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She developed SS at the age of 18 year showing intermittent swelling of parotid glands&#44; positive RF&#44; antinuclear antibodies &#40;ANA&#41; and anti-SSA antibodies&#44; elevated erythrocyte sedimentation rate &#40;ESR&#44; 25<span class="elsevierStyleHsp" style=""></span>mm&#47;1<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; but normal serum level of cryoglobulins&#44; IgG4 and complement&#46; The Schirmer test and serologic testing for virus were negative&#46; The minor SG biopsy showed focal lymphocytic sialadenitis but the histopathologic diagnosis did not meet SS-criteria&#46; Her follow-up showed the detection of a nodule on the hard palate with the diagnosis of B-cell lymphoma based on morphologic and immunohistochemical staining &#40;CD20&#43; B cells&#41; from nodule biopsy&#46; Gastrointestinal endoscopy showed chronic gastritis &#40;<span class="elsevierStyleItalic">Helicobacter pylori</span> negative&#41;&#46; The computerized tomography &#40;CT&#41; of neck&#44; chest&#44; abdomen&#44; and pelvis&#44; showed no additional evidence of disease&#46; Recently a new episode of right parotitis along with a biopsied cervical lymph node confirmed persistent lymphoma after 6 months of rituximab&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 2</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 16-year-old boy presented with intermittent painless cervical lymphadenopathy and bilateral parotid swelling for more than 5 years&#46; Neck CT demonstrated enlargement of the parotids&#46; A fine needle aspiration showed a benign lymphoid tissue with no evidence of malignancy&#46; Laboratory data showed an increased ESR &#40;122<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#41;&#46; Histopathology analysis showed infiltration of the salivary gland by a lymphocytic proliferation forming confluent nodular masses and follicular hyperplasia of the attached lymph nodes&#44; indicative of a lymphoid malignancy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Immunohistochemical stains demonstrated sheets of CD20&#43; B cells that were negative for CD5&#44; CD43&#44; and cyclin-D1&#44; confirming B-cell clonal proliferation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; CD10 and BCL-6 stains highlighted germinal centers which were negative for BCL-2&#46; A Ki-67 stain showed numerous positive cells within and between germinal centers &#40;20&#8211;30&#37; cells&#41;&#46; Parotidectomy and radiotherapy was performed&#46; Serologic testing revealed only a remote infection by CMV and EBV&#46; Immunological tests showed positive RF&#44; ANA&#44; anti-SSA and anti-SSB antibodies&#46; Despite only vague sicca symptoms&#44; ophthalmology exam revealed corneal and conjunctival erosions&#44; and the diagnosis of SS was made&#46; Hydroxychloroquine and rituximab were started&#46; There was no evidence of tumor recurrence after &#62;14 months follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">In childhood&#44; recurrent parotid swelling is the most common hallmark of SS&#44; usually proceeding to sicca symptoms as in our patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Diagnostic criteria are similar to those proposed in adults<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#59; however&#44; it showed low sensitivity and histological findings of the minor SG criteria &#40;&#62;1 focus of 50 lymphocytes&#47;4<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41; are often negative in children&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> It explains delayed diagnosis in the case 1&#44; despite exclusion of infectious diseases at onset&#46; The sensitivity increases by using a lesser score in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The occurrence of lymphoma in SS is extremely rare in childhood&#46; EMZL is a low-grade lymphoma that usually occurs in the setting of a benign myoepithelial sialadenitis &#40;MESA&#41; and biopsy confirms the diagnosis&#46; Clonal expansion to EMZL is believed to be triggered by chronic immune stimulation in the context of a preexisting inflammatory response from autoimmune diseases or chronic infections&#44; amyloidosis&#44; some translocations and common variable immunodeficiency&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;9</span></a> Differences in Rituximab response might be a higher pretreatment number of CD20&#43; B cells&#47;mm<span class="elsevierStyleSup">2</span> parotid gland parenchyma&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="par0030" class="elsevierStylePara elsevierViewall">SS requires child-specific criteria to role out lymphoma as unusual complication in children&#44; particularly for timely and appropriate referral&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Protection of human and animal subjects</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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Case Report
Extranodal marginal zone B cell lymphoma: An unexpected complication in children with Sjögren's syndrome
Linfoma no Hodgkin de linfocitos B de la zona marginal, extranodal: una complicación inesperada en niños con síndrome de Sjögren
Paz Colladoa,,
Autor para correspondencia
paxko10@gmail.com

Corresponding author.
, Aml Keladab,, Maria Cámarac, Andrew Zeftd, Aron Flaggb
a Department of Rheumatology/Paediatric Rheumatology Unit, Hospital Universitario Severo Ochoa, Madrid, Spain
b Department of Pediatric Hematology/Oncology and Blood & Marrow Transplant, Cleveland Clinic, OH, USA
c Pathologic Anatomy Department, Hospital Universitario Severo Ochoa, Madrid, Spain
d Center for Pediatric Rheumatology and Immunology Cleveland Clinic, OH, USA
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She developed SS at the age of 18 year showing intermittent swelling of parotid glands&#44; positive RF&#44; antinuclear antibodies &#40;ANA&#41; and anti-SSA antibodies&#44; elevated erythrocyte sedimentation rate &#40;ESR&#44; 25<span class="elsevierStyleHsp" style=""></span>mm&#47;1<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; but normal serum level of cryoglobulins&#44; IgG4 and complement&#46; The Schirmer test and serologic testing for virus were negative&#46; The minor SG biopsy showed focal lymphocytic sialadenitis but the histopathologic diagnosis did not meet SS-criteria&#46; Her follow-up showed the detection of a nodule on the hard palate with the diagnosis of B-cell lymphoma based on morphologic and immunohistochemical staining &#40;CD20&#43; B cells&#41; from nodule biopsy&#46; Gastrointestinal endoscopy showed chronic gastritis &#40;<span class="elsevierStyleItalic">Helicobacter pylori</span> negative&#41;&#46; The computerized tomography &#40;CT&#41; of neck&#44; chest&#44; abdomen&#44; and pelvis&#44; showed no additional evidence of disease&#46; Recently a new episode of right parotitis along with a biopsied cervical lymph node confirmed persistent lymphoma after 6 months of rituximab&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 2</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 16-year-old boy presented with intermittent painless cervical lymphadenopathy and bilateral parotid swelling for more than 5 years&#46; Neck CT demonstrated enlargement of the parotids&#46; A fine needle aspiration showed a benign lymphoid tissue with no evidence of malignancy&#46; Laboratory data showed an increased ESR &#40;122<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#41;&#46; Histopathology analysis showed infiltration of the salivary gland by a lymphocytic proliferation forming confluent nodular masses and follicular hyperplasia of the attached lymph nodes&#44; indicative of a lymphoid malignancy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Immunohistochemical stains demonstrated sheets of CD20&#43; B cells that were negative for CD5&#44; CD43&#44; and cyclin-D1&#44; confirming B-cell clonal proliferation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; CD10 and BCL-6 stains highlighted germinal centers which were negative for BCL-2&#46; A Ki-67 stain showed numerous positive cells within and between germinal centers &#40;20&#8211;30&#37; cells&#41;&#46; Parotidectomy and radiotherapy was performed&#46; Serologic testing revealed only a remote infection by CMV and EBV&#46; Immunological tests showed positive RF&#44; ANA&#44; anti-SSA and anti-SSB antibodies&#46; Despite only vague sicca symptoms&#44; ophthalmology exam revealed corneal and conjunctival erosions&#44; and the diagnosis of SS was made&#46; Hydroxychloroquine and rituximab were started&#46; There was no evidence of tumor recurrence after &#62;14 months follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">In childhood&#44; recurrent parotid swelling is the most common hallmark of SS&#44; usually proceeding to sicca symptoms as in our patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Diagnostic criteria are similar to those proposed in adults<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&#59; however&#44; it showed low sensitivity and histological findings of the minor SG criteria &#40;&#62;1 focus of 50 lymphocytes&#47;4<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41; are often negative in children&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> It explains delayed diagnosis in the case 1&#44; despite exclusion of infectious diseases at onset&#46; The sensitivity increases by using a lesser score in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The occurrence of lymphoma in SS is extremely rare in childhood&#46; EMZL is a low-grade lymphoma that usually occurs in the setting of a benign myoepithelial sialadenitis &#40;MESA&#41; and biopsy confirms the diagnosis&#46; Clonal expansion to EMZL is believed to be triggered by chronic immune stimulation in the context of a preexisting inflammatory response from autoimmune diseases or chronic infections&#44; amyloidosis&#44; some translocations and common variable immunodeficiency&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;9</span></a> Differences in Rituximab response might be a higher pretreatment number of CD20&#43; B cells&#47;mm<span class="elsevierStyleSup">2</span> parotid gland parenchyma&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="par0030" class="elsevierStylePara elsevierViewall">SS requires child-specific criteria to role out lymphoma as unusual complication in children&#44; particularly for timely and appropriate referral&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Ethical disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Protection of human and animal subjects</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sj&#246;gren&#39;s syndrome &#40;SS&#41; is a systemic autoimmune disease characterized by the infiltration of lymphocytes into exocrine glands&#44; resulting in the typical sicca symptoms&#46; Unlike adults&#44; primary SS is a very rare condition in childhood&#44; and the risk of malignancy in juvenile SS &#40;JSS&#41; has not been defined&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report the detection of extranodal marginal zone B-cell lymphoma &#40;EMZL&#41; occurring in two children with SS&#46; Fine needle aspiration of the salivary glands &#40;SG&#41; showed nonspecific findings that led to delayed diagnosis of SS&#46; The diagnosis of B-cell lymphoma associated with JSS was based on morphologic and immunohistochemical staining done during the biopsy&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">To highlight awareness of EMZL as a timely and appropriate update of an unusual complication in children with SS&#46;</p></span>"
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