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Vol. 17. Issue 8.
Pages 437-439 (October 2021)
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Vol. 17. Issue 8.
Pages 437-439 (October 2021)
Brief Report
DOI: 10.1016/j.reumae.2020.06.003
Psoriasis induced by biological therapy
Psoriasis inducida por terapia biológica
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Lydia Montolio Chivaa,
Corresponding author
lydiamontolio@gmail.com

Corresponding author.
, Àngels Martínez Ferrera, Almudena Mateu Puchadesb, Cristina Campos Fernándezc, Javier Narváez Garciad, Juan José Alegre Sanchoa
a Servicio de Reumatología, Hospital Universitario Doctor Peset, Valencia, Spain
b Servicio de Dermatología, Hospital Universitario Doctor Peset, Valencia, Spain
c Servicio de Reumatología y Metabolismo Óseo, Consorcio Hospital General Universitario, Valencia, Spain
d Servicio de Reumatología, Hospital Universitario de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
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Abstract
Objective

To describe a multicentre case series of new onset or worsening of psoriasis in patients treated with biological drugs.

Material and methods

Descriptive study. We reviewed the clinical history of patients with chronic inflammatory disease (CID) treated with biological drugs, who developed new onset or worsening of psoriasis during the follow-up period.

Results

Twenty-six cases of paradoxical psoriasis (PP) were recorded. Ninety-three percent of the patients were treated with anti-TNFα and adalimumab was responsible for 50% of the cases. Only 5 patients had a personal history of psoriasis. The biological drug was discontinued in 13 patients. Lesion recurrence was more frequent when another anti-TNFα was reintroduced.

Conclusions

The PP is a reversible adverse effect that can be observed in patients exposed to biological drugs, mainly anti-TNFα.

Keywords:
Chronic inflammatory disease
Biological drugs
Paradoxical psoriasis
Resumen
Objetivo

Describir una serie multicéntrica de casos de inducción o empeoramiento de psoriasis en pacientes tratados con fármacos biológicos.

Material y métodos

Estudio descriptivo. Se revisó la historia clínica de pacientes con enfermedad inflamatoria crónica (EIC) en tratamiento con fármacos biológicos, y que presentaron durante el período de seguimiento, psoriasis de nueva aparición o empeoramiento de la misma.

Resultados

Se registraron 26 casos de psoriasis paradójica (PP). El 93% de los pacientes estaban en tratamiento con un anti-TNFα, siendo el adalimumab el responsable del 50% de los casos. Solo 5 pacientes presentaban antecedentes personales de psoriasis. En 13 pacientes fue necesario retirar el fármaco biológico y la recidiva de las lesiones fue más frecuente en los pacientes en los que se reintrodujo otro anti-TNFα.

Conclusiones

La PP es un efecto adverso reversible que se puede observar en pacientes expuestos a fármacos biológicos, principalmente a anti-TNFα.

Palabras clave:
Enfermedad inflamatoria crónica
Fármacos biológicos
Psoriasis paradójica

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