se ha leído el artículo
array:24 [ "pii" => "S2173574312000160" "issn" => "21735743" "doi" => "10.1016/j.reumae.2011.10.007" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "381" "copyright" => "Elsevier España, S.L.. All rights reserved" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2012;8:294-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 11199 "formatos" => array:3 [ "EPUB" => 68 "HTML" => 10162 "PDF" => 969 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S1699258X11003184" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2011.10.010" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "381" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2012;8:294-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 21090 "formatos" => array:3 [ "EPUB" => 162 "HTML" => 18718 "PDF" => 2210 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Reumatología clínica en imágenes</span>" "titulo" => "Tofo tibial intraóseo en gota crónica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "294" "paginaFinal" => "297" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Intrabony tibial tophi in chronic gout" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1189 "Ancho" => 950 "Tamanyo" => 69417 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Radiografía de rodilla izquierda anteroposterior: se objetivan lesiones líticas de bordes bien delimitados en epífisis tibial y cambios degenerativos incipientes femorotibiales.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristóbal M. Rodríguez Leal, Raquel Almodóvar, Pedro Zarco, Ramón Mazzuchelli, Francisco Javier Quirós" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Cristóbal M." "apellidos" => "Rodríguez Leal" ] 1 => array:2 [ "nombre" => "Raquel" "apellidos" => "Almodóvar" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "Zarco" ] 3 => array:2 [ "nombre" => "Ramón" "apellidos" => "Mazzuchelli" ] 4 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Quirós" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574312000160" "doi" => "10.1016/j.reumae.2011.10.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312000160?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X11003184?idApp=UINPBA00004M" "url" => "/1699258X/0000000800000005/v1_201305061926/S1699258X11003184/v1_201305061926/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173574312000779" "issn" => "21735743" "doi" => "10.1016/j.reumae.2012.06.003" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "420" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2012;8:298-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3442 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 2777 "PDF" => 607 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Transverse Myelitis and Bilateral Optic Neuritis in a Patient With Systemic Lupus Erythematosus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "298" "paginaFinal" => "299" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mielitis transversa y neuritis óptica bilateral en una paciente con lupus eritematoso sistémico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Iñaki Hernando Rubio, Joaquín Belzunegui Otano, Olga Máiz Alonso, Belén Álvarez Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Iñaki" "apellidos" => "Hernando Rubio" ] 1 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Belzunegui Otano" ] 2 => array:2 [ "nombre" => "Olga" "apellidos" => "Máiz Alonso" ] 3 => array:2 [ "nombre" => "Belén" "apellidos" => "Álvarez Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X12000526" "doi" => "10.1016/j.reuma.2012.01.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X12000526?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312000779?idApp=UINPBA00004M" "url" => "/21735743/0000000800000005/v1_201305061645/S2173574312000779/v1_201305061645/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173574312000172" "issn" => "21735743" "doi" => "10.1016/j.reumae.2011.10.008" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "382" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2012;8:292-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7761 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 6982 "PDF" => 722 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>" "titulo" => "Tuberculous Spondylodiskitis With Lumbar Tumor" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "292" "paginaFinal" => "293" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Espondilodiscitis tuberculosa con tumoración lumbar" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1199 "Ancho" => 998 "Tamanyo" => 112635 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">L1 and L2 lytic lesion with a sclerotic border.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Cristina López-Sánchez, Gabriela Calvo Arrojo, Tomás Ramón Vázquez-Rodríguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María Cristina" "apellidos" => "López-Sánchez" ] 1 => array:2 [ "nombre" => "Gabriela" "apellidos" => "Calvo Arrojo" ] 2 => array:2 [ "nombre" => "Tomás Ramón" "apellidos" => "Vázquez-Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X11003196" "doi" => "10.1016/j.reuma.2011.10.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X11003196?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312000172?idApp=UINPBA00004M" "url" => "/21735743/0000000800000005/v1_201305061645/S2173574312000172/v1_201305061645/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>" "titulo" => "Intrabony Tibial Tophi in Chronic Gout" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "294" "paginaFinal" => "297" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cristóbal M. Rodríguez Leal, Raquel Almodóvar, Pedro Zarco, Ramón Mazzuchelli, Francisco Javier Quirós" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Cristóbal M." "apellidos" => "Rodríguez Leal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Raquel" "apellidos" => "Almodóvar" "email" => array:1 [ 0 => "ralmodovar@fhalcorcon.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Pedro" "apellidos" => "Zarco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ramón" "apellidos" => "Mazzuchelli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Francisco Javier" "apellidos" => "Quirós" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Medicina Interna, Hospital Universitario Fundación Alcorcón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Reumatología, Hospital Universitario Fundación Alcorcón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tofo tibial intraóseo en gota crónica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3a.jpeg" "Alto" => 917 "Ancho" => 944 "Tamanyo" => 128537 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Left knee coronal T1MRI. It shows a diffuse hypointense synovial proliferation with bone erosion of the posterolateral margin of the femoral condyle (blue arrow) and intercondylar notch. A hypointense lytic lesion is seen in the proximal tibial epiphysis with a maximum diameter of 5<span class="elsevierStyleHsp" style=""></span>cm (red arrows). (B) Sagittal T2. There is an increased signal heterogeneity at the level of the tibial epiphyseal lytic lesion (red arrows), along with a large Baker's cyst located behind the medial gastrocnemius muscle (green arrows), with areas of high and low signal for synovial hypertrophy. (C) Sagittal T1-Gd. After administration of gadolinium, enhancement shows the level of peripheral tibial lytic lesion (red arrows) and Baker's cyst (green arrows). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case Report</span><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of a 49-year-old male with a history of hyperlipidemia and significant alcohol intake. In May 2004, during an outpatient visit, he referred 10 years of recurrent episodes of monoarthritis lasting three days, successively affecting either the left knee, left tarsus, elbow, left or bilateral first metatarsophalangeal joints, with no other accompanying symptoms. Physical examination showed signs of a left knee effusion, restricting flexion to 90° and tophi on the left olecranon.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Laboratory tests showed uricemia of 9.4<span class="elsevierStyleHsp" style=""></span>mg/dl and GGT 166<span class="elsevierStyleHsp" style=""></span>U/dl. The remaining parameters (CBC, TSH, CPK, rheumatoid factor, HLA B27, anti-CCP antibodies, immunoglobulins, 24<span class="elsevierStyleHsp" style=""></span>h urine uric acid) were normal. X-rays of the left foot were performed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), showing marginal erosions and sclerotic borders of the first metatarsal head, with increased adjacent soft tissue. A left knee radiograph (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) showed lytic lesions with well-defined edges and incipient degenerative changes of the tibial epiphysis at the femorotibial level. We performed arthrocentesis of the left knee. Monosodium urate crystals were found in synovial fluid (SF). SF culture was negative.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis and Evolution</span><p id="par0015" class="elsevierStylePara elsevierViewall">Given the radiological lesions of the left knee, we completed the study with a left knee MRI (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) which showed synovial proliferation which revealed diffuse, hypointense lesions on T1, with bone erosions in the posterolateral margin of the femoral condyle. A large Baker's cyst with areas of high and low signal on T2 were seen, as well as lytic, hypointense lesion on T1, T2 with a heterogeneous signal level on the proximal tibial epiphysis and a maximum diameter of 5<span class="elsevierStyleHsp" style=""></span>cm that after administration of gadolinium showed enhancement, something characteristic of tophaceous deposits.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Based on the above, the patient was diagnosed with chronic gouty arthritis with intraosseous and intraarticular tophi. Dietary measures were initiated and treatment begun with allopurinol (300<span class="elsevierStyleHsp" style=""></span>mg/d) and colchicine 1<span class="elsevierStyleHsp" style=""></span>mg daily. Due to the persistence of clinical uricemia of 6.2<span class="elsevierStyleHsp" style=""></span>mg/dl, benzbromarone was added (up to 100<span class="elsevierStyleHsp" style=""></span>mg doses per day), until the patient was asymptomatic. Current levels of uric acid are 3.6<span class="elsevierStyleHsp" style=""></span>mg/dl and there was a slight decrease of the tibial intraosseous tophus size.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">It is estimated that the prevalence of gouty arthritis in the general population is 1.4%,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and represents approximately 5% of monoarthritis seen in consultation. The tophus is a nodular mass composed of sodium urate salts and surrounded by a chronic inflammatory reaction with abundant vascularization. It is a late complication of hyperuricemia maintained and present in only a minority of patients. They usually form in juxta-articular regions, although virtually any tissue<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> can present them. It is not uncommon for intraosseous tophi to form in advanced crystal arthropathy, reaching 13.3% in patients in some series.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A definitive diagnosis requires histopathological confirmation, but imaging tests may be useful. Plain radiographs can show juxta-articular and intraosseous calcifications and erosions of the articular surface, creating problems of differential diagnosis with avascular<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> necrosis and osteochondroma. The presence of bone erosions is a marker of intrabone<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> tophi. These can be seen as a soft tissue or intraosseous mass. The joint space is generally respected and periosteal new bone formation and subchondral collapse can appear. Is a useful tool to determine the severity of involvement, with standardized methods and a Sharp/Van der Heijde<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> score available for indexing. Ultrasound is a useful tool for its low cost, no radiation, and speed of implementation, also used to guide invasive techniques. It has a high sensitivity for detecting monosodium urate deposits, even in patients with asymptomatic hyperuricemia. It is able to appreciate bone erosions earlier than plain X-rays. On the other hand, it is the only standardized technique for measurement of tophi and can demonstrate subclinical inflammatory activity by capturing Doppler hypervascular areas around the monosodium urate deposits. The typical findings in gout with this technique are: a double contour sign, aggregated punctate echogenic tissue, “snow storm” synovial fluid appearance with hyperechogenic areas, and soft tissue edema, in addition to the aforementioned bone erosions and hypervascularity.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a> Computed tomography (CT) is useful in the recognition of monosodium urate deposits. These deposits have an attenuation of approximately 160 Hounsfield units (HU), while calcium crystals exhibit an attenuation of 450<span class="elsevierStyleHsp" style=""></span>HU, even bone tissue and calcified tophi.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> It provides more specific images than ultrasound or MRI, as well as aid in the diagnosis of complications, and intraosseous tophi and bone erosions, and can guide joint aspiration.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Magnetic resonance imaging (MRI) is a tool that, while non-specific and with certain limitations, such as suboptimal definition for intraosseous abnormalities, a high cost, and poor availability, is the method of choice for evaluating soft tissue, ligaments, muscles and tissues as well as juxta-articular joint space, and effusions or synovial proliferation, cartilage abnormalities, due to a spatial resolution far superior to other imaging tests. In particular, it has great utility in determining the etiology of functional limitations of unknown causes in the knee joint in patients with gout.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,6</span></a> Importantly, the synovial membrane is too thin to be assessed with this imaging method, so that it can only be seen when a pathological process enlarges it. The differential diagnosis of synovial thickening raises the possibility of longstanding rheumatoid arthritis, pyrophosphate arthropathy, villonodular synovitis, hemophilic arthropathy, amyloid arthropathy, synovial chondromatosis, and chronic granulomatous processes such as arthritis or fungal infection or tuberculosis.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,6,9</span></a> Gout is often found presenting a synovial effusion and synovial pannus. The tophi are seen as an amorphous lesion, eccentric and asymmetric, with variable intensity depending on their composition: protein, fibrous crystals, hemosiderin, and calcium, although the latter are rare and found in very old lesions. It is common to observe one of these morphological patterns: amorphous mass, linear crystalline deposits, or cystic lesions in the juxta-articular bursa. Intraosseous tophi are hypointense or of intermediate intensity on T1, heterogeneous-looking from hyper-to hypointense on T2, depending on the amount of calcium in the tophi, with more calcium, less intensity. It usually enhances after contrast administration, which translates hypervascularization and is a predictor of bone erosion. It also often is accompanied by juxta-articular findings such as erosions, edema of soft tissues, bone marrow edema, or extraarticular<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> tophi.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6,9–11</span></a> Isolated tophi may pose problems in differential diagnosis with tumors such as fibroblastic tumors and benign xantofibroma, but it is rare to find surrounding edema in these.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In short, chronic tophaceous gout presents a constellation of clinical and radiological findings which are important to know for a correct differential diagnosis and further treatment. Although MRI is not a specific test for the diagnosis of gout, it does allow early detection of intraosseous and intraarticular tophi and bone erosions in patients with gout, helping us to recognize this entity and avoid a bone biopsy in selected patients. Thus, MRI can play a special role in the identification of clinical complications and monitoring response to treatment.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects.</span> The authors declare that no experiments were performed on humans or animals for this investigation.</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data.</span> The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study.</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent.</span> The authors have obtained the informed consent of the patients and /or subjects mentioned in the article. The author for correspondence is in possession of this document.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case Report" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Diagnosis and Evolution" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Rodríguez Leal CM, et al. Tofo tibial intraóseo en gota crónica. Reumatol Clin. 2012. <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2011.10.010">doi:10.1016/j.reuma.2011.10.010</span>.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1887 "Ancho" => 1501 "Tamanyo" => 155504 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior and oblique X-ray of left foot: well demarcated marginal erosions are observed on the first metatarsal head, with increased adjacent soft tissue. The joint space and the density of the rest of the subchondral bone is preserved.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1189 "Ancho" => 951 "Tamanyo" => 69944 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Anteroposterior X-ray of the left knee: well demarcated lytic lesions are objectified in tibial epiphysis with incipient femorotibial degenerative changes.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3a.jpeg" "Alto" => 917 "Ancho" => 944 "Tamanyo" => 128537 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Left knee coronal T1MRI. It shows a diffuse hypointense synovial proliferation with bone erosion of the posterolateral margin of the femoral condyle (blue arrow) and intercondylar notch. A hypointense lytic lesion is seen in the proximal tibial epiphysis with a maximum diameter of 5<span class="elsevierStyleHsp" style=""></span>cm (red arrows). (B) Sagittal T2. There is an increased signal heterogeneity at the level of the tibial epiphyseal lytic lesion (red arrows), along with a large Baker's cyst located behind the medial gastrocnemius muscle (green arrows), with areas of high and low signal for synovial hypertrophy. (C) Sagittal T1-Gd. After administration of gadolinium, enhancement shows the level of peripheral tibial lytic lesion (red arrows) and Baker's cyst (green arrows). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)</p>" ] ] 3 => array:5 [ "identificador" => "pfig0005" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3bc.jpeg" "Alto" => 1887 "Ancho" => 945 "Tamanyo" => 224639 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The modern management of gout" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.G. Rider" 1 => "K.M. Jordan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/kep306" "Revista" => array:6 [ "tituloSerie" => "Rheumatology" "fecha" => "2010" "volumen" => "49" "paginaInicial" => "5" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19808695" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonseptic monoarthritis: imaging features with clinical and histopathologic correlation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Llauger" 1 => "J. Palmer" 2 => "N. Rosón" 3 => "S. Bagué" 4 => "A. Camins" 5 => "R. Cremades" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiographics.20.suppl_1.g00oc13s263" "Revista" => array:6 [ "tituloSerie" => "Radiographics" "fecha" => "2000" "volumen" => "20" "paginaInicial" => "S263" "paginaFinal" => "S278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11046178" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tophaceous gout of the knee: revisiting MRI patterns in 30 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.H. Ko" 1 => "Y.C. Hsu" 2 => "H.S. Lee" 3 => "C.H. Lee" 4 => "G.S. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RHU.0b013e3181e92c38" "Revista" => array:6 [ "tituloSerie" => "J Clin Rheumatol" "fecha" => "2010" "volumen" => "16" "paginaInicial" => "209" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20661066" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraosseous calcifications in tophaceous gout" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Resnick" 1 => "T.W. Broderick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "1981" "volumen" => "137" "paginaInicial" => "1157" "paginaFinal" => "1161" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Dalbeth" 1 => "B. Clark" 2 => "K. Gregory" 3 => "G. Gamble" 4 => "T. Sheehan" 5 => "A. Doyle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.094201" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "1290" "paginaFinal" => "1295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18708415" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of gout: findings and utility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Perez-Ruiz" 1 => "N. Dalbeth" 2 => "A. Urresola" 3 => "E. De Miguel" 4 => "N. Schlesinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar2687" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2009" "volumen" => "11" "paginaInicial" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19591633" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of ultrasound and other advanced imaging in the diagnosis and management of gout" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.G. Thiele" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11926-010-0156-4" "Revista" => array:6 [ "tituloSerie" => "Curr Rheumatol Rep" "fecha" => "2011" "volumen" => "13" "paginaInicial" => "146" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21210257" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of tophaceous gout: computed tomography provides specific images compared with magnetic resonance imaging and ultrasonography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.C. Gerster" 1 => "M. Landry" 2 => "L. Dufresne" 3 => "J.Y. Meuwly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2002" "volumen" => "61" "paginaInicial" => "52" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11779759" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypointense synovial lesions on T2-weighted images: differential diagnosis with pathologic correlation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Narváez" 1 => "J. Narváez" 2 => "R. Ortega" 3 => "E. De Lama" 4 => "Y. Roca" 5 => "N. Vidal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2214/ajr.181.3.1810761" "Revista" => array:6 [ "tituloSerie" => "AJR Am J Roentgenol" "fecha" => "2003" "volumen" => "181" "paginaInicial" => "761" "paginaFinal" => "769" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12933477" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MR imaging of tophaceous gout" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.S. Yu" 1 => "C. Chung" 2 => "M. Recht" 3 => "T. Dailiana" 4 => "R. Jurdi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "1997" "volumen" => "168" "paginaInicial" => "523" "paginaFinal" => "527" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging of tophi with an extremity-dedicated MRI system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Paparo" 1 => "G. Zampogna" 2 => "E. Fabbro" 3 => "M. Parodi" 4 => "R. Andracco" 5 => "G. Ferrero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2011" "volumen" => "29" "paginaInicial" => "519" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21722500" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000800000005/v1_201305061645/S2173574312000160/v1_201305061645/en/main.assets" "Apartado" => array:4 [ "identificador" => "5795" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in Clinical Rheumatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000800000005/v1_201305061645/S2173574312000160/v1_201305061645/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574312000160?idApp=UINPBA00004M" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 62 | 41 | 103 |
2024 Septiembre | 91 | 24 | 115 |
2024 Agosto | 89 | 46 | 135 |
2024 Julio | 81 | 34 | 115 |
2024 Junio | 76 | 40 | 116 |
2024 Mayo | 100 | 38 | 138 |
2024 Abril | 75 | 35 | 110 |
2024 Marzo | 67 | 52 | 119 |
2024 Febrero | 91 | 29 | 120 |
2024 Enero | 69 | 19 | 88 |
2023 Diciembre | 64 | 28 | 92 |
2023 Noviembre | 98 | 40 | 138 |
2023 Octubre | 92 | 28 | 120 |
2023 Septiembre | 151 | 52 | 203 |
2023 Agosto | 105 | 27 | 132 |
2023 Julio | 86 | 32 | 118 |
2023 Junio | 112 | 36 | 148 |
2023 Mayo | 90 | 28 | 118 |
2023 Abril | 87 | 19 | 106 |
2023 Marzo | 158 | 38 | 196 |
2023 Febrero | 102 | 39 | 141 |
2023 Enero | 89 | 36 | 125 |
2022 Diciembre | 133 | 56 | 189 |
2022 Noviembre | 112 | 40 | 152 |
2022 Octubre | 175 | 47 | 222 |
2022 Septiembre | 141 | 37 | 178 |
2022 Agosto | 95 | 38 | 133 |
2022 Julio | 89 | 75 | 164 |
2022 Junio | 101 | 53 | 154 |
2022 Mayo | 120 | 54 | 174 |
2022 Abril | 153 | 79 | 232 |
2022 Marzo | 134 | 85 | 219 |
2022 Febrero | 96 | 52 | 148 |
2022 Enero | 82 | 51 | 133 |
2021 Diciembre | 67 | 46 | 113 |
2021 Noviembre | 63 | 56 | 119 |
2021 Octubre | 79 | 81 | 160 |
2021 Septiembre | 63 | 47 | 110 |
2021 Agosto | 32 | 70 | 102 |
2021 Julio | 34 | 37 | 71 |
2021 Junio | 52 | 60 | 112 |
2021 Mayo | 65 | 80 | 145 |
2021 Abril | 127 | 120 | 247 |
2021 Marzo | 84 | 37 | 121 |
2021 Febrero | 66 | 32 | 98 |
2021 Enero | 41 | 25 | 66 |
2020 Diciembre | 40 | 27 | 67 |
2020 Noviembre | 52 | 26 | 78 |
2020 Octubre | 48 | 26 | 74 |
2020 Septiembre | 39 | 26 | 65 |
2020 Agosto | 31 | 22 | 53 |
2020 Julio | 29 | 40 | 69 |
2020 Junio | 62 | 22 | 84 |
2020 Mayo | 39 | 9 | 48 |
2020 Abril | 27 | 25 | 52 |
2020 Marzo | 19 | 13 | 32 |
2020 Enero | 4 | 0 | 4 |
2019 Septiembre | 4 | 0 | 4 |
2019 Junio | 1 | 0 | 1 |
2019 Marzo | 1 | 0 | 1 |
2019 Febrero | 1 | 0 | 1 |
2019 Enero | 8 | 0 | 8 |
2018 Diciembre | 3 | 0 | 3 |
2018 Mayo | 13 | 0 | 13 |
2018 Abril | 130 | 7 | 137 |
2018 Marzo | 111 | 8 | 119 |
2018 Febrero | 105 | 2 | 107 |
2018 Enero | 119 | 2 | 121 |
2017 Diciembre | 125 | 3 | 128 |
2017 Noviembre | 109 | 4 | 113 |
2017 Octubre | 90 | 15 | 105 |
2017 Septiembre | 123 | 12 | 135 |
2017 Agosto | 134 | 15 | 149 |
2017 Julio | 119 | 12 | 131 |
2017 Junio | 170 | 18 | 188 |
2017 Mayo | 180 | 23 | 203 |
2017 Abril | 148 | 18 | 166 |
2017 Marzo | 208 | 19 | 227 |
2017 Febrero | 198 | 13 | 211 |
2017 Enero | 139 | 12 | 151 |
2016 Diciembre | 158 | 19 | 177 |
2016 Noviembre | 212 | 11 | 223 |
2016 Octubre | 252 | 20 | 272 |
2016 Septiembre | 288 | 22 | 310 |
2016 Agosto | 332 | 19 | 351 |
2016 Julio | 130 | 19 | 149 |
2016 Marzo | 1 | 0 | 1 |
2016 Febrero | 1 | 0 | 1 |
2016 Enero | 2 | 0 | 2 |
2015 Diciembre | 2 | 0 | 2 |
2015 Noviembre | 1 | 22 | 23 |
2015 Octubre | 4 | 31 | 35 |
2015 Septiembre | 1 | 0 | 1 |
2015 Agosto | 0 | 23 | 23 |
2015 Julio | 136 | 9 | 145 |
2015 Junio | 195 | 9 | 204 |
2015 Mayo | 259 | 22 | 281 |
2015 Abril | 285 | 13 | 298 |
2015 Marzo | 315 | 12 | 327 |
2015 Febrero | 251 | 9 | 260 |
2015 Enero | 238 | 12 | 250 |
2014 Diciembre | 237 | 15 | 252 |
2014 Noviembre | 228 | 15 | 243 |
2014 Octubre | 219 | 15 | 234 |
2014 Septiembre | 184 | 14 | 198 |
2014 Agosto | 187 | 19 | 206 |
2014 Julio | 189 | 20 | 209 |
2014 Junio | 203 | 21 | 224 |
2014 Mayo | 235 | 16 | 251 |
2014 Abril | 207 | 17 | 224 |
2014 Marzo | 217 | 28 | 245 |
2014 Febrero | 205 | 21 | 226 |
2014 Enero | 207 | 22 | 229 |
2013 Diciembre | 163 | 17 | 180 |
2013 Noviembre | 186 | 18 | 204 |
2013 Octubre | 170 | 21 | 191 |
2013 Septiembre | 205 | 25 | 230 |
2013 Agosto | 150 | 22 | 172 |
2013 Julio | 141 | 10 | 151 |
2013 Junio | 134 | 24 | 158 |
2013 Mayo | 156 | 17 | 173 |
2013 Abril | 136 | 11 | 147 |
2013 Marzo | 144 | 22 | 166 |
2013 Febrero | 121 | 14 | 135 |
2013 Enero | 155 | 18 | 173 |
2012 Diciembre | 157 | 18 | 175 |
2012 Noviembre | 151 | 35 | 186 |
2012 Octubre | 169 | 19 | 188 |