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was accepted and has been used extensively&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case description</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of a 19-year-old black woman that presented to the Emergency Department with abdominal and left thigh pain&#46; Previous medical and obstetric history included a recent stillbirth 6 weeks ago&#44; at 36 weeks with positive lupus anticoagulant&#46; Recent admission to Hospital due to abdominal pain&#44; seen by Medical and Surgical team that ruled out acute pathology and was referred to Obstetrics service that discharged the patient with further follow-up&#46; At arrival the patient was agitated and uncooperative complaining of abdominal and left thigh pain&#46; The patient reported severe pain in her left leg accompanied by nausea&#44; she did not have chest pain&#44; shortness of breath&#44; fever&#44; chills&#44; dysuria&#44; constipation&#44; or diarrhoea&#46; The temperature was 37&#46;1<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; the pulse was 91&#44; and the respiratory rate 18&#46; The blood pressure was 135&#47;85<span class="elsevierStyleHsp" style=""></span>mmHg&#46; The patient was intermittently agitated&#46; Examination revealed diffusely tender abdomen but not distended&#59; the bowel sounds were normal&#46; Examination of the extremities demonstrated absent pedal pulses on both sides&#44; and a mild sensory loss on the left leg&#46; Morphine sulphate&#44; paracetamol and fluids were administered&#46; A point-of-care ultrasound of lower legs showed the absence of a flow signal suggestive of vascular occlusion&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Initially the patient was suspected to have a sickle cell pain crisis however a reviewed of recent blood tests including electrophoresis did not show the presence of homozygous HbS or documented other hemoglobinopathies&#46; Blood tests revealed&#59; Hb 110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; WBC 13&#46;6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#44; Platelets 151<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#44; total bilirubin 5<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#44; ALT 30<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; GGT 98<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; calcium 2&#46;36<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; phosphate 0&#46;95<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; ALP 125<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; sodium 136<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; potassium 3&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; urea 3&#46;0<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; creatinine 83<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L &#40;reference range&#58; 0&#8211;110&#41;&#44; AKI Stage 1&#44; blood gases showed lactic acidosis type A&#46; Increased reticulocytes and free haemoglobin indicated a hemolytic anaemia with scanty schistocytes on peripheral blood smear analysis&#46; Troponin T 61&#44; &#40;reference range&#58; &#60;14&#41; with no ST segment changes on electrocardiography&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An emergency CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; was requested that reported extensive fresh thrombus is noted in the left inflow&#44; left common femoral artery and the left superficial femoral artery&#46; Thrombus also noted in the right internal iliac&#44; right profound and superficial femoral artery origin&#46; Fresh thrombus noted in the right distal popliteal and trifurcation origin&#46; Multiple splenic and left renal infarcts noted&#44; a CT brain did not reported acute ischaemic changes&#46; The trachea was intubated&#44; and ventilatory assistance was begun&#46; Vascular surgeons were requested and the patient was operated on&#58; under general anaesthesia&#44; a left iliofemoral embolectomy associated to a fasciotomy&#44; a thrombus was found in the left common iliofemoral vessels&#46; The patient was anticoagulated with warfarin&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">A transthoracic echocardiogram and cardiac MRI were performed and did not detected any proximal source of emboli&#46; Anticardiolipin IgM 9&#46;8 MPL<span class="elsevierStyleHsp" style=""></span>&#956;&#47;ml&#44; aCL IgM negative &#40;&#60;10&#41;&#44; fibrinogen 5&#46;6<span class="elsevierStyleHsp" style=""></span>g&#47;L &#40;1&#46;50&#8211;4&#46;00&#41;&#44; DRVVT positive lupus anticoagulant&#46; An MRI 3 days after the onset showed axial FLAIR image showed right frontal borderzone infarction&#46; Extensive autoimmune testing looking for autoimmune disorders potentially responsible for thrombotic events were all negative&#46; Patient&#39;s clinical features were consistent with CAPS &#40;symptoms presenting in 24<span class="elsevierStyleHsp" style=""></span>h&#44; including multiple renal and splenic infarcts&#44; non-ST elevation myocardial infarction &#40;NSTEMI&#41;&#44; acute vascular thrombotic occlusion with arterial thrombi confirmed by pathology and positive lupus anticoagulant on two separate occasions 12 weeks apart&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Intravenous hydrocortisone 600<span class="elsevierStyleHsp" style=""></span>mg for 5 days was used followed by oral therapy with prednisone with an initial dose of 60<span class="elsevierStyleHsp" style=""></span>mg&#44; she was slowly tapered off prednisone and currently remains off steroid therapy&#46; At 1 year the patient&#39;s evolution has been satisfactory&#44; antiphospholipid tests and immunological screens has been performed and remained positive&#44; there were no clinical or serological features of SLE&#46; There was also no evidence of rheumatoid arthritis developing&#46; Anticoagulation with warfarin remains on to date&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">This case represents a complex medical patient in a busy ED service&#46; Upon arrival it was difficult to obtain a clear history due to her confusion state&#46; Initially her clinical symptoms suggested an acute vaso-occlusive crisis in the context of a suspected non-diagnosed sickle cell anaemia&#46; A bedside ultrasound showed a suspected occlusion of the left lower extremity and the blood tests were not suggestive of sickle cell disease&#46; CT showed multiple thrombotic events and a limb-threatening thrombosis&#46; The positive history of anticardiolipin antibodies and the recent stillbirth suggested the diagnosis of APS&#46; The patient had a successful recovery with a final diagnosis of CPAS syndrome&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical manifestations and pathological features present in patients with CAPS syndrome depend mainly on two factors&#58; the organs affected by the thrombotic events &#40;thrombosis extension&#41; and systemic inflammatory response syndrome manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> The occlusion of medium or large calibre vessels is rare in the CAPS&#46; Dysfunction of multiple organ is due to acute microangiopathy thrombosis affecting small vessels in various organs&#46; Our patient presented with acute lower limb vascular occlusion and multiple splenic and left renal infarcts&#44; acute confusion and NSTEMI&#46; No previous report of life threatening limb vascular occlusion has been reported&#46; The most significant laboratory findings include hemolytic anaemia and thrombocytopenia&#44; hemolytic anaemia has been described in 39&#37; of the patients with most of the cases with positive Coombs test&#46; Coagulation tests shows characteristics of intravascular disseminated coagulation &#40;DIC&#41;&#44; such as prolonged prothrombin time and increase in fibrinogen degradation products&#46; Blood smear may reveal schistocytes&#44; that are usually scanty&#44; unlike the abundant numbers seen in patients with thrombotic thrombocytopenic purpura&#44; the meaning of schistocytes is still uncertain&#46; 68&#37; of patients in the two main series of cases show antiphospholipid antibodies&#46; The diagnosis of CAPS can be challenging&#44; and sometimes the differential diagnosis cannot be narrowed to a single disease during the acute period&#46; Thus&#44; continuous assessment of patients is warranted&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">An interface of HELLP Syndrome and CAPS exists&#46; A series of 15 cases of CAPS&#44; which appeared during pregnancy or the puerperium were described&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> HELLP syndrome occurred in eight &#40;53&#37;&#41; of the patients&#46; Mortality from the obstetric catastrophic CAPS cohort was extraordinarily high&#44; with 46&#37; &#40;seven out of 15&#41; of the mothers and 64&#37; &#40;seven out of 13&#41; of the neonates succumbing to the disease process&#46; Our reported case was diagnosed in the puerperium&#44; although no previous diagnosis of preeclampsia or HELLP syndrome was established&#46; It is important to consider the possibility of the development of CAPS in those patients with signs of HELLP syndrome and multiorgan failure during pregnancy or puerperium&#44; especially in those patients with previous history of abortions and&#47;or thrombosis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Regarding the long term outcome of CAPS survivors&#59; an analysis of 130 patients showed that 66&#37; of patients who survive an initial event remained symptom free with anticoagulation during an average follow up of 67&#46;2 months&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Treatment with intensive anticoagulation&#44; plasma exchange&#44; and corticosteroids appears beneficial&#44; but no controlled trials have been performed&#46; Intravenous immunoglobulin may be of some benefit&#44; and rituximab or cyclophosphamide may be considered in selected cases&#44; especially in SLE-associated CAPS&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Patients with hypercoagulable states presents in EDs with several symptoms and signs including life-threatening conditions&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> the reported case is an example of the complexity of these complex pathologies&#44; therefore emergency physicians should be familiar with the diagnosis and start immediately lifesaving therapies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interests&#46;</p></span></span>"
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Case Report
Catastrophic antiphospholipid antibody syndrome presenting as acute vascular occlusion in a young female patient
Síndrome de anticuerpos antifosfolípidos catastrófico que se presenta con oclusión vascular aguda en una paciente joven
Joaquín Valle Alonsoa,
Autor para correspondencia
joa51274@hotmail.com

Corresponding author.
, Francisco Javier Fonseca del Pozob, Manuel Vaquero Álvarezc, Jorge Pedrazad, Miguel Angel Aguayod, Almudena Sanchezd
a Royal Bournemouth Hospital, Bournemouth, UK
b Emergency Medicine Montoro, Cordoba, Spain
c Unidad Gestión Clínica Linares (Jaén), Centro Salud San José, Spain
d Hospital Valle de los Pedroches, Cordoba, Spain
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was accepted and has been used extensively&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case description</span><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of a 19-year-old black woman that presented to the Emergency Department with abdominal and left thigh pain&#46; Previous medical and obstetric history included a recent stillbirth 6 weeks ago&#44; at 36 weeks with positive lupus anticoagulant&#46; Recent admission to Hospital due to abdominal pain&#44; seen by Medical and Surgical team that ruled out acute pathology and was referred to Obstetrics service that discharged the patient with further follow-up&#46; At arrival the patient was agitated and uncooperative complaining of abdominal and left thigh pain&#46; The patient reported severe pain in her left leg accompanied by nausea&#44; she did not have chest pain&#44; shortness of breath&#44; fever&#44; chills&#44; dysuria&#44; constipation&#44; or diarrhoea&#46; The temperature was 37&#46;1<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; the pulse was 91&#44; and the respiratory rate 18&#46; The blood pressure was 135&#47;85<span class="elsevierStyleHsp" style=""></span>mmHg&#46; The patient was intermittently agitated&#46; Examination revealed diffusely tender abdomen but not distended&#59; the bowel sounds were normal&#46; Examination of the extremities demonstrated absent pedal pulses on both sides&#44; and a mild sensory loss on the left leg&#46; Morphine sulphate&#44; paracetamol and fluids were administered&#46; A point-of-care ultrasound of lower legs showed the absence of a flow signal suggestive of vascular occlusion&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Initially the patient was suspected to have a sickle cell pain crisis however a reviewed of recent blood tests including electrophoresis did not show the presence of homozygous HbS or documented other hemoglobinopathies&#46; Blood tests revealed&#59; Hb 110<span class="elsevierStyleHsp" style=""></span>g&#47;L&#44; WBC 13&#46;6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#44; Platelets 151<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#44; total bilirubin 5<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L&#44; ALT 30<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; GGT 98<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; calcium 2&#46;36<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; phosphate 0&#46;95<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; ALP 125<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; sodium 136<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; potassium 3&#46;4<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; urea 3&#46;0<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; creatinine 83<span class="elsevierStyleHsp" style=""></span>&#956;mol&#47;L &#40;reference range&#58; 0&#8211;110&#41;&#44; AKI Stage 1&#44; blood gases showed lactic acidosis type A&#46; Increased reticulocytes and free haemoglobin indicated a hemolytic anaemia with scanty schistocytes on peripheral blood smear analysis&#46; Troponin T 61&#44; &#40;reference range&#58; &#60;14&#41; with no ST segment changes on electrocardiography&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An emergency CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; was requested that reported extensive fresh thrombus is noted in the left inflow&#44; left common femoral artery and the left superficial femoral artery&#46; Thrombus also noted in the right internal iliac&#44; right profound and superficial femoral artery origin&#46; Fresh thrombus noted in the right distal popliteal and trifurcation origin&#46; Multiple splenic and left renal infarcts noted&#44; a CT brain did not reported acute ischaemic changes&#46; The trachea was intubated&#44; and ventilatory assistance was begun&#46; Vascular surgeons were requested and the patient was operated on&#58; under general anaesthesia&#44; a left iliofemoral embolectomy associated to a fasciotomy&#44; a thrombus was found in the left common iliofemoral vessels&#46; The patient was anticoagulated with warfarin&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">A transthoracic echocardiogram and cardiac MRI were performed and did not detected any proximal source of emboli&#46; Anticardiolipin IgM 9&#46;8 MPL<span class="elsevierStyleHsp" style=""></span>&#956;&#47;ml&#44; aCL IgM negative &#40;&#60;10&#41;&#44; fibrinogen 5&#46;6<span class="elsevierStyleHsp" style=""></span>g&#47;L &#40;1&#46;50&#8211;4&#46;00&#41;&#44; DRVVT positive lupus anticoagulant&#46; An MRI 3 days after the onset showed axial FLAIR image showed right frontal borderzone infarction&#46; Extensive autoimmune testing looking for autoimmune disorders potentially responsible for thrombotic events were all negative&#46; Patient&#39;s clinical features were consistent with CAPS &#40;symptoms presenting in 24<span class="elsevierStyleHsp" style=""></span>h&#44; including multiple renal and splenic infarcts&#44; non-ST elevation myocardial infarction &#40;NSTEMI&#41;&#44; acute vascular thrombotic occlusion with arterial thrombi confirmed by pathology and positive lupus anticoagulant on two separate occasions 12 weeks apart&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Intravenous hydrocortisone 600<span class="elsevierStyleHsp" style=""></span>mg for 5 days was used followed by oral therapy with prednisone with an initial dose of 60<span class="elsevierStyleHsp" style=""></span>mg&#44; she was slowly tapered off prednisone and currently remains off steroid therapy&#46; At 1 year the patient&#39;s evolution has been satisfactory&#44; antiphospholipid tests and immunological screens has been performed and remained positive&#44; there were no clinical or serological features of SLE&#46; There was also no evidence of rheumatoid arthritis developing&#46; Anticoagulation with warfarin remains on to date&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">This case represents a complex medical patient in a busy ED service&#46; Upon arrival it was difficult to obtain a clear history due to her confusion state&#46; Initially her clinical symptoms suggested an acute vaso-occlusive crisis in the context of a suspected non-diagnosed sickle cell anaemia&#46; A bedside ultrasound showed a suspected occlusion of the left lower extremity and the blood tests were not suggestive of sickle cell disease&#46; CT showed multiple thrombotic events and a limb-threatening thrombosis&#46; The positive history of anticardiolipin antibodies and the recent stillbirth suggested the diagnosis of APS&#46; 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hemolytic anaemia has been described in 39&#37; of the patients with most of the cases with positive Coombs test&#46; Coagulation tests shows characteristics of intravascular disseminated coagulation &#40;DIC&#41;&#44; such as prolonged prothrombin time and increase in fibrinogen degradation products&#46; Blood smear may reveal schistocytes&#44; that are usually scanty&#44; unlike the abundant numbers seen in patients with thrombotic thrombocytopenic purpura&#44; the meaning of schistocytes is still uncertain&#46; 68&#37; of patients in the two main series of cases show antiphospholipid antibodies&#46; The diagnosis of CAPS can be challenging&#44; and sometimes the differential diagnosis cannot be narrowed to a single disease during the acute period&#46; Thus&#44; continuous assessment of patients is warranted&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">An interface of HELLP Syndrome and CAPS exists&#46; A series of 15 cases of CAPS&#44; which appeared during pregnancy or the puerperium were described&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> HELLP syndrome occurred in eight &#40;53&#37;&#41; of the patients&#46; Mortality from the obstetric catastrophic CAPS cohort was extraordinarily high&#44; with 46&#37; &#40;seven out of 15&#41; of the mothers and 64&#37; &#40;seven out of 13&#41; of the neonates succumbing to the disease process&#46; Our reported case was diagnosed in the puerperium&#44; although no previous diagnosis of preeclampsia or HELLP syndrome was established&#46; It is important to consider the possibility of the development of CAPS in those patients with signs of HELLP syndrome and multiorgan failure during pregnancy or puerperium&#44; especially in those patients with previous history of abortions and&#47;or thrombosis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Regarding the long term outcome of CAPS survivors&#59; an analysis of 130 patients showed that 66&#37; of patients who survive an initial event remained symptom free with anticoagulation during an average follow up of 67&#46;2 months&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Treatment with intensive anticoagulation&#44; plasma exchange&#44; and corticosteroids appears beneficial&#44; but no controlled trials have been performed&#46; Intravenous immunoglobulin may be of some benefit&#44; and rituximab or cyclophosphamide may be considered in selected cases&#44; especially in SLE-associated CAPS&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0050" class="elsevierStylePara elsevierViewall">Patients with hypercoagulable states presents in EDs with several symptoms and signs including life-threatening conditions&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> the reported case is an example of the complexity of these complex pathologies&#44; therefore emergency physicians should be familiar with the diagnosis and start immediately lifesaving therapies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acquired thrombotic and thromboembolic disorders may be presented initially with symptoms and signs of acute ischaemia or organ dysfunction that will lead many of these patients to seek care in the emergency department&#46; We report a case of a 19-year-old female patient who developed catastrophic antiphospholipid syndrome &#40;CAPS syndrome or Asherson syndrome&#41; 6 weeks post stillbirth with an initial presentation of acute vascular occlusion&#46; The patient was immediately operated and anticoagulated with significant improvement&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los trastornos tromb&#243;ticos y tromboemb&#243;licos adquiridos pueden manifestarse inicialmente con signos y s&#237;ntomas de isquemia aguda o disfunci&#243;n org&#225;nica que derivar&#225; a muchos de estos pacientes al servicio de urgencias&#46; Se presenta el caso de una paciente de 19 a&#241;os de edad que desarroll&#243; un s&#237;ndrome antifosfol&#237;pido catastr&#243;fico &#40;o s&#237;ndrome de Asherson&#41; 6 semanas despu&#233;s del parto de un feto muerto con una presentaci&#243;n inicial de oclusi&#243;n vascular aguda&#46; La paciente fue intervenida inmediatamente y se inici&#243; un tratamiento con anticoagulantes que supuso una mejora significativa&#46;</p></span>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&#46; Development of manifestations simultaneously or in less than a week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&#46; Confirmation by histopathology of small-vessel occlusion<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4 Laboratory confirmation of the presence of antiphospholipid antibodies<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8226; Criteria 1&#44; 2&#44; and 4&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">&#8220;Positive aPL&#8221; twice 12 weeks apart &#40;of note&#44; the original Sapporo APS classification criteria required two positive aPL tests 6 weeks apart&#44; which has been changed to 12 weeks as part of the updated Sapporo APS classification criteria&#46;</p>"
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                      "titulo" => "The catastrophic antiphospholipid syndrome"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "R&#46;A&#46; Asherson"
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                      "titulo" => "CAPS Registry"
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                            2 => "G&#46; Espinosa"
                            3 => "R&#46;A&#46; Asherson"
                            4 => "M&#46; Garcia Carrasco"
                            5 => "I&#46;P&#46; da Costa"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.061671"
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                            0 => "J&#46;G&#46; Kuntz"
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2020 Enero 114 31 145
2019 Diciembre 137 33 170
2019 Noviembre 102 25 127
2019 Octubre 149 27 176
2019 Septiembre 126 34 160
2019 Agosto 87 14 101
2019 Julio 90 22 112
2019 Junio 69 27 96
2019 Mayo 136 48 184
2019 Abril 78 35 113
2019 Marzo 138 32 170
2019 Febrero 43 17 60
2019 Enero 68 40 108
2018 Diciembre 121 63 184
2018 Noviembre 231 33 264
2018 Octubre 153 34 187
2018 Septiembre 41 27 68
2018 Agosto 32 10 42
2018 Julio 31 10 41
2018 Junio 0 1 1
2018 Marzo 76 32 108
2018 Febrero 208 133 341
2018 Enero 92 48 140
2017 Diciembre 0 11 11
2017 Noviembre 0 5 5
2017 Octubre 0 9 9
2017 Septiembre 0 13 13
2017 Agosto 0 10 10
2017 Julio 0 12 12
2017 Junio 0 11 11
2017 Mayo 0 15 15
2017 Abril 0 25 25
2017 Marzo 0 16 16
2017 Febrero 0 9 9
2017 Enero 0 18 18
2016 Diciembre 0 32 32
2016 Noviembre 0 37 37
2016 Octubre 0 48 48
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