Publish in this journal
Journal Information
Vol. 17. Issue 5.
Pages 263-267 (May 2021)
Download PDF
More article options
Vol. 17. Issue 5.
Pages 263-267 (May 2021)
Original Article
DOI: 10.1016/j.reumae.2019.08.003
Asymptomatic hyperuricaemia and coronary artery disease
Hiperuricemia asintomática y enfermedad arterial coronaria
Tomás Miranda-Aquinoa,
Corresponding author

Corresponding author.
, Silvia Esmeralda Pérez-Topeteb, Christian González-Padillaa, Jorge Eduardo Hernández-del Ríoa, Óscar Sergio Lomelí-Sáncheza, Ramón Miguel Esturau-Santalóa, Sergio Ramón Gutiérrez-Ureñab, Verónica González-Díazb
a Cardiología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico
b Reumatología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico
Article information
Full Text
Download PDF
Figures (2)
Tables (3)
Table 1. General characteristics of the population.
Table 2. Angiographic lesions.
Table 3. Association of complex coronary lesions.
Show moreShow less

Uric acid has been related to a tendency to precipitate to form crystals, presenting asymptomatically, until the formation of arthritis, tophi or renal lithiasis. Previously, the presence of asymptomatic hyperuricaemia has been associated with the presence of cardiovascular disease.


To determine the association of complex coronary artery disease in patients with asymptomatic hyperuricaemia.

Material and methods

An observational retrospective, transversal, unicentric study was conducted in a tertiary hospital in Mexico, in the period from June 2017 to March 2019. All patients admitted for coronary angiography were included; patients with gout, use of diuretics and chronic kidney disease were excluded.


During the study period, a total of 300 patients were collected, of which 40% presented hyperuricaemia. The patients with hyperuricaemia were older (59 vs. 63, P=.002). The group of patients with asymptomatic hyperuricaemia had a higher proportion of complex coronary lesions (64 vs. 35%, P.0001) as well as a higher SYNTAX I score (27 vs. 17, P.001). There was a higher probability of presenting complex coronary lesions in this group of patients (OR 3.4, P.0001). In addition, in the group division of uric acid levels, it was related to the presence of complex coronary lesions (Q1=.5, P=.06), (Q2=2, P=.01) and (Q3=3, P.0001).


Asymptomatic hyperuricaemia has a higher prevalence and association of presenting complex coronary lesions.

Coronary artery disease
Coronary angiography
Cardiovascular disease

El ácido úrico se ha relacionado con la tendencia de precipitarse para formar cristales, que se presenta desde manera asintomática hasta con artritis, tofos o litiasis renal. Con anterioridad, se ha asociado la hiperuricemia asintomática a la presencia de enfermedad cardiovascular.


Determinar la asociación de enfermedad arterial coronaria compleja en pacientes con hiperuricemia asintomática.

Material y métodos

Se realizó estudio observacional, transversal, retrospectivo, unicéntrico. En un hospital de tercer nivel de México, en el periodo comprendido de junio del 2017 a marzo del 2019. Se incluyó a todos los pacientes que ingresaron para realizar angiografía coronaria; se excluyó a los pacientes con gota, uso de diuréticos y enfermedad renal crónica.


Durante el periodo del estudio se seleccionó a un total de 300 pacientes, de los cuales 40% presentaron hiperuricemia. Los pacientes con hiperuricemia eran de mayor edad (59 vs. 63; p=0,002). El grupo de pacientes con hiperuricemia asintomática tuvo mayor proporción de lesiones coronarias complejas (64 vs. 35%; p0,0001), así como también mayor puntuación del SYNTAX I score (27 vs. 17; p0,001). Hubo mayor probabilidad de presentar lesiones coronarias complejas en este grupo de pacientes (OR 3,4; p0,0001). Además, en la división por grupos de nivel de ácido úrico, se relacionaba con la presencia de lesiones coronarias complejas (Q1=0,5; p=0,06); (Q2=2; p=0,01) y (Q3=3; p0,0001).


La hiperuricemia asintomática tiene mayor prevalencia y asociación de presentar lesiones coronarias complejas.

Palabras clave:
Angiografía coronaria
Enfermedad arterial coronaria
Enfermedad cardiovascular


These are the options to access the full texts of the publication Reumatología Clínica (English Edition)
If you are member of Sociedad Española de Reumatología (SER) or the Colegio Mexicano de Reumatología (CMR):
Please go to the member area of SER or CMR and log in.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Reumatología Clínica (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?