RESPONDIA. Ibero-American Spondyloarthropaties Registry: Portuguese Group
Registro Iberoamericano de Espondiloartritis (RESPONDIA): Portugal
Leído
11739
Vecesse ha leído el artículo
3210
Total PDF
8529
Total HTML
Compartir estadísticas
array:18 [ "pii" => "13130699" "issn" => "1699258X" "estado" => "S300" "fechaPublicacion" => "2008-11-30" "documento" => "article" "subdocumento" => "fla" "cita" => "Reumatol Clin. 2008;4 Supl E4:68-72" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4963 "formatos" => array:3 [ "EPUB" => 147 "HTML" => 3662 "PDF" => 1154 ] ] "itemSiguiente" => array:14 [ "pii" => "13130700" "issn" => "1699258X" "estado" => "S300" "fechaPublicacion" => "2008-11-30" "documento" => "article" "subdocumento" => "fla" "cita" => "Reumatol Clin. 2008;4 Supl E4:73-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3766 "formatos" => array:3 [ "EPUB" => 168 "HTML" => 2378 "PDF" => 1220 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Registro Iberoamericano de Espondiloartritis (RESPONDIA): Uruguay" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "73" "paginaFinal" => "78" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RESPONDIA. Iberoamerican Spondyloarthritis Registry: Uruguay" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "273v4nExtra.4-13130700fig01.jpg" "Alto" => 737 "Ancho" => 966 "Tamanyo" => 47961 ] ] "descripcion" => array:1 [ "es" => "Subgrupos diagnosticados en 53 pacientes con SpA. APs: artritis psoriásica; EA: espondilitis anquilosante; U-SpA: espondiloartritis indiferenciada; SpA EII: espondiloartritis asociada a enfermedad inflamatoria intestinal; SpAJuv: espondiloartritis juvenil." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniel R Palleiro, Emilia Spangenberg" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Daniel R" "apellidos" => "Palleiro" ] 1 => array:2 [ "nombre" => "Emilia" "apellidos" => "Spangenberg" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13130700?idApp=UINPBA00004M" "url" => "/1699258X/0000000400000SE4/v0_201507131049/13130700/v0_201507131050/es/main.assets" ] "itemAnterior" => array:14 [ "pii" => "13130698" "issn" => "1699258X" "estado" => "S300" "fechaPublicacion" => "2008-11-30" "documento" => "article" "subdocumento" => "fla" "cita" => "Reumatol Clin. 2008;4 Supl E4:63-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6004 "formatos" => array:3 [ "EPUB" => 174 "HTML" => 4222 "PDF" => 1608 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Registro Iberoamericano de Espondiloartritis (RESPONDIA): Perú" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "63" "paginaFinal" => "67" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RESPONDIA. Iberoamerican Spondyloarthritis Registry: Perú" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "273v4nExtra.4-13130698fig07.jpg" "Alto" => 887 "Ancho" => 962 "Tamanyo" => 53885 ] ] "descripcion" => array:1 [ "es" => "Tipo de espondiloartritis en el momento del diagnóstico. APs: artritis psoriásica; ARe: artritis reactivas; EA: espondilitis anquilosante; EA-Ps: espondilitis anquilosante asociada a psoriasis. SpA: espondiloartritis; SpAJuv: espondiloartritis juvenil; SpA EII: espondiloartritis asociada a enfermedad inflamatoria intestinal; USpA: espondiloartitis indiferenciadas." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José E Chávez-Corrales, Manuel Montero Jáuregui, Magaly Alva Linares, Claudia Mora, Patricia Ramos Valencia, Elmer Garcia, Tatiana Miraval N de Guzman, Eduardo Rhor, Isabel Castañeda Rosero, Felipe Becerra Rojas" "autores" => array:10 [ 0 => array:2 [ "nombre" => "José E" "apellidos" => "Chávez-Corrales" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Montero Jáuregui" ] 2 => array:2 [ "nombre" => "Magaly" "apellidos" => "Alva Linares" ] 3 => array:2 [ "nombre" => "Claudia" "apellidos" => "Mora" ] 4 => array:2 [ "nombre" => "Patricia" "apellidos" => "Ramos Valencia" ] 5 => array:2 [ "nombre" => "Elmer" "apellidos" => "Garcia" ] 6 => array:2 [ "nombre" => "Tatiana" "apellidos" => "Miraval N de Guzman" ] 7 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Rhor" ] 8 => array:2 [ "nombre" => "Isabel" "apellidos" => "Castañeda Rosero" ] 9 => array:2 [ "nombre" => "Felipe" "apellidos" => "Becerra Rojas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13130698?idApp=UINPBA00004M" "url" => "/1699258X/0000000400000SE4/v0_201507131049/13130698/v0_201507131050/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "RESPONDIA. Ibero-American Spondyloarthropaties Registry: Portuguese Group" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "68" "paginaFinal" => "72" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Elsa Sousa, Miguel Sousa, Fernando Pimentel, Ana Filipa Mourão, Ana Rodrigues, Helena Santos, Viana Queiroz, Ana Teixeira, Jaime Branco, Anabela Barcelos" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Elsa" "apellidos" => "Sousa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Miguel" "apellidos" => "Sousa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Fernando" "apellidos" => "Pimentel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 3 => array:3 [ "nombre" => "Ana" "apellidos" => "Filipa Mourão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 4 => array:3 [ "nombre" => "Ana" "apellidos" => "Rodrigues" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "nombre" => "Helena" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 6 => array:3 [ "nombre" => "Viana" "apellidos" => "Queiroz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 7 => array:3 [ "nombre" => "Ana" "apellidos" => "Teixeira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 8 => array:3 [ "nombre" => "Jaime" "apellidos" => "Branco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 9 => array:3 [ "nombre" => "Anabela" "apellidos" => "Barcelos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Hospital de Santa Maria. Lisboa. Portugal." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Instituto Português de Reumatologia. Lisboa. Portugal." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Centro Hospitalar Lisboa Ocidental. Hospital Egas Moniz. Lisboa. Portugal." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] 3 => array:3 [ "entidad" => "Hospital Infante D. Pedro. Aveiro. Portugal." "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Registro Iberoamericano de Espondiloartritis (RESPONDIA): Portugal" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "273v4nExtra.4-13130699fig02.jpg" "Alto" => 916 "Ancho" => 975 "Tamanyo" => 79677 ] ] "descripcion" => array:1 [ "en" => "SpA. Subtypes." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"> Spondyloarthropaties (SpA) are a group of chronic inflammatory rheumatic diseases that include ankylosing spondylitis (AS), psoriatic arthritis (PsA) reactive arthritis (ReA), spondyloarthritis associated with inflammatory bowel diseases (IBD) and undifferentiated spondyloarthropaties (U-SpA)<span class="elsevierStyleSup">1</span>. Although each of these entities has specific characteristics they do share some clinical, radiologic and genetic manifestations.</p><p class="elsevierStylePara">The main common feature of SpA is back pain due to spinal inflammation (spondylitis and/or sacroiliitis). Other common characteristics are peripheral arthritis, usually oligoarticular affecting lower limbs, enthesitis and extra-articular involvement (acute anterior uveitis, inflammatory bowel lesions and psoriasis)<span class="elsevierStyleSup">2</span>.</p><p class="elsevierStylePara">As opposed to other rheumatic diseases like Rheumatoid Arthritis, the incidence and prevalence of SpA is not well known and in Portugal this data is not available. The clinical course and prognosis of SpA is diverse due to the group heterogeneity but also to different clinical presentations with each disease<span class="elsevierStyleSup">3</span>.</p><p class="elsevierStylePara">In AS the age of disease onset is around the second or third decade<span class="elsevierStyleSup">4</span>, but in the other subtypes of SpA it's not possible to define a risk period for the development of the disease.</p> Although SpA classically have been described as affecting more males than females<span class="elsevierStyleSup">4</span>, it is now beginning to be accepted that its prevalence may be similar in both genders. Despite this controversy it is more or less consensual that some clinical forms are more common in males while other subtypes affect equally both or are more common in females. The genetic influence in the development of these diseases, evidenced by a prevalence of HLA-B27 allele in Spa patients that ranges between 50 and 95%, is reflected in a trend to familiar association, which is recognized in multiple epidemiologic contexts<span class="elsevierStyleSup">5,6</span>. <p class="elsevierStylePara">For historical reasons, the Ibero-american countries share many characteristics. We decided to participate in the RESPONDIA group with the purpose of discovering the similarities and the differences between these countries concerning the genetic, clinical and socioeconomic aspects of spondyloarthropaties.</p><p class="elsevierStylePara">The objective of this work is to give a descriptive analysis of the main characteristics of the Portuguese patients with spondyloarthropaties included in the RESPONDIA study.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleBold"> Material and methods</span></span></p><p class="elsevierStylePara">This was an observational and transversal study that included patients recruited from 4 Portuguese Rheumatology Departments (Instituto Português de Reumatologia, Lisboa; Hospital de Santa Maria, Lisboa; Centro Hospitalar Lisboa Ocidental - Hospital Egas Moniz, Lisboa e Hospital Infante D. Pedro, Aveiro), between June 2007 and March 2008. All the data was registered in the REGISPONSER (Registro de Espondioartropatías de la Sociedad Española de Reumatología) online database<span class="elsevierStyleSup">7</span>. The general methodology, including inclusion criteria, study variables, online database development and data analysis are described in other article published in this journal<span class="elsevierStyleSup">8</span>. Patients that were included fulfilled the European Spondyloarthropaties Study Group (ESSG) classification criteria<span class="elsevierStyleSup">9</span> or the Amor criteria<span class="elsevierStyleSup">10</span>.</p><p class="elsevierStylePara"> Portugal characterization</p><p class="elsevierStylePara">Portugal is a country located in the southwest of Europe, situated in the western part of the Iberian Peninsula as well as in North Atlantic archipelagos. Its total surface area is 92,391 km2 and it is the most occidental nation of the European continent. The Portuguese Gross Domestic Product (GDP) is of $253,557 billions USD a year and the GDP per capita (estimation of 2006) of $27,621USD a year.</p><p class="elsevierStylePara">On 31<span class="elsevierStyleSup">st</span> December 2006, according to the Portuguese National Statistic Institute<span class="elsevierStyleSup">11</span>, the resident population was estimated at 10 599 095 people, of which 5 129 937 are male and 5 469 158 female. 15.5% are children (0-14 years old); 67.3% are of working age (15-64 years old), 17.5% are older than 65 years and people older than 75 years represent 7.7% of the total population. According to the United Nations Children's Fund (UNICEF) report: "The state of the world's children 2007"<span class="elsevierStyleSup">12</span>, Portugal is ranked 13th among more than 180 countries with the lowest child mortality rate. The report also notices that Portugal is one of the countries with the highest like expectancy in the world, 78 years.</p><p class="elsevierStylePara">Nowadays there are around 550 thousand immigrants living in Portugal, which represents approximately 5% of the whole population, most of them being from Brazil (66,700), Ukraine (65,800) and Cape Verde (64,300), between other countries, such as Moldavia, Romania, Guinea-Bissau, Angola, East-Timor, Mozambique, Saint Tome and Principe and Russia<span class="elsevierStyleSup">11</span>.</p><p class="elsevierStylePara">The majority of the Portuguese population is white. The literacy rate (older than 15 years that know how to read and write) is of 93.3% (95.5% for males and 91.3% for females)<span class="elsevierStyleSup">13</span>.</p><p class="elsevierStylePara">In Portugal health is a constitutional right. The health system is almost exclusively supported by the government, which has its own primary and secondary care structures.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleBold"> Results</span></span></p><p class="elsevierStylePara">110 patients with the diagnosis of SpA (59 males [58.4%] and 42 females [41.6%]), and with a mean age of 46.5 ± 12,9 years, were included. Socio-demographic characteristics of this population are described in table 1. The most common diagnosis among SpA was Ankylosing Spondylitis (AS) followed by Psoriatic Arthritis (PsA) (fig. 1).</p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig01.jpg"></img></p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig02.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 1.</span></span></span><span class="elsevierStyleItalic"><span class="elsevierStyleItalic">SpA. Subtypes.</span></span></p><p class="elsevierStylePara">The mean age of disease onset was 26.7 ± 10.9 years being before the age of 18 in 19% of patients while in 40% the first symptoms started between the age of 21 and 30. The diagnosis was established before the age of 18 in only 2% of patients. The majority of patients were diagnosed between the age of 21 and 30 (34%) and between the age of 31 and 40 (26.8%) The delay in the diagnosis was longer than 10 years in 25.5% of the patients.</p><p class="elsevierStylePara">The most common initial manifestation was lower back pain in 63.4% (table 2). The axial involvement was more frequent (50.5%) followed by the association of peripheral arthritis and axial symptoms (47.5%). Lower limb joints were more affected than upper limb joints. With regard to extra-articular manifestations acute anterior uveitis and dactilitis were the most common (34% and 7.9% of patients, respectively) (table 3).</p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig03.jpg"></img></p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig04.jpg"></img></p><p class="elsevierStylePara">Previous family history of spondyloarthropaties was identified in 29 patients (29.9%).</p><p class="elsevierStylePara">The majority of patients (94.8%) had previously taken non-steroidal anti-inflammatory drugs (NSAIDs): 55.2% daily and 39.6% on demand, and also corticosteroids in 29%. The disease-modifying antirheumatic drugs (DMARDs) most used were sulfasalazine (47.3%) and methotrexate (23.1%). Only 10.8% of patients had previously been prescribed TNF alpha blockers agents (fig. 2).</p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig05.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 2.</span></span></span><span class="elsevierStyleItalic"><span class="elsevierStyleItalic">Previous prescribed treatments.</span></span></p><p class="elsevierStylePara">The results of the medical physical observation and applied questionnaires were very diverse. The mean Bath ankylosing spondylitis disease activity index (BASDAI) was of 4.2 cm and the mean Bath ankylosing spondylitis disease functional index (BASFI) was of 3.6 cm.</p><p class="elsevierStylePara">The HLA B27 was positive in 34 patients (85%) and negative in 6 (15%). In 61 patients this information was not available.</p><p class="elsevierStylePara"> Results of the ankylosing spondylitis group</p><p class="elsevierStylePara">85 patients were included, mainly male (59%) with a mean age of disease onset of 26 ± 11.3 years and mean disease duration of 1.8 ± 0.9 years. The delay in the diagnosis was of 1 to 5 years in 35 patients, 6 to 10 years in 13 and more than 10 years in 25 patients. The axial involvement was predominant (54%) while the combination of axial and peripheral arthritis was verified in the remaining patients (46%). Low back pain was the most frequent complaint (97.6%). Asymmetric arthritis of the lower limbs was referred to in 42.3% and enthesitis in 35.3% of patients.</p><p class="elsevierStylePara">Acute anterior uveitis was the most common extra-articular manifestation (36.5%) (table 4).</p><p class="elsevierStylePara"><img src="273v4nExtra.4-13130699fig06.jpg"></img></p><p class="elsevierStylePara">The majority of patients (88.8%) were taking NSAIDs (46.3% daily and 42.5% on demand) and 19.5% were undergoing cortisteroids. Concerning DMARDs, 38.5% patients were using sulfasalazine, methotrexate by 22.1% patients and TNF alpha blockers by 11.8% patients. None of them were taking leflunomide.</p><p class="elsevierStylePara">There was not a history of previous genitourinary, intestinal or respiratory infections in any of the patients. 27 patients had family history of spondyloarthropaties. 8 patients had undergone hip replacement surgery. The mean BASDAI in this group was 4.1cm and the mean BASFI 3.7cm. 13 patients were incapable of work (11 permanently and 2 temporarily). HLA B27 was positive in 85.7% patients, negative in 14.2% and it was not known in 50 patients.</p><p class="elsevierStylePara">The other subtype groups (Psoriatic arthritis, Reactive arthritis, Spondyloarthritis associated with inflammatory bowel diseases and Undifferentiated spondyloarthritis included few patients not allowing an individual characterization.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleBold"> Conclusions</span></span></p><p class="elsevierStylePara">In this group of portuguese patients ankylosing spondylitis was the most frequent subtype of spondyloarthropaty. Males were predominantly affected which is according to the literature data<span class="elsevierStyleSup">14</span>. The mean age of disease onset was also similar to that found in the literature. The axial involvement was the most common and the acute anterior uveitis the most frequent extra-articular manifestation. Contrary to what is described in other countries, namely in Mexico<span class="elsevierStyleSup">15</span>, tarsitis in not a common characteristic in AS Portuguese patients. 13 of these patients were incapable of work with significant socioeconomic consequences. Sulfasalazine was the most used DMARD while leflunomide was never prescribed. NSAIDs are still the most common drugs used to treat AS. Although the BASDAI score is higher than 4, there was only a small number of patients (n=10), were undergoing TNF alpha blocking agents.</p><p class="elsevierStylePara">The high number of AS patients treated with corticosteroids (n=24) is probably related to its used to treat acute anterior uveitis (n=31). This study has many limitations including the small number of patients, the methodology for data collection without previous inter and intra investigator analysis.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleBold"> Acknowledgments</span></span></p><p class="elsevierStylePara">The Portuguese RESPONDIA group would like to thank Prof. Eduardo Collantes-Estevez for all the unconditional support given to this project from day one and also to the Portuguese Rheumatology Society. This group also thanks Dra. Pilar Font for the development of the database, and Dra. Janitzia Vázquez-Mellado for the coordination and analysis of patients' data.</p><hr></hr><p class="elsevierStylePara"> Correspondence:<br></br> Dra. A. Barcelos.<br></br> Unidade de Reumatologia. Hospital Infante D. Pedro. Av Artur Ravara. 3814-501 Aveiro. Portugal.<br></br> E-mail: <a href="mailto:barcelos.a@clix.pt" class="elsevierStyleCrossRefs"> barcelos.a@clix.pt</a></p>" "pdfFichero" => "273v4nExtra.4a13130699pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec551261" "palabras" => array:3 [ 0 => "Espondiloartropatías" 1 => "Espondilitis anquilosante" 2 => "Portugal" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec551260" "palabras" => array:3 [ 0 => "Spondyloarthropaties" 1 => "Spondylitis ankylosing" 2 => "Portugal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Socio-demographic variations may influence spondyloarthropaties (SpAs) clinical and laboratorial characteristics and prognosis. In the Portuguese population the information available related with this disease is scarce Objective. To characterize demographic, clinical and laboratory features of SpAs patients in Portugal. Patients and methods. Patients followed at four participating Rheumatology Departments with the diagnosis of SpA were enrolled. Results. 110 patients were included, 58.4% were males, essentially Caucasian with an average age of 46.5 years. The most frequent clinical feature was inflammatory back pain (63.4%) and acute anterior uveitis was the most common extra-articular manifestation. The predominant type of SpAs found was Ankylosing Spondylitis (AS). Conclusions. Patients with AS presented clinical features similar to those observed in other populations, except for tarsitis." ] "es" => array:1 [ "resumen" => "Las variaciones sociodemográficas pueden influir las características clínicas y de los laboratorios, así como el pronóstico de las espondiloartropatías (SpA). La información al respecto es escasa en la población portuguesa. Objetivo: Caracterizar los datos demográficos, clínicos y de laboratorio de pacientes con SpA en Portugal. Pacientes y métodos: Los pacientes fueron controlados en 4 departamentos de reumatología participantes y se incluyó a los que tenían diagnóstico de espondilitis anquilosante (EA). Resultados: Se incluyó en el estudio a 110 pacientes, 58,4% varones, específicamente caucásicos, con una edad media de 46,5 años. La característica clínica más frecuente fue la lumbalgia inflamatoria (63,4%) y la uveítis aguda anterior fue la manifestación extraarticular más común. El tipo predominante de SpA fue la EA. Conclusiones: Los pacientes con EA tienen características clínicas similares a las vistas en otras poblaciones, excepto en el caso de tarsitis." ] ] "multimedia" => array:12 [ 0 => array:8 [ "identificador" => "tbl1" "etiqueta" => "TABLE 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "273v4nExtra.4-13130699fig01.jpg" "imagenAlto" => 2283 "imagenAncho" => 979 "imagenTamanyo" => 253783 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Socio-demographic characteristics of the studied population" ] ] 1 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "273v4nExtra.4-13130699fig02.jpg" "Alto" => 916 "Ancho" => 975 "Tamanyo" => 79677 ] ] "descripcion" => array:1 [ "en" => "SpA. Subtypes." ] ] 2 => array:8 [ "identificador" => "tbl2" "etiqueta" => "TABLE 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "273v4nExtra.4-13130699fig03.jpg" "imagenAlto" => 762 "imagenAncho" => 991 "imagenTamanyo" => 86272 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Initial manifestations in SpAs" ] ] 3 => array:8 [ "identificador" => "tbl3" "etiqueta" => "TABLE 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "273v4nExtra.4-13130699fig04.jpg" "imagenAlto" => 962 "imagenAncho" => 970 "imagenTamanyo" => 111514 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Extra-articular manifestations in SpAs" ] ] 4 => array:8 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "273v4nExtra.4-13130699fig05.jpg" "Alto" => 937 "Ancho" => 966 "Tamanyo" => 72320 ] ] "descripcion" => array:1 [ "en" => "Previous prescribed treatments." ] ] 5 => array:8 [ "identificador" => "tbl4" "etiqueta" => "TABLE 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "273v4nExtra.4-13130699fig06.jpg" "imagenAlto" => 945 "imagenAncho" => 970 "imagenTamanyo" => 92236 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Extra-articular manifestations in AS" ] ] 6 => array:5 [ "identificador" => "fig3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] 7 => array:5 [ "identificador" => "fig4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] 8 => array:5 [ "identificador" => "fig5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] 9 => array:5 [ "identificador" => "fig6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] 10 => array:5 [ "identificador" => "fig7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] 11 => array:5 [ "identificador" => "fig8" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "Classification of spondyloarthropaties. In: Hochberg M, editors. Rheumatology. Section 9: Spondyloarthropaties. Spain: Elsevier; 2003. p. 1149-51." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Classification of spondyloarthropaties. In: Hochberg M, editors. Rheumatology. Section 9: Spondyloarthropaties. Spain: Elsevier; 2003. p. 1149-51." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Van Der Linden S" 1 => "Van Der Heijde D." ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "Clinical features of ankylosing spondylitis. In: Hochberg M, editors. Rheumatology. Section 9: Spondyloarthropaties. Spain: Elsevier; 2003. p. 1161-81." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Clinical features of ankylosing spondylitis. In: Hochberg M, editors. Rheumatology. Section 9: Spondyloarthropaties. Spain: Elsevier; 2003. p. 1161-81." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Khan MA." ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Patients with Ankylosing Spondylitis show individuals patterns of variation in disease activity. BMJ. 1991;30:336-8." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Patients with Ankylosing Spondylitis show individuals patterns of variation in disease activity." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Goodare JA" 1 => "Mander M" 2 => "Carson DW." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "1991" "volumen" => "30" "paginaInicial" => "336" "paginaFinal" => "8" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ankylosing Spondylitis: an overview. Ann Rheum Dis. 2002;61(Suppl III):iii8-iii18." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Ankylosing Spondylitis: an overview." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Sieper J" 1 => "Braun J" 2 => "Rudwaleit M" 3 => "Boonen A" 4 => "Zink A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2002" "volumen" => "61" "paginaInicial" => "iii8" "paginaFinal" => "iii18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12381506" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Seronegative Spondyloarthritides. Baillieres Clin Rheumatol. 2002;16:723-39." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Seronegative Spondyloarthritides." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Olivieri I" 1 => "Van Tubergen A" 2 => "Salvarani C." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Baillieres Clin Rheumatol" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "723" "paginaFinal" => "39" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "HLA B27 and its subtypes in world populations. Curr Opin Rheumatol. 1995;7:263-9." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "HLA B27 and its subtypes in world populations." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Khan MA." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Rheumatol" "fecha" => "1995" "volumen" => "7" "paginaInicial" => "263" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7547102" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "ser.es/cgi-bin/regisponser /index.html" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "ser.es/cgi-bin/regisponser /index.html" "idioma" => "nl" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "http://biobadaser.s." ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Reumatol Clin. 2008;3(Supl 4):17-22." "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Espondiloartropatías en Iberoamérica." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "17" "paginaFinal" => "22" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The European Spondyloarthropathy Study Group Preliminary Criteria for the Classification of Spondyloartropathy. Arthritis Rheum. 1991;34:1218-27." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The European Spondyloarthropathy Study Group Preliminary Criteria for the Classification of Spondyloartropathy." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Dougados M" 1 => "Van der Linden S" 2 => "Juhlin R" 3 => "Huitfeldt A" 4 => "Amor B" 5 => "Calin A" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1991" "volumen" => "34" "paginaInicial" => "1218" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1930310" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Critéres diagnostiques des spondyloarthropathies. Rev Rheum Mal Osteoartic. 1990;57:85-9." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Critéres diagnostiques des spondyloarthropathies." "idioma" => "fr" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Amor B" 1 => "Dougados M" 2 => "Mijiyawa M." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Rheum Mal Osteoartic" "fecha" => "1990" "volumen" => "57" "paginaInicial" => "85" "paginaFinal" => "9" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "ine.pt" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "ine.pt" "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "www.i." ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "unicef.pt" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "unicef.pt" "idioma" => "ro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "www.u." ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "indexmundi.com" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "indexmundi.com" "idioma" => "it" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "www.i." ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ankylosing Spondylitis and associated diseases. Rheum Dis Clin North Am. 1990;16:551-79." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Ankylosing Spondylitis and associated diseases." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Khan MA" 1 => "Van der Linden SM." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "1990" "volumen" => "16" "paginaInicial" => "551" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2217958" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "referenciaCompleta" => "The Juvenile-Onset Spondyloarthritides. In: Weisman MH, editors. Ankylosing Spondylitis and the Spondyloartthropaties. Mosby Elsevier; 2006. p. 94-106." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The Juvenile-Onset Spondyloarthritides. In: Weisman MH, editors. Ankylosing Spondylitis and the Spondyloartthropaties. Mosby Elsevier; 2006. p. 94-106." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Burgos-Vargas R." ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/1699258X/0000000400000SE4/v0_201507131049/13130699/v0_201507131050/en/main.assets" "Apartado" => array:4 [ "identificador" => "17517" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Monográfico: Espondiloartritis en Iberoamérica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000000400000SE4/v0_201507131049/13130699/v0_201507131050/en/273v4nExtra.4a13130699pdf001.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13130699?idApp=UINPBA00004M" ]
Información del artículo
ISSN: 1699258XIdioma original: Inglés
Datos actualizados diariamente
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 21 | 13 | 34 |
| 2024 Octubre | 116 | 53 | 169 |
| 2024 Septiembre | 127 | 21 | 148 |
| 2024 Agosto | 151 | 40 | 191 |
| 2024 Julio | 129 | 35 | 164 |
| 2024 Junio | 142 | 38 | 180 |
| 2024 Mayo | 144 | 30 | 174 |
| 2024 Abril | 142 | 23 | 165 |
| 2024 Marzo | 146 | 38 | 184 |
| 2024 Febrero | 139 | 18 | 157 |
| 2024 Enero | 124 | 17 | 141 |
| 2023 Diciembre | 145 | 20 | 165 |
| 2023 Noviembre | 144 | 29 | 173 |
| 2023 Octubre | 121 | 39 | 160 |
| 2023 Septiembre | 125 | 40 | 165 |
| 2023 Agosto | 125 | 16 | 141 |
| 2023 Julio | 131 | 27 | 158 |
| 2023 Junio | 138 | 22 | 160 |
| 2023 Mayo | 146 | 27 | 173 |
| 2023 Abril | 136 | 16 | 152 |
| 2023 Marzo | 140 | 36 | 176 |
| 2023 Febrero | 122 | 24 | 146 |
| 2023 Enero | 130 | 20 | 150 |
| 2022 Diciembre | 156 | 47 | 203 |
| 2022 Noviembre | 113 | 38 | 151 |
| 2022 Octubre | 51 | 28 | 79 |
| 2022 Septiembre | 50 | 36 | 86 |
| 2022 Agosto | 50 | 41 | 91 |
| 2022 Julio | 43 | 48 | 91 |
| 2022 Junio | 45 | 45 | 90 |
| 2022 Mayo | 46 | 43 | 89 |
| 2022 Abril | 62 | 46 | 108 |
| 2022 Marzo | 68 | 67 | 135 |
| 2022 Febrero | 37 | 27 | 64 |
| 2022 Enero | 34 | 51 | 85 |
| 2021 Diciembre | 39 | 45 | 84 |
| 2021 Noviembre | 48 | 53 | 101 |
| 2021 Octubre | 49 | 49 | 98 |
| 2021 Septiembre | 54 | 47 | 101 |
| 2021 Agosto | 39 | 47 | 86 |
| 2021 Julio | 45 | 36 | 81 |
| 2021 Junio | 58 | 46 | 104 |
| 2021 Mayo | 52 | 65 | 117 |
| 2021 Abril | 100 | 76 | 176 |
| 2021 Marzo | 67 | 29 | 96 |
| 2021 Febrero | 57 | 29 | 86 |
| 2021 Enero | 59 | 36 | 95 |
| 2020 Diciembre | 60 | 38 | 98 |
| 2020 Noviembre | 65 | 24 | 89 |
| 2020 Octubre | 38 | 17 | 55 |
| 2020 Septiembre | 49 | 52 | 101 |
| 2020 Agosto | 32 | 47 | 79 |
| 2020 Julio | 33 | 21 | 54 |
| 2020 Junio | 40 | 25 | 65 |
| 2020 Mayo | 47 | 43 | 90 |
| 2020 Abril | 41 | 26 | 67 |
| 2020 Marzo | 42 | 31 | 73 |
| 2020 Febrero | 45 | 33 | 78 |
| 2020 Enero | 43 | 25 | 68 |
| 2019 Diciembre | 30 | 17 | 47 |
| 2019 Noviembre | 38 | 24 | 62 |
| 2019 Octubre | 28 | 16 | 44 |
| 2019 Septiembre | 37 | 29 | 66 |
| 2019 Agosto | 26 | 14 | 40 |
| 2019 Julio | 63 | 24 | 87 |
| 2019 Junio | 97 | 45 | 142 |
| 2019 Mayo | 60 | 59 | 119 |
| 2019 Abril | 24 | 36 | 60 |
| 2019 Marzo | 20 | 20 | 40 |
| 2019 Febrero | 23 | 13 | 36 |
| 2019 Enero | 26 | 26 | 52 |
| 2018 Diciembre | 43 | 39 | 82 |
| 2018 Noviembre | 37 | 9 | 46 |
| 2018 Octubre | 20 | 12 | 32 |
| 2018 Septiembre | 25 | 5 | 30 |
| 2018 Agosto | 31 | 8 | 39 |
| 2018 Julio | 15 | 6 | 21 |
| 2018 Mayo | 8 | 0 | 8 |
| 2018 Abril | 30 | 9 | 39 |
| 2018 Marzo | 53 | 2 | 55 |
| 2018 Febrero | 27 | 4 | 31 |
| 2018 Enero | 25 | 12 | 37 |
| 2017 Diciembre | 28 | 8 | 36 |
| 2017 Noviembre | 33 | 8 | 41 |
| 2017 Octubre | 38 | 7 | 45 |
| 2017 Septiembre | 32 | 7 | 39 |
| 2017 Agosto | 44 | 10 | 54 |
| 2017 Julio | 42 | 12 | 54 |
| 2017 Junio | 67 | 21 | 88 |
| 2017 Mayo | 73 | 10 | 83 |
| 2017 Abril | 56 | 11 | 67 |
| 2017 Marzo | 46 | 21 | 67 |
| 2017 Febrero | 26 | 8 | 34 |
| 2017 Enero | 28 | 11 | 39 |
| 2016 Diciembre | 63 | 21 | 84 |
| 2016 Noviembre | 52 | 13 | 65 |
| 2016 Octubre | 59 | 10 | 69 |
| 2016 Septiembre | 36 | 11 | 47 |
| 2016 Agosto | 10 | 7 | 17 |
| 2016 Julio | 13 | 10 | 23 |
| 2016 Junio | 1 | 9 | 10 |
| 2016 Mayo | 2 | 16 | 18 |
| 2016 Abril | 0 | 17 | 17 |
| 2016 Marzo | 0 | 11 | 11 |
| 2016 Febrero | 0 | 25 | 25 |
| 2016 Enero | 3 | 0 | 3 |
| 2015 Diciembre | 55 | 18 | 73 |
| 2015 Noviembre | 224 | 23 | 247 |
| 2015 Octubre | 260 | 0 | 260 |
| 2015 Septiembre | 336 | 24 | 360 |
| 2015 Agosto | 55 | 0 | 55 |
| 2015 Julio | 16 | 14 | 30 |
| 2015 Junio | 13 | 11 | 24 |
| 2015 Mayo | 28 | 20 | 48 |
| 2015 Abril | 31 | 10 | 41 |
| 2015 Marzo | 6 | 9 | 15 |
| 2015 Febrero | 20 | 5 | 25 |
| 2015 Enero | 17 | 12 | 29 |
| 2014 Diciembre | 28 | 14 | 42 |
| 2014 Noviembre | 19 | 14 | 33 |
| 2014 Octubre | 24 | 9 | 33 |
| 2014 Septiembre | 23 | 14 | 37 |
| 2014 Agosto | 24 | 8 | 32 |
| 2014 Julio | 18 | 8 | 26 |
| 2014 Junio | 26 | 13 | 39 |
| 2014 Mayo | 53 | 13 | 66 |
| 2014 Abril | 42 | 12 | 54 |
| 2014 Marzo | 57 | 11 | 68 |
| 2014 Febrero | 88 | 20 | 108 |
| 2014 Enero | 54 | 9 | 63 |
| 2013 Diciembre | 31 | 5 | 36 |
| 2013 Noviembre | 30 | 7 | 37 |
| 2013 Octubre | 48 | 10 | 58 |
| 2013 Septiembre | 47 | 12 | 59 |
| 2013 Agosto | 35 | 7 | 42 |
| 2013 Julio | 44 | 9 | 53 |
| 2013 Junio | 29 | 11 | 40 |
| 2013 Mayo | 23 | 9 | 32 |
| 2013 Abril | 33 | 14 | 47 |
| 2013 Marzo | 23 | 6 | 29 |
| 2013 Febrero | 21 | 2 | 23 |
| 2013 Enero | 16 | 3 | 19 |
| 2012 Diciembre | 22 | 5 | 27 |
| 2012 Noviembre | 12 | 3 | 15 |
| 2012 Octubre | 7 | 2 | 9 |
| 2012 Septiembre | 3 | 2 | 5 |
| 2011 Mayo | 2 | 0 | 2 |
| 2011 Abril | 1 | 0 | 1 |
| 2011 Marzo | 23 | 0 | 23 |
| 2011 Febrero | 5 | 0 | 5 |
| 2011 Enero | 8 | 0 | 8 |
| 2010 Diciembre | 4 | 0 | 4 |
| 2010 Noviembre | 4 | 0 | 4 |
| 2010 Septiembre | 3 | 0 | 3 |
| 2010 Agosto | 7 | 0 | 7 |
| 2010 Julio | 1 | 0 | 1 |
| 2010 Junio | 4 | 0 | 4 |
| 2010 Mayo | 2 | 0 | 2 |
| 2010 Abril | 9 | 0 | 9 |
| 2010 Marzo | 1 | 0 | 1 |
| 2010 Enero | 1 | 0 | 1 |
| 2009 Noviembre | 6 | 0 | 6 |
| 2009 Octubre | 4 | 0 | 4 |
| 2009 Agosto | 2 | 0 | 2 |
| 2009 Julio | 2 | 0 | 2 |
| 2009 Junio | 8 | 0 | 8 |
| 2009 Mayo | 5 | 0 | 5 |
| 2009 Abril | 5 | 0 | 5 |
| 2009 Marzo | 1 | 0 | 1 |
| 2009 Enero | 1 | 0 | 1 |
Mostrar todo
