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Vol. 17. Issue 2.
Pages 67-73 (February 2021)
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Vol. 17. Issue 2.
Pages 67-73 (February 2021)
Original Article
DOI: 10.1016/j.reumae.2019.02.008
Frequency of ANA/DFS70 in relatives of patients with rheumatoid arthritis compared to patients with rheumatoid arthritis and a healthy population, and its association with health status
Frecuencia de ANA/DFS70 en familiares de pacientes con artritis reumatoide comparados con pacientes con artritis reumatoide y población sana y su asociación con el estado de salud
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Verónica Romero-Álvareza,
Corresponding author
romeromaria@unbosque.edu.co

Corresponding author.
, Diana Alejandra Acero-Molinab, Adriana Beltrán-Ostosc, Juan Manuel Bello-Gualterosa, Consuelo Romero-Sánchezb
a Grupo de Inmunología Clínica, Servicio de Reumatología e Inmunología, Hospital Militar-Universidad Militar Nueva Granada, Bogotá, Colombia
b Servicio de Reumatología e Inmunología, Hospital Militar Central, Bogotá, Colombia
c Unidad de Investigación Científica, Subdirección de Docencia e Investigación Científica, Hospital Militar Central, Bogotá, Colombia
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Figures (4)
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Tables (4)
Table 1. Demographic characteristics of the study groups.
Table 2. Distribution of inflamed joints in the BR groups of patients with RA.
Table 3. Percentage distribution of dense fine speckled pattern by positive ANA-IIF in HEp-2 substrate by study groups.
Table 4. Percentage distribution of the dense fine speckled pattern by ANA-DFS70 in modifieda HEp-2 by study groups.
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Abstract
Introduction

DFS70 ANAs have attracted interest due to their frequency in individuals with no clinical evidence of systemic autoimmune rheumatic disease (SARD), groups with genetic risk for rheumatoid arthritis (RA) were not assessed.

Objective

To determine the frequency of ANA and DFS70 ANA in blood relatives (BR) of people with RA compared to patients with early RA (ERA), and control individuals, and its association with health status.

Methodology

A cross-sectional study with an analytical component. Sixty ERA patients, 60 BR and 120 control individuals paired by age and sex were studied. Hep2-ANA and DFS70 ANA were studied. The absolute and relative frequencies and associations were established using logistic regression models, with a significance level of 95%

Results

43% ANA in ERA, 30% in BR, and 25%-8% in control individuals 1:80. The fine dense granular pattern based on conventional Hep2 was found in 12%-9% of the positive samples, and 1.66% of the total samples. There was no detection of DFS70 ANAs in patients with ERA. In ERA there was an association between the presence of ANA and inflamed joints (P = .02), CRP (P = .01), DAS28CRP (P = .03) and HAQ (P = .04). There was an association between ANA and elevated CRP (P = .05) in the BR. In the control individuals, there was an association between ANA and painful joints (P = .02). In DFS70 ANA individuals we observed an association between a normal ESR P = .032, BR (-), P = .044 and absence of painful joints, p = .039

Conclusions

The frequency of DFS70 ANA in the groups studied was low, none of the patients with ERA was positive. The presence of DFS70 ANA was only confirmed in systemically healthy individuals.

Keywords:
Anticuerpos anti-DFS70
Anticuerpos antinucleares
Artritis reumatoide temprana
Patrón granular fino denso
Resumen
Introducción

Los ANA/DFS70 han atraído el interés por su frecuencia en individuos sin evidencia clínica de enfermedad reumática sistémica autoinmune (ERAS), no se han evaluado grupos de riesgo genético para artritis reumatoide (AR).

Objetivo

Determinar la frecuencia de ANA y ANA/DFS70 en familiares consanguíneos (FC) de AR comparada con pacientes con AR temprana (ARt) e individuos control y su asociación con el estado de salud.

Metodología

Estudio de corte transversal con componente analítico. Análisis de 60 pacientes ARt, 60 FC y 120 individuos control pareados por edad y sexo. Se analizaron ANA-HEp2 y ANA/DFS70. Establecieron las frecuencias absolutas y relativas y asociaciones con modelos de regresión logística, con un nivel de significancia del 95%.

Resultados

ANA de 43% en ARt, 30% en FC y 25,8% en individuos control a título 1:80. El patrón granular fino denso por Hep2 convencional se encontró en el 12,9% de las muestras positivas y el 1,66% del total de muestras. En ANA/DFS70 (+) en 1,66% en FC y 2,5% de individuos control, representando el 75% de la muestras positivas y el 1,25% del total de las muestras. No hubo detección de ANAS-DFS70 en pacientes con ARt. En ARt hubo asociación entre la presencia de ANA y articulaciones inflamadas (p = 0,02), PCR (p = 0,01), DAS28PCR (p = 0,03) y HAQ (p = 0,04). Asociación entre ANA y PCR elevada (p = 0,05) en FC. En individuos control entre ANA y articulaciones dolorosas (p = 0,02). En individuos ANA-DFS70 observamos asociación con VSG normal p = 0,032, FR(-), p = 0,044 y ausencia de articulaciones dolorosas, p = 0,039

Conclusiones

La frecuencia de ANA/DFS70 en los grupos estudiados fue baja, ninguno de los pacientes con ARt fue positivo. Se confirma la presencia de ANA/DFS70 solo en individuos sanos sistémicamente.

Palabras clave:
Artritis reumatoide temprana
Anticuerpos antinucleares
Anticuerpos antiDFS70
Patrón granular fino denso

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