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Vol. 15. Issue 3.
Pages 179-181 (May - June 2019)
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Vol. 15. Issue 3.
Pages 179-181 (May - June 2019)
Case Report
DOI: 10.1016/j.reumae.2017.03.011
Acute Tubulointerstitial Nephritis in an HLA-B27-positive Patient With Axial Spondyloarthritis Being Treated With Adalimumab
Nefritis túbulo-intersticial aguda en paciente con espondiloartritis axial HLA-B27 en tratamiento con adalimumab
David Castro Corredora,
Corresponding author

Corresponding author.
, María Dolores Sánchez de la Nietab, Isabel María de Lara Simónc
a Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
b Servicio de Nefrología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
c Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
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Antagonists of tumour necrosis factor-alpha (ATNF) are used for the treatment of multiple diseases such as psoriatic arthritis, Crohn's disease, ankylosing spondylitis and juvenile idiopathic arthritis, usually, when they are refractory to first-line treatment.1 The use of ATNF has been associated with the induction of autoimmune diseases such as systemic lupus erythematosus-like disease, vasculitis, sarcoidosis-like diseases and, recently, acute granulomatous tubulointerstitial nephritis. We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab.

Acute tubulointerstitial nephritis
Tumour necrosis factor-alpha antagonists
Crohn's disease

Los antagonistas del factor de necrosis tumoral-alfa (ATNF) se utilizan en el tratamiento de múltiples enfermedades, como artritis psoriásica, enfermedad de Crohn, espondilitis anquilosante, artritis idiopática juvenil, generalmente, cuando son refractarias al tratamiento de primera línea.1 La utilización de los ATNF se ha asociado con la inducción de enfermedades autoinmunes, como lupus eritematoso sistémico-like, vasculitis, sarcoidosis-like y, recientemente, nefritis túbulo-intersticial aguda granulomatosa. Describimos un caso de nefritis túbulo-intersticial aguda no granulomatosa en un paciente con espondiloartritis axial HLA-B27 positiva y enfermedad de Crohn en tratamiento con adalimumab.

Palabras clave:
Nefritis túbulo-intersticial aguda
Antagonistas del factor de necrosis tumoral-alfa
Enfermedad de Crohn


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