dolores Pastor Cubilloa
a Servicio de Reumatología y Metabolismo Óseo, Consorcio Hospital General Universitario, Valencia, Spain
b Servicio de Medicina Interna, Hospital de Manises, Valencia, Spain
Este artículo ha recibido
Información del artículo
Abstract

Behçet's disease (BD) is a systemic vasculitis, with a more aggressive course in young males. Orogenital ulcers, uveitis and cutaneous lesions are the most frequent manifestations.

We analyzed the effects of adalimumab on six patients with BD pretreated with inmunosupressive therapy, two of whom had received infliximab. We observed a good clinical response in all patients. To date, after a mean follow-up of 26.8 months, patients continue receiving adalimumab, with good clinical control, no adverse effects have been reported with adalimumab.

Keywords:
Behçet's disease
Uveitis
Adalimumab
Anti-TNF
Resumen

La enfermedad de Behçet (EB) es una vasculitis sistémica, y afecta con mayor agresividad a varones jóvenes. Sus manifestaciones más frecuentes son las aftas orogenitales, la uveítis y las lesiones cutáneas.

Analizamos 6 pacientes con EB, que recibieron adalimumab para controlar la enfermedad. Todos habían recibido terapia inmunosupresora, además 2 de ellos recibieron infliximab. Observamos una buena respuesta clínica al fármaco. Actualmente, con un seguimiento medio de 26,8 meses, los pacientes siguen en tratamiento con adalimumab, con buen control clínico y sin que se hayan detectado efectos adversos relacionados con el anti-TNF.

Palabras clave:
Enfermedad de Behçet
Uveítis
Adalimumab
Anti-TNF
El Texto completo está disponible en PDF
References
[1.]
H. Yazici, Y. Tüzün, H. Pazarli, S. Yurdakul, Y. Ozyazgan, H. Ozdoğan, et al.
Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome.
Ann Rheum Dis, 43 (1984), pp. 783-789
[2.]
E. Kural-Seyahi, I. Fresko, N. Seyahi, Y. Ozyazgan, C. Mat, V. Hamuryudan, et al.
The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center.
Medicine (Baltimore), 82 (2003), pp. 60-76
[3.]
A.T. Chan, O. Flossmann, C. Mukhtyar, D.R. Jayne, R.A. Luqmani.
The role of biologic therapies in the management of systemic vasculitis.
Autoimmun Rev, 5 (2006), pp. 273-278
[4.]
B. Mushtaq, T. Saeed, R.D. Situnayake, P.I. Murray.
Adalimumab for sight-threatening uveitis in Behçet's disease.
[5.]
J.L. Callejas-Rubio, D. Sánchez-Cano, R. Ríos-Férnandez, N. Ortego-Centeno.
Treatment of Behçet's disease with adalimumab.
Med Clin (Barc), 131 (2008), pp. 438-439
[6.]
J. Belzunegui, L. López, I. Paniagua, J.J. Intxausti, O. Maíz.
Efficacy of infliximab and adalimumab in the treatment of a patient with severe neuro-Behçet's disease.
Clin Exp Rheumatol, 26 (2008), pp. S133-S134
[7.]
Yildiz N, Alkan H, Ardic F, Topuz O. Successful treatment with adalimumab in a patient with coexisting Behçet's disease and ankylosing spondylitis. Rheumatol Int. Published online 2010 march 30.
[8.]
S.W. Lee, S.Y. Lee, K.N. Kim, J.K. Jung, W.T. Chung.
Adalimumab treatment for life threatening pulmonary artery aneurysm in Behçet disease: a case report.
Clin Rheumatol, 29 (2010), pp. 91-93
[9.]
A. Ariyachaipanich, C. Berkelhammer, H. Nicola.
Intestinal Behçet's disease: Maintenance of remission with adalimumab monotherapy.
Inflamm Bowel Dis, 15 (2009), pp. 1769-1771
[10.]
Takase K, Ohno S, Ideguchi H, Uchio E, Takeno M, Ishigatsubo Y. Successful switching to adalimumab in an infliximab-allergic patient with severe Behçet disease-related uveitis. Rheumatol Int Published online. 2009.
[11.]
I. Olivieri, S. D’Angelo, A. Padula, P. Leccese, G.A. Mennillo.
Successful treatment of recalcitrant genital ulcers of Behçet's disease with adalimumab after failure of infliximab and etanercept.
Clin Exp Rheumatol, 27 (2009), pp. S112
[12.]
J.A. Van Laar, T. Missotten, P.L. Van Daele, A. Jamnitski, G.S. Baarsma, P.M. Van Hagen.
Adalimumab: a new modality for Behçet's disease?.
Ann Rheum Dis, 66 (2007), pp. 565-566
[13.]
Criteria for diagnosis of Behçet's disease.
International Study Group for Behçet's Disease [no authors listed].
Lancet, 335 (1990), pp. 1078-1080
[14.]
V. Rodríguez-Valverde, R. Cáliz Cáliz, J.M. Álvaro-Gracia Álvaro, J.L. Marenco de la Fuente, J. Mulero Mendoza, J. Tornero Molina, et al.
III Actualización del Consenso de la Sociedad Española de Reumatología sobre terapia biológica en la artritis reumatoide.
Reumatol Clin, 2 (2006), pp. S52-S59
[15.]
B. Turan, H. Gallati, H. Erdi, A. Gürler, B.A. Michel, P.M. Villiger.
Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behçet's disease;soluble TNFR-75 as a biological marker of disease activity.
J Rheumatol, 24 (1997), pp. 128-132
[16.]
G.M. Verjans, P.M. Van Hagen, A. Van der Kooi, A.D. Osterhaus, G.S. Baarsma.
Vgamma9Vdelta2 T cells recovered from eyes of patients with Behcet's disease recognize non-peptide prenyl pyrophosphate antigens.
J Neuroimmunol, 130 (2002), pp. 46-54
[17.]
C. Evereklioglu.
Current concepts in the etiology and treatment of behcet disease.
Surv Ophthalmol, 50 (2005), pp. 297-350
[18.]
P.P. Sfikakis, N. Markomichelakis, E. Alpsoy, S. Assaad-Khalil, B. Bodaghi, A. Gul, et al.
Anti-TNF therapy in the management of Behçet's disease−review and basis for recommendations.
Rheumatology, 46 (2007), pp. 736-741
[19.]
G. Hatemi, A. Silman, D. Bang, B. Bodaghi, A.M. Chamberlain, A. Gul, et al.
EULAR Expert Committee. EULAR recommendations for the management of Behçet disease.
Ann Rheum Dis, 67 (2008), pp. 1656-1662
[20.]
G. Hatemi, A. Silman, D. Bang, B. Bodaghi, A.M. Chamberlain, A. Gul, M.H. Houman, et al.
Management of Behçet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behçet disease.
Ann Rheum Dis, 68 (2009), pp. 1528-1534
Copyright © 2011. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
Descargar PDF
Idiomas
Reumatología Clínica
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?