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Vol. 15. Issue 2.
Pages 117-120 (March - April 2019)
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Vol. 15. Issue 2.
Pages 117-120 (March - April 2019)
Case Report
DOI: 10.1016/j.reumae.2017.02.004
Neuroimmunological Response in Neuro-Behçet's
Respuesta neuroinmunológica en neuro-Behçet
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Alexis Alejandro Garcia-Riveroa, Javier Gonzalez-Argotea,
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jargote@infomed.sld.cu

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, José Pedro Martínez Larrarteb, Ivonne Margarita Iglesias Gonzálezb, Alberto Juan Dorta-Contrerasb
a Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba
b Laboratorio Central del Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba
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Abstract

Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterised by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was diagnosed with Behçet's disease with neurological manifestations (neuro-Behçet's disease). She had a good response to treatment. IgG, IgA, IgM and albumin were quantified in serum and cerebrospinal fluid by single radial immunodiffusion. Intrathecal synthesis was found for the three classes of immunoglobulins. This is the first case in which the Reibergram was used to evaluate the neuroimmunological response in a patient with Behçet's disease, suggesting the use of this diagnostic means for the active phase of the disease.

Keywords:
Blood–cerebrospinal fluid barrier
Behçet's disease
Immunoglobulins
Neuro-Behçet's disease
Reibergram
Intrathecal synthesis
Resumen

La enfermedad de Behçet es una vasculitis crónica, multisistémica y autoinmune caracterizada por una tríada de signos claves presentes en los pacientes que la padecen. Se presenta una paciente femenina, caucásica, de 16 años, con cefalea, mareos y paresia en hemicuerpo izquierdo que, tras examen físico y métodos complementarios, se diagnosticó como enfermedad de Behçet con manifestaciones neurológicas (neurobehçet), y a la que se impuso tratamiento, con buena respuesta. Se cuantificó IgG, IgA, IgM y albúmina en suero y LCR, por inmunodifusión radial simple, encontrándose síntesis intratecal de las 3 clases de inmunoglobulinas mayores. Los hallazgos en este caso constituyen el primer estudio donde se utiliza el reibergrama para evaluar la respuesta neuroinmunológica en un paciente con enfermedad de Behçet, siendo indicativo este medio diagnóstico de fase activa de la enfermedad.

Palabras clave:
Barrera sangre-líquido cefalorraquídeo
Enfermedad de Behçet
Inmunoglobulinas
Neurobeçhet
Reibergrama
Síntesis intratecal

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