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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old woman presented to the rheumatology clinic with complaints of progressive pain and oedema in the fingertips&#44; sometimes with ulceration and extrusion calcium-like material&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient had a 12-year history of limited Systemic Sclerosis &#40;SSc&#41; with symptoms of Raynaud&#44; dyspnoea&#44; heartburn&#44; pain and swelling in the fingertips&#46; By the time of diagnosis physical examination revealed telangiectasias&#44; sclerodactyly and subcutaneous nodularities in the tip of the 1st and 3rd fingers of the right hand&#46; Laboratory analyses were positive for Topoisomerase I&#47;Scl-70&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the 12 years of follow-up&#44; the most prominent complaints were related to the function limitation caused by calcinosis cutis&#46; She also developed exuberant widespread calcinosis in other fingers&#44; right elbow&#44; right shoulder and hips&#46; Several therapies were tried&#44; including bisphosphonates&#44; diltiazem&#44; colchicine&#44; minocycline and intravenous immunoglobulin&#44; without any benefit&#46; Three surgeries on the 1st and 3rd fingers of her right hand were performed to excise calcium deposits&#59; despite that&#44; calcinosis returned at the same locations&#46; Current radiographic images show the ineffectiveness of treating calcinosis cutis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">SSc-related calcinosis is a common and debilitating manifestation&#46; Frequent complications are ulceration&#44; infection&#44; pain and impaired function&#46; The scarcity of effective options makes the treatment of calcinosis a major clinical challenge&#46; Together&#44; these factors make calcinosis a major contributor to the disease burden in SSc patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">1&#44;2</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethics</span><p id="par0025" class="elsevierStylePara elsevierViewall">This article was written in compliance with the Helsinki Declaration&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no funding sources&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors&#8217; contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">All authors contributed for the care of the patient and equally contribute to the article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflict of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">We declare no conflict of interest&#46;</p></span></span>"
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