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Vol. 18. Núm. 1.
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Vol. 18. Núm. 1.
Páginas 59-60 (enero 2021)
Images in Clinical Rheumatology
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Calcinosis in Limited Systemic Sclerosis
Calcinosis en la esclerosis sistémica limitada
Visitas
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Emanuel Costa
Autor para correspondencia
emanueldavidecosta@gmail.com

Corresponding author.
, Diogo Almeida, Joana Sousa-Neves
Rheumatology Department, Hospital de Braga, Braga, Portugal
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Texto completo

A 68-year-old woman presented to the rheumatology clinic with complaints of progressive pain and oedema in the fingertips, sometimes with ulceration and extrusion calcium-like material.

The patient had a 12-year history of limited Systemic Sclerosis (SSc) with symptoms of Raynaud, dyspnoea, heartburn, pain and swelling in the fingertips. By the time of diagnosis physical examination revealed telangiectasias, sclerodactyly and subcutaneous nodularities in the tip of the 1st and 3rd fingers of the right hand. Laboratory analyses were positive for Topoisomerase I/Scl-70.

During the 12 years of follow-up, the most prominent complaints were related to the function limitation caused by calcinosis cutis. She also developed exuberant widespread calcinosis in other fingers, right elbow, right shoulder and hips. Several therapies were tried, including bisphosphonates, diltiazem, colchicine, minocycline and intravenous immunoglobulin, without any benefit. Three surgeries on the 1st and 3rd fingers of her right hand were performed to excise calcium deposits; despite that, calcinosis returned at the same locations. Current radiographic images show the ineffectiveness of treating calcinosis cutis (Fig. 1).

Fig. 1.

Calcinosis cutis in systemic sclerosis. X-rays show soft tissue calcium deposits in hips (A), right elbow (B), right shoulder (C) and fingers (D).

(0.28MB).

SSc-related calcinosis is a common and debilitating manifestation. Frequent complications are ulceration, infection, pain and impaired function. The scarcity of effective options makes the treatment of calcinosis a major clinical challenge. Together, these factors make calcinosis a major contributor to the disease burden in SSc patients.1,2

Ethics

This article was written in compliance with the Helsinki Declaration.

Funding

The authors declare no funding sources.

Authors’ contributions

All authors contributed for the care of the patient and equally contribute to the article.

Conflict of interest

We declare no conflict of interest.

References
[1]
A. Valenzuela, L. Chung.
Management of calcinosis associated with systemic sclerosis.
Curr Treat Opt Rheumatol, 2 (2016), pp. 85-96
[2]
H. Traineau, R. Aggarwal, J. Monfort, P. Senet, C. Oddis, C. Chizzolini, et al.
Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: a review of the literature.
J Am Acad Dermatol, 82 (2020), pp. 317-325
Copyright © 2021. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
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